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The map label for this gene is dnaX [H]

Identifier: 84622621

GI number: 84622621

Start: 1053363

End: 1055459

Strand: Direct

Name: dnaX [H]

Synonym: XOO_0964

Alternate gene names: 84622621

Gene position: 1053363-1055459 (Clockwise)

Preceding gene: 84622620

Following gene: 84622622

Centisome position: 21.32

GC content: 66.67

Gene sequence:

>2097_bases
ATGTCCTATCTCGTTCTCGCCCGCAAGTGGCGCCCGAAGCGTTTTGCCGAACTCGTAGGCCAGGAACACGTGGTCCGCGC
GCTCAGTAACGCGCTCGACAGTGGGCGCGTGCATCACGCGTTCCTGTTCACCGGCACCCGCGGCGTGGGCAAGACCACCA
TTGCGCGCATCTTCGCCAAGTCGCTCAACTGCGAGACCGGTACAAGTGCCGACCCATGCGGCCAGTGCCCGGCCTGCCTG
GACATCGACGCCGGTCGTTACATCGACCTGCTGGAGATCGATGCCGCGTCCAACACCGGCGTGGACGATGTGCGCGAGGT
GATCGAGAACGCGCAGTACATGCCCTCGCGCGGCAAGTTCAAGGTTTACCTGATCGACGAAGTGCACATGCTGTCCAAGG
CGGCGTTCAATGCGCTGCTCAAGACGCTGGAAGAGCCGCCGGAGCACGTGAAGTTCCTGCTGGCTACCACCGACCCGCAG
AAATTGCCGGTGACGGTGCTGTCGCGCTGCTTGCAGTTCAACCTCAAGCGGCTGGACGAGGACCAGATTCAGGGCCAGAT
GACCCGCATCCTGGCCGCCGAGCAGATCGAATCGGATCTGTCGGCGATTGTGCAGCTGTCCAAGGCAGCCGACGGCTCGT
TGCGCGATGGCCTGTCGCTGCTGGATCAGGCGATCGCCTATGCCGGCGGCGCGCTGCGCGAGGACGTGGTGCGCACCATG
TTGGGCACGGTCGATCGCACCCAGGTCGGCGCGATGCTGCAATCGCTGGCCGATGGCGATGGCGCGCGCCTGATGCAGGT
CGTGGCCGCGCTGGCTGAGTTTTCGCCCGATTGGAGCGGGGTGTTGGAGGCCCTGGCCGAGGCGTTGCATCGCGTGCAGG
TGCAGCAGCTGGTGCCGTCGGTGGCCTTTGTTGGCGACGGCATCGACCCGACTCCTTTTGCGGCGCAGTTGCGGCCGGAA
GTGGTGCAGCTGTGGTACCAGATGGCGCTCAACGGGCGTCGTGATCTGTATCTGGCGCCCAGTCCGCGCGCTGGCTTCGA
GATGGCAGTGCTGCGCATGCTCGCCTTCCGCCCCGCTGCGGCGGTGCCGGCTGGCGGCTCGGACGACGGACGCGGCACCA
CGGCGGGCGGTGGTGCGCGTTCTGCCGCTGCCGGCGGTCAGGCTGCTGCGCCGGCACTGGCAGCGCCGGTGACAGCTGCG
CCCCCCATGGTGGCCGCGACTGCTGCGGTGACGGATACGATGCCTGTGGCGGCGGCGGAGGCGTCCCTGCCGGCATCCGC
GACCCAGGCAACTCCGACTCCGGCCGCAGCTCCGGCGCCGGCTCCCGTTGTCATGCTTCCTCCCCAAGAATCTTCTTCGC
CCAGTCGCGCGTCTGCAGCCAGCGCGCGCATTGACGACACGCCGCCGTGGGCAGTGGACGATGCGCCGGTGCGCACGCAG
GCCACAACTGCGTCCGACACGATGGCCGTGCTTGCGCCTGAAGCCGCGATGGCTTCGCCGTCGTCCGCACCCGTCGAGCT
CGCACAACCCGTTGCGATCGCGTCCGACGCCGCAGAGGACGCTCCGGTTTCGGTTGCAACATCTTCGCCGGCCGCGCTTG
TCGAGCCCTCATCGTTTGCAGAGCCAGCAGTGGTCACGCCACCAGCAACGGCAGTATCCGCAGCAGACTCAGCAGCCGAT
GCATCGGCTTTGCTCGACGACGGCTGTATCGCCGATGCCGAGCAATGGCTGGAGCTGGTCACGCGCAGTGGCTTGAATGG
ACCGTCGCGGCAGCTGGCCGCCAACGCCGCGTTTATCGGTCATCGCGATGGCGTGCTGCGGCTGGCGCTGGCGCCGGGTT
TTGAATATCTCCATTCCGAGCGCTCCATCGCCAACCTCGCGCAGGCGTTGGCACCGGTGTTGGGAAACACGCCGCGCATC
GTCATCGAAACCGGTAGCGCCGATGTCGAAACCTTGCACGAGCGTGCCAACCGCCAGAAAGGCGAGCGCCAGAGCGCGGC
CGAAACAGCCTTTATGAACGACCCGACGGTGCAGCTGCTGATCCAGCAGCAAGGCGCGCGGATCGTCCCCGATTCCATCC
GCCCTTACGACGAGTAA

Upstream 100 bases:

>100_bases
GTCTAGCCGTCGCCGGCCCGTACCACAAGCTGAATCTTCCAGCCGCAGCCGTTGAGACCGGGCGTGGCACAATATCGGCT
CAAACAGAGCCGGTTGCCCG

Downstream 100 bases:

>100_bases
CGCCCCATGCGTGGAAACATTGCCCAACTGATGCAGCAGGCGCAGAAGATGCAGGAAAACCTGCAGCGCGCCCAGGAAGA
ACTGGCCAAGCTGGAAGTCA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 698; Mature: 697

Protein sequence:

>698_residues
MSYLVLARKWRPKRFAELVGQEHVVRALSNALDSGRVHHAFLFTGTRGVGKTTIARIFAKSLNCETGTSADPCGQCPACL
DIDAGRYIDLLEIDAASNTGVDDVREVIENAQYMPSRGKFKVYLIDEVHMLSKAAFNALLKTLEEPPEHVKFLLATTDPQ
KLPVTVLSRCLQFNLKRLDEDQIQGQMTRILAAEQIESDLSAIVQLSKAADGSLRDGLSLLDQAIAYAGGALREDVVRTM
LGTVDRTQVGAMLQSLADGDGARLMQVVAALAEFSPDWSGVLEALAEALHRVQVQQLVPSVAFVGDGIDPTPFAAQLRPE
VVQLWYQMALNGRRDLYLAPSPRAGFEMAVLRMLAFRPAAAVPAGGSDDGRGTTAGGGARSAAAGGQAAAPALAAPVTAA
PPMVAATAAVTDTMPVAAAEASLPASATQATPTPAAAPAPAPVVMLPPQESSSPSRASAASARIDDTPPWAVDDAPVRTQ
ATTASDTMAVLAPEAAMASPSSAPVELAQPVAIASDAAEDAPVSVATSSPAALVEPSSFAEPAVVTPPATAVSAADSAAD
ASALLDDGCIADAEQWLELVTRSGLNGPSRQLAANAAFIGHRDGVLRLALAPGFEYLHSERSIANLAQALAPVLGNTPRI
VIETGSADVETLHERANRQKGERQSAAETAFMNDPTVQLLIQQQGARIVPDSIRPYDE

Sequences:

>Translated_698_residues
MSYLVLARKWRPKRFAELVGQEHVVRALSNALDSGRVHHAFLFTGTRGVGKTTIARIFAKSLNCETGTSADPCGQCPACL
DIDAGRYIDLLEIDAASNTGVDDVREVIENAQYMPSRGKFKVYLIDEVHMLSKAAFNALLKTLEEPPEHVKFLLATTDPQ
KLPVTVLSRCLQFNLKRLDEDQIQGQMTRILAAEQIESDLSAIVQLSKAADGSLRDGLSLLDQAIAYAGGALREDVVRTM
LGTVDRTQVGAMLQSLADGDGARLMQVVAALAEFSPDWSGVLEALAEALHRVQVQQLVPSVAFVGDGIDPTPFAAQLRPE
VVQLWYQMALNGRRDLYLAPSPRAGFEMAVLRMLAFRPAAAVPAGGSDDGRGTTAGGGARSAAAGGQAAAPALAAPVTAA
PPMVAATAAVTDTMPVAAAEASLPASATQATPTPAAAPAPAPVVMLPPQESSSPSRASAASARIDDTPPWAVDDAPVRTQ
ATTASDTMAVLAPEAAMASPSSAPVELAQPVAIASDAAEDAPVSVATSSPAALVEPSSFAEPAVVTPPATAVSAADSAAD
ASALLDDGCIADAEQWLELVTRSGLNGPSRQLAANAAFIGHRDGVLRLALAPGFEYLHSERSIANLAQALAPVLGNTPRI
VIETGSADVETLHERANRQKGERQSAAETAFMNDPTVQLLIQQQGARIVPDSIRPYDE
>Mature_697_residues
SYLVLARKWRPKRFAELVGQEHVVRALSNALDSGRVHHAFLFTGTRGVGKTTIARIFAKSLNCETGTSADPCGQCPACLD
IDAGRYIDLLEIDAASNTGVDDVREVIENAQYMPSRGKFKVYLIDEVHMLSKAAFNALLKTLEEPPEHVKFLLATTDPQK
LPVTVLSRCLQFNLKRLDEDQIQGQMTRILAAEQIESDLSAIVQLSKAADGSLRDGLSLLDQAIAYAGGALREDVVRTML
GTVDRTQVGAMLQSLADGDGARLMQVVAALAEFSPDWSGVLEALAEALHRVQVQQLVPSVAFVGDGIDPTPFAAQLRPEV
VQLWYQMALNGRRDLYLAPSPRAGFEMAVLRMLAFRPAAAVPAGGSDDGRGTTAGGGARSAAAGGQAAAPALAAPVTAAP
PMVAATAAVTDTMPVAAAEASLPASATQATPTPAAAPAPAPVVMLPPQESSSPSRASAASARIDDTPPWAVDDAPVRTQA
TTASDTMAVLAPEAAMASPSSAPVELAQPVAIASDAAEDAPVSVATSSPAALVEPSSFAEPAVVTPPATAVSAADSAADA
SALLDDGCIADAEQWLELVTRSGLNGPSRQLAANAAFIGHRDGVLRLALAPGFEYLHSERSIANLAQALAPVLGNTPRIV
IETGSADVETLHERANRQKGERQSAAETAFMNDPTVQLLIQQQGARIVPDSIRPYDE

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=298, Percent_Identity=25.8389261744966, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI31881687, Length=298, Percent_Identity=25.8389261744966, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI6677723, Length=258, Percent_Identity=24.031007751938, Blast_Score=66, Evalue=1e-10,
Organism=Escherichia coli, GI1786676, Length=370, Percent_Identity=53.7837837837838, Blast_Score=409, Evalue=1e-115,
Organism=Escherichia coli, GI1787341, Length=146, Percent_Identity=37.6712328767123, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1787119, Length=191, Percent_Identity=27.7486910994764, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71986063, Length=273, Percent_Identity=23.0769230769231, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324039, Length=259, Percent_Identity=24.7104247104247, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322528, Length=303, Percent_Identity=24.0924092409241, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324478, Length=227, Percent_Identity=24.6696035242291, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI18859927, Length=295, Percent_Identity=24.0677966101695, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17647857, Length=284, Percent_Identity=26.056338028169, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 72887; Mature: 72756

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00018 EF_HAND_1 ; PS00136 SUBTILASE_ASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYLVLARKWRPKRFAELVGQEHVVRALSNALDSGRVHHAFLFTGTRGVGKTTIARIFAK
CCEEEEECCCCHHHHHHHHCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHH
SLNCETGTSADPCGQCPACLDIDAGRYIDLLEIDAASNTGVDDVREVIENAQYMPSRGKF
HCCCCCCCCCCCCCCCCCEEECCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCE
KVYLIDEVHMLSKAAFNALLKTLEEPPEHVKFLLATTDPQKLPVTVLSRCLQFNLKRLDE
EEEEEHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHCCH
DQIQGQMTRILAAEQIESDLSAIVQLSKAADGSLRDGLSLLDQAIAYAGGALREDVVRTM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
LGTVDRTQVGAMLQSLADGDGARLMQVVAALAEFSPDWSGVLEALAEALHRVQVQQLVPS
HCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
VAFVGDGIDPTPFAAQLRPEVVQLWYQMALNGRRDLYLAPSPRAGFEMAVLRMLAFRPAA
HHHHCCCCCCCCCHHHHCHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHCCCC
AVPAGGSDDGRGTTAGGGARSAAAGGQAAAPALAAPVTAAPPMVAATAAVTDTMPVAAAE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHCCCCHHHHH
ASLPASATQATPTPAAAPAPAPVVMLPPQESSSPSRASAASARIDDTPPWAVDDAPVRTQ
CCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCC
ATTASDTMAVLAPEAAMASPSSAPVELAQPVAIASDAAEDAPVSVATSSPAALVEPSSFA
CCCCCCCEEEEECHHHHCCCCCCCHHHHCCHHHHCCCCCCCCEEEECCCCCEEECCCCCC
EPAVVTPPATAVSAADSAADASALLDDGCIADAEQWLELVTRSGLNGPSRQLAANAAFIG
CCCEECCCCHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHEEE
HRDGVLRLALAPGFEYLHSERSIANLAQALAPVLGNTPRIVIETGSADVETLHERANRQK
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHC
GERQSAAETAFMNDPTVQLLIQQQGARIVPDSIRPYDE
CHHHHHHHHHHCCCCHHEEEEECCCCEECCCCCCCCCC
>Mature Secondary Structure 
SYLVLARKWRPKRFAELVGQEHVVRALSNALDSGRVHHAFLFTGTRGVGKTTIARIFAK
CEEEEECCCCHHHHHHHHCHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHH
SLNCETGTSADPCGQCPACLDIDAGRYIDLLEIDAASNTGVDDVREVIENAQYMPSRGKF
HCCCCCCCCCCCCCCCCCEEECCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCE
KVYLIDEVHMLSKAAFNALLKTLEEPPEHVKFLLATTDPQKLPVTVLSRCLQFNLKRLDE
EEEEEHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEECCCCCCCHHHHHHHHHHHHHHCCH
DQIQGQMTRILAAEQIESDLSAIVQLSKAADGSLRDGLSLLDQAIAYAGGALREDVVRTM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
LGTVDRTQVGAMLQSLADGDGARLMQVVAALAEFSPDWSGVLEALAEALHRVQVQQLVPS
HCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
VAFVGDGIDPTPFAAQLRPEVVQLWYQMALNGRRDLYLAPSPRAGFEMAVLRMLAFRPAA
HHHHCCCCCCCCCHHHHCHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHCCCC
AVPAGGSDDGRGTTAGGGARSAAAGGQAAAPALAAPVTAAPPMVAATAAVTDTMPVAAAE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHCCCCHHHHH
ASLPASATQATPTPAAAPAPAPVVMLPPQESSSPSRASAASARIDDTPPWAVDDAPVRTQ
CCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCC
ATTASDTMAVLAPEAAMASPSSAPVELAQPVAIASDAAEDAPVSVATSSPAALVEPSSFA
CCCCCCCEEEEECHHHHCCCCCCCHHHHCCHHHHCCCCCCCCEEEECCCCCEEECCCCCC
EPAVVTPPATAVSAADSAADASALLDDGCIADAEQWLELVTRSGLNGPSRQLAANAAFIG
CCCEECCCCHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHEEE
HRDGVLRLALAPGFEYLHSERSIANLAQALAPVLGNTPRIVIETGSADVETLHERANRQK
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHC
GERQSAAETAFMNDPTVQLLIQQQGARIVPDSIRPYDE
CHHHHHHHHHHCCCCHHEEEEECCCCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]