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The map label for this gene is lon

Identifier: 84622591

GI number: 84622591

Start: 1019066

End: 1021429

Strand: Direct

Name: lon

Synonym: XOO_0934

Alternate gene names: 84622591

Gene position: 1019066-1021429 (Clockwise)

Preceding gene: 84622590

Following gene: 84622592

Centisome position: 20.63

GC content: 62.56

Gene sequence:

>2364_bases
ATGCGCGCGCTGGAGAAAGCCATGGAGGCGGACAAGCGCATCCTGCTGGTAGCGCAGAAGTCGGCCGAAACCGATGACCC
GGCTGCCGTCGATCTGCACACCGTCGGCACCCTGGCGCAGGTGCTGCAACTGCTCAAGCTCCCGGATGGCACCATCAAGG
TGTTGGTCGAAGGCTTGTCGCGGGTCACCGTCGACAAGGTCGTCGAGCAGGACGGCGCGTTGCAAGGGCAGGGCACGGAA
GTGGAGGCCAGTGATGCGCGCGAACCGCGCGAAGTGGAGGCGATCGCGCGTTCGCTGATGTCGCTGTTCGAACAGTACGT
CAAGACCAACCGCAAGTTGCCGCCGGAGCTGCTGCAGACCCTGGCCGGCATCGACGAGCCGGGTCGCCTGGCCGACACCA
TTGCCCCGCACATCGGTGTGCGTCTGGCTGACAAGCAGCGCCTGCTGGAAATTACCGACATCGGTGAGCGGCTGGAGTTG
CTGGTGGGGCTGGTCGACGGCGAAATCGATGTGCAGCAGCTGGAAAAGCGCATCCGCGGCCGCGTGAAGTCGCAGATGGA
AAAGAGCCAGCGCGAGTACTACCTCAACGAGCAGATGAAGGCGATCCAGAAGGAGCTGGGCGATCTGGACGACGTGCCCG
GCGAGCTGGAAGAACTCGCGCGCAAGATCGCTGAGGCGGGCATGCCCAAGCCGGTCGAAACCAAGGCCAAGGCCGAGCTC
AACAAACTCAAGCAGATGTCGCCGATGTCCGCCGAAGCGGCGGTGGTACGCAACTATCTGGACTGGCTGCTGGGCGTGCC
GTGGAAGAAGCGCACCAAGGTCCGCAAGGATCTGAAGGTGGCCGAAGACACGCTGGACGCCGATCACTACGGTCTGGACA
AGGTCAAGGAGCGCATCCTTGAGTACTTGGCCGTGCAGTCGCGCGTGAAGCAGATGAAGGGGCCGATCCTGTGCTTGGTC
GGGCCGCCGGGCGTGGGCAAGACCTCGCTTGGGCAGTCGATCGCCAAGGCGACCAACCGCAAGTTTGTGCGCATGAGTCT
GGGCGGCATCCGTGACGAGGCCGAAATTCGTGGCCACCGCCGGACCTACGTCGGCTCGATGCCCGGGCGTCTGGTGCAGA
ACCTCAACAAGGTCGGCAGCAAGAACCCGCTGTTCCTGCTGGACGAAATCGACAAGATGTCGATGGACTTCCGTGGCGAC
CCTTCGTCGGCGCTGCTGGAGGTGCTCGATCCCGAGCAGAACAACTCCTTCAACGATCACTATCTGGAGGTCGATCTGGA
CCTGTCGGAGGTGATGTTCGTCGCCACCTCCAACTCGCTCAACATTCCGGGCCCGCTGCTGGACCGCATGGAAGTCATCC
GCATCCCCGGCTACACCGAGGATGAAAAGCTCAACATCGCGATGCGCTACCTGGTGCCCAAGCAGATCAAGGCCAACGGC
TTGAAGCCGGAAGAGATCGAGATCGGCGGCGACGCCATCCAGGACATCGTGCGGTATTACACGCGCGAGTCGGGTGTGCG
TAATCTCGAACGCGAAGTCGCCAAGATCTGCCGCAAGGTGGTCAAGGAAATCGCGCTCGCCGGTCCGCAGCCGGCCGCCA
AGAAAGCGGTGGCCAAGAAGGGAAAGCCGAAGGCGCTGGTGACCGTCAACGCGAAGAATCTCGACAAATATCTGGGTGTG
CGTCGCTTCGATTTCGGTCGTGCCGAAGAAGAAAACGAGATCGGCCTAGTCACCGGTCTGGCATGGACCGAGGTTGGTGG
CGAACTGCTGCAGGTCGAGTCCACGCTGGTGCCGGGCAAGGGCAATCTGATCCTCACCGGCCAGCTTGGCAACGTCATGA
AGGAATCGGCATCGGCTGCGTTGTCGGTGGTCCGTTCGCGCGCCGAGCGACTTGGCATTGATGTGGATTTTCTGCAGAAG
CAGGACGTGCACGTGCATGTGCCCGATGGCGCAACACCGAAGGACGGCCCAAGCGCCGGTATCGCGATGGTGACCTCGCT
GGTGTCGGTGTTGACCAAGGTACCGATCCGAGCGGATGTGGCGATGACCGGCGAAATCACCTTGCGTGGTCGCGTCTCGG
CGATTGGCGGCCTGAAGGAGAAGTTGCTGGCGGCCCTGCGCGGCGGTATCCGCACCGTGCTGATTCCTGGCGAGAACCGC
AAGGATCTTGCCGACATCCCAGCCAACGTCACCCGCGATCTGAAGATCGTGCCGGTGAAGTGGATCGACGAAGTGCTCGA
TCTGGCATTGGAGCGTCCGCTGACGCCGAAGAAGGCCGGCAAGGAAAAAGCACGCAAGACAGCCCCGCGCGTCGCCGTGC
GCGGCAAGTCGCGTAGTACACCCGGTACCCGCGTCAAGCACTAA

Upstream 100 bases:

>100_bases
AGTCCCAACCCGAAGTTCTCGATCTGCCAGTGTTGCCGCTGCGCGACGTGGTGGTGTTTCCGCACATGGTGATCCCGCTG
TTCGTCGCCGTGACAAGTCG

Downstream 100 bases:

>100_bases
CGGGGGCTGTCTAGGCTCTCGCAAAACAAGCCAAAACCCGCGTCGTTATTGGGTTTCGGCTTGCGTGCAGTTGGGGGCGC
TGGTATAACTGCACGATTCG

Product: ATP-dependent serine proteinase La

Products: NA

Alternate protein names: ATP-dependent protease La

Number of amino acids: Translated: 787; Mature: 787

Protein sequence:

>787_residues
MRALEKAMEADKRILLVAQKSAETDDPAAVDLHTVGTLAQVLQLLKLPDGTIKVLVEGLSRVTVDKVVEQDGALQGQGTE
VEASDAREPREVEAIARSLMSLFEQYVKTNRKLPPELLQTLAGIDEPGRLADTIAPHIGVRLADKQRLLEITDIGERLEL
LVGLVDGEIDVQQLEKRIRGRVKSQMEKSQREYYLNEQMKAIQKELGDLDDVPGELEELARKIAEAGMPKPVETKAKAEL
NKLKQMSPMSAEAAVVRNYLDWLLGVPWKKRTKVRKDLKVAEDTLDADHYGLDKVKERILEYLAVQSRVKQMKGPILCLV
GPPGVGKTSLGQSIAKATNRKFVRMSLGGIRDEAEIRGHRRTYVGSMPGRLVQNLNKVGSKNPLFLLDEIDKMSMDFRGD
PSSALLEVLDPEQNNSFNDHYLEVDLDLSEVMFVATSNSLNIPGPLLDRMEVIRIPGYTEDEKLNIAMRYLVPKQIKANG
LKPEEIEIGGDAIQDIVRYYTRESGVRNLEREVAKICRKVVKEIALAGPQPAAKKAVAKKGKPKALVTVNAKNLDKYLGV
RRFDFGRAEEENEIGLVTGLAWTEVGGELLQVESTLVPGKGNLILTGQLGNVMKESASAALSVVRSRAERLGIDVDFLQK
QDVHVHVPDGATPKDGPSAGIAMVTSLVSVLTKVPIRADVAMTGEITLRGRVSAIGGLKEKLLAALRGGIRTVLIPGENR
KDLADIPANVTRDLKIVPVKWIDEVLDLALERPLTPKKAGKEKARKTAPRVAVRGKSRSTPGTRVKH

Sequences:

>Translated_787_residues
MRALEKAMEADKRILLVAQKSAETDDPAAVDLHTVGTLAQVLQLLKLPDGTIKVLVEGLSRVTVDKVVEQDGALQGQGTE
VEASDAREPREVEAIARSLMSLFEQYVKTNRKLPPELLQTLAGIDEPGRLADTIAPHIGVRLADKQRLLEITDIGERLEL
LVGLVDGEIDVQQLEKRIRGRVKSQMEKSQREYYLNEQMKAIQKELGDLDDVPGELEELARKIAEAGMPKPVETKAKAEL
NKLKQMSPMSAEAAVVRNYLDWLLGVPWKKRTKVRKDLKVAEDTLDADHYGLDKVKERILEYLAVQSRVKQMKGPILCLV
GPPGVGKTSLGQSIAKATNRKFVRMSLGGIRDEAEIRGHRRTYVGSMPGRLVQNLNKVGSKNPLFLLDEIDKMSMDFRGD
PSSALLEVLDPEQNNSFNDHYLEVDLDLSEVMFVATSNSLNIPGPLLDRMEVIRIPGYTEDEKLNIAMRYLVPKQIKANG
LKPEEIEIGGDAIQDIVRYYTRESGVRNLEREVAKICRKVVKEIALAGPQPAAKKAVAKKGKPKALVTVNAKNLDKYLGV
RRFDFGRAEEENEIGLVTGLAWTEVGGELLQVESTLVPGKGNLILTGQLGNVMKESASAALSVVRSRAERLGIDVDFLQK
QDVHVHVPDGATPKDGPSAGIAMVTSLVSVLTKVPIRADVAMTGEITLRGRVSAIGGLKEKLLAALRGGIRTVLIPGENR
KDLADIPANVTRDLKIVPVKWIDEVLDLALERPLTPKKAGKEKARKTAPRVAVRGKSRSTPGTRVKH
>Mature_787_residues
MRALEKAMEADKRILLVAQKSAETDDPAAVDLHTVGTLAQVLQLLKLPDGTIKVLVEGLSRVTVDKVVEQDGALQGQGTE
VEASDAREPREVEAIARSLMSLFEQYVKTNRKLPPELLQTLAGIDEPGRLADTIAPHIGVRLADKQRLLEITDIGERLEL
LVGLVDGEIDVQQLEKRIRGRVKSQMEKSQREYYLNEQMKAIQKELGDLDDVPGELEELARKIAEAGMPKPVETKAKAEL
NKLKQMSPMSAEAAVVRNYLDWLLGVPWKKRTKVRKDLKVAEDTLDADHYGLDKVKERILEYLAVQSRVKQMKGPILCLV
GPPGVGKTSLGQSIAKATNRKFVRMSLGGIRDEAEIRGHRRTYVGSMPGRLVQNLNKVGSKNPLFLLDEIDKMSMDFRGD
PSSALLEVLDPEQNNSFNDHYLEVDLDLSEVMFVATSNSLNIPGPLLDRMEVIRIPGYTEDEKLNIAMRYLVPKQIKANG
LKPEEIEIGGDAIQDIVRYYTRESGVRNLEREVAKICRKVVKEIALAGPQPAAKKAVAKKGKPKALVTVNAKNLDKYLGV
RRFDFGRAEEENEIGLVTGLAWTEVGGELLQVESTLVPGKGNLILTGQLGNVMKESASAALSVVRSRAERLGIDVDFLQK
QDVHVHVPDGATPKDGPSAGIAMVTSLVSVLTKVPIRADVAMTGEITLRGRVSAIGGLKEKLLAALRGGIRTVLIPGENR
KDLADIPANVTRDLKIVPVKWIDEVLDLALERPLTPKKAGKEKARKTAPRVAVRGKSRSTPGTRVKH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI31377667, Length=787, Percent_Identity=39.5171537484117, Blast_Score=529, Evalue=1e-150,
Organism=Homo sapiens, GI21396489, Length=681, Percent_Identity=41.4096916299559, Blast_Score=511, Evalue=1e-145,
Organism=Escherichia coli, GI1786643, Length=751, Percent_Identity=65.5126498002663, Blast_Score=989, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=655, Percent_Identity=41.2213740458015, Blast_Score=498, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17556486, Length=546, Percent_Identity=39.010989010989, Blast_Score=410, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6319449, Length=721, Percent_Identity=40.6380027739251, Blast_Score=513, Evalue=1e-146,
Organism=Drosophila melanogaster, GI221513036, Length=692, Percent_Identity=42.0520231213873, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24666867, Length=692, Percent_Identity=42.0520231213873, Blast_Score=525, Evalue=1e-149,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON_XANOR (Q5H432)

Other databases:

- EMBL:   AE013598
- RefSeq:   YP_199674.1
- ProteinModelPortal:   Q5H432
- MEROPS:   S16.001
- GeneID:   3264921
- GenomeReviews:   AE013598_GR
- KEGG:   xoo:XOO1035
- NMPDR:   fig|291331.3.peg.1035
- HOGENOM:   HBG566281
- OMA:   HTFQDHY
- ProtClustDB:   CLSK497099
- BioCyc:   XORY291331:XOO1035-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- SMART:   SM00464
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 86541; Mature: 86541

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 721-721 ACT_SITE 764-764

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALEKAMEADKRILLVAQKSAETDDPAAVDLHTVGTLAQVLQLLKLPDGTIKVLVEGLS
CCHHHHHHHCCCEEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
RVTVDKVVEQDGALQGQGTEVEASDAREPREVEAIARSLMSLFEQYVKTNRKLPPELLQT
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LAGIDEPGRLADTIAPHIGVRLADKQRLLEITDIGERLELLVGLVDGEIDVQQLEKRIRG
HHCCCCCCHHHHHHHHHHCEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
RVKSQMEKSQREYYLNEQMKAIQKELGDLDDVPGELEELARKIAEAGMPKPVETKAKAEL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHH
NKLKQMSPMSAEAAVVRNYLDWLLGVPWKKRTKVRKDLKVAEDTLDADHYGLDKVKERIL
HHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
EYLAVQSRVKQMKGPILCLVGPPGVGKTSLGQSIAKATNRKFVRMSLGGIRDEAEIRGHR
HHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCEEEEEHHCCCCCHHHHCCCH
RTYVGSMPGRLVQNLNKVGSKNPLFLLDEIDKMSMDFRGDPSSALLEVLDPEQNNSFNDH
HHHCCCCHHHHHHHHHHHCCCCCEEEEECHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCC
YLEVDLDLSEVMFVATSNSLNIPGPLLDRMEVIRIPGYTEDEKLNIAMRYLVPKQIKANG
EEEEECCHHHEEEEEECCCCCCCCHHHCCHHEEECCCCCCCCHHHHHHHHHCCHHHHCCC
LKPEEIEIGGDAIQDIVRYYTRESGVRNLEREVAKICRKVVKEIALAGPQPAAKKAVAKK
CCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
GKPKALVTVNAKNLDKYLGVRRFDFGRAEEENEIGLVTGLAWTEVGGELLQVESTLVPGK
CCCCEEEEEEHHHHHHHHCCHHCCCCCCCCCCCCEEEECCHHHHHCCHHEEEHHHCCCCC
GNLILTGQLGNVMKESASAALSVVRSRAERLGIDVDFLQKQDVHVHVPDGATPKDGPSAG
CCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCEEECCCCCCCCCCCCHH
IAMVTSLVSVLTKVPIRADVAMTGEITLRGRVSAIGGLKEKLLAALRGGIRTVLIPGENR
HHHHHHHHHHHHHCCCEECEEEECEEEEEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
KDLADIPANVTRDLKIVPVKWIDEVLDLALERPLTPKKAGKEKARKTAPRVAVRGKSRST
CCHHHCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCHHCCHHHHHHHCCCEEECCCCCCC
PGTRVKH
CCCCCCC
>Mature Secondary Structure
MRALEKAMEADKRILLVAQKSAETDDPAAVDLHTVGTLAQVLQLLKLPDGTIKVLVEGLS
CCHHHHHHHCCCEEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
RVTVDKVVEQDGALQGQGTEVEASDAREPREVEAIARSLMSLFEQYVKTNRKLPPELLQT
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LAGIDEPGRLADTIAPHIGVRLADKQRLLEITDIGERLELLVGLVDGEIDVQQLEKRIRG
HHCCCCCCHHHHHHHHHHCEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
RVKSQMEKSQREYYLNEQMKAIQKELGDLDDVPGELEELARKIAEAGMPKPVETKAKAEL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHH
NKLKQMSPMSAEAAVVRNYLDWLLGVPWKKRTKVRKDLKVAEDTLDADHYGLDKVKERIL
HHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
EYLAVQSRVKQMKGPILCLVGPPGVGKTSLGQSIAKATNRKFVRMSLGGIRDEAEIRGHR
HHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHCCEEEEEHHCCCCCHHHHCCCH
RTYVGSMPGRLVQNLNKVGSKNPLFLLDEIDKMSMDFRGDPSSALLEVLDPEQNNSFNDH
HHHCCCCHHHHHHHHHHHCCCCCEEEEECHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCC
YLEVDLDLSEVMFVATSNSLNIPGPLLDRMEVIRIPGYTEDEKLNIAMRYLVPKQIKANG
EEEEECCHHHEEEEEECCCCCCCCHHHCCHHEEECCCCCCCCHHHHHHHHHCCHHHHCCC
LKPEEIEIGGDAIQDIVRYYTRESGVRNLEREVAKICRKVVKEIALAGPQPAAKKAVAKK
CCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
GKPKALVTVNAKNLDKYLGVRRFDFGRAEEENEIGLVTGLAWTEVGGELLQVESTLVPGK
CCCCEEEEEEHHHHHHHHCCHHCCCCCCCCCCCCEEEECCHHHHHCCHHEEEHHHCCCCC
GNLILTGQLGNVMKESASAALSVVRSRAERLGIDVDFLQKQDVHVHVPDGATPKDGPSAG
CCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCEEECCCCCCCCCCCCHH
IAMVTSLVSVLTKVPIRADVAMTGEITLRGRVSAIGGLKEKLLAALRGGIRTVLIPGENR
HHHHHHHHHHHHHCCCEECEEEECEEEEEEHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
KDLADIPANVTRDLKIVPVKWIDEVLDLALERPLTPKKAGKEKARKTAPRVAVRGKSRST
CCHHHCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCHHCCHHHHHHHCCCEEECCCCCCC
PGTRVKH
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA