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The map label for this gene is adk [H]

Identifier: 84622536

GI number: 84622536

Start: 964599

End: 965162

Strand: Direct

Name: adk [H]

Synonym: XOO_0879

Alternate gene names: 84622536

Gene position: 964599-965162 (Clockwise)

Preceding gene: 84622533

Following gene: 84622537

Centisome position: 19.53

GC content: 63.83

Gene sequence:

>564_bases
ATGCGATTGGTTCTGTTGGGACCGCCCGGTTCGGGCAAGGGCACCCAGGCGACACGTCTCAAAGACACGTTTGAGATCCC
GCATATTTCTACCGGTGATCTGTTACGCGCCGAAGTGGCCGCCGGCTCGCCGCTGGGTCTGAAGGCCAAGGAAGTGATGG
CACGCGGCGACTTGGTGTCCGACGACATCCTGCTCGGCATGCTCGAGGCGCGACTCGGCCAAGCCGATGTGGCCAAGGGT
TTCATCCTGGATGGCTATCCGCGCAACGTAGCGCAGGCCAATGCGCTGTGTGCGCTGCTCAGCAAGATCGGTCAGCCGCT
GGATGCCGTGGTGCAGTTGGATGTGGCCAGCGAGTTGCTGGTCGAGCGCATCGCCGGTCGCGCCAAGGCCGAAGGCCGCG
AAGACGACAACCCGGAATCGGTGCGCAAGCGTCTGCAGGTCTATACCGATTCCACCGCGCCGGTGATCGGCTTCTACGAG
CAGCGCGGCAAATTGACGCGTGTGGATGGCGTGGGTTCGCTGGACGAAGTGCTGGAGCGCATCCGCAAGGCGCTCGGCCG
CTGA

Upstream 100 bases:

>100_bases
GGATGCGGTAAGCTGCACTACCACACGGTCAGCGCTGGCGAAGGCTTGAGTCTAACGCCGCCAACCGCAACGCGTTTTTA
TTCGAAAGTGGAGTCCACTG

Downstream 100 bases:

>100_bases
GTCGGCAGGGACCGGGTGCACGTCCCGGTTGTTGGCGGTCGCGGCGTCTGGCCGCGCCGCGTTCTTGTAGGGATCGCCCG
AAACGGGATTGCCCAACAGA

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MRLVLLGPPGSGKGTQATRLKDTFEIPHISTGDLLRAEVAAGSPLGLKAKEVMARGDLVSDDILLGMLEARLGQADVAKG
FILDGYPRNVAQANALCALLSKIGQPLDAVVQLDVASELLVERIAGRAKAEGREDDNPESVRKRLQVYTDSTAPVIGFYE
QRGKLTRVDGVGSLDEVLERIRKALGR

Sequences:

>Translated_187_residues
MRLVLLGPPGSGKGTQATRLKDTFEIPHISTGDLLRAEVAAGSPLGLKAKEVMARGDLVSDDILLGMLEARLGQADVAKG
FILDGYPRNVAQANALCALLSKIGQPLDAVVQLDVASELLVERIAGRAKAEGREDDNPESVRKRLQVYTDSTAPVIGFYE
QRGKLTRVDGVGSLDEVLERIRKALGR
>Mature_187_residues
MRLVLLGPPGSGKGTQATRLKDTFEIPHISTGDLLRAEVAAGSPLGLKAKEVMARGDLVSDDILLGMLEARLGQADVAKG
FILDGYPRNVAQANALCALLSKIGQPLDAVVQLDVASELLVERIAGRAKAEGREDDNPESVRKRLQVYTDSTAPVIGFYE
QRGKLTRVDGVGSLDEVLERIRKALGR

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI4502011, Length=180, Percent_Identity=41.1111111111111, Blast_Score=148, Evalue=3e-36,
Organism=Homo sapiens, GI4502013, Length=214, Percent_Identity=38.3177570093458, Blast_Score=142, Evalue=1e-34,
Organism=Homo sapiens, GI7524346, Length=214, Percent_Identity=38.3177570093458, Blast_Score=142, Evalue=1e-34,
Organism=Homo sapiens, GI28144897, Length=184, Percent_Identity=33.695652173913, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI28144899, Length=184, Percent_Identity=33.695652173913, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI7706497, Length=190, Percent_Identity=34.7368421052632, Blast_Score=112, Evalue=1e-25,
Organism=Homo sapiens, GI19923437, Length=198, Percent_Identity=33.3333333333333, Blast_Score=110, Evalue=5e-25,
Organism=Homo sapiens, GI310110345, Length=202, Percent_Identity=34.1584158415842, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI53832003, Length=202, Percent_Identity=34.1584158415842, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI8051579, Length=202, Percent_Identity=34.1584158415842, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI53832001, Length=202, Percent_Identity=34.1584158415842, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI209915597, Length=107, Percent_Identity=38.3177570093458, Blast_Score=80, Evalue=8e-16,
Organism=Homo sapiens, GI22749187, Length=127, Percent_Identity=33.8582677165354, Blast_Score=68, Evalue=4e-12,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=40.3669724770642, Blast_Score=152, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17552384, Length=214, Percent_Identity=37.3831775700935, Blast_Score=143, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17567503, Length=178, Percent_Identity=40.4494382022472, Blast_Score=142, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17550688, Length=185, Percent_Identity=34.0540540540541, Blast_Score=104, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17533833, Length=185, Percent_Identity=33.5135135135135, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17537943, Length=217, Percent_Identity=30.4147465437788, Blast_Score=86, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI25147457, Length=189, Percent_Identity=24.8677248677249, Blast_Score=70, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6320432, Length=215, Percent_Identity=39.5348837209302, Blast_Score=151, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6322828, Length=190, Percent_Identity=34.2105263157895, Blast_Score=108, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6321018, Length=198, Percent_Identity=34.8484848484849, Blast_Score=101, Evalue=8e-23,
Organism=Drosophila melanogaster, GI22026816, Length=215, Percent_Identity=40.4651162790698, Blast_Score=154, Evalue=4e-38,
Organism=Drosophila melanogaster, GI17737899, Length=197, Percent_Identity=36.0406091370558, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24645822, Length=197, Percent_Identity=36.0406091370558, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24663208, Length=161, Percent_Identity=38.5093167701863, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17647141, Length=161, Percent_Identity=38.5093167701863, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI221459597, Length=185, Percent_Identity=32.4324324324324, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI21356893, Length=185, Percent_Identity=32.4324324324324, Blast_Score=108, Evalue=3e-24,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850 [H]

Pfam domain/function: PF00406 ADK [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 20028; Mature: 20028

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVLLGPPGSGKGTQATRLKDTFEIPHISTGDLLRAEVAAGSPLGLKAKEVMARGDLVS
CEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHCCCCCH
DDILLGMLEARLGQADVAKGFILDGYPRNVAQANALCALLSKIGQPLDAVVQLDVASELL
HHHHHHHHHHHCCHHHHHCCCEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VERIAGRAKAEGREDDNPESVRKRLQVYTDSTAPVIGFYEQRGKLTRVDGVGSLDEVLER
HHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEEHHHCCCEEECCCCCCHHHHHHH
IRKALGR
HHHHHCC
>Mature Secondary Structure
MRLVLLGPPGSGKGTQATRLKDTFEIPHISTGDLLRAEVAAGSPLGLKAKEVMARGDLVS
CEEEEECCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHCCCCCH
DDILLGMLEARLGQADVAKGFILDGYPRNVAQANALCALLSKIGQPLDAVVQLDVASELL
HHHHHHHHHHHCCHHHHHCCCEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
VERIAGRAKAEGREDDNPESVRKRLQVYTDSTAPVIGFYEQRGKLTRVDGVGSLDEVLER
HHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCEEEEHHHCCCEEECCCCCCHHHHHHH
IRKALGR
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]