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The map label for this gene is glmS [H]

Identifier: 84622335

GI number: 84622335

Start: 730448

End: 732277

Strand: Direct

Name: glmS [H]

Synonym: XOO_0678

Alternate gene names: 84622335

Gene position: 730448-732277 (Clockwise)

Preceding gene: 84622333

Following gene: 84622336

Centisome position: 14.79

GC content: 64.54

Gene sequence:

>1830_bases
ATGTGCGGCATTGTCGGAGCGATCGCCGGGCGCGATGTGGTCCCGGTCCTGATCGAGGGACTCAAGCGCCTGGAATACCG
CGGCTACGATTCCTCCGGCATTGCAGTGCTCGACGGCGCGCAGGTGCGCCGGGTGCGTCGCACCGGGCGGGTGGCCGAGA
TGGCGCAGGCCGCGCAGGCCGAACAGTTCGGTGCCACGCTGGGCATCGGCCACACCCGCTGGGCCACCCACGGCGGCGTG
ACCGAAGCCAATGCGCACCCGCACATCAGCGCCGGCGTGGCGCTGGTGCATAACGGCATCATCGAAAACCACGAAGAGCA
GCGCGAAAAACTGCGCGCGCTTGGCTACACCTTCGAGTCGCAGACCGACACCGAAGTCATCGCGCACCTCATCCATCACC
ATCTGGGCAGCGCTGGCGACCTGCTTACCGCGCTGCAGCGCACCGTCAAGGAACTTACCGGTGCCTACGCACTGGCAGTG
ATGAGCCAGGCCGAACCGGAACGTTTCGTCTGCGCACGCATGGGCTGCCCGTTGCTGATCGGGGTGGGTGAGGGCGAGAG
TTTCGTCGCCTCCGACGTGTCGGCCATCGTGCAGGCTACGCGCCAGGTGATCTTCCTCGAAGAAGGCGACACCGCCGAAC
TCCGCCGCGATGGCGTGCGCATCTTCGACGGCAACAATGCGCCGATCGAGCGCCCGCTGCACCTGTCGGACGTGTCGCTG
GCCTCACTAGAGCTGGGGCCGTTCCGCCATTTCATGCAGAAGGAAATCCACGAGCAGCCGCGCGCGCTGGCCGACACCAT
CGAAGCGGCGATCGATGCCAAGGGTTTCCCGTCATCGCTGTTCGGTGCCAACGCAGAAGTGGTGCTGCGCGACATCGAAG
GCGTGCAGATCCTGGCCTGCGGCACCAGCTACTACGCCGGCATGACCGCGCGTTACTGGATCGAAGCCATCGCCGGGCTG
CCGTGCAGCGTTGAGATCGCCAGCGAGTACCGCTACCGCGCCGCGTATGCGAACCCACAGCATCTGATCGTGACCATTTC
GCAGTCCGGCGAAACGCTGGACACGATGGAAGCGCTGAAGTACGCCAAATCGCTGGGGCATCTGCACACGCTATCCATCT
GCAACGTGCCGGAAAGCGCGATCCCGCGCGCCAGCGAACTGGTCTGCTATACGCGTGCCGGTGCCGAGATCGGCGTGGCC
TCGACCAAGGCGTTCACCACCCAGCTGGCAGTGCTGTTCCAGCTCGCCATGGTGCTGGGCAAACTGCAGGGCCGTATCAG
CGACGCCGAAGAAGCGCAGTCTCTGGAGCAGCTGCGTTTCCTGCCCGGTAGCGTGCAGCACGCGTTGAATCTTGAGCCGC
AGATCATGGCCTGGGCGGAACGTTTTTCGCCGAAAGAAAATGCGCTGTTTCTCGGCCGTGGCCTGCATTATCCGATCGCG
CTGGAAGGCGCGCTCAAGCTCAAGGAAATTTCCTACATCCACGCCGAAGCGTATCCGGCCGGCGAGTTGAAGCATGGCCC
GCTGGCACTGGTGGATGCGGGGATGCCGGTGGTGGTGATCGCGCCGAACGACCGCCTGCTGGAGAAGGTCAAATCTAACA
TGCAGGAAGTGCGCGCACGCGGCGGCGAACTGTTCGTGTTTGCCGACCAGGACAGCCACTTCAGCGAATCCGAAGGCGTG
CATGTCATCCGTACCCCACGCCATGCCGGCGTGCTGTCGCCGGTGACCCACACCATCCCGGTACAACTGCTGGCCTACCA
CACCGCCCTGGCACGCGGCACCGATGTGGACAAGCCGCGCAATCTGGCCAAGTCGGTGACGGTGGAGTAG

Upstream 100 bases:

>100_bases
CCGCGGACACTGGCGGCGGACACGCTGTCCGGGCGTGGTCATGCAGCGGACAAGAGCGGACACGCTAAAATGTCCGACTT
CATTTTGCGAGAGCTGTCCC

Downstream 100 bases:

>100_bases
GTCAGCGCGCTCTGCGTGCAGCGTCGGGACCCGTGTGCGCGTCGGCGTTGGCACTTGCATAGTGTGCGGGTGCTGGCGTC
GTTACTGTGCTGAGCACCTT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 609; Mature: 609

Protein sequence:

>609_residues
MCGIVGAIAGRDVVPVLIEGLKRLEYRGYDSSGIAVLDGAQVRRVRRTGRVAEMAQAAQAEQFGATLGIGHTRWATHGGV
TEANAHPHISAGVALVHNGIIENHEEQREKLRALGYTFESQTDTEVIAHLIHHHLGSAGDLLTALQRTVKELTGAYALAV
MSQAEPERFVCARMGCPLLIGVGEGESFVASDVSAIVQATRQVIFLEEGDTAELRRDGVRIFDGNNAPIERPLHLSDVSL
ASLELGPFRHFMQKEIHEQPRALADTIEAAIDAKGFPSSLFGANAEVVLRDIEGVQILACGTSYYAGMTARYWIEAIAGL
PCSVEIASEYRYRAAYANPQHLIVTISQSGETLDTMEALKYAKSLGHLHTLSICNVPESAIPRASELVCYTRAGAEIGVA
STKAFTTQLAVLFQLAMVLGKLQGRISDAEEAQSLEQLRFLPGSVQHALNLEPQIMAWAERFSPKENALFLGRGLHYPIA
LEGALKLKEISYIHAEAYPAGELKHGPLALVDAGMPVVVIAPNDRLLEKVKSNMQEVRARGGELFVFADQDSHFSESEGV
HVIRTPRHAGVLSPVTHTIPVQLLAYHTALARGTDVDKPRNLAKSVTVE

Sequences:

>Translated_609_residues
MCGIVGAIAGRDVVPVLIEGLKRLEYRGYDSSGIAVLDGAQVRRVRRTGRVAEMAQAAQAEQFGATLGIGHTRWATHGGV
TEANAHPHISAGVALVHNGIIENHEEQREKLRALGYTFESQTDTEVIAHLIHHHLGSAGDLLTALQRTVKELTGAYALAV
MSQAEPERFVCARMGCPLLIGVGEGESFVASDVSAIVQATRQVIFLEEGDTAELRRDGVRIFDGNNAPIERPLHLSDVSL
ASLELGPFRHFMQKEIHEQPRALADTIEAAIDAKGFPSSLFGANAEVVLRDIEGVQILACGTSYYAGMTARYWIEAIAGL
PCSVEIASEYRYRAAYANPQHLIVTISQSGETLDTMEALKYAKSLGHLHTLSICNVPESAIPRASELVCYTRAGAEIGVA
STKAFTTQLAVLFQLAMVLGKLQGRISDAEEAQSLEQLRFLPGSVQHALNLEPQIMAWAERFSPKENALFLGRGLHYPIA
LEGALKLKEISYIHAEAYPAGELKHGPLALVDAGMPVVVIAPNDRLLEKVKSNMQEVRARGGELFVFADQDSHFSESEGV
HVIRTPRHAGVLSPVTHTIPVQLLAYHTALARGTDVDKPRNLAKSVTVE
>Mature_609_residues
MCGIVGAIAGRDVVPVLIEGLKRLEYRGYDSSGIAVLDGAQVRRVRRTGRVAEMAQAAQAEQFGATLGIGHTRWATHGGV
TEANAHPHISAGVALVHNGIIENHEEQREKLRALGYTFESQTDTEVIAHLIHHHLGSAGDLLTALQRTVKELTGAYALAV
MSQAEPERFVCARMGCPLLIGVGEGESFVASDVSAIVQATRQVIFLEEGDTAELRRDGVRIFDGNNAPIERPLHLSDVSL
ASLELGPFRHFMQKEIHEQPRALADTIEAAIDAKGFPSSLFGANAEVVLRDIEGVQILACGTSYYAGMTARYWIEAIAGL
PCSVEIASEYRYRAAYANPQHLIVTISQSGETLDTMEALKYAKSLGHLHTLSICNVPESAIPRASELVCYTRAGAEIGVA
STKAFTTQLAVLFQLAMVLGKLQGRISDAEEAQSLEQLRFLPGSVQHALNLEPQIMAWAERFSPKENALFLGRGLHYPIA
LEGALKLKEISYIHAEAYPAGELKHGPLALVDAGMPVVVIAPNDRLLEKVKSNMQEVRARGGELFVFADQDSHFSESEGV
HVIRTPRHAGVLSPVTHTIPVQLLAYHTALARGTDVDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=687, Percent_Identity=35.2256186317322, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI4826742, Length=686, Percent_Identity=35.4227405247813, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI29570798, Length=178, Percent_Identity=29.7752808988764, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1790167, Length=610, Percent_Identity=55.5737704918033, Blast_Score=681, Evalue=0.0,
Organism=Escherichia coli, GI1788651, Length=176, Percent_Identity=32.3863636363636, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17539970, Length=716, Percent_Identity=33.3798882681564, Blast_Score=354, Evalue=8e-98,
Organism=Caenorhabditis elegans, GI17532899, Length=723, Percent_Identity=33.4716459197787, Blast_Score=353, Evalue=2e-97,
Organism=Caenorhabditis elegans, GI17532897, Length=435, Percent_Identity=38.1609195402299, Blast_Score=276, Evalue=3e-74,
Organism=Saccharomyces cerevisiae, GI6322745, Length=441, Percent_Identity=38.3219954648526, Blast_Score=281, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6323731, Length=430, Percent_Identity=28.1395348837209, Blast_Score=183, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6323730, Length=206, Percent_Identity=37.8640776699029, Blast_Score=124, Evalue=4e-29,
Organism=Drosophila melanogaster, GI21357745, Length=697, Percent_Identity=34.8637015781922, Blast_Score=378, Evalue=1e-105,
Organism=Drosophila melanogaster, GI28573187, Length=275, Percent_Identity=27.6363636363636, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65957; Mature: 65957

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGAIAGRDVVPVLIEGLKRLEYRGYDSSGIAVLDGAQVRRVRRTGRVAEMAQAAQA
CCCCCHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
EQFGATLGIGHTRWATHGGVTEANAHPHISAGVALVHNGIIENHEEQREKLRALGYTFES
HHHCCEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCHHCCCHHHHHHHHHHCCCCCC
QTDTEVIAHLIHHHLGSAGDLLTALQRTVKELTGAYALAVMSQAEPERFVCARMGCPLLI
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEE
GVGEGESFVASDVSAIVQATRQVIFLEEGDTAELRRDGVRIFDGNNAPIERPLHLSDVSL
ECCCCCHHHHHHHHHHHHHHHEEEEEECCCHHHHHHCCEEEECCCCCCCCCCCCCCCCCH
ASLELGPFRHFMQKEIHEQPRALADTIEAAIDAKGFPSSLFGANAEVVLRDIEGVQILAC
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCEEEEEECCCCEEEEE
GTSYYAGMTARYWIEAIAGLPCSVEIASEYRYRAAYANPQHLIVTISQSGETLDTMEALK
CCHHHHCCHHHHHHHHHHCCCCEEEHHHHHHHHEECCCCCEEEEEEECCCCHHHHHHHHH
YAKSLGHLHTLSICNVPESAIPRASELVCYTRAGAEIGVASTKAFTTQLAVLFQLAMVLG
HHHHHCCEEEEEECCCCHHHCCCCHHEEEEEECCCEECCCCHHHHHHHHHHHHHHHHHHH
KLQGRISDAEEAQSLEQLRFLPGSVQHALNLEPQIMAWAERFSPKENALFLGRGLHYPIA
HHHCCCCCHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHCCCCCCEEEEECCCCCCEE
LEGALKLKEISYIHAEAYPAGELKHGPLALVDAGMPVVVIAPNDRLLEKVKSNMQEVRAR
ECCCEEEHHHHEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHC
GGELFVFADQDSHFSESEGVHVIRTPRHAGVLSPVTHTIPVQLLAYHTALARGTDVDKPR
CCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHH
NLAKSVTVE
HHHHHCCCC
>Mature Secondary Structure
MCGIVGAIAGRDVVPVLIEGLKRLEYRGYDSSGIAVLDGAQVRRVRRTGRVAEMAQAAQA
CCCCCHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
EQFGATLGIGHTRWATHGGVTEANAHPHISAGVALVHNGIIENHEEQREKLRALGYTFES
HHHCCEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCHHCCCHHHHHHHHHHCCCCCC
QTDTEVIAHLIHHHLGSAGDLLTALQRTVKELTGAYALAVMSQAEPERFVCARMGCPLLI
CCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEE
GVGEGESFVASDVSAIVQATRQVIFLEEGDTAELRRDGVRIFDGNNAPIERPLHLSDVSL
ECCCCCHHHHHHHHHHHHHHHEEEEEECCCHHHHHHCCEEEECCCCCCCCCCCCCCCCCH
ASLELGPFRHFMQKEIHEQPRALADTIEAAIDAKGFPSSLFGANAEVVLRDIEGVQILAC
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCEEEEEECCCCEEEEE
GTSYYAGMTARYWIEAIAGLPCSVEIASEYRYRAAYANPQHLIVTISQSGETLDTMEALK
CCHHHHCCHHHHHHHHHHCCCCEEEHHHHHHHHEECCCCCEEEEEEECCCCHHHHHHHHH
YAKSLGHLHTLSICNVPESAIPRASELVCYTRAGAEIGVASTKAFTTQLAVLFQLAMVLG
HHHHHCCEEEEEECCCCHHHCCCCHHEEEEEECCCEECCCCHHHHHHHHHHHHHHHHHHH
KLQGRISDAEEAQSLEQLRFLPGSVQHALNLEPQIMAWAERFSPKENALFLGRGLHYPIA
HHHCCCCCHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHCCCCCCEEEEECCCCCCEE
LEGALKLKEISYIHAEAYPAGELKHGPLALVDAGMPVVVIAPNDRLLEKVKSNMQEVRAR
ECCCEEEHHHHEEEECCCCCCCCCCCCEEEEECCCCEEEECCCHHHHHHHHHHHHHHHHC
GGELFVFADQDSHFSESEGVHVIRTPRHAGVLSPVTHTIPVQLLAYHTALARGTDVDKPR
CCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHH
NLAKSVTVE
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]