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The map label for this gene is zwf [H]

Identifier: 84622089

GI number: 84622089

Start: 466584

End: 468380

Strand: Direct

Name: zwf [H]

Synonym: XOO_0432

Alternate gene names: 84622089

Gene position: 466584-468380 (Clockwise)

Preceding gene: 84622088

Following gene: 84622090

Centisome position: 9.44

GC content: 63.38

Gene sequence:

>1797_bases
ATGAGTGAGCAAGCAACGACCCCGCCGTGCATCATTGTGGTGTTCGGCGCACGCGGCGATTTGACCAAGCGCCTGGTGAT
GCCGGCGCTGTACAACCTGCGCCGCGCTGGCGCATTGGGCGAGCAATTCGCCATCGTCGGCATGGACCATGGCGACATCA
GCGAGCGTGCGTGGCGCAGCAACATGGGGCAATCGATGACGCAGCTGCTCAGCAGCCGCGATGCCGAATTCCAGGCCGGC
GAATTCGACACCGCCCCCTGGGACTGGCTGCGCGAGCGCATGCATTACCTGTGCGGCGACTTCACCGACCTGGGTGCGTA
TCAGGCGCTGGGTGGCTTGCTGGACAAACTGCACAAGCGCTACGGCACCCAGGGCAATGTGCTGTTCTATCTGGCCACTG
CTGCGCGTTTCTTCGAGCCGGTGCTGCTTAACCTGGGCGAAGCTGGCCTGGTCAAGCAACGCGAGAACGACGGCTGGCGG
CGGGTGATCGTGGAAAAACCCTTCGGCCACGATCTGCCCAGCGCCAAGCACCTCAATGCCACTGTCGCCAAAGTGCTGCA
CGAAGATCAGGTGTTCCGCATCGATCATTTCCTGGGCAAGGAAACCGTGCAGAACATTCTTGCGTTCCGCTTCGCCAACG
GCTTGTTCGAGCCGGTGTGGAATCGCGACCGCATCGACCATGTGCAGATCACTGCGGCCGAAACCATCGGCGTGGAAGGG
CGCGGGCGTTTCTACGACCCCACCGGCTGCCTGCGCGACATGGTGCCGAACCATCTGTTCCAGTTGCTGGCAATGATTGC
GATGGAACCGCCGGCGGCATTTACGACGGAGGCAATGCATCGCCGTCGCGCCGAAGTCATCGAAGCGGTGCGCCCGATCA
AACCCGAAGATGTGGTGCGCGGGCAATACGCCTCCGGTGCGGTCAGCCGTAGCGCGGTACCGGGCTATCGCGAAGAAGAC
ACCGTGCCGGAGGATTCGGAAACCGAAACCTATGTGGCGATGAAGCTGCAGGTGGATACCTGGCGCTGGGCCGGCGTGCC
GTTTTACTTGCGCACCGGCAAGCGCCTGCGCGAGCGCACCACCGAGATCGCGATCCGCTTCAAGCCGGCACCGCTGGCGC
CATTCCGCAGCACCGAAGTGGGCGGCTATGGCCCTGACTGGCTGGTGCTGCATATCCAGCCGGATGAAGGCATCTCGCTG
CAGTTCGATGTCAAACGCCCAGGCGCACAAGTGGCACTGGCGCCGGTGCGCATGGATTTTCGCTACCGCGACTGGTTTCC
CAAGGAATACACCGTGGGCTACGAACGCCTGCTGCAGGACTGCATGAACGGCGAAGCCGGCCTGTTCCAGGATGCGGCCA
TGGTGGAAGGCGCATGGCGCATCGTGCAACCGATCCTGGATGCGTGGAAACAACCGCCGAGCGATTTTCCCAATTACGCC
GCCGGCAGCGCCGGCCCCTCGGCCGCCGACGCCTTGCTGGCAATGAATGGCGGACATGCCTGGCGCGCACTTACCCCAGG
GCGCAAACCGCCACCGCGGCGCCCGCCGGAAACGCGTGCTGGTGCTGCAACGCCGGTGAAGAAAGCTGTCAAGAAAGCTG
CGAATAAGCCAAGCAAGGTGCCCGCAAAGCGCACCACGTCTGCGGCTGCTGCGGCAAGCAACGTGGCGCAAACCGCACCC
AAACGCGTAGCGAAGACGGGGGCAACGCCGGCGAAAGCTGTTGGCAAGCCCGCAGCTGGACGCAGCGGGGCGAAGAAGTC
GGTCAGAAAATCCACGGCACCCAAATCGAGAAGTTGA

Upstream 100 bases:

>100_bases
AACGCATGCTCGGCAACTTCCCGCAAGGGTATTCCCACGTGGCCCTGGTCAATGCGGCATTGCGCCTGCACGGACGCATG
GGCGAAAAGGAAACGCATCC

Downstream 100 bases:

>100_bases
GTGGCACGCGTCAGCCGCCGCTAGGCGGTTGACGCATTTATGTGCGCGGTGACAAAGCAGAGTGATCTAACATCGTACGA
TCGCCATGGTTAGCAGCAGT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 598; Mature: 597

Protein sequence:

>598_residues
MSEQATTPPCIIVVFGARGDLTKRLVMPALYNLRRAGALGEQFAIVGMDHGDISERAWRSNMGQSMTQLLSSRDAEFQAG
EFDTAPWDWLRERMHYLCGDFTDLGAYQALGGLLDKLHKRYGTQGNVLFYLATAARFFEPVLLNLGEAGLVKQRENDGWR
RVIVEKPFGHDLPSAKHLNATVAKVLHEDQVFRIDHFLGKETVQNILAFRFANGLFEPVWNRDRIDHVQITAAETIGVEG
RGRFYDPTGCLRDMVPNHLFQLLAMIAMEPPAAFTTEAMHRRRAEVIEAVRPIKPEDVVRGQYASGAVSRSAVPGYREED
TVPEDSETETYVAMKLQVDTWRWAGVPFYLRTGKRLRERTTEIAIRFKPAPLAPFRSTEVGGYGPDWLVLHIQPDEGISL
QFDVKRPGAQVALAPVRMDFRYRDWFPKEYTVGYERLLQDCMNGEAGLFQDAAMVEGAWRIVQPILDAWKQPPSDFPNYA
AGSAGPSAADALLAMNGGHAWRALTPGRKPPPRRPPETRAGAATPVKKAVKKAANKPSKVPAKRTTSAAAAASNVAQTAP
KRVAKTGATPAKAVGKPAAGRSGAKKSVRKSTAPKSRS

Sequences:

>Translated_598_residues
MSEQATTPPCIIVVFGARGDLTKRLVMPALYNLRRAGALGEQFAIVGMDHGDISERAWRSNMGQSMTQLLSSRDAEFQAG
EFDTAPWDWLRERMHYLCGDFTDLGAYQALGGLLDKLHKRYGTQGNVLFYLATAARFFEPVLLNLGEAGLVKQRENDGWR
RVIVEKPFGHDLPSAKHLNATVAKVLHEDQVFRIDHFLGKETVQNILAFRFANGLFEPVWNRDRIDHVQITAAETIGVEG
RGRFYDPTGCLRDMVPNHLFQLLAMIAMEPPAAFTTEAMHRRRAEVIEAVRPIKPEDVVRGQYASGAVSRSAVPGYREED
TVPEDSETETYVAMKLQVDTWRWAGVPFYLRTGKRLRERTTEIAIRFKPAPLAPFRSTEVGGYGPDWLVLHIQPDEGISL
QFDVKRPGAQVALAPVRMDFRYRDWFPKEYTVGYERLLQDCMNGEAGLFQDAAMVEGAWRIVQPILDAWKQPPSDFPNYA
AGSAGPSAADALLAMNGGHAWRALTPGRKPPPRRPPETRAGAATPVKKAVKKAANKPSKVPAKRTTSAAAAASNVAQTAP
KRVAKTGATPAKAVGKPAAGRSGAKKSVRKSTAPKSRS
>Mature_597_residues
SEQATTPPCIIVVFGARGDLTKRLVMPALYNLRRAGALGEQFAIVGMDHGDISERAWRSNMGQSMTQLLSSRDAEFQAGE
FDTAPWDWLRERMHYLCGDFTDLGAYQALGGLLDKLHKRYGTQGNVLFYLATAARFFEPVLLNLGEAGLVKQRENDGWRR
VIVEKPFGHDLPSAKHLNATVAKVLHEDQVFRIDHFLGKETVQNILAFRFANGLFEPVWNRDRIDHVQITAAETIGVEGR
GRFYDPTGCLRDMVPNHLFQLLAMIAMEPPAAFTTEAMHRRRAEVIEAVRPIKPEDVVRGQYASGAVSRSAVPGYREEDT
VPEDSETETYVAMKLQVDTWRWAGVPFYLRTGKRLRERTTEIAIRFKPAPLAPFRSTEVGGYGPDWLVLHIQPDEGISLQ
FDVKRPGAQVALAPVRMDFRYRDWFPKEYTVGYERLLQDCMNGEAGLFQDAAMVEGAWRIVQPILDAWKQPPSDFPNYAA
GSAGPSAADALLAMNGGHAWRALTPGRKPPPRRPPETRAGAATPVKKAVKKAANKPSKVPAKRTTSAAAAASNVAQTAPK
RVAKTGATPAKAVGKPAAGRSGAKKSVRKSTAPKSRS

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=490, Percent_Identity=34.6938775510204, Blast_Score=287, Evalue=2e-77,
Organism=Homo sapiens, GI108773793, Length=490, Percent_Identity=34.6938775510204, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI52145310, Length=368, Percent_Identity=31.25, Blast_Score=159, Evalue=9e-39,
Organism=Escherichia coli, GI1788158, Length=505, Percent_Identity=37.6237623762376, Blast_Score=335, Evalue=4e-93,
Organism=Caenorhabditis elegans, GI17538218, Length=505, Percent_Identity=33.8613861386139, Blast_Score=294, Evalue=7e-80,
Organism=Saccharomyces cerevisiae, GI6324088, Length=525, Percent_Identity=33.1428571428571, Blast_Score=273, Evalue=7e-74,
Organism=Drosophila melanogaster, GI24643350, Length=504, Percent_Identity=31.9444444444444, Blast_Score=258, Evalue=6e-69,
Organism=Drosophila melanogaster, GI24643352, Length=504, Percent_Identity=31.9444444444444, Blast_Score=258, Evalue=9e-69,
Organism=Drosophila melanogaster, GI221513548, Length=484, Percent_Identity=30.3719008264463, Blast_Score=206, Evalue=4e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 66053; Mature: 65922

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQATTPPCIIVVFGARGDLTKRLVMPALYNLRRAGALGEQFAIVGMDHGDISERAWRS
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHH
NMGQSMTQLLSSRDAEFQAGEFDTAPWDWLRERMHYLCGDFTDLGAYQALGGLLDKLHKR
HHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
YGTQGNVLFYLATAARFFEPVLLNLGEAGLVKQRENDGWRRVIVEKPFGHDLPSAKHLNA
HCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHH
TVAKVLHEDQVFRIDHFLGKETVQNILAFRFANGLFEPVWNRDRIDHVQITAAETIGVEG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHCCCCC
RGRFYDPTGCLRDMVPNHLFQLLAMIAMEPPAAFTTEAMHRRRAEVIEAVRPIKPEDVVR
CCCEECHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHC
GQYASGAVSRSAVPGYREEDTVPEDSETETYVAMKLQVDTWRWAGVPFYLRTGKRLRERT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCEEECCCCCEECCCHHHHHHH
TEIAIRFKPAPLAPFRSTEVGGYGPDWLVLHIQPDEGISLQFDVKRPGAQVALAPVRMDF
HEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCEEEEEEEECC
RYRDWFPKEYTVGYERLLQDCMNGEAGLFQDAAMVEGAWRIVQPILDAWKQPPSDFPNYA
CCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
AGSAGPSAADALLAMNGGHAWRALTPGRKPPPRRPPETRAGAATPVKKAVKKAANKPSKV
CCCCCCHHHHHHEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
PAKRTTSAAAAASNVAQTAPKRVAKTGATPAKAVGKPAAGRSGAKKSVRKSTAPKSRS
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SEQATTPPCIIVVFGARGDLTKRLVMPALYNLRRAGALGEQFAIVGMDHGDISERAWRS
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHH
NMGQSMTQLLSSRDAEFQAGEFDTAPWDWLRERMHYLCGDFTDLGAYQALGGLLDKLHKR
HHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
YGTQGNVLFYLATAARFFEPVLLNLGEAGLVKQRENDGWRRVIVEKPFGHDLPSAKHLNA
HCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHH
TVAKVLHEDQVFRIDHFLGKETVQNILAFRFANGLFEPVWNRDRIDHVQITAAETIGVEG
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHHHCCCCC
RGRFYDPTGCLRDMVPNHLFQLLAMIAMEPPAAFTTEAMHRRRAEVIEAVRPIKPEDVVR
CCCEECHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHC
GQYASGAVSRSAVPGYREEDTVPEDSETETYVAMKLQVDTWRWAGVPFYLRTGKRLRERT
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCEEECCCCCEECCCHHHHHHH
TEIAIRFKPAPLAPFRSTEVGGYGPDWLVLHIQPDEGISLQFDVKRPGAQVALAPVRMDF
HEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCEEEEEEEECC
RYRDWFPKEYTVGYERLLQDCMNGEAGLFQDAAMVEGAWRIVQPILDAWKQPPSDFPNYA
CCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
AGSAGPSAADALLAMNGGHAWRALTPGRKPPPRRPPETRAGAATPVKKAVKKAANKPSKV
CCCCCCHHHHHHEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCC
PAKRTTSAAAAASNVAQTAPKRVAKTGATPAKAVGKPAAGRSGAKKSVRKSTAPKSRS
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]