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The map label for this gene is eif6

Identifier: 84489407

GI number: 84489407

Start: 694692

End: 695366

Strand: Direct

Name: eif6

Synonym: Msp_0598

Alternate gene names: 84489407

Gene position: 694692-695366 (Clockwise)

Preceding gene: 84489406

Following gene: 84489408

Centisome position: 39.31

GC content: 32.59

Gene sequence:

>675_bases
ATGATACAAAAATTTGATATTGATGGAAATCCTAATTTAGGTGTTTCTATTTTGGCAAAGGATAATGTTGCTATAGTTTC
ACCAGGACTCCAAGATTCATACTTAAAAAGTATTAAGGAAACATTAAATGTACCAATAATTAAAACACCAATCTGTGGTA
GTAATCTAGCAGGAGCATTAATGGCTGGAAATTCTAACGGTCTACTTATATCACCATATGTCTTTTCACATGAATTAGAT
GTATTACGTGAACATGATATTAATGTTGAAATTATGCCTGATAAATTAACTGCAATAGGTAATATTATTGTAGCTAATGA
TAATGGAGCACTAGTAAATCCAAGTTTATCTGATGAAGCTAAAAGAATTATTAAAAATACTCTTGAAGTAGAAGTTGTTG
AAACTTCTATAGCTGGTTTAGATATTGTGGGTTCATTAGTTGCAGCTACCAATAGAGGCGCATTAGTACATCCAGATGCA
TCAGAAGAGGAATTAGATTTAGTTGAAGATGTATTAGGTGTACCTGCAGAAATCGGTACAGTTAACCGTGGAGTTAAACT
CGTAGGAGCATGTATCATTGCAAATTCTAATGGAGTCATTGTAGGAAATAAAACTACAGGACCCGAACTAGCAAGGATTG
ATCAAGTATTTAATTTATTTGAGGGATCATTATGA

Upstream 100 bases:

>100_bases
CTACTTAAATATAATCTAAAATATTTTAGAGATGGGTATTTTGATTATATTGATACATATTTAATAAAAAAAATAATAGT
ACACAGATGGAGTAATAAAA

Downstream 100 bases:

>100_bases
AAACAAAAATATATAGAGTAAAAGGAAAATTATTAGATATAGATAAAACTAAACCATTTACACGTGAATTAAAAGGGACC
AAAGAAGCAGATGTAGAAGA

Product: translation initiation factor IF-6

Products: NA

Alternate protein names: aIF-6

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MIQKFDIDGNPNLGVSILAKDNVAIVSPGLQDSYLKSIKETLNVPIIKTPICGSNLAGALMAGNSNGLLISPYVFSHELD
VLREHDINVEIMPDKLTAIGNIIVANDNGALVNPSLSDEAKRIIKNTLEVEVVETSIAGLDIVGSLVAATNRGALVHPDA
SEEELDLVEDVLGVPAEIGTVNRGVKLVGACIIANSNGVIVGNKTTGPELARIDQVFNLFEGSL

Sequences:

>Translated_224_residues
MIQKFDIDGNPNLGVSILAKDNVAIVSPGLQDSYLKSIKETLNVPIIKTPICGSNLAGALMAGNSNGLLISPYVFSHELD
VLREHDINVEIMPDKLTAIGNIIVANDNGALVNPSLSDEAKRIIKNTLEVEVVETSIAGLDIVGSLVAATNRGALVHPDA
SEEELDLVEDVLGVPAEIGTVNRGVKLVGACIIANSNGVIVGNKTTGPELARIDQVFNLFEGSL
>Mature_224_residues
MIQKFDIDGNPNLGVSILAKDNVAIVSPGLQDSYLKSIKETLNVPIIKTPICGSNLAGALMAGNSNGLLISPYVFSHELD
VLREHDINVEIMPDKLTAIGNIIVANDNGALVNPSLSDEAKRIIKNTLEVEVVETSIAGLDIVGSLVAATNRGALVHPDA
SEEELDLVEDVLGVPAEIGTVNRGVKLVGACIIANSNGVIVGNKTTGPELARIDQVFNLFEGSL

Specific function: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex

COG id: COG1976

COG function: function code J; Translation initiation factor 6 (eIF-6)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-6 family

Homologues:

Organism=Homo sapiens, GI4504771, Length=228, Percent_Identity=29.8245614035088, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI31563378, Length=228, Percent_Identity=29.8245614035088, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI31563374, Length=118, Percent_Identity=36.4406779661017, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17506075, Length=226, Percent_Identity=28.3185840707965, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6325273, Length=224, Percent_Identity=32.5892857142857, Blast_Score=127, Evalue=2e-30,
Organism=Drosophila melanogaster, GI21492634, Length=224, Percent_Identity=32.1428571428571, Blast_Score=119, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF6_METST (Q2NGQ7)

Other databases:

- EMBL:   CP000102
- RefSeq:   YP_447639.1
- ProteinModelPortal:   Q2NGQ7
- SMR:   Q2NGQ7
- STRING:   Q2NGQ7
- GeneID:   3855884
- GenomeReviews:   CP000102_GR
- KEGG:   mst:Msp_0598
- NMPDR:   fig|339860.6.peg.579
- eggNOG:   arNOG10240
- HOGENOM:   HBG589638
- OMA:   QFENSNE
- PhylomeDB:   Q2NGQ7
- ProtClustDB:   PRK04046
- BioCyc:   MSTA339860:MSP_0598-MONOMER
- HAMAP:   MF_00032
- InterPro:   IPR002769
- PANTHER:   PTHR10784
- PIRSF:   PIRSF006413
- SMART:   SM00654
- TIGRFAMs:   TIGR00323

Pfam domain/function: PF01912 eIF-6

EC number: NA

Molecular weight: Translated: 23526; Mature: 23526

Theoretical pI: Translated: 4.23; Mature: 4.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQKFDIDGNPNLGVSILAKDNVAIVSPGLQDSYLKSIKETLNVPIIKTPICGSNLAGAL
CCEEECCCCCCCCCEEEEEECCEEEEECCCCHHHHHHHHHHHCCCEEECCCCCCCCCCEE
MAGNSNGLLISPYVFSHELDVLREHDINVEIMPDKLTAIGNIIVANDNGALVNPSLSDEA
EECCCCCEEEECCHHHHHHHHHHHCCCCEEEECCCCCEECEEEEECCCCCEECCCCCHHH
KRIIKNTLEVEVVETSIAGLDIVGSLVAATNRGALVHPDASEEELDLVEDVLGVPAEIGT
HHHHHHHHEEEEEEEHHCCHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCCCC
VNRGVKLVGACIIANSNGVIVGNKTTGPELARIDQVFNLFEGSL
CCCCCEEEEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIQKFDIDGNPNLGVSILAKDNVAIVSPGLQDSYLKSIKETLNVPIIKTPICGSNLAGAL
CCEEECCCCCCCCCEEEEEECCEEEEECCCCHHHHHHHHHHHCCCEEECCCCCCCCCCEE
MAGNSNGLLISPYVFSHELDVLREHDINVEIMPDKLTAIGNIIVANDNGALVNPSLSDEA
EECCCCCEEEECCHHHHHHHHHHHCCCCEEEECCCCCEECEEEEECCCCCEECCCCCHHH
KRIIKNTLEVEVVETSIAGLDIVGSLVAATNRGALVHPDASEEELDLVEDVLGVPAEIGT
HHHHHHHHEEEEEEEHHCCHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCCCC
VNRGVKLVGACIIANSNGVIVGNKTTGPELARIDQVFNLFEGSL
CCCCCEEEEEEEEECCCCEEEECCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA