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The map label for this gene is hmgA

Identifier: 84489393

GI number: 84489393

Start: 676171

End: 677379

Strand: Direct

Name: hmgA

Synonym: Msp_0584

Alternate gene names: 84489393

Gene position: 676171-677379 (Clockwise)

Preceding gene: 84489392

Following gene: 84489394

Centisome position: 38.26

GC content: 32.18

Gene sequence:

>1209_bases
ATGGATTTAACTCAAGATGAAATAATTGAAAAATTAGATTCTGGCGAAATCAGAATATTTGAAATTGAAAAATATACAAA
AACAGCAAATGAAGCAGCAGATATACGAAGAAAATATATTGAAATAAAAACAGGCACACAACTTAAACACATATCCAAAT
ATTCTATTGACATGACAGATACTGCTAAGAAAAATATTGAAAATCCTATAGGAACTATTCAAATACCTGTAGGTGTAGTT
GGACCTATTGTTATTGATAATAATGAAGAGAATATTGAAACATATGTACCTATGGCAACAACTGAAGGTGCATTACTTGC
TAGTGTAAATAGGGGTTGTTCTGTTATAAGACGTTCTAATGGATGTAATGTTTCAATACTTTCAAATCAAATGACAAGAG
CTCCTGTTCTTAAAACTAAATCTGTTCATGATGCTAATAAATTGAAAAAATGGATAGAAGATAATTTTGATAAAATAAAA
GAAGTTGCACAGTCAACAACAAATCATGGAAAATTACTTAAAATAGATCCAATTGCTATAGTGGGAAGATTTGTATATCC
ACGTTTTGTATATGAAACTGGAGATAGTATGGGTATGAATATGGTAACTATTGCTACTCAAAAAGCATTAGATCTTATAG
AAAAAGAAAATAATATTCATATCATAGCTTTAAGTGGAAATTTCTGTGTAGATAAGAAAGCATCTGCAGTAAATCTTATT
GAAGGTCGTGGAAAAAGTGTTGTGGCAGAAGTAATTGTACCTAAAGAAGTTGTTGAAAGAGTACTAAAAACTACAACAGA
TGCAATTGTTGAAGTAAATTATGCTAAAAACTTAGTAGGCTCTGCAATTGCTGGAAGTTATGGTTATAATGCACATTATG
CAAACATGGTGGCAGCAATCTTTTTAGCGACAGGACAAGATCCTGCACATGTGGTAGAGGGAAGTCTTGGTATAACTTCT
GCTGAAAATGATAATGGAGATTTATATTTCAGTGTAACTTTACCTGATTTACCAGTTGCAACTGTTGGTGGTGGAACTAG
ACTTGAAACAGCTGTTGAGTCATTAAATTTACTTAATGCTAAAGGTTCTAATAAAGTCAATAGATATGCATCTATTGTTG
CAGGAATTGTACTTGCAGGAGAATTATCATTGGTTGGGGCCTTAGCTGCAGGTCATTTGGCTCGTGCACATGAAGAATTA
GGTAGATAA

Upstream 100 bases:

>100_bases
AATAATTATAATAGACTATAAATTATAAAATAATAATTACACTATTATATTAGAATAAATAAATATTGTTATTAACAACA
ATTCTAGATGGTGCATTTTC

Downstream 100 bases:

>100_bases
ATCAAGAATACAATAAATTTAAGAGTAAGATTAAATATGAAAGTAACATTAAAACAAATTATTAAAGATTATATTGCAAT
GAGTAGGTATGTTGCATTAG

Product: HmgA

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MDLTQDEIIEKLDSGEIRIFEIEKYTKTANEAADIRRKYIEIKTGTQLKHISKYSIDMTDTAKKNIENPIGTIQIPVGVV
GPIVIDNNEENIETYVPMATTEGALLASVNRGCSVIRRSNGCNVSILSNQMTRAPVLKTKSVHDANKLKKWIEDNFDKIK
EVAQSTTNHGKLLKIDPIAIVGRFVYPRFVYETGDSMGMNMVTIATQKALDLIEKENNIHIIALSGNFCVDKKASAVNLI
EGRGKSVVAEVIVPKEVVERVLKTTTDAIVEVNYAKNLVGSAIAGSYGYNAHYANMVAAIFLATGQDPAHVVEGSLGITS
AENDNGDLYFSVTLPDLPVATVGGGTRLETAVESLNLLNAKGSNKVNRYASIVAGIVLAGELSLVGALAAGHLARAHEEL
GR

Sequences:

>Translated_402_residues
MDLTQDEIIEKLDSGEIRIFEIEKYTKTANEAADIRRKYIEIKTGTQLKHISKYSIDMTDTAKKNIENPIGTIQIPVGVV
GPIVIDNNEENIETYVPMATTEGALLASVNRGCSVIRRSNGCNVSILSNQMTRAPVLKTKSVHDANKLKKWIEDNFDKIK
EVAQSTTNHGKLLKIDPIAIVGRFVYPRFVYETGDSMGMNMVTIATQKALDLIEKENNIHIIALSGNFCVDKKASAVNLI
EGRGKSVVAEVIVPKEVVERVLKTTTDAIVEVNYAKNLVGSAIAGSYGYNAHYANMVAAIFLATGQDPAHVVEGSLGITS
AENDNGDLYFSVTLPDLPVATVGGGTRLETAVESLNLLNAKGSNKVNRYASIVAGIVLAGELSLVGALAAGHLARAHEEL
GR
>Mature_402_residues
MDLTQDEIIEKLDSGEIRIFEIEKYTKTANEAADIRRKYIEIKTGTQLKHISKYSIDMTDTAKKNIENPIGTIQIPVGVV
GPIVIDNNEENIETYVPMATTEGALLASVNRGCSVIRRSNGCNVSILSNQMTRAPVLKTKSVHDANKLKKWIEDNFDKIK
EVAQSTTNHGKLLKIDPIAIVGRFVYPRFVYETGDSMGMNMVTIATQKALDLIEKENNIHIIALSGNFCVDKKASAVNLI
EGRGKSVVAEVIVPKEVVERVLKTTTDAIVEVNYAKNLVGSAIAGSYGYNAHYANMVAAIFLATGQDPAHVVEGSLGITS
AENDNGDLYFSVTLPDLPVATVGGGTRLETAVESLNLLNAKGSNKVNRYASIVAGIVLAGELSLVGALAAGHLARAHEEL
GR

Specific function: Converts HMG-CoA to mevalonate [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

Organism=Homo sapiens, GI4557643, Length=410, Percent_Identity=44.1463414634146, Blast_Score=313, Evalue=1e-85,
Organism=Homo sapiens, GI196049380, Length=290, Percent_Identity=48.2758620689655, Blast_Score=248, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI25144592, Length=412, Percent_Identity=42.9611650485437, Blast_Score=292, Evalue=3e-79,
Organism=Saccharomyces cerevisiae, GI6323565, Length=411, Percent_Identity=40.632603406326, Blast_Score=285, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6323483, Length=398, Percent_Identity=40.7035175879397, Blast_Score=280, Evalue=2e-76,
Organism=Drosophila melanogaster, GI281362379, Length=419, Percent_Identity=40.5727923627685, Blast_Score=242, Evalue=3e-64,
Organism=Drosophila melanogaster, GI45553469, Length=419, Percent_Identity=40.5727923627685, Blast_Score=242, Evalue=3e-64,
Organism=Drosophila melanogaster, GI24649399, Length=419, Percent_Identity=40.5727923627685, Blast_Score=242, Evalue=3e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR004554
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.34 [H]

Molecular weight: Translated: 43407; Mature: 43407

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00066 HMG_COA_REDUCTASE_1 ; PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLTQDEIIEKLDSGEIRIFEIEKYTKTANEAADIRRKYIEIKTGTQLKHISKYSIDMTD
CCCCHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHEECCCCH
TAKKNIENPIGTIQIPVGVVGPIVIDNNEENIETYVPMATTEGALLASVNRGCSVIRRSN
HHHHHCCCCCCEEEECCCCCCCEEECCCCCCCEEEECEECCCCHHEEHHHHCHHHEECCC
GCNVSILSNQMTRAPVLKTKSVHDANKLKKWIEDNFDKIKEVAQSTTNHGKLLKIDPIAI
CCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEECHHHH
VGRFVYPRFVYETGDSMGMNMVTIATQKALDLIEKENNIHIIALSGNFCVDKKASAVNLI
HHHHHHHEEEEECCCCCCCEEEEEHHHHHHHHHHCCCCEEEEEEECCEEECCCCCEEEHC
EGRGKSVVAEVIVPKEVVERVLKTTTDAIVEVNYAKNLVGSAIAGSYGYNAHYANMVAAI
CCCCCEEEHHHHCCHHHHHHHHHCCHHHEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHH
FLATGQDPAHVVEGSLGITSAENDNGDLYFSVTLPDLPVATVGGGTRLETAVESLNLLNA
HEECCCCHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCCHHHHHHHHHHHHCC
KGSNKVNRYASIVAGIVLAGELSLVGALAAGHLARAHEELGR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDLTQDEIIEKLDSGEIRIFEIEKYTKTANEAADIRRKYIEIKTGTQLKHISKYSIDMTD
CCCCHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHEECCCCH
TAKKNIENPIGTIQIPVGVVGPIVIDNNEENIETYVPMATTEGALLASVNRGCSVIRRSN
HHHHHCCCCCCEEEECCCCCCCEEECCCCCCCEEEECEECCCCHHEEHHHHCHHHEECCC
GCNVSILSNQMTRAPVLKTKSVHDANKLKKWIEDNFDKIKEVAQSTTNHGKLLKIDPIAI
CCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEECHHHH
VGRFVYPRFVYETGDSMGMNMVTIATQKALDLIEKENNIHIIALSGNFCVDKKASAVNLI
HHHHHHHEEEEECCCCCCCEEEEEHHHHHHHHHHCCCCEEEEEEECCEEECCCCCEEEHC
EGRGKSVVAEVIVPKEVVERVLKTTTDAIVEVNYAKNLVGSAIAGSYGYNAHYANMVAAI
CCCCCEEEHHHHCCHHHHHHHHHCCHHHEEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHH
FLATGQDPAHVVEGSLGITSAENDNGDLYFSVTLPDLPVATVGGGTRLETAVESLNLLNA
HEECCCCHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCCHHHHHHHHHHHHCC
KGSNKVNRYASIVAGIVLAGELSLVGALAAGHLARAHEELGR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]