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The map label for this gene is dys

Identifier: 84489207

GI number: 84489207

Start: 458749

End: 459666

Strand: Direct

Name: dys

Synonym: Msp_0395

Alternate gene names: 84489207

Gene position: 458749-459666 (Clockwise)

Preceding gene: 84489206

Following gene: 84489208

Centisome position: 25.96

GC content: 32.03

Gene sequence:

>918_bases
ATGAAAGTTAAACATTTAAATATAACAGAAAACATGACAATCTCTGAATTTATAACTCAACTAGATGAATCAGGTGTTTT
AGGGGCAGGTAGAATTGCACATGCAACAAATTTACTTGCAGATTCAATGAAAGATCCTGAAACAAAGATATTTCTAAGTC
TGGCAGGACCAATGGTTCCTGGAGGATTAAGAAAGGTAGTTCGAGATTTAGTAAAAAATGGATATGTTGATTTGATAATA
TCAAGTGGAGCAAATTTAACACATGACTTAGTAGAATCATTTGGTGGAAGACATTATGCAGGTTTACATGAAGATGATGA
ATCACTACAAGATAGTGGAATTGGACGTATAGGTGATATCTATACAAAATCTGAGGACTTTGAAGTGTTTGAAGAGGAAA
TACATAAAATATTTGCTAAGATAAATGAGAAATATAATTCAATATCCATTCAAAAATTTTTATATGAAATTGGATTGTTA
ATTGAGGATGATGAATCTATTATTAAAACAGCAGCTTCTAACAATGTTCCAATATTTGCACCAGGCTTAATTGATTGTAT
GATTGGATTACAACTATGGATTTACTGTCAAGATCATGATTTTACAATAAGTGCAGTGGAAGATATGGCATATTTATCTG
ATTTTGTATATAACTCTAAAAATGTAACTGCATGCATGCTTGGTGGAGGATTACCAAAACATTATACCTTAGCATCTAAC
ATATTAACTGGTGGAATTGATGCTGGAATTCAAATTACATTAGATAGGAGTGAAGGTGGAAGTTTAAGTGGAGCACCACT
TGAAGAAGCAAAATCATGGGCAAAAGCTAAAAAAGGTTCTAATCTAGTAACAGTTGTGGGTGATGCAACAGTACTATTTC
CATTGATTGTTGCAGGCGCATTAGATAAAATAAAATAA

Upstream 100 bases:

>100_bases
AAAAGATTATTAGATTCTTCAAATTAATCTTTTTCCAACTTATTTTATTTCAACTCCCAGAAATTTTTTTTAAATTTATT
TTTTTATGAGGTTAATTACA

Downstream 100 bases:

>100_bases
GGTTTTTTTCATGTTATTTGATGCGTTATGTTATGCTTTATCTGGATTTTTTATGAAATTCTCAGATGAAGCTATGGATA
CTAAAAATAATAAGGTACTT

Product: putative deoxyhypusine synthase

Products: NA

Alternate protein names: DHS [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MKVKHLNITENMTISEFITQLDESGVLGAGRIAHATNLLADSMKDPETKIFLSLAGPMVPGGLRKVVRDLVKNGYVDLII
SSGANLTHDLVESFGGRHYAGLHEDDESLQDSGIGRIGDIYTKSEDFEVFEEEIHKIFAKINEKYNSISIQKFLYEIGLL
IEDDESIIKTAASNNVPIFAPGLIDCMIGLQLWIYCQDHDFTISAVEDMAYLSDFVYNSKNVTACMLGGGLPKHYTLASN
ILTGGIDAGIQITLDRSEGGSLSGAPLEEAKSWAKAKKGSNLVTVVGDATVLFPLIVAGALDKIK

Sequences:

>Translated_305_residues
MKVKHLNITENMTISEFITQLDESGVLGAGRIAHATNLLADSMKDPETKIFLSLAGPMVPGGLRKVVRDLVKNGYVDLII
SSGANLTHDLVESFGGRHYAGLHEDDESLQDSGIGRIGDIYTKSEDFEVFEEEIHKIFAKINEKYNSISIQKFLYEIGLL
IEDDESIIKTAASNNVPIFAPGLIDCMIGLQLWIYCQDHDFTISAVEDMAYLSDFVYNSKNVTACMLGGGLPKHYTLASN
ILTGGIDAGIQITLDRSEGGSLSGAPLEEAKSWAKAKKGSNLVTVVGDATVLFPLIVAGALDKIK
>Mature_305_residues
MKVKHLNITENMTISEFITQLDESGVLGAGRIAHATNLLADSMKDPETKIFLSLAGPMVPGGLRKVVRDLVKNGYVDLII
SSGANLTHDLVESFGGRHYAGLHEDDESLQDSGIGRIGDIYTKSEDFEVFEEEIHKIFAKINEKYNSISIQKFLYEIGLL
IEDDESIIKTAASNNVPIFAPGLIDCMIGLQLWIYCQDHDFTISAVEDMAYLSDFVYNSKNVTACMLGGGLPKHYTLASN
ILTGGIDAGIQITLDRSEGGSLSGAPLEEAKSWAKAKKGSNLVTVVGDATVLFPLIVAGALDKIK

Specific function: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine

COG id: COG1899

COG function: function code O; Deoxyhypusine synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the deoxyhypusine synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503325, Length=254, Percent_Identity=27.1653543307087, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI7108338, Length=253, Percent_Identity=23.7154150197628, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI7108340, Length=253, Percent_Identity=22.5296442687747, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17536927, Length=260, Percent_Identity=29.2307692307692, Blast_Score=126, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6321859, Length=278, Percent_Identity=26.2589928057554, Blast_Score=110, Evalue=2e-25,
Organism=Drosophila melanogaster, GI45550569, Length=265, Percent_Identity=26.0377358490566, Blast_Score=117, Evalue=9e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002773
- InterPro:   IPR022899 [H]

Pfam domain/function: PF01916 DS [H]

EC number: =2.5.1.46 [H]

Molecular weight: Translated: 33056; Mature: 33056

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVKHLNITENMTISEFITQLDESGVLGAGRIAHATNLLADSMKDPETKIFLSLAGPMVP
CCEEEECCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCC
GGLRKVVRDLVKNGYVDLIISSGANLTHDLVESFGGRHYAGLHEDDESLQDSGIGRIGDI
HHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCCCEECCCCCCHHHHHHCCCCCCCHH
YTKSEDFEVFEEEIHKIFAKINEKYNSISIQKFLYEIGLLIEDDESIIKTAASNNVPIFA
HCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCEEECCHHHHHHHCCCCCCEEE
PGLIDCMIGLQLWIYCQDHDFTISAVEDMAYLSDFVYNSKNVTACMLGGGLPKHYTLASN
CHHHHHHHHHEEEEEECCCCEEHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHH
ILTGGIDAGIQITLDRSEGGSLSGAPLEEAKSWAKAKKGSNLVTVVGDATVLFPLIVAGA
HHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHH
LDKIK
HHHCC
>Mature Secondary Structure
MKVKHLNITENMTISEFITQLDESGVLGAGRIAHATNLLADSMKDPETKIFLSLAGPMVP
CCEEEECCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCC
GGLRKVVRDLVKNGYVDLIISSGANLTHDLVESFGGRHYAGLHEDDESLQDSGIGRIGDI
HHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCCCEECCCCCCHHHHHHCCCCCCCHH
YTKSEDFEVFEEEIHKIFAKINEKYNSISIQKFLYEIGLLIEDDESIIKTAASNNVPIFA
HCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCEEECCHHHHHHHCCCCCCEEE
PGLIDCMIGLQLWIYCQDHDFTISAVEDMAYLSDFVYNSKNVTACMLGGGLPKHYTLASN
CHHHHHHHHHEEEEEECCCCEEHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHH
ILTGGIDAGIQITLDRSEGGSLSGAPLEEAKSWAKAKKGSNLVTVVGDATVLFPLIVAGA
HHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHH
LDKIK
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]