Click here to switch to the map view.

The map label for this gene is cobB [H]

Identifier: 83721430

GI number: 83721430

Start: 1718255

End: 1719286

Strand: Direct

Name: cobB [H]

Synonym: BTH_I1518

Alternate gene names: 83721430

Gene position: 1718255-1719286 (Clockwise)

Preceding gene: 83719042

Following gene: 83719585

Centisome position: 45.11

GC content: 69.28

Gene sequence:

>1032_bases
GTGCCTGCGCTTGCGACTTGCCACTCGCCACTCGCCACTCGCCACTCGTCGCTCGTCGCTCAAAGTCCAAAACGTTTCCG
GCGGCACGCCGCGCGAGCGTATGATCGTCCCGACTTCGAACGAAATTTGAAGCGAGAACGCCGCGCCATGTCCGATTCAC
GCCGCCCGCCTTCGAACCCGCCTTCCGAGATGCGCGCAGCCGCATCGCCCGTCGCCGCCGAGCTCATCGACGCGGCCGTT
CGTGCGCTGTCGCGCGCCGATGCGCTGCTCGTCACGGCGGGCGCAGGCATGGGCATCGATTCCGGGCTGCCGGATTTCCG
GGGCGTCGAGGGATTGTGGCGCGCGTATCCGGCGCTCGGCCATGTCGGCTACGCGTTCCACGAGATCGCGTCGCCGCGCG
CGTTTCGCGAGCGTCCGCGCCTCGCGTGGGGCTTTTACGGCCATCGGCTCGCGATGTACCGGGCAACCGTTCCGCACGAA
GGGTTTCGCATTCTGCGGCGCTGGATCGGCGCGATGCGCGACGGCGGCTTCGTGTTCACGAGCAACGTCGACGGCCAGTT
CCAGACGGCGGGCTTCGATCCCGAGCGGATCGTCGAAGTCCACGGCTCGATTCATGCGATGCAGTGCCTGAGCCCTTGCT
CGGCGCACACATGGGATGCGGGATCGTTCGCGCCTGTCGTAGACGAGCCGGCGTGCAGCCTCGTCGGCGACGTCCCCGCG
TGTCCGCATTGCGGCGGCATCGCGCGGCCGAACATCCTGATGTTCGACGACGCGGGCTGGCTCGGCGCGCGCTACGACGC
GCAGCACGATGCGCTGCGCGACTGGTTCGCGCGTGCGGGGCGCGTGGCGGTGGTCGAAATCGGCGCCGGCACCGCGGTAC
CGACGGTGCGCGTCTTCAGCGAACGCATCGGCGACGACGTGATCCGAATCAACGTCCGTGAAGCGCACGCGCGGCGCGGC
GACGTGATCGGATTGCCCGGCGGCGCGCTCGAGACGCTGCGCGCGCTCGACGAAGCGTGGCGGCGGGATTGA

Upstream 100 bases:

>100_bases
ATCGCCGAGCGGGTGCAGCGCACGCCCGCGTTGCAGCGGTCGAGCGCGGCGGCGCGCTGATCGCGCGGCGGGTGCGCCTG
AGGACGCGCATCGATCGATC

Downstream 100 bases:

>100_bases
CGGCCGACCACGCGCGCGACGGCCGCTACCGTGCGGGCGATTCGCACGCTTGCGCGTGCCGGTCCGTGCCGTTGCCGGCC
GTTGGGCGAACGATTGACGG

Product: Sir2 family transcriptional regulator

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MPALATCHSPLATRHSSLVAQSPKRFRRHAARAYDRPDFERNLKRERRAMSDSRRPPSNPPSEMRAAASPVAAELIDAAV
RALSRADALLVTAGAGMGIDSGLPDFRGVEGLWRAYPALGHVGYAFHEIASPRAFRERPRLAWGFYGHRLAMYRATVPHE
GFRILRRWIGAMRDGGFVFTSNVDGQFQTAGFDPERIVEVHGSIHAMQCLSPCSAHTWDAGSFAPVVDEPACSLVGDVPA
CPHCGGIARPNILMFDDAGWLGARYDAQHDALRDWFARAGRVAVVEIGAGTAVPTVRVFSERIGDDVIRINVREAHARRG
DVIGLPGGALETLRALDEAWRRD

Sequences:

>Translated_343_residues
MPALATCHSPLATRHSSLVAQSPKRFRRHAARAYDRPDFERNLKRERRAMSDSRRPPSNPPSEMRAAASPVAAELIDAAV
RALSRADALLVTAGAGMGIDSGLPDFRGVEGLWRAYPALGHVGYAFHEIASPRAFRERPRLAWGFYGHRLAMYRATVPHE
GFRILRRWIGAMRDGGFVFTSNVDGQFQTAGFDPERIVEVHGSIHAMQCLSPCSAHTWDAGSFAPVVDEPACSLVGDVPA
CPHCGGIARPNILMFDDAGWLGARYDAQHDALRDWFARAGRVAVVEIGAGTAVPTVRVFSERIGDDVIRINVREAHARRG
DVIGLPGGALETLRALDEAWRRD
>Mature_342_residues
PALATCHSPLATRHSSLVAQSPKRFRRHAARAYDRPDFERNLKRERRAMSDSRRPPSNPPSEMRAAASPVAAELIDAAVR
ALSRADALLVTAGAGMGIDSGLPDFRGVEGLWRAYPALGHVGYAFHEIASPRAFRERPRLAWGFYGHRLAMYRATVPHEG
FRILRRWIGAMRDGGFVFTSNVDGQFQTAGFDPERIVEVHGSIHAMQCLSPCSAHTWDAGSFAPVVDEPACSLVGDVPAC
PHCGGIARPNILMFDDAGWLGARYDAQHDALRDWFARAGRVAVVEIGAGTAVPTVRVFSERIGDDVIRINVREAHARRGD
VIGLPGGALETLRALDEAWRRD

Specific function: Modulates the activity of chromatin proteins, thereby having an effect on transcription per subunit [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=181, Percent_Identity=28.1767955801105, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI13787215, Length=192, Percent_Identity=27.6041666666667, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI6912664, Length=192, Percent_Identity=27.6041666666667, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 37559; Mature: 37428

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPALATCHSPLATRHSSLVAQSPKRFRRHAARAYDRPDFERNLKRERRAMSDSRRPPSNP
CCCCHHCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCC
PSEMRAAASPVAAELIDAAVRALSRADALLVTAGAGMGIDSGLPDFRGVEGLWRAYPALG
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
HVGYAFHEIASPRAFRERPRLAWGFYGHRLAMYRATVPHEGFRILRRWIGAMRDGGFVFT
HHHHHHHHHCCCHHHHHCCCEEEHHHHHHHEEHCCCCCHHHHHHHHHHHHHHCCCCEEEE
SNVDGQFQTAGFDPERIVEVHGSIHAMQCLSPCSAHTWDAGSFAPVVDEPACSLVGDVPA
CCCCCCEEECCCCHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCC
CPHCGGIARPNILMFDDAGWLGARYDAQHDALRDWFARAGRVAVVEIGAGTAVPTVRVFS
CCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHH
ERIGDDVIRINVREAHARRGDVIGLPGGALETLRALDEAWRRD
HHHCCCEEEEEEHHHHHCCCCEEECCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PALATCHSPLATRHSSLVAQSPKRFRRHAARAYDRPDFERNLKRERRAMSDSRRPPSNP
CCCHHCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCC
PSEMRAAASPVAAELIDAAVRALSRADALLVTAGAGMGIDSGLPDFRGVEGLWRAYPALG
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
HVGYAFHEIASPRAFRERPRLAWGFYGHRLAMYRATVPHEGFRILRRWIGAMRDGGFVFT
HHHHHHHHHCCCHHHHHCCCEEEHHHHHHHEEHCCCCCHHHHHHHHHHHHHHCCCCEEEE
SNVDGQFQTAGFDPERIVEVHGSIHAMQCLSPCSAHTWDAGSFAPVVDEPACSLVGDVPA
CCCCCCEEECCCCHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCC
CPHCGGIARPNILMFDDAGWLGARYDAQHDALRDWFARAGRVAVVEIGAGTAVPTVRVFS
CCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHH
ERIGDDVIRINVREAHARRGDVIGLPGGALETLRALDEAWRRD
HHHCCCEEEEEEHHHHHCCCCEEECCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA