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The map label for this gene is purM [H]

Identifier: 83721293

GI number: 83721293

Start: 1477611

End: 1478666

Strand: Direct

Name: purM [H]

Synonym: BTH_I1317

Alternate gene names: 83721293

Gene position: 1477611-1478666 (Clockwise)

Preceding gene: 83718649

Following gene: 83718914

Centisome position: 38.79

GC content: 67.9

Gene sequence:

>1056_bases
ATGAATCCTCCGAAATCCGCTCCCGACGCCCAGGGTCTGTCCTACCGTGACGCGGGCGTCGACATCGACGCGGGCGACGC
GCTCGTCGACAAGATCAAGCCCTTTGCGAAGAAAACGCTGCGCGACGGCGTGCTCGGCGGCATCGGCGGGTTCGGCGCGC
TGTTCGAGGTGCCGAAGAAGTACCGGGAGCCCGTGCTCGTGTCGGGCACGGACGGCGTCGGCACGAAGCTCAAGCTCGCG
TTTCATCTGAACAAACACGATACGGTCGGCCAGGATCTCGTCGCGATGAGCGTGAACGACATCCTCGTGCAGGGCGCCGA
GCCGCTGTTCTTCCTCGACTATTTCGCGTGCGGCAAGCTCGACGTCGAGACGGCCGCGACCGTCGTCAAGGGCATCGCGA
CGGGCTGCGAGCTGGCGGGCTGCGCGCTGATCGGCGGCGAGACGGCCGAGATGCCGGGCATGTACCCGGACGGCGAGTAC
GATCTCGCGGGCTTCGCGGTCGGCGCGGTCGAGAAGAGCAAGATCATCGACGGCAGCGCGATCGCCGAGGGCGACGTCGT
GCTGGGCCTCGCGTCGAGCGGCATCCATTCGAACGGTTTCTCGCTCGTGCGCAAGATCATCGAGCGCGCGAATCCGGACC
TGTCTGCCGATTTCCACGGCCGCTCGCTCGCCGACGCGCTGATGGCGCCGACGCGCATCTACGTGAAGCCGCTCCTCGCG
CTGATGGAGAAGATCGCGGTGAAGGGGATGGCGCACATCACGGGCGGCGGCCTCGTCGAGAACATTCCGCGCGTGCTGCG
CGACGGCCTCACGGCCGAACTCGACCAGCGCGCGTGGCCGCTGCCGCCGCTCTTCCAGTGGCTGCAGCAGCACGGCGGCG
TCGCCGATGCGGAGATGCACCGCGTGTTCAACTGCGGGATCGGGATGGCCGTGATCGTGTCGGCCGCCGATGCCGACGAA
GCGCTCCGCCAGTTGACCGAAGCGGGCGAGCAGGTGTGGAAGATCGGCACCGTGCGCGCAAGCCGCGAAGGCGAGGCGCA
GACGGTCGTGGTCTGA

Upstream 100 bases:

>100_bases
CGGGGCAAGTTGCTTTCCCTGAAGAATCGGTGCGGGGAATTCCGGCCGCCCGGCCGGCTTCGGGTAAAATCGCATTTTAC
CGACCTTCTCGCATTCCCCC

Downstream 100 bases:

>100_bases
CGCACCGCACCGTCGAGACGATCTCGAAAGCCGCTCGGAGCCGATCCGGGCGGCTTTTTTTCTGGCCGCGCGCCGCGAAG
GGCGGCGGGGCATGGGGGCG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MNPPKSAPDAQGLSYRDAGVDIDAGDALVDKIKPFAKKTLRDGVLGGIGGFGALFEVPKKYREPVLVSGTDGVGTKLKLA
FHLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVETAATVVKGIATGCELAGCALIGGETAEMPGMYPDGEY
DLAGFAVGAVEKSKIIDGSAIAEGDVVLGLASSGIHSNGFSLVRKIIERANPDLSADFHGRSLADALMAPTRIYVKPLLA
LMEKIAVKGMAHITGGGLVENIPRVLRDGLTAELDQRAWPLPPLFQWLQQHGGVADAEMHRVFNCGIGMAVIVSAADADE
ALRQLTEAGEQVWKIGTVRASREGEAQTVVV

Sequences:

>Translated_351_residues
MNPPKSAPDAQGLSYRDAGVDIDAGDALVDKIKPFAKKTLRDGVLGGIGGFGALFEVPKKYREPVLVSGTDGVGTKLKLA
FHLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVETAATVVKGIATGCELAGCALIGGETAEMPGMYPDGEY
DLAGFAVGAVEKSKIIDGSAIAEGDVVLGLASSGIHSNGFSLVRKIIERANPDLSADFHGRSLADALMAPTRIYVKPLLA
LMEKIAVKGMAHITGGGLVENIPRVLRDGLTAELDQRAWPLPPLFQWLQQHGGVADAEMHRVFNCGIGMAVIVSAADADE
ALRQLTEAGEQVWKIGTVRASREGEAQTVVV
>Mature_351_residues
MNPPKSAPDAQGLSYRDAGVDIDAGDALVDKIKPFAKKTLRDGVLGGIGGFGALFEVPKKYREPVLVSGTDGVGTKLKLA
FHLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKLDVETAATVVKGIATGCELAGCALIGGETAEMPGMYPDGEY
DLAGFAVGAVEKSKIIDGSAIAEGDVVLGLASSGIHSNGFSLVRKIIERANPDLSADFHGRSLADALMAPTRIYVKPLLA
LMEKIAVKGMAHITGGGLVENIPRVLRDGLTAELDQRAWPLPPLFQWLQQHGGVADAEMHRVFNCGIGMAVIVSAADADE
ALRQLTEAGEQVWKIGTVRASREGEAQTVVV

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=349, Percent_Identity=54.7277936962751, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI209869995, Length=349, Percent_Identity=54.7277936962751, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI209869993, Length=349, Percent_Identity=54.7277936962751, Blast_Score=377, Evalue=1e-104,
Organism=Escherichia coli, GI1788845, Length=343, Percent_Identity=60.0583090379009, Blast_Score=419, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17567511, Length=346, Percent_Identity=45.6647398843931, Blast_Score=273, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6321203, Length=335, Percent_Identity=49.2537313432836, Blast_Score=321, Evalue=1e-88,
Organism=Drosophila melanogaster, GI24582400, Length=303, Percent_Identity=43.5643564356436, Blast_Score=251, Evalue=4e-67,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36961; Mature: 36961

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPPKSAPDAQGLSYRDAGVDIDAGDALVDKIKPFAKKTLRDGVLGGIGGFGALFEVPKK
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
YREPVLVSGTDGVGTKLKLAFHLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKL
HCCCEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHCCCC
DVETAATVVKGIATGCELAGCALIGGETAEMPGMYPDGEYDLAGFAVGAVEKSKIIDGSA
CHHHHHHHHHHHHHCCHHHCEEEECCCCCCCCCCCCCCCCCCHHEEECCCHHHHCCCCCC
IAEGDVVLGLASSGIHSNGFSLVRKIIERANPDLSADFHGRSLADALMAPTRIYVKPLLA
CCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHH
LMEKIAVKGMAHITGGGLVENIPRVLRDGLTAELDQRAWPLPPLFQWLQQHGGVADAEMH
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHCCCCHHHHH
RVFNCGIGMAVIVSAADADEALRQLTEAGEQVWKIGTVRASREGEAQTVVV
HHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCEEECCCCCCCEEEC
>Mature Secondary Structure
MNPPKSAPDAQGLSYRDAGVDIDAGDALVDKIKPFAKKTLRDGVLGGIGGFGALFEVPKK
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
YREPVLVSGTDGVGTKLKLAFHLNKHDTVGQDLVAMSVNDILVQGAEPLFFLDYFACGKL
HCCCEEEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEHHHHCCCC
DVETAATVVKGIATGCELAGCALIGGETAEMPGMYPDGEYDLAGFAVGAVEKSKIIDGSA
CHHHHHHHHHHHHHCCHHHCEEEECCCCCCCCCCCCCCCCCCHHEEECCCHHHHCCCCCC
IAEGDVVLGLASSGIHSNGFSLVRKIIERANPDLSADFHGRSLADALMAPTRIYVKPLLA
CCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHH
LMEKIAVKGMAHITGGGLVENIPRVLRDGLTAELDQRAWPLPPLFQWLQQHGGVADAEMH
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHCCCCHHHHH
RVFNCGIGMAVIVSAADADEALRQLTEAGEQVWKIGTVRASREGEAQTVVV
HHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCEEECCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA