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The map label for this gene is metE [H]

Identifier: 83720717

GI number: 83720717

Start: 1804010

End: 1806304

Strand: Direct

Name: metE [H]

Synonym: BTH_I1606

Alternate gene names: 83720717

Gene position: 1804010-1806304 (Clockwise)

Preceding gene: 83718823

Following gene: 83718426

Centisome position: 47.36

GC content: 70.54

Gene sequence:

>2295_bases
ATGACCACCGCACACATCCTGGGTTTTCCGCGCATCGGCGCGCAACGGGAACTGAAGTTCGCCCTTGAACGCTATTGGCG
CGACGGCGCGTCGGCCGACGCCGAGCGCGCGCTCGTCGACACCGGCCGCGCGCTGCGCGCCGCGCATTGGCAGACGCAGC
GAGACGCCGGGCTCGACTGCGTGACCGTGGGCGATTTCGCGTGGTACGACCACGTGCTGACGACGCTCGCGCACGTCGGC
GGCCTGCCGCGGCGCTTCGGCTTCGACGCGCGCGCGCTCACGCTCGCCGATTACTTCGCGGCCGCGCGCGGCAACGCCGC
GCAGCCGGCGATGGAAATGACGAAGTGGTTCGATACGAACTACCACTATCTCGTGCCCGAGTATTCGCCGGCGACGACGT
TCGGGCCGGGCGTCGAGTGGCTCTTCGACGAGGTGCGCGAAGCGCGCGCGCTCGGTCATCGCCCGAAGGCGGCGCTCGTC
GGCCCGCTCACGCTGCTGTGGCTCGGCAAGGCGCGCGATGGGCTCGCCGATCGTCTCGAACTGCTGCCGCGCCTCGTGCC
CGCGTATCGCGCGCTGCTCGCGCGGCTAAGGGAGGCGGGCGTCGACTGGGTGCAGATCGACGAGCCGATCTTCGCGCTCG
ATTTGCCCGCCGCGTGGCGCGACGCGGCGCGGCCCGCGTACGAAGCGCTCGTGCCCGGCGCGCCGAAGCTGCTCGTCGCG
ACGTATTTCGACGATGTGAGCGAGCACGCGGCGCTGTTGAAGGCGCTGCCCGTCGCGGGCCTGCATGTCGATCTCGTGCG
CGGCGATGCGCAGCTCGACGCGTTCGTCGCGGACTATCCGGCCGACAAGGTGCTCTCGTGCGGCATCGTCGACGGCCGCA
ACGTGTGGCGCAACGATCTCGACCGCTCGCTCGCTCGGCTCGCGCCGGTGCATGAAACGCTCGGCGAGCGGCTGTGGATC
GCGACGAGCTGCTCGCTGCTGCATGCGCCCGTCGATCTCGCGCACGAACCGAAGCTCGACGACGAACTGAAGGCGTGGCT
CGCGTTCGCCGTGCAGAAGACGCGCGAAGTCGCCGCGCTGCGTGACGCGCTCGCGAAGGGGCGCGCGGCGGTCGCGGCGG
AGTTCGACGCCGCCGCTGTGGCGGCGGCCGCGCGACGCACGTCGGCGCGCATCCACAATCCGCTCGTCAAGCGCCGCGTC
GCCGCGTTGACCGACGCCGACGCGCGCCGCGCGAGCGCTTATCCGGCGCGCGCGGCCGCGCAGCGCGCGCGCTTCGACTT
GCCGCCGCTGCCGACGACGACGATCGGCTCGTTCCCGCAGACGCCGGAGATCCGCCGCGCGCGCGCCGCGTTCCGGCAGG
GCGTGCTCGATCACCTCGGCTATCTGGAGGCGATGCGCGAGCAGGTGCGCATCGCGATCGACAAGCAGCTCTCGTACGGC
CTCGACGTGCTCGTGCACGGCGAGGCGGAGCGCAACGACATGGTCGAGTACTTCGGCGAGCTGATGTGGGGCTTCGCGAT
CACGAGCAACGGCTGGGTGCAGAGCTACGGATCGCGCTGCGTGAAGCCGCCCCTCGTCTACGGCGACGTCTATCTGCCGG
AGCCGATGACGGTCGGCTGGGCGTCGTATGCGCAGAGCCTGACGACCAAGCCGGTGAAGGGCATGCTGACGGGGCCCGTG
ACGATGCTGCAATGGTCGTTCGTGCGAGACGACCAGCCGCGCGCGACGACGGCGCTGCAGATCGCGCTCGCGCTGCGGCA
GGAGACGCTCGATCTGGAGAAGGCCGGCATCGGGATGATCCAGGTCGACGAGCCGGCGCTGCGCGAGGGGCTGCCGCTGA
AGGCGCGCGATCGCGCCGAGTATCTGGACTGGGCGGTGCGCGCGTTCAGGATCGCGGCGTCGGGCGTCGCGGACGACACG
CAGATCCACACGCACATGTGCTATTCGGAGTTCGGCGACATTCTGCCGTCGATCGCGGCGCTCGACGCGGACGTGATCTC
GATCGAGACGACCCGCTCGAACATGGAGCTGCTCGACGCGTTCGAGACGTTCGAGTATCCGAACGAGATCGGGCCGGGCG
TCTACGACATCCATTCGCCTCGCGTGCCGGACGCCGACGAGATCGAGCGGCTCATCCTGCTCGCGCTCGAGCGGATTCCG
GCGCAGCGCCTGTGGGTGAATCCGGATTGCGGGCTGAAGACGCGCGAGTGGCGGCAGGTCGACGCGGCGCTCGCGGCGAT
GGTCGACGCGGCCAAGCGCGTGCGGCAGACGGTCGAGCAGGCGGTGCCGGCTTGA

Upstream 100 bases:

>100_bases
AGATTTGATGTTGAAAAATATTCATGTTGTGCGGCAAAAACTTTCGTTTGAGTAATGATAGGGCAAATCCGATACTGCCG
GTCACTTCTGGAGGATCGAG

Downstream 100 bases:

>100_bases
TGCGGCGCGAGCGCGCGCGAGGGGCGTGGTCGTGCGCGTGCGGACGCGAATGCGCGTGAACGAGGCGCGCCGAGCGCGGC
GTATGCGCTGGATGCGGCCG

Product: 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase

Products: NA

Alternate protein names: Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme [H]

Number of amino acids: Translated: 764; Mature: 763

Protein sequence:

>764_residues
MTTAHILGFPRIGAQRELKFALERYWRDGASADAERALVDTGRALRAAHWQTQRDAGLDCVTVGDFAWYDHVLTTLAHVG
GLPRRFGFDARALTLADYFAAARGNAAQPAMEMTKWFDTNYHYLVPEYSPATTFGPGVEWLFDEVREARALGHRPKAALV
GPLTLLWLGKARDGLADRLELLPRLVPAYRALLARLREAGVDWVQIDEPIFALDLPAAWRDAARPAYEALVPGAPKLLVA
TYFDDVSEHAALLKALPVAGLHVDLVRGDAQLDAFVADYPADKVLSCGIVDGRNVWRNDLDRSLARLAPVHETLGERLWI
ATSCSLLHAPVDLAHEPKLDDELKAWLAFAVQKTREVAALRDALAKGRAAVAAEFDAAAVAAAARRTSARIHNPLVKRRV
AALTDADARRASAYPARAAAQRARFDLPPLPTTTIGSFPQTPEIRRARAAFRQGVLDHLGYLEAMREQVRIAIDKQLSYG
LDVLVHGEAERNDMVEYFGELMWGFAITSNGWVQSYGSRCVKPPLVYGDVYLPEPMTVGWASYAQSLTTKPVKGMLTGPV
TMLQWSFVRDDQPRATTALQIALALRQETLDLEKAGIGMIQVDEPALREGLPLKARDRAEYLDWAVRAFRIAASGVADDT
QIHTHMCYSEFGDILPSIAALDADVISIETTRSNMELLDAFETFEYPNEIGPGVYDIHSPRVPDADEIERLILLALERIP
AQRLWVNPDCGLKTREWRQVDAALAAMVDAAKRVRQTVEQAVPA

Sequences:

>Translated_764_residues
MTTAHILGFPRIGAQRELKFALERYWRDGASADAERALVDTGRALRAAHWQTQRDAGLDCVTVGDFAWYDHVLTTLAHVG
GLPRRFGFDARALTLADYFAAARGNAAQPAMEMTKWFDTNYHYLVPEYSPATTFGPGVEWLFDEVREARALGHRPKAALV
GPLTLLWLGKARDGLADRLELLPRLVPAYRALLARLREAGVDWVQIDEPIFALDLPAAWRDAARPAYEALVPGAPKLLVA
TYFDDVSEHAALLKALPVAGLHVDLVRGDAQLDAFVADYPADKVLSCGIVDGRNVWRNDLDRSLARLAPVHETLGERLWI
ATSCSLLHAPVDLAHEPKLDDELKAWLAFAVQKTREVAALRDALAKGRAAVAAEFDAAAVAAAARRTSARIHNPLVKRRV
AALTDADARRASAYPARAAAQRARFDLPPLPTTTIGSFPQTPEIRRARAAFRQGVLDHLGYLEAMREQVRIAIDKQLSYG
LDVLVHGEAERNDMVEYFGELMWGFAITSNGWVQSYGSRCVKPPLVYGDVYLPEPMTVGWASYAQSLTTKPVKGMLTGPV
TMLQWSFVRDDQPRATTALQIALALRQETLDLEKAGIGMIQVDEPALREGLPLKARDRAEYLDWAVRAFRIAASGVADDT
QIHTHMCYSEFGDILPSIAALDADVISIETTRSNMELLDAFETFEYPNEIGPGVYDIHSPRVPDADEIERLILLALERIP
AQRLWVNPDCGLKTREWRQVDAALAAMVDAAKRVRQTVEQAVPA
>Mature_763_residues
TTAHILGFPRIGAQRELKFALERYWRDGASADAERALVDTGRALRAAHWQTQRDAGLDCVTVGDFAWYDHVLTTLAHVGG
LPRRFGFDARALTLADYFAAARGNAAQPAMEMTKWFDTNYHYLVPEYSPATTFGPGVEWLFDEVREARALGHRPKAALVG
PLTLLWLGKARDGLADRLELLPRLVPAYRALLARLREAGVDWVQIDEPIFALDLPAAWRDAARPAYEALVPGAPKLLVAT
YFDDVSEHAALLKALPVAGLHVDLVRGDAQLDAFVADYPADKVLSCGIVDGRNVWRNDLDRSLARLAPVHETLGERLWIA
TSCSLLHAPVDLAHEPKLDDELKAWLAFAVQKTREVAALRDALAKGRAAVAAEFDAAAVAAAARRTSARIHNPLVKRRVA
ALTDADARRASAYPARAAAQRARFDLPPLPTTTIGSFPQTPEIRRARAAFRQGVLDHLGYLEAMREQVRIAIDKQLSYGL
DVLVHGEAERNDMVEYFGELMWGFAITSNGWVQSYGSRCVKPPLVYGDVYLPEPMTVGWASYAQSLTTKPVKGMLTGPVT
MLQWSFVRDDQPRATTALQIALALRQETLDLEKAGIGMIQVDEPALREGLPLKARDRAEYLDWAVRAFRIAASGVADDTQ
IHTHMCYSEFGDILPSIAALDADVISIETTRSNMELLDAFETFEYPNEIGPGVYDIHSPRVPDADEIERLILLALERIPA
QRLWVNPDCGLKTREWRQVDAALAAMVDAAKRVRQTVEQAVPA

Specific function: Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation [H]

COG id: COG0620

COG function: function code E; Methionine synthase II (cobalamin-independent)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the vitamin-B12 independent methionine synthase family [H]

Homologues:

Organism=Escherichia coli, GI2367304, Length=757, Percent_Identity=57.4636723910172, Blast_Score=843, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320936, Length=775, Percent_Identity=46.4516129032258, Blast_Score=647, Evalue=0.0,

Paralogues:

None

Copy number: 45,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013215
- InterPro:   IPR006276
- InterPro:   IPR002629 [H]

Pfam domain/function: PF08267 Meth_synt_1; PF01717 Meth_synt_2 [H]

EC number: =2.1.1.14 [H]

Molecular weight: Translated: 84430; Mature: 84299

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAHILGFPRIGAQRELKFALERYWRDGASADAERALVDTGRALRAAHWQTQRDAGLDC
CCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHCCCHHCCCCCE
VTVGDFAWYDHVLTTLAHVGGLPRRFGFDARALTLADYFAAARGNAAQPAMEMTKWFDTN
EEECCHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
YHYLVPEYSPATTFGPGVEWLFDEVREARALGHRPKAALVGPLTLLWLGKARDGLADRLE
CCEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHCCHHHHEECCCCCCHHHHHH
LLPRLVPAYRALLARLREAGVDWVQIDEPIFALDLPAAWRDAARPAYEALVPGAPKLLVA
HHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEECCHHHHHHCCHHHHHHCCCCCCEEHH
TYFDDVSEHAALLKALPVAGLHVDLVRGDAQLDAFVADYPADKVLSCGIVDGRNVWRNDL
HHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHCCCHHHHEECCCCCCCHHHHHHH
DRSLARLAPVHETLGERLWIATSCSLLHAPVDLAHEPKLDDELKAWLAFAVQKTREVAAL
HHHHHHHHHHHHHHHCEEEEEECHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RDALAKGRAAVAAEFDAAAVAAAARRTSARIHNPLVKRRVAALTDADARRASAYPARAAA
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHH
QRARFDLPPLPTTTIGSFPQTPEIRRARAAFRQGVLDHLGYLEAMREQVRIAIDKQLSYG
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LDVLVHGEAERNDMVEYFGELMWGFAITSNGWVQSYGSRCVKPPLVYGDVYLPEPMTVGW
CEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCEEECCEECCCCCCCCH
ASYAQSLTTKPVKGMLTGPVTMLQWSFVRDDQPRATTALQIALALRQETLDLEKAGIGMI
HHHHHHHCCCCCCCHHCCCHHHHEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEE
QVDEPALREGLPLKARDRAEYLDWAVRAFRIAASGVADDTQIHTHMCYSEFGDILPSIAA
EECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
LDADVISIETTRSNMELLDAFETFEYPNEIGPGVYDIHSPRVPDADEIERLILLALERIP
CCCCEEEEEECCCHHHHHHHHHHHCCCHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHCC
AQRLWVNPDCGLKTREWRQVDAALAAMVDAAKRVRQTVEQAVPA
HHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTAHILGFPRIGAQRELKFALERYWRDGASADAERALVDTGRALRAAHWQTQRDAGLDC
CCCEEECCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHCCCHHCCCCCE
VTVGDFAWYDHVLTTLAHVGGLPRRFGFDARALTLADYFAAARGNAAQPAMEMTKWFDTN
EEECCHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCC
YHYLVPEYSPATTFGPGVEWLFDEVREARALGHRPKAALVGPLTLLWLGKARDGLADRLE
CCEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHCCHHHHEECCCCCCHHHHHH
LLPRLVPAYRALLARLREAGVDWVQIDEPIFALDLPAAWRDAARPAYEALVPGAPKLLVA
HHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEECCHHHHHHCCHHHHHHCCCCCCEEHH
TYFDDVSEHAALLKALPVAGLHVDLVRGDAQLDAFVADYPADKVLSCGIVDGRNVWRNDL
HHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHCCCHHHHEECCCCCCCHHHHHHH
DRSLARLAPVHETLGERLWIATSCSLLHAPVDLAHEPKLDDELKAWLAFAVQKTREVAAL
HHHHHHHHHHHHHHHCEEEEEECHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RDALAKGRAAVAAEFDAAAVAAAARRTSARIHNPLVKRRVAALTDADARRASAYPARAAA
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHH
QRARFDLPPLPTTTIGSFPQTPEIRRARAAFRQGVLDHLGYLEAMREQVRIAIDKQLSYG
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LDVLVHGEAERNDMVEYFGELMWGFAITSNGWVQSYGSRCVKPPLVYGDVYLPEPMTVGW
CEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCEEECCEECCCCCCCCH
ASYAQSLTTKPVKGMLTGPVTMLQWSFVRDDQPRATTALQIALALRQETLDLEKAGIGMI
HHHHHHHCCCCCCCHHCCCHHHHEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEE
QVDEPALREGLPLKARDRAEYLDWAVRAFRIAASGVADDTQIHTHMCYSEFGDILPSIAA
EECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
LDADVISIETTRSNMELLDAFETFEYPNEIGPGVYDIHSPRVPDADEIERLILLALERIP
CCCCEEEEEECCCHHHHHHHHHHHCCCHHCCCCCEECCCCCCCCHHHHHHHHHHHHHHCC
AQRLWVNPDCGLKTREWRQVDAALAAMVDAAKRVRQTVEQAVPA
HHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA