Click here to switch to the map view.

The map label for this gene is yhfN [H]

Identifier: 83720705

GI number: 83720705

Start: 1877943

End: 1879202

Strand: Reverse

Name: yhfN [H]

Synonym: BTH_I1669

Alternate gene names: 83720705

Gene position: 1879202-1877943 (Counterclockwise)

Preceding gene: 83720171

Following gene: 161723147

Centisome position: 49.33

GC content: 66.67

Gene sequence:

>1260_bases
ATGTCCGCCTATACCTTCACCCTGCTCTTCGCCGTCGCGATCGTCGCGATGACGGGCACCAAGCTGTGGCTCGCGTCGCG
GCAGATCCGCTTCGTCGCCGCGCATCGCGGCCGCGTGCCCGCACAGTTCCGCGAGACGATTCCGCTCGCCGCGCACCAGC
GCGCCGCCGACTACACGATCGAGCGCACGCGGCTCACGATGTTCGAGATCGTCGTCGCGTCGGCGGTGCTCGTGGGCCTC
ACGCTCCTCGGCGGCGTCGGCGCGCTCGATTCGCTGCTCGCCGGCCGGCTCGGCCACGGCTACGGCCAGCAGGTCGCGCT
CGTCGCCGCGGTGCTCGTGATCTCCAGCGCGATCGATCTGCCGTTCGAGTATTACCGCCAGTTCAGCGTCGAAGAGCGCT
TCGGCTTCAACCGGATGACAAGGCGCCTGTTCTTCACCGATCTCGCGAAGAACGCGCTGCTCGGCGCGGCGCTCGGCCTG
CCGCTCCTCTTCGTCGTGCTGTGGCTGATGAATCAGGCGGGCGCGCTGTGGTGGCTGTGGACATGGATCGTGTGGGTCGG
CTTCCAGATGCTCGTTCTCGTGCTCTATCCGACCTTCATCGCGCCGCTGTTCAACAAGTTCGAGCCGCTTGCCGACGATG
CGCTGCGCATGCGCATCGAAGGATTGATGAAGCGCTGCGGCTTCGCGGCGAAGGGCCTCTTCGTGATGGACGGCAGCCGC
CGCTCCGCGCACGGCAATGCGTATTTCACGGGCTTCGGCGCGTCGAAGCGGATCGTGTTCTTCGATACCCTGCTCGCCCG
CCTGACGGGCAACGAGATCGAAGCGGTGCTCGCGCACGAGCTCGGCCATTTCAAGCGCCGCCACGTGATGAAGCGGATGC
TGTGGACTTTCGCGCTGAGCCTCGCGCTTCTCGCGCTGCTCGGCTGGCTCGCGCAGCGCGCCTGGTTCTACACGGGCCTC
GGCGTGATGCCGTCGCTCGCCGGCAGCAACGCGGGCGTCGCGCTCGTGCTGTTCTTCCTGTCGATGCCGGTGTTCCTGTT
CTTCGTCACGCCGCTCGGCAGCCTGAGCTCGCGCAAGCACGAATTCGAGGCCGACGCGTTCGCCGCGAGCCAGACCGACG
CGCGCGATCTCGTCAACGCACTCGTGAAACTCTACGAAGACAATGCGTCGACGCTCACGCCCGACCCCGTCTACACCGCG
TTCTACTACTCGCATCCGCCCGCGTCGCAACGCATCGACCGGCTGCTCCAGCTCTCATGA

Upstream 100 bases:

>100_bases
AGCGGGCGGCGCGCGCGCCGCCGGGCGGGCCGGCAAACGGCGAGCGGGCCGGCTCCGCAAGAACATATAATTCTCGCATA
GATACCCACCAGCGCCTTCG

Downstream 100 bases:

>100_bases
AGCGCGCGCCGACGAAGCAGCCGGCCATGGCCATGGCGGCCGCGCGCGGCGGCGAGCGCGCCGAAGGGCGCGTGATCGCC
GCGCACGGCCGCCACTACAT

Product: M48 family peptidase

Products: NA

Alternate protein names: PSP23 [H]

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MSAYTFTLLFAVAIVAMTGTKLWLASRQIRFVAAHRGRVPAQFRETIPLAAHQRAADYTIERTRLTMFEIVVASAVLVGL
TLLGGVGALDSLLAGRLGHGYGQQVALVAAVLVISSAIDLPFEYYRQFSVEERFGFNRMTRRLFFTDLAKNALLGAALGL
PLLFVVLWLMNQAGALWWLWTWIVWVGFQMLVLVLYPTFIAPLFNKFEPLADDALRMRIEGLMKRCGFAAKGLFVMDGSR
RSAHGNAYFTGFGASKRIVFFDTLLARLTGNEIEAVLAHELGHFKRRHVMKRMLWTFALSLALLALLGWLAQRAWFYTGL
GVMPSLAGSNAGVALVLFFLSMPVFLFFVTPLGSLSSRKHEFEADAFAASQTDARDLVNALVKLYEDNASTLTPDPVYTA
FYYSHPPASQRIDRLLQLS

Sequences:

>Translated_419_residues
MSAYTFTLLFAVAIVAMTGTKLWLASRQIRFVAAHRGRVPAQFRETIPLAAHQRAADYTIERTRLTMFEIVVASAVLVGL
TLLGGVGALDSLLAGRLGHGYGQQVALVAAVLVISSAIDLPFEYYRQFSVEERFGFNRMTRRLFFTDLAKNALLGAALGL
PLLFVVLWLMNQAGALWWLWTWIVWVGFQMLVLVLYPTFIAPLFNKFEPLADDALRMRIEGLMKRCGFAAKGLFVMDGSR
RSAHGNAYFTGFGASKRIVFFDTLLARLTGNEIEAVLAHELGHFKRRHVMKRMLWTFALSLALLALLGWLAQRAWFYTGL
GVMPSLAGSNAGVALVLFFLSMPVFLFFVTPLGSLSSRKHEFEADAFAASQTDARDLVNALVKLYEDNASTLTPDPVYTA
FYYSHPPASQRIDRLLQLS
>Mature_418_residues
SAYTFTLLFAVAIVAMTGTKLWLASRQIRFVAAHRGRVPAQFRETIPLAAHQRAADYTIERTRLTMFEIVVASAVLVGLT
LLGGVGALDSLLAGRLGHGYGQQVALVAAVLVISSAIDLPFEYYRQFSVEERFGFNRMTRRLFFTDLAKNALLGAALGLP
LLFVVLWLMNQAGALWWLWTWIVWVGFQMLVLVLYPTFIAPLFNKFEPLADDALRMRIEGLMKRCGFAAKGLFVMDGSRR
SAHGNAYFTGFGASKRIVFFDTLLARLTGNEIEAVLAHELGHFKRRHVMKRMLWTFALSLALLALLGWLAQRAWFYTGLG
VMPSLAGSNAGVALVLFFLSMPVFLFFVTPLGSLSSRKHEFEADAFAASQTDARDLVNALVKLYEDNASTLTPDPVYTAF
YYSHPPASQRIDRLLQLS

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Homo sapiens, GI18379366, Length=439, Percent_Identity=28.246013667426, Blast_Score=177, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17505484, Length=423, Percent_Identity=29.5508274231678, Blast_Score=182, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6322577, Length=309, Percent_Identity=37.5404530744337, Blast_Score=212, Evalue=7e-56,
Organism=Drosophila melanogaster, GI19922414, Length=439, Percent_Identity=30.2961275626424, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI78707252, Length=411, Percent_Identity=27.2506082725061, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI78707254, Length=411, Percent_Identity=27.2506082725061, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24654305, Length=431, Percent_Identity=25.754060324826, Blast_Score=111, Evalue=9e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 46682; Mature: 46551

Theoretical pI: Translated: 10.22; Mature: 10.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHCCC
>Mature Secondary Structure 
SAYTFTLLFAVAIVAMTGTKLWLASRQIRFVAAHRGRVPAQFRETIPLAAHQRAADYTI
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHEEHHHCCCCCHHHHHCCCHHHHHHHHCCHH
ERTRLTMFEIVVASAVLVGLTLLGGVGALDSLLAGRLGHGYGQQVALVAAVLVISSAIDL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
PFEYYRQFSVEERFGFNRMTRRLFFTDLAKNALLGAALGLPLLFVVLWLMNQAGALWWLW
CHHHHHHHCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
TWIVWVGFQMLVLVLYPTFIAPLFNKFEPLADDALRMRIEGLMKRCGFAAKGLFVMDGSR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHCCEEEECCCC
RSAHGNAYFTGFGASKRIVFFDTLLARLTGNEIEAVLAHELGHFKRRHVMKRMLWTFALS
CCCCCCEEEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LALLALLGWLAQRAWFYTGLGVMPSLAGSNAGVALVLFFLSMPVFLFFVTPLGSLSSRKH
HHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCH
EFEADAFAASQTDARDLVNALVKLYEDNASTLTPDPVYTAFYYSHPPASQRIDRLLQLS
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 3145906 [H]