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The map label for this gene is bcr [H]

Identifier: 83720671

GI number: 83720671

Start: 1745758

End: 1746993

Strand: Direct

Name: bcr [H]

Synonym: BTH_I1546

Alternate gene names: 83720671

Gene position: 1745758-1746993 (Clockwise)

Preceding gene: 83720178

Following gene: 83720257

Centisome position: 45.83

GC content: 69.9

Gene sequence:

>1236_bases
ATGCCTCACGTCGCAAGACGCCGGCCCGACGGCCGGCTGATCCTGTTGCTCGGCGCGCTCGCAGCGTGCGGGCCGATCGC
CACCGACATGTATCTGCCGAGCCTGCCCGCGATCGCGGACGGCTTCGGCGTGACCGCCGCCGCCGCGCAGCGCACGCTGA
CGAGCTTCATGGCCGGCTTTTCGATCGGCATGCTGCTCTACGGCCCGCTGTCCGATACCTATGGCCGCCGCCCCGTGCTG
CTCGGCGGCATCGCGCTGTTCACGCTCGCGAGCATCGGCTGCTTCGTCGCCACGTCGATCGACATGCTGATCGTCGTCCG
CTTTCTGCAGGCGTTCGGCGCGGGTGCCGCGTCAGTGCTCGCACGCGCGATCGCGCGCGACGCGCACGAGCCGTCCGACG
CCGCGAAGGTGCTGTCGATGGTCGCGATCGTCACCGCGATCGGGCCGCTTCTCGCGCCGCTCATCGGCGGGCAGGTGCTG
CGCTTTTCCGGCTGGCGCGGCGTGTTCGTCGTGCTCACGCTGTTCGGCGCGGTCTGCGCGACGGCCGCGTTCCTGCGCGT
GCCCGAGACCTGGCCGCGCGAAAAGCGCGCGAGCTCGGCCGTGCTGAATTCGTTCGCCGCGTATGGACGCATCCTCGCCG
ATCCGGTCGCATGGGGCCATATGCTGTGCGGCGGAATGGCGTTCGCGTCGATGTTCGCGTACATCACCGCGACGCCGTTC
GTCTATATCGACTACTTCCACGTGTCGCCGCAGCATTACGGGCTGCTGTTCGGGCTGAACGTCGTCGGCATCATGATCGG
CAATTTCCTGAACACGCGCCTCGTCGGCCGAGTCGGCTCGCTGAAGATCATCGCGGGCGCGTCGCTGCTGAGCGGCGCGG
CGTCGTTCTGCGTCGCGTTCTTCGCGCTGACGGGGCTGGGCGGATTGTGGTCGATCGTCGCGAGCCTGTTCTTCGTCGTC
AGCGTGGTCGGCATCCTGTCCGCGAACTGCACGACCGACCTGATGCTGCGCTATCCGCACAACGCGGGCGCCGCGGCCGC
CGTGTTCGGCGCGATGCAGCTCGCGCTCGGCGCGCTCGCAAGCGTCGCGATCGGCGCGCTCGCGGACGGCACGCCGTTCG
CGATGGGCGTGACGATCGGCGCGACCGGCCTGCTGTGCCTTGGCGGGCGCGTGCTCGTGCTGCGCTGGCACGGCCGGCCG
GTGAAGGGCAGGCTCGGCAGCGCCGACGTCGCGTAA

Upstream 100 bases:

>100_bases
CAATCTGGTCGTTTCGGCGTCGACCCGACCGGCCGCCGTCCTCCTTGCCCGCCCGTCTCGTGCGCCATCCGCGCGAGGCG
GCCGCTTCCGTGGAATTCCA

Downstream 100 bases:

>100_bases
CGCCGCCGGCGGGCGCGGCGAGCGGCTCAGTGCAGGATCTTGTCGAGGAATTCGCGCGCGCGCTCGGAGCGCGGCGCGGC
GAAGAACGCGTCGCTCGGCG

Product: Bcr/CflA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Sulfonamide resistance protein [H]

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MPHVARRRPDGRLILLLGALAACGPIATDMYLPSLPAIADGFGVTAAAAQRTLTSFMAGFSIGMLLYGPLSDTYGRRPVL
LGGIALFTLASIGCFVATSIDMLIVVRFLQAFGAGAASVLARAIARDAHEPSDAAKVLSMVAIVTAIGPLLAPLIGGQVL
RFSGWRGVFVVLTLFGAVCATAAFLRVPETWPREKRASSAVLNSFAAYGRILADPVAWGHMLCGGMAFASMFAYITATPF
VYIDYFHVSPQHYGLLFGLNVVGIMIGNFLNTRLVGRVGSLKIIAGASLLSGAASFCVAFFALTGLGGLWSIVASLFFVV
SVVGILSANCTTDLMLRYPHNAGAAAAVFGAMQLALGALASVAIGALADGTPFAMGVTIGATGLLCLGGRVLVLRWHGRP
VKGRLGSADVA

Sequences:

>Translated_411_residues
MPHVARRRPDGRLILLLGALAACGPIATDMYLPSLPAIADGFGVTAAAAQRTLTSFMAGFSIGMLLYGPLSDTYGRRPVL
LGGIALFTLASIGCFVATSIDMLIVVRFLQAFGAGAASVLARAIARDAHEPSDAAKVLSMVAIVTAIGPLLAPLIGGQVL
RFSGWRGVFVVLTLFGAVCATAAFLRVPETWPREKRASSAVLNSFAAYGRILADPVAWGHMLCGGMAFASMFAYITATPF
VYIDYFHVSPQHYGLLFGLNVVGIMIGNFLNTRLVGRVGSLKIIAGASLLSGAASFCVAFFALTGLGGLWSIVASLFFVV
SVVGILSANCTTDLMLRYPHNAGAAAAVFGAMQLALGALASVAIGALADGTPFAMGVTIGATGLLCLGGRVLVLRWHGRP
VKGRLGSADVA
>Mature_410_residues
PHVARRRPDGRLILLLGALAACGPIATDMYLPSLPAIADGFGVTAAAAQRTLTSFMAGFSIGMLLYGPLSDTYGRRPVLL
GGIALFTLASIGCFVATSIDMLIVVRFLQAFGAGAASVLARAIARDAHEPSDAAKVLSMVAIVTAIGPLLAPLIGGQVLR
FSGWRGVFVVLTLFGAVCATAAFLRVPETWPREKRASSAVLNSFAAYGRILADPVAWGHMLCGGMAFASMFAYITATPFV
YIDYFHVSPQHYGLLFGLNVVGIMIGNFLNTRLVGRVGSLKIIAGASLLSGAASFCVAFFALTGLGGLWSIVASLFFVVS
VVGILSANCTTDLMLRYPHNAGAAAAVFGAMQLALGALASVAIGALADGTPFAMGVTIGATGLLCLGGRVLVLRWHGRPV
KGRLGSADVA

Specific function: Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=397, Percent_Identity=33.7531486146096, Blast_Score=235, Evalue=5e-63,
Organism=Escherichia coli, GI48994889, Length=373, Percent_Identity=29.7587131367292, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1790146, Length=202, Percent_Identity=32.6732673267327, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1787065, Length=279, Percent_Identity=30.8243727598566, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI87082312, Length=344, Percent_Identity=27.3255813953488, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1790794, Length=221, Percent_Identity=23.0769230769231, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790195, Length=138, Percent_Identity=28.9855072463768, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789207, Length=142, Percent_Identity=34.5070422535211, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1787880, Length=230, Percent_Identity=28.2608695652174, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319657, Length=168, Percent_Identity=27.3809523809524, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324264, Length=178, Percent_Identity=25.8426966292135, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6319480, Length=362, Percent_Identity=21.8232044198895, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322071, Length=165, Percent_Identity=27.8787878787879, Blast_Score=63, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42499; Mature: 42368

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHVARRRPDGRLILLLGALAACGPIATDMYLPSLPAIADGFGVTAAAAQRTLTSFMAGF
CCCCCCCCCCCCEEHHHHHHHHCCHHHHHHHCCCCCCHHCCCCHHHHHHHHHHHHHHHHH
SIGMLLYGPLSDTYGRRPVLLGGIALFTLASIGCFVATSIDMLIVVRFLQAFGAGAASVL
HHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
ARAIARDAHEPSDAAKVLSMVAIVTAIGPLLAPLIGGQVLRFSGWRGVFVVLTLFGAVCA
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHH
TAAFLRVPETWPREKRASSAVLNSFAAYGRILADPVAWGHMLCGGMAFASMFAYITATPF
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
VYIDYFHVSPQHYGLLFGLNVVGIMIGNFLNTRLVGRVGSLKIIAGASLLSGAASFCVAF
EEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHH
FALTGLGGLWSIVASLFFVVSVVGILSANCTTDLMLRYPHNAGAAAAVFGAMQLALGALA
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHH
SVAIGALADGTPFAMGVTIGATGLLCLGGRVLVLRWHGRPVKGRLGSADVA
HHHHHHHCCCCCEEEEEHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
PHVARRRPDGRLILLLGALAACGPIATDMYLPSLPAIADGFGVTAAAAQRTLTSFMAGF
CCCCCCCCCCCEEHHHHHHHHCCHHHHHHHCCCCCCHHCCCCHHHHHHHHHHHHHHHHH
SIGMLLYGPLSDTYGRRPVLLGGIALFTLASIGCFVATSIDMLIVVRFLQAFGAGAASVL
HHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
ARAIARDAHEPSDAAKVLSMVAIVTAIGPLLAPLIGGQVLRFSGWRGVFVVLTLFGAVCA
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHH
TAAFLRVPETWPREKRASSAVLNSFAAYGRILADPVAWGHMLCGGMAFASMFAYITATPF
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
VYIDYFHVSPQHYGLLFGLNVVGIMIGNFLNTRLVGRVGSLKIIAGASLLSGAASFCVAF
EEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHH
FALTGLGGLWSIVASLFFVVSVVGILSANCTTDLMLRYPHNAGAAAAVFGAMQLALGALA
HHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHH
SVAIGALADGTPFAMGVTIGATGLLCLGGRVLVLRWHGRPVKGRLGSADVA
HHHHHHHCCCCCEEEEEHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8486276; 9278503; 2694948 [H]