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The map label for this gene is uvrD [H]

Identifier: 83719885

GI number: 83719885

Start: 1633823

End: 1636585

Strand: Direct

Name: uvrD [H]

Synonym: BTH_I1443

Alternate gene names: 83719885

Gene position: 1633823-1636585 (Clockwise)

Preceding gene: 83718997

Following gene: 83719167

Centisome position: 42.89

GC content: 53.09

Gene sequence:

>2763_bases
ATGGATCGCTCGAAGTTCACGAAAAGCCAAATCGCCGCAATTGACCACGTGAATGGAAACCTGCAGCTAATTGCTTGCGC
AGGTTCCGGTAAGACAGAGGTTGTCGCTCAACGGGTTGTAAGATTGCTGCAGCCTATTTCCGTGGGAGGCGCTGGCTGCC
ATCCCGAGAACATTGTTGCGTTTACGTTTACGGACAAGGCTGCAGCGGAACTCAAGGAGCGCATACATACCCGTTGTCAC
GAGCAAATCGGCAACGTTACAGGCCTGGCTGATATGTACGTCGGCACCATCCATGGCTATTGTTTGGAGTTGCTTAAGTC
GGAGGTACCTCAGTACATGAAGTACGAGGTTCTCAACGACGTCCAGCAGGCACTGTTTGTCGATCGCCACTCGAAGGCAT
CTGGTCTAACGCAAAGCACGACGCTGGATGGGAAACCGCTCAAGCGTTATACCGACACTCGGAACTACGTATCTGCGTTG
GCGATCCTGCGCGAGGATCATCCATGTGATGAGGCCCTCCTCGAGGACAACACTGTCGCTTCGCACCTCAAGATCTACGA
GGATCTAACTGACAAGAAAGGATATCTAGATTACTCTGGAATCCTAAATCGTGCTGTGGCAGAGCTAACGCGGAATAGAG
AGCTACGGGAGCGATTAGCGCTGCGTGTCAAGCATGTGATCGTCGACGAATATCAAGATGTCAATCCAGTCCAGGAGGCG
ATAGTTGCGGAACTACGTCAACTTGGCGCTGACATTTGTGTGGTCGGCGATGACGATCAGACGATCTACCAGTGGCGAGG
TAGCGAAGTACAAAACATTCTCACCTTTGATCGCCGATACAACGATGTGACGCAAGTGCGGCTTGAAGAGAATTTTCGCT
CGAGCGAAGGTGTCGTAGCACTGGCTCGTGAATTCATCAGTCATCTAAACCACCGCTTGCCGAAGGAGATGAAAGCTACA
CATGCGCAATCCTATGAAGATGGTGACATCGTAGCGCTCGGGTTCGACTCACCTGAGGAAGAGGCAGAATATATTGCAAA
GACTTGCATGGCTCTGCGGGGAGTTGTTGTCCATGAAAGTAGTAGTGAACGCGGTATCTCATGGTCCGACATGGCGGTGT
TGCTTCGATCCGTAAGGCGAGACGCACCGGCAGTGACAGCCGCGTTGGATGCGGTGAGGGTGCCATATGTCATCACCGGT
ATGGACAACCTTTTTCAGAAGGAAGAGGTGGAGGCAGCACGCCAGCTTTTTTATTTTTTGGCAGGCGAGATAGAGATGAA
CGAGTTGCGTGCTGCCTGGCAACGTGCTGACCTTGGCATCACCAAGCATGCCCTTGAAGGTGCTATTGCAGCGGCAGCCG
AGGCTCGCGTAGACATGCAGGACGCGGAAATAGGGCAGTTCAAGGTCTACAACCTGCAGCGGCAGTTTATCGCTTTTATG
GAGAAGTCCGAACTGCGAGAGGAACGAGTACCAGGCGGCCGTGGCGAGATCGTCTTCTACAACCTTGGAAAGTTTAGCCA
GGCGATCTCCGATTTCGAAAGCATTCACTTTCATTCCGATCCGGTAGAGAAATACAAGAGCTTTGCGGGCTTTCTGCGTT
TCCATGCCGAAAATGCGTACCCGGAGGGATGGCAAGATAACGGTTTTGTTAGTCCCGATGCCGTCCGCATCATGACCGTG
CACCAGGCAAAGGGGCTCCAGTGGCCGGTAGTATTTATTCCTCAATTGGTAAAGAATCGCTTTCCGGCAAAGGGTGGTGG
CGGGCGAAACGCTTGGCATCTTCTGCCCTCTGAAGCATTTTCCAATGCCGCTCGCTATCGGGGAGGCGCTGACGACGAGC
GACGACTCTTCTACGTTGCGGTGACACGCGCACAGAAGTATTTGCACATGACGTGGGCACCACATGAGGGTAACCGCACG
GCGCAAGTGGCGTCGGATTTCTACAATGAGGTCTTGGCATCGAAATACGTGAAACGGCGAGTTCAGAATTACGCTACCCG
ACAGCAACTGACGCCAGCGCCTAAGGCATCGGTAGCGAACGTCACGTTGTCGTTCTCGGATGTAAAGTACTTCTTTGAGT
GTCCCTATCAGTTCAAGCTGCGCATCCTCTACGGATTCAACGCGCCGCTCGACGAGGCCTTGGGGTACGGAAAGTCGCTG
CACGACGCCTTGGCCGAGGTTCACGCACGTGCGTTGCGCGGAGAGACCATTGACTCCCGCGAAGCCGAAGAATTGATCGA
GCGCCACTTGCGGGCACCATATGCCTATCCGGATTTGAAGGACAAGTTGAAGAGCGCCGCTGTGAAAGTCGTGGCTGCAT
ACATTCGGAAAAATGCGGCTGAGTTCAACAATTTGGAGTTTTCTGAGAAGGCGATAGAGATTGCTCTTGGCGATGGCGTT
TCAGTGGCTGGAAGAATCGACTTGGTACGGAGAATGGATACTGACGAAGTCACTATCGTTGACCTGAAGTCGAATGACCG
GGCACAGGCTGAAGCAGTTACCGAAACACAACTCCATATTTATGCGCTAGGTTATAAGGAGCTTACTGGGCGACCCGCCG
ACTATGTCGAGATTTACGAGCTTGACAATCAACGACAAAAACGACGATCTGTCGATGGAGATTTCACCGACGACGTGAGG
CGGGACGTACTCGCGGCTGCTACGGCACTGCGGCGAAATCAATTGCCACCAAAGCCTGGCAAGAAAGCTTGCGGAGCGTG
CGACTACTGCAACCTTTGCTCGGCCGCTGTCAATAAGAGCTAG

Upstream 100 bases:

>100_bases
CTCAACGCTATCGCACGTGCCAACTGATCGTGAACTCTGGCTCTTTGGCGACATGCCGGGTAGCATAACCAGTAGTACAA
GTTGGGCAAACGGGGGAGAA

Downstream 100 bases:

>100_bases
TCAAGAAGAGGGGCAGCGTCGCAAATGTCTGTTGATGCCATCTTATTCGACGCATTTGGCACTCTCTGTGAACTTAAGGC
GAAGACGCAACCGTTCGTCA

Product: superfamily I DNA/RNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 920; Mature: 920

Protein sequence:

>920_residues
MDRSKFTKSQIAAIDHVNGNLQLIACAGSGKTEVVAQRVVRLLQPISVGGAGCHPENIVAFTFTDKAAAELKERIHTRCH
EQIGNVTGLADMYVGTIHGYCLELLKSEVPQYMKYEVLNDVQQALFVDRHSKASGLTQSTTLDGKPLKRYTDTRNYVSAL
AILREDHPCDEALLEDNTVASHLKIYEDLTDKKGYLDYSGILNRAVAELTRNRELRERLALRVKHVIVDEYQDVNPVQEA
IVAELRQLGADICVVGDDDQTIYQWRGSEVQNILTFDRRYNDVTQVRLEENFRSSEGVVALAREFISHLNHRLPKEMKAT
HAQSYEDGDIVALGFDSPEEEAEYIAKTCMALRGVVVHESSSERGISWSDMAVLLRSVRRDAPAVTAALDAVRVPYVITG
MDNLFQKEEVEAARQLFYFLAGEIEMNELRAAWQRADLGITKHALEGAIAAAAEARVDMQDAEIGQFKVYNLQRQFIAFM
EKSELREERVPGGRGEIVFYNLGKFSQAISDFESIHFHSDPVEKYKSFAGFLRFHAENAYPEGWQDNGFVSPDAVRIMTV
HQAKGLQWPVVFIPQLVKNRFPAKGGGGRNAWHLLPSEAFSNAARYRGGADDERRLFYVAVTRAQKYLHMTWAPHEGNRT
AQVASDFYNEVLASKYVKRRVQNYATRQQLTPAPKASVANVTLSFSDVKYFFECPYQFKLRILYGFNAPLDEALGYGKSL
HDALAEVHARALRGETIDSREAEELIERHLRAPYAYPDLKDKLKSAAVKVVAAYIRKNAAEFNNLEFSEKAIEIALGDGV
SVAGRIDLVRRMDTDEVTIVDLKSNDRAQAEAVTETQLHIYALGYKELTGRPADYVEIYELDNQRQKRRSVDGDFTDDVR
RDVLAAATALRRNQLPPKPGKKACGACDYCNLCSAAVNKS

Sequences:

>Translated_920_residues
MDRSKFTKSQIAAIDHVNGNLQLIACAGSGKTEVVAQRVVRLLQPISVGGAGCHPENIVAFTFTDKAAAELKERIHTRCH
EQIGNVTGLADMYVGTIHGYCLELLKSEVPQYMKYEVLNDVQQALFVDRHSKASGLTQSTTLDGKPLKRYTDTRNYVSAL
AILREDHPCDEALLEDNTVASHLKIYEDLTDKKGYLDYSGILNRAVAELTRNRELRERLALRVKHVIVDEYQDVNPVQEA
IVAELRQLGADICVVGDDDQTIYQWRGSEVQNILTFDRRYNDVTQVRLEENFRSSEGVVALAREFISHLNHRLPKEMKAT
HAQSYEDGDIVALGFDSPEEEAEYIAKTCMALRGVVVHESSSERGISWSDMAVLLRSVRRDAPAVTAALDAVRVPYVITG
MDNLFQKEEVEAARQLFYFLAGEIEMNELRAAWQRADLGITKHALEGAIAAAAEARVDMQDAEIGQFKVYNLQRQFIAFM
EKSELREERVPGGRGEIVFYNLGKFSQAISDFESIHFHSDPVEKYKSFAGFLRFHAENAYPEGWQDNGFVSPDAVRIMTV
HQAKGLQWPVVFIPQLVKNRFPAKGGGGRNAWHLLPSEAFSNAARYRGGADDERRLFYVAVTRAQKYLHMTWAPHEGNRT
AQVASDFYNEVLASKYVKRRVQNYATRQQLTPAPKASVANVTLSFSDVKYFFECPYQFKLRILYGFNAPLDEALGYGKSL
HDALAEVHARALRGETIDSREAEELIERHLRAPYAYPDLKDKLKSAAVKVVAAYIRKNAAEFNNLEFSEKAIEIALGDGV
SVAGRIDLVRRMDTDEVTIVDLKSNDRAQAEAVTETQLHIYALGYKELTGRPADYVEIYELDNQRQKRRSVDGDFTDDVR
RDVLAAATALRRNQLPPKPGKKACGACDYCNLCSAAVNKS
>Mature_920_residues
MDRSKFTKSQIAAIDHVNGNLQLIACAGSGKTEVVAQRVVRLLQPISVGGAGCHPENIVAFTFTDKAAAELKERIHTRCH
EQIGNVTGLADMYVGTIHGYCLELLKSEVPQYMKYEVLNDVQQALFVDRHSKASGLTQSTTLDGKPLKRYTDTRNYVSAL
AILREDHPCDEALLEDNTVASHLKIYEDLTDKKGYLDYSGILNRAVAELTRNRELRERLALRVKHVIVDEYQDVNPVQEA
IVAELRQLGADICVVGDDDQTIYQWRGSEVQNILTFDRRYNDVTQVRLEENFRSSEGVVALAREFISHLNHRLPKEMKAT
HAQSYEDGDIVALGFDSPEEEAEYIAKTCMALRGVVVHESSSERGISWSDMAVLLRSVRRDAPAVTAALDAVRVPYVITG
MDNLFQKEEVEAARQLFYFLAGEIEMNELRAAWQRADLGITKHALEGAIAAAAEARVDMQDAEIGQFKVYNLQRQFIAFM
EKSELREERVPGGRGEIVFYNLGKFSQAISDFESIHFHSDPVEKYKSFAGFLRFHAENAYPEGWQDNGFVSPDAVRIMTV
HQAKGLQWPVVFIPQLVKNRFPAKGGGGRNAWHLLPSEAFSNAARYRGGADDERRLFYVAVTRAQKYLHMTWAPHEGNRT
AQVASDFYNEVLASKYVKRRVQNYATRQQLTPAPKASVANVTLSFSDVKYFFECPYQFKLRILYGFNAPLDEALGYGKSL
HDALAEVHARALRGETIDSREAEELIERHLRAPYAYPDLKDKLKSAAVKVVAAYIRKNAAEFNNLEFSEKAIEIALGDGV
SVAGRIDLVRRMDTDEVTIVDLKSNDRAQAEAVTETQLHIYALGYKELTGRPADYVEIYELDNQRQKRRSVDGDFTDDVR
RDVLAAATALRRNQLPPKPGKKACGACDYCNLCSAAVNKS

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=655, Percent_Identity=27.3282442748092, Blast_Score=185, Evalue=1e-47,
Organism=Escherichia coli, GI48994965, Length=419, Percent_Identity=26.2529832935561, Blast_Score=130, Evalue=4e-31,
Organism=Escherichia coli, GI1787196, Length=359, Percent_Identity=24.5125348189415, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6322369, Length=440, Percent_Identity=26.8181818181818, Blast_Score=119, Evalue=3e-27,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 103373; Mature: 103373

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRSKFTKSQIAAIDHVNGNLQLIACAGSGKTEVVAQRVVRLLQPISVGGAGCHPENIVA
CCCCHHHHHHHHHHEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
FTFTDKAAAELKERIHTRCHEQIGNVTGLADMYVGTIHGYCLELLKSEVPQYMKYEVLND
EEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
VQQALFVDRHSKASGLTQSTTLDGKPLKRYTDTRNYVSALAILREDHPCDEALLEDNTVA
HHHHHHHHCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHH
SHLKIYEDLTDKKGYLDYSGILNRAVAELTRNRELRERLALRVKHVIVDEYQDVNPVQEA
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCHHHHH
IVAELRQLGADICVVGDDDQTIYQWRGSEVQNILTFDRRYNDVTQVRLEENFRSSEGVVA
HHHHHHHCCCCEEEECCCCCEEEEECCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHH
LAREFISHLNHRLPKEMKATHAQSYEDGDIVALGFDSPEEEAEYIAKTCMALRGVVVHES
HHHHHHHHHHHHCCHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCEEEECC
SSERGISWSDMAVLLRSVRRDAPAVTAALDAVRVPYVITGMDNLFQKEEVEAARQLFYFL
CCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHH
AGEIEMNELRAAWQRADLGITKHALEGAIAAAAEARVDMQDAEIGQFKVYNLQRQFIAFM
HCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHH
EKSELREERVPGGRGEIVFYNLGKFSQAISDFESIHFHSDPVEKYKSFAGFLRFHAENAY
HHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCC
PEGWQDNGFVSPDAVRIMTVHQAKGLQWPVVFIPQLVKNRFPAKGGGGRNAWHLLPSEAF
CCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEECCCHHH
SNAARYRGGADDERRLFYVAVTRAQKYLHMTWAPHEGNRTAQVASDFYNEVLASKYVKRR
HHHHHHCCCCCCCCEEEEEEEEHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
VQNYATRQQLTPAPKASVANVTLSFSDVKYFFECPYQFKLRILYGFNAPLDEALGYGKSL
HHHHHHHHHCCCCCCCCEEEEEEEHHHHHHHHCCCCEEEEEEEEECCCCHHHHHCCCHHH
HDALAEVHARALRGETIDSREAEELIERHLRAPYAYPDLKDKLKSAAVKVVAAYIRKNAA
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
EFNNLEFSEKAIEIALGDGVSVAGRIDLVRRMDTDEVTIVDLKSNDRAQAEAVTETQLHI
HCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCEEEE
YALGYKELTGRPADYVEIYELDNQRQKRRSVDGDFTDDVRRDVLAAATALRRNQLPPKPG
EEECHHHHCCCCCCEEEEEECCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
KKACGACDYCNLCSAAVNKS
CCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MDRSKFTKSQIAAIDHVNGNLQLIACAGSGKTEVVAQRVVRLLQPISVGGAGCHPENIVA
CCCCHHHHHHHHHHEECCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
FTFTDKAAAELKERIHTRCHEQIGNVTGLADMYVGTIHGYCLELLKSEVPQYMKYEVLND
EEECCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
VQQALFVDRHSKASGLTQSTTLDGKPLKRYTDTRNYVSALAILREDHPCDEALLEDNTVA
HHHHHHHHCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHH
SHLKIYEDLTDKKGYLDYSGILNRAVAELTRNRELRERLALRVKHVIVDEYQDVNPVQEA
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCHHHHH
IVAELRQLGADICVVGDDDQTIYQWRGSEVQNILTFDRRYNDVTQVRLEENFRSSEGVVA
HHHHHHHCCCCEEEECCCCCEEEEECCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHH
LAREFISHLNHRLPKEMKATHAQSYEDGDIVALGFDSPEEEAEYIAKTCMALRGVVVHES
HHHHHHHHHHHHCCHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHCEEEECC
SSERGISWSDMAVLLRSVRRDAPAVTAALDAVRVPYVITGMDNLFQKEEVEAARQLFYFL
CCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHH
AGEIEMNELRAAWQRADLGITKHALEGAIAAAAEARVDMQDAEIGQFKVYNLQRQFIAFM
HCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHH
EKSELREERVPGGRGEIVFYNLGKFSQAISDFESIHFHSDPVEKYKSFAGFLRFHAENAY
HHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCC
PEGWQDNGFVSPDAVRIMTVHQAKGLQWPVVFIPQLVKNRFPAKGGGGRNAWHLLPSEAF
CCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEECCCHHH
SNAARYRGGADDERRLFYVAVTRAQKYLHMTWAPHEGNRTAQVASDFYNEVLASKYVKRR
HHHHHHCCCCCCCCEEEEEEEEHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHH
VQNYATRQQLTPAPKASVANVTLSFSDVKYFFECPYQFKLRILYGFNAPLDEALGYGKSL
HHHHHHHHHCCCCCCCCEEEEEEEHHHHHHHHCCCCEEEEEEEEECCCCHHHHHCCCHHH
HDALAEVHARALRGETIDSREAEELIERHLRAPYAYPDLKDKLKSAAVKVVAAYIRKNAA
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
EFNNLEFSEKAIEIALGDGVSVAGRIDLVRRMDTDEVTIVDLKSNDRAQAEAVTETQLHI
HCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHCEEEE
YALGYKELTGRPADYVEIYELDNQRQKRRSVDGDFTDDVRRDVLAAATALRRNQLPPKPG
EEECHHHHCCCCCCEEEEEECCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
KKACGACDYCNLCSAAVNKS
CCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]