Click here to switch to the map view.

The map label for this gene is holA [H]

Identifier: 83719754

GI number: 83719754

Start: 1358974

End: 1360062

Strand: Direct

Name: holA [H]

Synonym: BTH_I1213

Alternate gene names: 83719754

Gene position: 1358974-1360062 (Clockwise)

Preceding gene: 83718745

Following gene: 83720441

Centisome position: 35.68

GC content: 73.0

Gene sequence:

>1089_bases
ATGCAACTGCGACTTGACGCGCTGGAGCCGCATCTCTCGAAGGGGCTCGCCGGGCTGTACGTCGTCTACGGTGACGAGCC
GCTGCTCGCGCAGGAGGCGTGCGACAAGATCCGCGCCGCCGCGCGCGCGGCGGGCTTCACCGAGCGCTCGGTGCACACCG
TCGAGCGCGGCTTCGACTGGAGCACGCTGATCGGCGCGAGCCAGGCGATGTCGCTGTTCGGCGAGCGGCAGCTCGTCGAG
CTGCGGATTCCGTCCGGCAAGCCGGGCAAGGATGGCGCCGACGCATTGAAGACGCTCGCCGGCGCGGACAACCCGGATGC
GCTGATGCTCGTCACGCTGCCGCGGCTCGATTCGGCGACGCAGAAGTCCGCGTGGTTCACGGCGCTCGTGAACGGCGGCG
TCGCGCTGAAGGTCGATCCCGTCGAGCGCGCGCAGTTGCCGAACTGGATCGGCCAGCGGCTCGCGCTGCAGGGGCAGCGG
GTCGCGCCGGGCGACGACGGGCGGCGCGCGCTCGCGTTCGTCGCCGAGCGTGTCGAGGGCAACCTGCTCGCCGCGCATCA
GGAAATCCAGAAGCTCGGCCTGCTGTATCCGGCGGGCACGCTGACGTTCGAGCAGATCCACGACGCGGTGCTGAACGTCG
CGCGCTACGACGTGTTCAAGCTCAACGAGGCGATGCTCGCGGGCGACGCCGCGCGGCTTTCGCGGATGATCGACGGCCTG
AAGGGCGAGGGCGAGGCGCTCGTGCTCGTGCTGTGGGCGGTCGTCGAGGAGTTGCGCACGCTGCTTCGGATCAAGCGCGG
CGTCGCGGCGGGCAAGCCGCTTGCCGTGCTCGTGCGCGAGAACCGCGTATGGGGGGCGCGCGAGCGGCTCGTCGGGCCGG
CGCTCGCGCGCGTCTCGGAGGCGGCGCTCGAGCACGCGCTCGCGTTCGCCGCGCGGCTCGACCGGCAGGTCAAGGGGCTT
TCCGCCGTATCGCGCGGCGCGGCGCGCGGCGAGCCGCCGCCCGATCCGTGGGACGGCCTGTTCCAGCTCGCGATGACCGT
CGCGCGCGCGTCCGGGCCGGCCGGCGACGCACCGCGCCGGCCGGCCTGA

Upstream 100 bases:

>100_bases
CAAGGGCGTGCCGGCCGTTGCGCCGCGCGCGCCGCTGCCGCCGCCGCCGCTGTGATCGCCGCGTTTTTCCTCTCCTCCTC
AACGATCGACGCACGAACCG

Downstream 100 bases:

>100_bases
GCGCGCTTTCGCGCCGGCGCTTACAATCGGCGTGAACCGGCAGCGCGAGCGCCGACGCGGTGCCCGGCGCCCCCGTTTTC
CGACAATCGTTTTTTCGCCG

Product: DNA polymerase III subunit delta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MQLRLDALEPHLSKGLAGLYVVYGDEPLLAQEACDKIRAAARAAGFTERSVHTVERGFDWSTLIGASQAMSLFGERQLVE
LRIPSGKPGKDGADALKTLAGADNPDALMLVTLPRLDSATQKSAWFTALVNGGVALKVDPVERAQLPNWIGQRLALQGQR
VAPGDDGRRALAFVAERVEGNLLAAHQEIQKLGLLYPAGTLTFEQIHDAVLNVARYDVFKLNEAMLAGDAARLSRMIDGL
KGEGEALVLVLWAVVEELRTLLRIKRGVAAGKPLAVLVRENRVWGARERLVGPALARVSEAALEHALAFAARLDRQVKGL
SAVSRGAARGEPPPDPWDGLFQLAMTVARASGPAGDAPRRPA

Sequences:

>Translated_362_residues
MQLRLDALEPHLSKGLAGLYVVYGDEPLLAQEACDKIRAAARAAGFTERSVHTVERGFDWSTLIGASQAMSLFGERQLVE
LRIPSGKPGKDGADALKTLAGADNPDALMLVTLPRLDSATQKSAWFTALVNGGVALKVDPVERAQLPNWIGQRLALQGQR
VAPGDDGRRALAFVAERVEGNLLAAHQEIQKLGLLYPAGTLTFEQIHDAVLNVARYDVFKLNEAMLAGDAARLSRMIDGL
KGEGEALVLVLWAVVEELRTLLRIKRGVAAGKPLAVLVRENRVWGARERLVGPALARVSEAALEHALAFAARLDRQVKGL
SAVSRGAARGEPPPDPWDGLFQLAMTVARASGPAGDAPRRPA
>Mature_362_residues
MQLRLDALEPHLSKGLAGLYVVYGDEPLLAQEACDKIRAAARAAGFTERSVHTVERGFDWSTLIGASQAMSLFGERQLVE
LRIPSGKPGKDGADALKTLAGADNPDALMLVTLPRLDSATQKSAWFTALVNGGVALKVDPVERAQLPNWIGQRLALQGQR
VAPGDDGRRALAFVAERVEGNLLAAHQEIQKLGLLYPAGTLTFEQIHDAVLNVARYDVFKLNEAMLAGDAARLSRMIDGL
KGEGEALVLVLWAVVEELRTLLRIKRGVAAGKPLAVLVRENRVWGARERLVGPALARVSEAALEHALAFAARLDRQVKGL
SAVSRGAARGEPPPDPWDGLFQLAMTVARASGPAGDAPRRPA

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The delta subunit seems to interact with the gamma subunit to transfer the b

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786859, Length=313, Percent_Identity=33.8658146964856, Blast_Score=160, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 38791; Mature: 38791

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: PS00041 HTH_ARAC_FAMILY_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLRLDALEPHLSKGLAGLYVVYGDEPLLAQEACDKIRAAARAAGFTERSVHTVERGFDW
CCEECCHHCHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCH
STLIGASQAMSLFGERQLVELRIPSGKPGKDGADALKTLAGADNPDALMLVTLPRLDSAT
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCH
QKSAWFTALVNGGVALKVDPVERAQLPNWIGQRLALQGQRVAPGDDGRRALAFVAERVEG
HHHHHHHHEECCCEEEEECCHHHHHCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCC
NLLAAHQEIQKLGLLYPAGTLTFEQIHDAVLNVARYDVFKLNEAMLAGDAARLSRMIDGL
CHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
KGEGEALVLVLWAVVEELRTLLRIKRGVAAGKPLAVLVRENRVWGARERLVGPALARVSE
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHH
AALEHALAFAARLDRQVKGLSAVSRGAARGEPPPDPWDGLFQLAMTVARASGPAGDAPRR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
PA
CC
>Mature Secondary Structure
MQLRLDALEPHLSKGLAGLYVVYGDEPLLAQEACDKIRAAARAAGFTERSVHTVERGFDW
CCEECCHHCHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCH
STLIGASQAMSLFGERQLVELRIPSGKPGKDGADALKTLAGADNPDALMLVTLPRLDSAT
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCH
QKSAWFTALVNGGVALKVDPVERAQLPNWIGQRLALQGQRVAPGDDGRRALAFVAERVEG
HHHHHHHHEECCCEEEEECCHHHHHCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCC
NLLAAHQEIQKLGLLYPAGTLTFEQIHDAVLNVARYDVFKLNEAMLAGDAARLSRMIDGL
CHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
KGEGEALVLVLWAVVEELRTLLRIKRGVAAGKPLAVLVRENRVWGARERLVGPALARVSE
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHH
AALEHALAFAARLDRQVKGLSAVSRGAARGEPPPDPWDGLFQLAMTVARASGPAGDAPRR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
PA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8505303; 1400251; 8905232; 9278503; 3316191; 8505304; 1575709 [H]