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The map label for this gene is nrdB [H]

Identifier: 83719302

GI number: 83719302

Start: 1301815

End: 1302948

Strand: Direct

Name: nrdB [H]

Synonym: BTH_I1154

Alternate gene names: 83719302

Gene position: 1301815-1302948 (Clockwise)

Preceding gene: 83719828

Following gene: 83720051

Centisome position: 34.18

GC content: 61.38

Gene sequence:

>1134_bases
ATGGCTGTCGGATTGCAGGCTGCGGTGCCTGCCGCTCATCAAGCTTCGTCGGCCCGCGACATCTTCGCGGGAGACTTCGC
CGTGGCGCCGAATGCGTCGGCCGCCGTCGCTTCGGAAGCGCGGGTCAATGTCGCCGACAAGCGCATCATCAACGGCCAGA
CCGACGTCAACCAGCTCGTGCCGTTCAAGTACAAGTGGGCGTGGGAGAAGTACCTGGCCGGTTGCGCGAATCACTGGATG
CCGCAGGAAATCAACATGTCCCGCGACATCGCGCTCTGGAAGGACCCGAACGGCCTGACGGAAGACGAGCGCCGGATCGT
CAAGCGCAACCTCGGCTTCTTCGTGACGGCCGATTCGCTCGCGGCAAACAACATCGTGCTCGGCACGTACCGCCACATCA
CCGCGCCGGAGTGCCGGCAGTTCCTGCTGCGCCAGGCGTTCGAAGAGGCGATCCACACGCACGCGTACCAATATATTGTC
GAATCGCTCGGCCTCGACGAAGGCGAGATCTTCAACGCGTACCACGAGGTGCCGTCGATCCGCGCGAAGGACGAGTTTCT
GATTCCGTTCATCCATACGCTGACCGATCCGGCCTTCAAGACGGGCACGCTGGAAGCCGATCAGAAGCTGCTGAAGTCGC
TGATCGTGTTCGCGTGCATCATGGAAGGCCTGTTCTTCTACGTCGGCTTCACGCAGATTCTCGCGCTCGGCCGTCAGAAC
AAGATGACGGGCGCGGCGGAGCAATACCAGTACATCCTCCGCGACGAATCGATGCACTGCAACTTCGGGATCGACCTGAT
CAACCAGATCAAGCTCGAGAACCCGCACCTGTGGACGGCGGAGTTCCGCGCCGAGATCCGCGAGCTGTTCAAGCACGCCG
TCGATCTCGAGTACCGCTACGCGGAAGATACGATGCCGCGCGGCGTGCTGGGCCTGAACGCATCGATGTTCAAGAGCTAC
CTGCGCTTCATCAGCAACCGCCGCTGCCAGCAGATCGGCCTCGATCCGCTGTTCCCGAACGAGGAAAACCCGTTCCCGTG
GATGAGCGAGATGATCGACTTGAAGAAGGAGCGAAACTTCTTCGAGACGCGGGTGATCGAGTATCAGACGGGCGGTGCGC
TGTCGTGGGAATGA

Upstream 100 bases:

>100_bases
AAATTGATGGTGAGAATTTATGCTCAACTGGGATGACGAGAAGACTGCCGTAACTCCCGCGAGCGGAGCGCAGCACAACG
CGATGCGCGACCCCGCAGGA

Downstream 100 bases:

>100_bases
CCCGACGCGCAGCCGACGAGTAACGATGTGGATGCCGGGCACCGTGCCCGGCACAAGGTTTAGGAGCAAGCACGCCTGAT
GCAAAGCATGTCCGGCGCCT

Product: ribonucleotide-diphosphate reductase subunit beta

Products: NA

Alternate protein names: Ribonucleotide reductase small subunit [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MAVGLQAAVPAAHQASSARDIFAGDFAVAPNASAAVASEARVNVADKRIINGQTDVNQLVPFKYKWAWEKYLAGCANHWM
PQEINMSRDIALWKDPNGLTEDERRIVKRNLGFFVTADSLAANNIVLGTYRHITAPECRQFLLRQAFEEAIHTHAYQYIV
ESLGLDEGEIFNAYHEVPSIRAKDEFLIPFIHTLTDPAFKTGTLEADQKLLKSLIVFACIMEGLFFYVGFTQILALGRQN
KMTGAAEQYQYILRDESMHCNFGIDLINQIKLENPHLWTAEFRAEIRELFKHAVDLEYRYAEDTMPRGVLGLNASMFKSY
LRFISNRRCQQIGLDPLFPNEENPFPWMSEMIDLKKERNFFETRVIEYQTGGALSWE

Sequences:

>Translated_377_residues
MAVGLQAAVPAAHQASSARDIFAGDFAVAPNASAAVASEARVNVADKRIINGQTDVNQLVPFKYKWAWEKYLAGCANHWM
PQEINMSRDIALWKDPNGLTEDERRIVKRNLGFFVTADSLAANNIVLGTYRHITAPECRQFLLRQAFEEAIHTHAYQYIV
ESLGLDEGEIFNAYHEVPSIRAKDEFLIPFIHTLTDPAFKTGTLEADQKLLKSLIVFACIMEGLFFYVGFTQILALGRQN
KMTGAAEQYQYILRDESMHCNFGIDLINQIKLENPHLWTAEFRAEIRELFKHAVDLEYRYAEDTMPRGVLGLNASMFKSY
LRFISNRRCQQIGLDPLFPNEENPFPWMSEMIDLKKERNFFETRVIEYQTGGALSWE
>Mature_376_residues
AVGLQAAVPAAHQASSARDIFAGDFAVAPNASAAVASEARVNVADKRIINGQTDVNQLVPFKYKWAWEKYLAGCANHWMP
QEINMSRDIALWKDPNGLTEDERRIVKRNLGFFVTADSLAANNIVLGTYRHITAPECRQFLLRQAFEEAIHTHAYQYIVE
SLGLDEGEIFNAYHEVPSIRAKDEFLIPFIHTLTDPAFKTGTLEADQKLLKSLIVFACIMEGLFFYVGFTQILALGRQNK
MTGAAEQYQYILRDESMHCNFGIDLINQIKLENPHLWTAEFRAEIRELFKHAVDLEYRYAEDTMPRGVLGLNASMFKSYL
RFISNRRCQQIGLDPLFPNEENPFPWMSEMIDLKKERNFFETRVIEYQTGGALSWE

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0208

COG function: function code F; Ribonucleotide reductase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonucleoside diphosphate reductase small chain family [H]

Homologues:

Organism=Homo sapiens, GI289177074, Length=360, Percent_Identity=27.2222222222222, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI42544136, Length=348, Percent_Identity=26.7241379310345, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI4557845, Length=364, Percent_Identity=27.7472527472527, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI260064013, Length=364, Percent_Identity=27.7472527472527, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI289177076, Length=298, Percent_Identity=28.5234899328859, Blast_Score=127, Evalue=1e-29,
Organism=Escherichia coli, GI1788567, Length=293, Percent_Identity=25.938566552901, Blast_Score=99, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17551968, Length=321, Percent_Identity=27.7258566978193, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI193206379, Length=304, Percent_Identity=22.3684210526316, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17567153, Length=227, Percent_Identity=27.7533039647577, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322434, Length=330, Percent_Identity=31.2121212121212, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6321619, Length=320, Percent_Identity=23.125, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI18079279, Length=320, Percent_Identity=27.5, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009078
- InterPro:   IPR012348
- InterPro:   IPR000358 [H]

Pfam domain/function: PF00268 Ribonuc_red_sm [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 43077; Mature: 42945

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVGLQAAVPAAHQASSARDIFAGDFAVAPNASAAVASEARVNVADKRIINGQTDVNQLV
CCCCCCHHCCCHHHCCCCCHHHCCCEEECCCCCHHHHHHHHCCHHHHHEECCCCCHHHHC
PFKYKWAWEKYLAGCANHWMPQEINMSRDIALWKDPNGLTEDERRIVKRNLGFFVTADSL
CCEEHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEECCC
AANNIVLGTYRHITAPECRQFLLRQAFEEAIHTHAYQYIVESLGLDEGEIFNAYHEVPSI
CCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
RAKDEFLIPFIHTLTDPAFKTGTLEADQKLLKSLIVFACIMEGLFFYVGFTQILALGRQN
CCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KMTGAAEQYQYILRDESMHCNFGIDLINQIKLENPHLWTAEFRAEIRELFKHAVDLEYRY
CCCCHHHHHHHHHCCCCCCCCCCHHHHHHEECCCCCEEHHHHHHHHHHHHHHHHCCCEEE
AEDTMPRGVLGLNASMFKSYLRFISNRRCQQIGLDPLFPNEENPFPWMSEMIDLKKERNF
CCCCCCCCEECCCHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCH
FETRVIEYQTGGALSWE
HHHEEEEEECCCCCCCC
>Mature Secondary Structure 
AVGLQAAVPAAHQASSARDIFAGDFAVAPNASAAVASEARVNVADKRIINGQTDVNQLV
CCCCCHHCCCHHHCCCCCHHHCCCEEECCCCCHHHHHHHHCCHHHHHEECCCCCHHHHC
PFKYKWAWEKYLAGCANHWMPQEINMSRDIALWKDPNGLTEDERRIVKRNLGFFVTADSL
CCEEHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEECCC
AANNIVLGTYRHITAPECRQFLLRQAFEEAIHTHAYQYIVESLGLDEGEIFNAYHEVPSI
CCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
RAKDEFLIPFIHTLTDPAFKTGTLEADQKLLKSLIVFACIMEGLFFYVGFTQILALGRQN
CCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KMTGAAEQYQYILRDESMHCNFGIDLINQIKLENPHLWTAEFRAEIRELFKHAVDLEYRY
CCCCHHHHHHHHHCCCCCCCCCCHHHHHHEECCCCCEEHHHHHHHHHHHHHHHHCCCEEE
AEDTMPRGVLGLNASMFKSYLRFISNRRCQQIGLDPLFPNEENPFPWMSEMIDLKKERNF
CCCCCCCCEECCCHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCH
FETRVIEYQTGGALSWE
HHHEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]