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The map label for this gene is ubiH [H]

Identifier: 83718864

GI number: 83718864

Start: 1398986

End: 1400179

Strand: Reverse

Name: ubiH [H]

Synonym: BTH_I1253

Alternate gene names: 83718864

Gene position: 1400179-1398986 (Counterclockwise)

Preceding gene: 83721643

Following gene: 83720266

Centisome position: 36.76

GC content: 73.03

Gene sequence:

>1194_bases
ATGACGACCGCCGCCTCCACGCCCGCTTTCGACTTCGACATCGCGATCGTCGGCGCCGGGCCGGTCGGGCTCGCGCTCGC
CGGCTGGCTCGCGCGCCGCAGCGCGACCCGTGCGCTGTCGATCGCCCTCATCGACGCGCGCGAGCCCGACGCGAGCGCGA
ACGATCCGCGCGCGATCGCGGTGTCGCAAGGCAGCCGGATGCTGCTCGACACGCTCGGCTGGCCGGGCGACGCGACGCCG
ATCGAGCACATCCACGTTTCGCAGCGCGGCCACTTCGGCCGCACGCTGATCGATCGCGACGAGCACGACCTCGCCGCGCT
CGGCTACGTCGTGCGCTACGGCTCGATCGTGCAGGCGCTCGCCCGCGCGGTGCGCGGCACGCCGGCGCACTGGCTCACGT
CGACGGCCGCGCATTCGCCGGCGCAAGACGCCGACGGCGTGACCATCACGCTCGACACGCCGCAAGGCCCGCGCACGTTG
CGCGCGCGCGTGCTCGTCAACGCGGAGGGCGGGCTCTTCAACGATCGCAAGCGCAAGCTGACCGACAGCGCGCAGAGCCG
CGACTACGGGCAGACGGCGCTCATCGGCACCGTCACGGTCTCGTCGCCGCGGCCGCGCGTCGCATGGGAGCGCTTCACCG
CCGAAGGCCCGCTCGCGCTGCTGCCGCTCGGCGGCCCGCAGCAAGCGGACTACGCGCTCGTCTGGTGCTGCGCGCCGGAC
GTCGCGCGACGTCGCGGCGAACTGTCCGACGACGCGTTCCTGCACGAGCTCGGCGCGACGTTCGGCTCGCGAATGGGGCG
CTTCACGCGGATCGCCGGGCGCGCGACATTCCCGCTCGGACTCGCCGCGGCGCAAACGCTCGTCGAAGGCCGGATCGCGA
TCGTCGGCAACGCCGCGCAAACCTTGCATCCGGTCGCGGGCCAGGGGCTCAACCTCGGACTGCGCGATGCGCATACGCTC
GCCGAGACGCTGTCCGAGCACGGCGCGACGCCGCTCGCGCTCGCGACATTCAACGCGCGCCGCGCGCTCGACAGGCGCAT
GACGATCGGCGCAACCGACACGCTCGCGCGCCTGTTCACCATCGATTCGCGGCCGCTCGCGATGCTGCGCGGCGCGGCGC
TCACCGCCCTCGAATTCGTGCCGCCGCTGAAAACGGCGATCGCGCGGCAGATGATGTTCGGGCAGCGCCGGTAA

Upstream 100 bases:

>100_bases
GAGATCGAGGCGCTGATGCGCGACGCGCAGGCGCCGAGCCCCCGCCCGCAGCCGTGATCCGCGCGCGCTGCTTCCTACCG
AGATCCACGATTCAAGAACG

Downstream 100 bases:

>100_bases
GCGCGGCGCTCACGCGCGCGCCGCGTCGCAGCTACCGCGCTTCGCAGGCACGCACGATGCGGCATCCCGCTTTCACGCAA
GATTCATCGGCGATTTAACG

Product: hypothetical protein

Products: H2O; 2-octaprenyl-6-methoxy-1,4-benzoquinone [C]

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MTTAASTPAFDFDIAIVGAGPVGLALAGWLARRSATRALSIALIDAREPDASANDPRAIAVSQGSRMLLDTLGWPGDATP
IEHIHVSQRGHFGRTLIDRDEHDLAALGYVVRYGSIVQALARAVRGTPAHWLTSTAAHSPAQDADGVTITLDTPQGPRTL
RARVLVNAEGGLFNDRKRKLTDSAQSRDYGQTALIGTVTVSSPRPRVAWERFTAEGPLALLPLGGPQQADYALVWCCAPD
VARRRGELSDDAFLHELGATFGSRMGRFTRIAGRATFPLGLAAAQTLVEGRIAIVGNAAQTLHPVAGQGLNLGLRDAHTL
AETLSEHGATPLALATFNARRALDRRMTIGATDTLARLFTIDSRPLAMLRGAALTALEFVPPLKTAIARQMMFGQRR

Sequences:

>Translated_397_residues
MTTAASTPAFDFDIAIVGAGPVGLALAGWLARRSATRALSIALIDAREPDASANDPRAIAVSQGSRMLLDTLGWPGDATP
IEHIHVSQRGHFGRTLIDRDEHDLAALGYVVRYGSIVQALARAVRGTPAHWLTSTAAHSPAQDADGVTITLDTPQGPRTL
RARVLVNAEGGLFNDRKRKLTDSAQSRDYGQTALIGTVTVSSPRPRVAWERFTAEGPLALLPLGGPQQADYALVWCCAPD
VARRRGELSDDAFLHELGATFGSRMGRFTRIAGRATFPLGLAAAQTLVEGRIAIVGNAAQTLHPVAGQGLNLGLRDAHTL
AETLSEHGATPLALATFNARRALDRRMTIGATDTLARLFTIDSRPLAMLRGAALTALEFVPPLKTAIARQMMFGQRR
>Mature_396_residues
TTAASTPAFDFDIAIVGAGPVGLALAGWLARRSATRALSIALIDAREPDASANDPRAIAVSQGSRMLLDTLGWPGDATPI
EHIHVSQRGHFGRTLIDRDEHDLAALGYVVRYGSIVQALARAVRGTPAHWLTSTAAHSPAQDADGVTITLDTPQGPRTLR
ARVLVNAEGGLFNDRKRKLTDSAQSRDYGQTALIGTVTVSSPRPRVAWERFTAEGPLALLPLGGPQQADYALVWCCAPDV
ARRRGELSDDAFLHELGATFGSRMGRFTRIAGRATFPLGLAAAQTLVEGRIAIVGNAAQTLHPVAGQGLNLGLRDAHTLA
ETLSEHGATPLALATFNARRALDRRMTIGATDTLARLFTIDSRPLAMLRGAALTALEFVPPLKTAIARQMMFGQRR

Specific function: Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiH/COQ6 family [H]

Homologues:

Organism=Homo sapiens, GI32967305, Length=401, Percent_Identity=27.431421446384, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI32967307, Length=352, Percent_Identity=27.8409090909091, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1789274, Length=403, Percent_Identity=36.2282878411911, Blast_Score=189, Evalue=4e-49,
Organism=Escherichia coli, GI1789273, Length=399, Percent_Identity=31.077694235589, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1786883, Length=383, Percent_Identity=30.2872062663185, Blast_Score=116, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6321694, Length=467, Percent_Identity=23.3404710920771, Blast_Score=79, Evalue=9e-16,
Organism=Drosophila melanogaster, GI19920760, Length=453, Percent_Identity=26.2693156732892, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042
- InterPro:   IPR018168
- InterPro:   IPR010971
- InterPro:   IPR011295 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: 1.14.13.- [C]

Molecular weight: Translated: 42290; Mature: 42159

Theoretical pI: Translated: 10.45; Mature: 10.45

Prosite motif: PS01304 UBIH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAASTPAFDFDIAIVGAGPVGLALAGWLARRSATRALSIALIDAREPDASANDPRAIA
CCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCEEE
VSQGSRMLLDTLGWPGDATPIEHIHVSQRGHFGRTLIDRDEHDLAALGYVVRYGSIVQAL
ECCCCEEEHHHCCCCCCCCCHHEEEECCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHH
ARAVRGTPAHWLTSTAAHSPAQDADGVTITLDTPQGPRTLRARVLVNAEGGLFNDRKRKL
HHHHCCCCCHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEEEEEEEECCCCCCCCHHHHH
TDSAQSRDYGQTALIGTVTVSSPRPRVAWERFTAEGPLALLPLGGPQQADYALVWCCAPD
HHHHHCCCCCCEEEEEEEEECCCCCCCHHHHCCCCCCEEEEECCCCCCCCEEEEEEECCH
VARRRGELSDDAFLHELGATFGSRMGRFTRIAGRATFPLGLAAAQTLVEGRIAIVGNAAQ
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEECCHH
TLHPVAGQGLNLGLRDAHTLAETLSEHGATPLALATFNARRALDRRMTIGATDTLARLFT
HHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHCEECCCHHHHHHHHC
IDSRPLAMLRGAALTALEFVPPLKTAIARQMMFGQRR
CCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TTAASTPAFDFDIAIVGAGPVGLALAGWLARRSATRALSIALIDAREPDASANDPRAIA
CCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCEEE
VSQGSRMLLDTLGWPGDATPIEHIHVSQRGHFGRTLIDRDEHDLAALGYVVRYGSIVQAL
ECCCCEEEHHHCCCCCCCCCHHEEEECCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHH
ARAVRGTPAHWLTSTAAHSPAQDADGVTITLDTPQGPRTLRARVLVNAEGGLFNDRKRKL
HHHHCCCCCHHHHHHHCCCCCCCCCCEEEEEECCCCCCEEEEEEEEECCCCCCCCHHHHH
TDSAQSRDYGQTALIGTVTVSSPRPRVAWERFTAEGPLALLPLGGPQQADYALVWCCAPD
HHHHHCCCCCCEEEEEEEEECCCCCCCHHHHCCCCCCEEEEECCCCCCCCEEEEEEECCH
VARRRGELSDDAFLHELGATFGSRMGRFTRIAGRATFPLGLAAAQTLVEGRIAIVGNAAQ
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCEEEEECCHH
TLHPVAGQGLNLGLRDAHTLAETLSEHGATPLALATFNARRALDRRMTIGATDTLARLFT
HHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHCEECCCHHHHHHHHC
IDSRPLAMLRGAALTALEFVPPLKTAIARQMMFGQRR
CCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-octaprenyl-6-methoxyphenol; O2 [C]

Specific reaction: 2-octaprenyl-6-methoxyphenol + O2 = H2O + 2-octaprenyl-6-methoxy-1,4-benzoquinone [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1339425; 9278503 [H]