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The map label for this gene is hemH [H]

Identifier: 83718645

GI number: 83718645

Start: 1463552

End: 1464619

Strand: Direct

Name: hemH [H]

Synonym: BTH_I1303

Alternate gene names: 83718645

Gene position: 1463552-1464619 (Clockwise)

Preceding gene: 83721380

Following gene: 83719179

Centisome position: 38.42

GC content: 69.1

Gene sequence:

>1068_bases
ATGCGCTTTGACCTCGAACCGCCGTCGCACGCGTCGGCCGCCCACCGCGTCGCCGTGCTGCTCGTCAATCTGGGCACGCC
CGACGAGCCGACGCCGCGCGCGGTGCGCCGCTATCTTGCGCAGTTCCTGTCCGATCCGCGCGTCGTCGAGATCCCGCAAC
TCGTCTGGCAGGTGATCCTGCGCACGCTGATCCTGCCGCTGCGCGGCCGCGCGTCCGCGAAGAAGTACGCGGCCGTCTGG
CTGCCCGAGGGCTCGCCGCTGCGCGTCTATACGGAGCGCCAGGTCGAGAGCTTGAAGCCGCTGTTCGCGGCGAACGGCTA
CCGCGTGATCGTCGACTATGCGATGCGCTACGGCACGCCGAGCATCGCCGACGTGCTCGCGCAACTGAAGCGCGCGGGCG
CCGAGCGCGTGCTGCTGCTGCCGATGTATCCGCAATATTCGGCCTCGACGACGGCCACCGCGTTCGACGCGGCGTTCGCC
GCGCTCGGCCGGATGCGCAACCAGCCGGAGGTGCGCACCGTGCGCCACTACGCGGATCACCCGGCCTATATCCATGCGCT
CGCCGAGCAGGTTCGCCAGTATTGGGCGGCGCACGGCAGGCCGGCATTCGATTCGGGCGACAAGCTCGTGCTGAGCTTTC
ACGGCGTGCCCAAGCGAACGCTCGATCTCGGCGATCCGTACCACGACCAATGCCAGCAGACGGCCGCGCTCCTGATGTCC
GCGCTCGGCCTGACGACGTTCGAGTGCCGGGTCACGTTCCAGTCGCGCTTCGGCAAGGCGGAGTGGCTTCAGCCTTATAC
TGCGCCGACCCTCAAGGAGCTCGGCGCGGCGGGTGTGCGGCGCGCGGACGTGTTCTGCCCGGGCTTCACCGCCGACTGCC
TGGAGACGATCGAGGAGATCGGAATGGAAGTGCGCGACGAGTTCCTGCATGGCGGCGGCAAGGAGTTCCACCGGATTCCT
TGCCTGAACGCGTCGCACGCGTGGATCGCGGCGCTCGGCGAGATCGCCGCCGAAAACCTGCAAGGCTGGCCGGTGCGCGT
CGCGACGGCGCCGGAAGCCGTGACCTGA

Upstream 100 bases:

>100_bases
CGCCGGGCGCCGCGCAATTGGCCGGACGGCCGAGTGGTGGCGCCCGGCCGCCCCGCTATAATGAGTGTCGTTCGATTCGG
TGCCCCGGCACGCTCTTTCC

Downstream 100 bases:

>100_bases
TTGCCATGAATTTCAAGATCTCGACCGAACCCGGCGCGCGGCTGCGCATCGACAAGTGGCTCTGGGCCGCGCGCTTTTTC
AAGACTCGCTCGCTCGCGGC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MRFDLEPPSHASAAHRVAVLLVNLGTPDEPTPRAVRRYLAQFLSDPRVVEIPQLVWQVILRTLILPLRGRASAKKYAAVW
LPEGSPLRVYTERQVESLKPLFAANGYRVIVDYAMRYGTPSIADVLAQLKRAGAERVLLLPMYPQYSASTTATAFDAAFA
ALGRMRNQPEVRTVRHYADHPAYIHALAEQVRQYWAAHGRPAFDSGDKLVLSFHGVPKRTLDLGDPYHDQCQQTAALLMS
ALGLTTFECRVTFQSRFGKAEWLQPYTAPTLKELGAAGVRRADVFCPGFTADCLETIEEIGMEVRDEFLHGGGKEFHRIP
CLNASHAWIAALGEIAAENLQGWPVRVATAPEAVT

Sequences:

>Translated_355_residues
MRFDLEPPSHASAAHRVAVLLVNLGTPDEPTPRAVRRYLAQFLSDPRVVEIPQLVWQVILRTLILPLRGRASAKKYAAVW
LPEGSPLRVYTERQVESLKPLFAANGYRVIVDYAMRYGTPSIADVLAQLKRAGAERVLLLPMYPQYSASTTATAFDAAFA
ALGRMRNQPEVRTVRHYADHPAYIHALAEQVRQYWAAHGRPAFDSGDKLVLSFHGVPKRTLDLGDPYHDQCQQTAALLMS
ALGLTTFECRVTFQSRFGKAEWLQPYTAPTLKELGAAGVRRADVFCPGFTADCLETIEEIGMEVRDEFLHGGGKEFHRIP
CLNASHAWIAALGEIAAENLQGWPVRVATAPEAVT
>Mature_355_residues
MRFDLEPPSHASAAHRVAVLLVNLGTPDEPTPRAVRRYLAQFLSDPRVVEIPQLVWQVILRTLILPLRGRASAKKYAAVW
LPEGSPLRVYTERQVESLKPLFAANGYRVIVDYAMRYGTPSIADVLAQLKRAGAERVLLLPMYPQYSASTTATAFDAAFA
ALGRMRNQPEVRTVRHYADHPAYIHALAEQVRQYWAAHGRPAFDSGDKLVLSFHGVPKRTLDLGDPYHDQCQQTAALLMS
ALGLTTFECRVTFQSRFGKAEWLQPYTAPTLKELGAAGVRRADVFCPGFTADCLETIEEIGMEVRDEFLHGGGKEFHRIP
CLNASHAWIAALGEIAAENLQGWPVRVATAPEAVT

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=269, Percent_Identity=25.2788104089219, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI60499025, Length=269, Percent_Identity=25.2788104089219, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1786681, Length=322, Percent_Identity=45.6521739130435, Blast_Score=274, Evalue=8e-75,
Organism=Saccharomyces cerevisiae, GI6324750, Length=338, Percent_Identity=23.3727810650888, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17864156, Length=339, Percent_Identity=25.9587020648968, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24651774, Length=268, Percent_Identity=26.4925373134328, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 39371; Mature: 39371

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFDLEPPSHASAAHRVAVLLVNLGTPDEPTPRAVRRYLAQFLSDPRVVEIPQLVWQVIL
CCCCCCCCCCHHHHHEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHHHH
RTLILPLRGRASAKKYAAVWLPEGSPLRVYTERQVESLKPLFAANGYRVIVDYAMRYGTP
HHHHHHCCCCCCCCCEEEEECCCCCCEEEEEHHHHHHHHHHHHCCCCEEHHHHHHHCCCC
SIADVLAQLKRAGAERVLLLPMYPQYSASTTATAFDAAFAALGRMRNQPEVRTVRHYADH
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
PAYIHALAEQVRQYWAAHGRPAFDSGDKLVLSFHGVPKRTLDLGDPYHDQCQQTAALLMS
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
ALGLTTFECRVTFQSRFGKAEWLQPYTAPTLKELGAAGVRRADVFCPGFTADCLETIEEI
HHCCCEEEEEEEHHHHCCCHHHCCCCCCHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHH
GMEVRDEFLHGGGKEFHRIPCLNASHAWIAALGEIAAENLQGWPVRVATAPEAVT
HHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCC
>Mature Secondary Structure
MRFDLEPPSHASAAHRVAVLLVNLGTPDEPTPRAVRRYLAQFLSDPRVVEIPQLVWQVIL
CCCCCCCCCCHHHHHEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHHHHH
RTLILPLRGRASAKKYAAVWLPEGSPLRVYTERQVESLKPLFAANGYRVIVDYAMRYGTP
HHHHHHCCCCCCCCCEEEEECCCCCCEEEEEHHHHHHHHHHHHCCCCEEHHHHHHHCCCC
SIADVLAQLKRAGAERVLLLPMYPQYSASTTATAFDAAFAALGRMRNQPEVRTVRHYADH
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
PAYIHALAEQVRQYWAAHGRPAFDSGDKLVLSFHGVPKRTLDLGDPYHDQCQQTAALLMS
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
ALGLTTFECRVTFQSRFGKAEWLQPYTAPTLKELGAAGVRRADVFCPGFTADCLETIEEI
HHCCCEEEEEEEHHHHCCCHHHCCCCCCHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHH
GMEVRDEFLHGGGKEFHRIPCLNASHAWIAALGEIAAENLQGWPVRVATAPEAVT
HHHHHHHHHHCCCCHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA