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The map label for this gene is rotA [H]

Identifier: 83718640

GI number: 83718640

Start: 2184865

End: 2185491

Strand: Reverse

Name: rotA [H]

Synonym: BTH_I1939

Alternate gene names: 83718640

Gene position: 2185491-2184865 (Counterclockwise)

Preceding gene: 83720318

Following gene: 83719512

Centisome position: 57.37

GC content: 64.91

Gene sequence:

>627_bases
ATGACGCGCGGCGGCCGCCGCGCCTTTCCTTCACCCACCCAGAGGACCGTTATGAAACGTCTGTTGCTGGCGCTCGGCAG
CGCCGCCCTCCTCGCGACCGCCCCCGCGTTCGCGCAATCGGCCGCGACGCACCCCGTCGTGCAGCTGAAGACCACGCAGG
GCGACATCCGCGTCGAGCTGTACCCGGAGAAGGCGCCGAAGACCGTCGCCAACTTCCTCGATTACGTGAAGGCGGGCCAG
TACAACGGCACGATCTTCCATCGCGTGATCAAGGGCTTCATGATCCAGGGCGGCGGCTACAAGACGAATTTCGACGAGAA
GCCGACTCGCGCACCGATCCCGCTCGAGAGCAAGAACGGCCTGAAGAACGCGACGGGCACCATCGCGATGGCGCGCACGA
GCGATCCGAACTCGGCGACCGCGCAGTTCTTCATCAACACCGTCGACAACGCGGGCCTCGACTATCCGAATCCGGACGGC
AACGGCTACGCGGTGTTCGGCAAGGTCGTGTCGGGCATGGACGTCGTGAAGAAGATCGAGGCCACGCCGACGACGGTGCG
CGGCCCGATGCGCGACGTGCCGGAAAAGCCGATCGTGATCGAATCGGCGACGATCGTCTCGAAATAA

Upstream 100 bases:

>100_bases
GTGACGACGACCACGCTGCCGCTCTCTCCGACATTCCAGTTCGGCGGCCCGAGCGGCATGCTCGCGATGCCGCCTTACGT
CGCACCGTCGCAATGACGCA

Downstream 100 bases:

>100_bases
GCCAGCCCGACTCTTTCGCGCGGCCGCGTCGTCCCGAGCGGCCGCGCGCCGTTTAAACCCCATCCATCGAAGGAATCATC
ATGGTCGAACTGCATACGAA

Product: peptidyl-prolyl cis-trans isomerase A

Products: NA

Alternate protein names: PPIase A; Cyclophilin A; Rotamase A [H]

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MTRGGRRAFPSPTQRTVMKRLLLALGSAALLATAPAFAQSAATHPVVQLKTTQGDIRVELYPEKAPKTVANFLDYVKAGQ
YNGTIFHRVIKGFMIQGGGYKTNFDEKPTRAPIPLESKNGLKNATGTIAMARTSDPNSATAQFFINTVDNAGLDYPNPDG
NGYAVFGKVVSGMDVVKKIEATPTTVRGPMRDVPEKPIVIESATIVSK

Sequences:

>Translated_208_residues
MTRGGRRAFPSPTQRTVMKRLLLALGSAALLATAPAFAQSAATHPVVQLKTTQGDIRVELYPEKAPKTVANFLDYVKAGQ
YNGTIFHRVIKGFMIQGGGYKTNFDEKPTRAPIPLESKNGLKNATGTIAMARTSDPNSATAQFFINTVDNAGLDYPNPDG
NGYAVFGKVVSGMDVVKKIEATPTTVRGPMRDVPEKPIVIESATIVSK
>Mature_207_residues
TRGGRRAFPSPTQRTVMKRLLLALGSAALLATAPAFAQSAATHPVVQLKTTQGDIRVELYPEKAPKTVANFLDYVKAGQY
NGTIFHRVIKGFMIQGGGYKTNFDEKPTRAPIPLESKNGLKNATGTIAMARTSDPNSATAQFFINTVDNAGLDYPNPDGN
GYAVFGKVVSGMDVVKKIEATPTTVRGPMRDVPEKPIVIESATIVSK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=166, Percent_Identity=36.144578313253, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI22547212, Length=162, Percent_Identity=34.5679012345679, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI7657473, Length=162, Percent_Identity=34.5679012345679, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI22547215, Length=162, Percent_Identity=34.5679012345679, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI24308049, Length=189, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI5454154, Length=185, Percent_Identity=34.5945945945946, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI7706339, Length=162, Percent_Identity=33.9506172839506, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI4758950, Length=201, Percent_Identity=32.8358208955224, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI64276486, Length=181, Percent_Identity=30.3867403314917, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI310110104, Length=138, Percent_Identity=34.7826086956522, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI10863927, Length=140, Percent_Identity=35.7142857142857, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI20911035, Length=153, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1789763, Length=191, Percent_Identity=53.4031413612565, Blast_Score=184, Evalue=5e-48,
Organism=Escherichia coli, GI1786736, Length=162, Percent_Identity=53.7037037037037, Blast_Score=178, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71980594, Length=137, Percent_Identity=40.1459854014599, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71980590, Length=137, Percent_Identity=40.1459854014599, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17539496, Length=142, Percent_Identity=35.9154929577465, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17552780, Length=207, Percent_Identity=31.8840579710145, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17532641, Length=167, Percent_Identity=32.9341317365269, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17559074, Length=158, Percent_Identity=33.5443037974684, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17506311, Length=142, Percent_Identity=35.2112676056338, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17565860, Length=167, Percent_Identity=32.3353293413174, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17566266, Length=158, Percent_Identity=32.9113924050633, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17506307, Length=140, Percent_Identity=35.7142857142857, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17532643, Length=175, Percent_Identity=35.4285714285714, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323562, Length=197, Percent_Identity=34.010152284264, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320359, Length=139, Percent_Identity=35.9712230215827, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19922912, Length=166, Percent_Identity=37.3493975903614, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17986117, Length=170, Percent_Identity=32.3529411764706, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19922376, Length=170, Percent_Identity=31.7647058823529, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI45549139, Length=135, Percent_Identity=40, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI20130249, Length=157, Percent_Identity=36.9426751592357, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24652460, Length=149, Percent_Identity=30.8724832214765, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17136360, Length=209, Percent_Identity=27.7511961722488, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24664125, Length=157, Percent_Identity=35.031847133758, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21357783, Length=157, Percent_Identity=35.031847133758, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 22311; Mature: 22180

Theoretical pI: Translated: 10.46; Mature: 10.46

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRGGRRAFPSPTQRTVMKRLLLALGSAALLATAPAFAQSAATHPVVQLKTTQGDIRVEL
CCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHCHHHHHHCCCCCEEEEEECCCCEEEEE
YPEKAPKTVANFLDYVKAGQYNGTIFHRVIKGFMIQGGGYKTNFDEKPTRAPIPLESKNG
ECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCC
LKNATGTIAMARTSDPNSATAQFFINTVDNAGLDYPNPDGNGYAVFGKVVSGMDVVKKIE
CCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHC
ATPTTVRGPMRDVPEKPIVIESATIVSK
CCCCCCCCCHHHCCCCCEEEECCEECCC
>Mature Secondary Structure 
TRGGRRAFPSPTQRTVMKRLLLALGSAALLATAPAFAQSAATHPVVQLKTTQGDIRVEL
CCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHCHHHHHHCCCCCEEEEEECCCCEEEEE
YPEKAPKTVANFLDYVKAGQYNGTIFHRVIKGFMIQGGGYKTNFDEKPTRAPIPLESKNG
ECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCC
LKNATGTIAMARTSDPNSATAQFFINTVDNAGLDYPNPDGNGYAVFGKVVSGMDVVKKIE
CCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHC
ATPTTVRGPMRDVPEKPIVIESATIVSK
CCCCCCCCCHHHCCCCCEEEECCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9418240 [H]