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The map label for this gene is serS [H]

Identifier: 83718513

GI number: 83718513

Start: 1766953

End: 1768254

Strand: Direct

Name: serS [H]

Synonym: BTH_I1565

Alternate gene names: 83718513

Gene position: 1766953-1768254 (Clockwise)

Preceding gene: 83720479

Following gene: 83718497

Centisome position: 46.39

GC content: 67.74

Gene sequence:

>1302_bases
ATGCTCGACATCCAGTTGCTGCGCAAAGACCTCGACGGCGTCGCGAAACGCCTCGCCGATCGCGGCTACACCCTCGACGT
CGCCGCGTTTTCCGCGCTCGAAGCGGAACGCCGGGCGATCCAGACACGCACGGAAGAACTGCAGGCGCGCCGCAACAGCC
TGTCGAAGCAGATCGGCGCGATGAAGGGGCGGGGCGAGGACACGTCGGCGGTGATGGCCGAGGTGGGCGGCATCGGCGAC
GAGATGAAGGCCTCGGCGGTGAAGCTCGACGAGATTCAGGCGCGCCTGTCCGAGCTGATGCTGGAGATGCCGAACGTGCC
GCACGAGAGCGTGCCCGTCGGCCGCGACGAGACGGAGAACGTCGAAGTGCGCCGCTGGGGCGCGCCGCGCCAGTTCGATT
TCGACGTGAAGGACCACGTCGATGTGGGCACGCCGCTCGGCCTCGATTTCGAGACGGGCGCGAAGCTCTCCGGCGCGCGC
TTCACGGTGCTGCGCGGGCCGATCGCGCGCCTGCATCGCGCGCTCGCGCAGTTCATGCTGGACACGCACACGCAGCAGCA
CGGCTACAGCGAGACGTACACGCCTTACATCGTGAATCCGGACGTGCTGTACGGCACGGGCCAGTTGCCGAAGTTCGCGG
AGGACATGTTCCGCGTCGAGAAGGGCGGCGCGGAGAACACGGTCACGCAATACCTGATCTCGACCTCGGAGATCTCGCTG
ACGAACACCGTGCGCGATTCGATCGTCGACGCGTCCGCGCTGCCGATCAAGCTGACCGCGCATTCGCCGTGCTTCCGCTC
GGAGGCGGGCTCGTACGGCCGCGACACGCGCGGGATGATCCGCCAGCACCAGTTCGACAAGGTCGAGATGGTGCAGATCG
TCGCGCCGGAAGCATCGTACGCGGCGCTCGACGAGATGGTCGGCCACGCGGAGGCGATCCTGCAGACGCTCGAACTGCCG
TACCGCGTGGTCGCGCTATGCACGGGCGACATGGGTTTCTCGGCGGCGAAGACGTTCGACCTCGAGGTGTGGCTGCCCGC
GCAGAACACGTATCGCGAGATCTCGAGCTGCTCGAATACCGAATCGTTCCAGGCGCGCCGCATGCAGGCGCGGTTCCGCA
ACGCGCAGGGCAAGCCCGAGCTCGTGCATACGCTGAACGGCTCGGGCCTCGCGGTCGGCCGCACGCTCGTCGCGGTGCTG
GAGAACTACCAGAACGCCGACGGCTCGGTGACGGTGCCCGTCGCGTTGCGGCCTTACATGGGCGGCGTCGAGCGGATCGC
CGCGCCTTCGAGCGCGGCCTGA

Upstream 100 bases:

>100_bases
ACGGACGGCCGGTTTGCGACACCGGCCGTTTGGCCGACGCCGTAGCGGGCGCGCGGTGCGTTAGAATTCCCCCCTTACAC
AACGATTTTCCTGTCCTCCC

Downstream 100 bases:

>100_bases
ACGGCCTTCCGGGCGGCTTCGAAAATATTTGAAGAAAATACTTGGAAGTTTGCGGAAGGTTGTTCTATAATCTTCGCTTC
GCCGGGACGACCTGCCGGTG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MLDIQLLRKDLDGVAKRLADRGYTLDVAAFSALEAERRAIQTRTEELQARRNSLSKQIGAMKGRGEDTSAVMAEVGGIGD
EMKASAVKLDEIQARLSELMLEMPNVPHESVPVGRDETENVEVRRWGAPRQFDFDVKDHVDVGTPLGLDFETGAKLSGAR
FTVLRGPIARLHRALAQFMLDTHTQQHGYSETYTPYIVNPDVLYGTGQLPKFAEDMFRVEKGGAENTVTQYLISTSEISL
TNTVRDSIVDASALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVAPEASYAALDEMVGHAEAILQTLELP
YRVVALCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNTESFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVL
ENYQNADGSVTVPVALRPYMGGVERIAAPSSAA

Sequences:

>Translated_433_residues
MLDIQLLRKDLDGVAKRLADRGYTLDVAAFSALEAERRAIQTRTEELQARRNSLSKQIGAMKGRGEDTSAVMAEVGGIGD
EMKASAVKLDEIQARLSELMLEMPNVPHESVPVGRDETENVEVRRWGAPRQFDFDVKDHVDVGTPLGLDFETGAKLSGAR
FTVLRGPIARLHRALAQFMLDTHTQQHGYSETYTPYIVNPDVLYGTGQLPKFAEDMFRVEKGGAENTVTQYLISTSEISL
TNTVRDSIVDASALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVAPEASYAALDEMVGHAEAILQTLELP
YRVVALCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNTESFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVL
ENYQNADGSVTVPVALRPYMGGVERIAAPSSAA
>Mature_433_residues
MLDIQLLRKDLDGVAKRLADRGYTLDVAAFSALEAERRAIQTRTEELQARRNSLSKQIGAMKGRGEDTSAVMAEVGGIGD
EMKASAVKLDEIQARLSELMLEMPNVPHESVPVGRDETENVEVRRWGAPRQFDFDVKDHVDVGTPLGLDFETGAKLSGAR
FTVLRGPIARLHRALAQFMLDTHTQQHGYSETYTPYIVNPDVLYGTGQLPKFAEDMFRVEKGGAENTVTQYLISTSEISL
TNTVRDSIVDASALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVAPEASYAALDEMVGHAEAILQTLELP
YRVVALCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNTESFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVL
ENYQNADGSVTVPVALRPYMGGVERIAAPSSAA

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=469, Percent_Identity=33.6886993603412, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI8923421, Length=418, Percent_Identity=29.6650717703349, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI225579074, Length=347, Percent_Identity=31.9884726224784, Blast_Score=173, Evalue=3e-43,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=62.7906976744186, Blast_Score=562, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI17539260, Length=439, Percent_Identity=32.3462414578588, Blast_Score=229, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17542084, Length=352, Percent_Identity=30.3977272727273, Blast_Score=146, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6320226, Length=406, Percent_Identity=33.2512315270936, Blast_Score=211, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6321799, Length=384, Percent_Identity=29.6875, Blast_Score=180, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24581334, Length=468, Percent_Identity=33.1196581196581, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI17737985, Length=342, Percent_Identity=30.7017543859649, Blast_Score=145, Evalue=5e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47526; Mature: 47526

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIQLLRKDLDGVAKRLADRGYTLDVAAFSALEAERRAIQTRTEELQARRNSLSKQIGA
CCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKGRGEDTSAVMAEVGGIGDEMKASAVKLDEIQARLSELMLEMPNVPHESVPVGRDETEN
CCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEVRRWGAPRQFDFDVKDHVDVGTPLGLDFETGAKLSGARFTVLRGPIARLHRALAQFML
EEEEECCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHH
DTHTQQHGYSETYTPYIVNPDVLYGTGQLPKFAEDMFRVEKGGAENTVTQYLISTSEISL
HHHHHHCCCCCCCCCEEECCCEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCEEH
TNTVRDSIVDASALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVAPEASY
HHHHHHHHHCCCCCEEEEECCCCCHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCHH
AALDEMVGHAEAILQTLELPYRVVALCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNT
HHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEEEEEEECCCHHHHHHHHCCCC
ESFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVLENYQNADGSVTVPVALRPYM
HHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCHH
GGVERIAAPSSAA
CCHHHHCCCCCCC
>Mature Secondary Structure
MLDIQLLRKDLDGVAKRLADRGYTLDVAAFSALEAERRAIQTRTEELQARRNSLSKQIGA
CCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKGRGEDTSAVMAEVGGIGDEMKASAVKLDEIQARLSELMLEMPNVPHESVPVGRDETEN
CCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEVRRWGAPRQFDFDVKDHVDVGTPLGLDFETGAKLSGARFTVLRGPIARLHRALAQFML
EEEEECCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHH
DTHTQQHGYSETYTPYIVNPDVLYGTGQLPKFAEDMFRVEKGGAENTVTQYLISTSEISL
HHHHHHCCCCCCCCCEEECCCEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCEEH
TNTVRDSIVDASALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQIVAPEASY
HHHHHHHHHCCCCCEEEEECCCCCHHHCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCHH
AALDEMVGHAEAILQTLELPYRVVALCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNT
HHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEEEEEEECCCHHHHHHHHCCCC
ESFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVLENYQNADGSVTVPVALRPYM
HHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEEECCHH
GGVERIAAPSSAA
CCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA