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The map label for this gene is lhgO [H]

Identifier: 83593980

GI number: 83593980

Start: 3077550

End: 3078680

Strand: Direct

Name: lhgO [H]

Synonym: Rru_A2648

Alternate gene names: 83593980

Gene position: 3077550-3078680 (Clockwise)

Preceding gene: 83593978

Following gene: 83593981

Centisome position: 70.7

GC content: 69.76

Gene sequence:

>1131_bases
ATGAGCGAAGCCGTCGATTGCGTCGTTATCGGGGCCGGGGTGGTCGGGCTGGCCGTCGCCCGGGCCCTGGCGCGGGCCGG
GCGCGAGGTGATGATCCTCGAGCAGGCACCCTCCTTTGGTACCGCCACCTCCTCGCGCAACAGCGAGGTCATCCATGCCG
GTCTCTATTACGCTCCGGGCAGCCTGAAGGCCCGCCTCTGCGTGGAAGGCCGGACCAAGCTTCTGGCCTTCTGCGCCGAG
GCCGGGGTCACCGCCCTGATCTGCGGCAAGCTGATCGTCGCCTCGGAAGAAGGCGGAGAGGCCGAGCTGGAGCGCTTGCG
GGCGATCCGCGCCCGCGCCGAAAGCGCCGGGGTCACCCTTGATTGGCTGACCGCCGCCGAAGCCCGGGCGATGGAACCGG
CGCTCCGCTGCACCGCCGCCCTGCACTCGCCGGGCACCGGCATCATCGACAGCCACGCCCTGATGCTGGCCCTGCTTGGC
GAGGCCGAGGCGCGGGGCGCCCTGCTTGTCACCCAGGCTCCGGTGACCGGCGGCCGGGTCTTGGCGGGTGGCCTTGCCCT
GGAGGTCGGCGGCGCCGAGCCGATGACCCTGGAGGCGCGCACGGTGATCAATTGCGCCGGCCATGGCGCCTCGGCGCTGT
CGCGGGCCCTGATCGGCCTCGATCCCGCCCGCGTTCCCCCCCACCATGTCTGCAAGGGATCGTATTTCAGCCTGAGCGGT
CGCCCGCCCTTCCAGCGCCTGATCTATCCGACCCCGGGCGAGGCCTCGCTCGGCCTGCATTACACCCGCGATCTGGCCGG
GCGCGGCCGCTTCGGCCCCGATGCTGTTTGGCTTGACGATCCCGATCCCGGGCGATTCGACTATCGGGTCGCCGCCGACG
GCGCCCTGGCTTTCGTCGAAGCGATCCGCCGCTATTGGCCCGAGCTGACGGCCGAGCGCCTCACCCCCGATTATTCGGGC
ATGCGCCCGAAAATCCAGGCCGCCGGCGAACCGGCCCATGATTTCGTCATCCATGGCCCTTCGGCGACCGGCGTTAACGG
TTACATAGCCCTCTACGGAATAGAATCGCCCGGATTGACATCCTGTCTGGCAATCGCCGATCTGGTGGCGGAGGAAGCCC
GGTGCGTCTGA

Upstream 100 bases:

>100_bases
ACGACAGGGCGGCTTGTCATTGGCGCGCGGTTGGGTTTGCATGGGCCGCGCAACGGTGGTCACTTAAGCCACGTCAGCGA
CAGGGGGGCAAGGAAGCCGA

Downstream 100 bases:

>100_bases
GATTTATTTCATCCCACGTGGCCGGGCACCTCGCCGGCGGCTGCTTGGTTTTCGCCCTGGGGCTGGCGCTGTGCGCGCCG
CTCCAGGCCCAGGACACCCA

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MSEAVDCVVIGAGVVGLAVARALARAGREVMILEQAPSFGTATSSRNSEVIHAGLYYAPGSLKARLCVEGRTKLLAFCAE
AGVTALICGKLIVASEEGGEAELERLRAIRARAESAGVTLDWLTAAEARAMEPALRCTAALHSPGTGIIDSHALMLALLG
EAEARGALLVTQAPVTGGRVLAGGLALEVGGAEPMTLEARTVINCAGHGASALSRALIGLDPARVPPHHVCKGSYFSLSG
RPPFQRLIYPTPGEASLGLHYTRDLAGRGRFGPDAVWLDDPDPGRFDYRVAADGALAFVEAIRRYWPELTAERLTPDYSG
MRPKIQAAGEPAHDFVIHGPSATGVNGYIALYGIESPGLTSCLAIADLVAEEARCV

Sequences:

>Translated_376_residues
MSEAVDCVVIGAGVVGLAVARALARAGREVMILEQAPSFGTATSSRNSEVIHAGLYYAPGSLKARLCVEGRTKLLAFCAE
AGVTALICGKLIVASEEGGEAELERLRAIRARAESAGVTLDWLTAAEARAMEPALRCTAALHSPGTGIIDSHALMLALLG
EAEARGALLVTQAPVTGGRVLAGGLALEVGGAEPMTLEARTVINCAGHGASALSRALIGLDPARVPPHHVCKGSYFSLSG
RPPFQRLIYPTPGEASLGLHYTRDLAGRGRFGPDAVWLDDPDPGRFDYRVAADGALAFVEAIRRYWPELTAERLTPDYSG
MRPKIQAAGEPAHDFVIHGPSATGVNGYIALYGIESPGLTSCLAIADLVAEEARCV
>Mature_375_residues
SEAVDCVVIGAGVVGLAVARALARAGREVMILEQAPSFGTATSSRNSEVIHAGLYYAPGSLKARLCVEGRTKLLAFCAEA
GVTALICGKLIVASEEGGEAELERLRAIRARAESAGVTLDWLTAAEARAMEPALRCTAALHSPGTGIIDSHALMLALLGE
AEARGALLVTQAPVTGGRVLAGGLALEVGGAEPMTLEARTVINCAGHGASALSRALIGLDPARVPPHHVCKGSYFSLSGR
PPFQRLIYPTPGEASLGLHYTRDLAGRGRFGPDAVWLDDPDPGRFDYRVAADGALAFVEAIRRYWPELTAERLTPDYSGM
RPKIQAAGEPAHDFVIHGPSATGVNGYIALYGIESPGLTSCLAIADLVAEEARCV

Specific function: Oxidizes L-2-hydroxyglutarate, probably to recover alpha-ketoglutarate mistakenly reduced by other enzymes or formed during growth on propionate [H]

COG id: COG0579

COG function: function code R; Predicted dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the L2HGDH family [H]

Homologues:

Organism=Homo sapiens, GI13376331, Length=405, Percent_Identity=26.9135802469136, Blast_Score=115, Evalue=7e-26,
Organism=Escherichia coli, GI87082148, Length=254, Percent_Identity=33.8582677165354, Blast_Score=130, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17565764, Length=412, Percent_Identity=30.5825242718447, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI24585081, Length=385, Percent_Identity=28.3116883116883, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015657
- InterPro:   IPR006076 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: =1.1.3.15 [H]

Molecular weight: Translated: 39213; Mature: 39082

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAVDCVVIGAGVVGLAVARALARAGREVMILEQAPSFGTATSSRNSEVIHAGLYYAPG
CCCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEEEEEEECCC
SLKARLCVEGRTKLLAFCAEAGVTALICGKLIVASEEGGEAELERLRAIRARAESAGVTL
CCEEEEEECCCHHHHHHHHHCCCCEEECCEEEEEECCCCHHHHHHHHHHHHHHHHCCCEE
DWLTAAEARAMEPALRCTAALHSPGTGIIDSHALMLALLGEAEARGALLVTQAPVTGGRV
EEHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEE
LAGGLALEVGGAEPMTLEARTVINCAGHGASALSRALIGLDPARVPPHHVCKGSYFSLSG
EECCEEEEECCCCCEEEEHEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHCCCCEEEECC
RPPFQRLIYPTPGEASLGLHYTRDLAGRGRFGPDAVWLDDPDPGRFDYRVAADGALAFVE
CCCHHHEEECCCCCCCCCEEEEHHHCCCCCCCCCEEECCCCCCCCEEEEEECCHHHHHHH
AIRRYWPELTAERLTPDYSGMRPKIQAAGEPAHDFVIHGPSATGVNGYIALYGIESPGLT
HHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCEEEECCCCCCCCCEEEEEEECCCCHH
SCLAIADLVAEEARCV
HHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEAVDCVVIGAGVVGLAVARALARAGREVMILEQAPSFGTATSSRNSEVIHAGLYYAPG
CCCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEEEEEEECCC
SLKARLCVEGRTKLLAFCAEAGVTALICGKLIVASEEGGEAELERLRAIRARAESAGVTL
CCEEEEEECCCHHHHHHHHHCCCCEEECCEEEEEECCCCHHHHHHHHHHHHHHHHCCCEE
DWLTAAEARAMEPALRCTAALHSPGTGIIDSHALMLALLGEAEARGALLVTQAPVTGGRV
EEHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEE
LAGGLALEVGGAEPMTLEARTVINCAGHGASALSRALIGLDPARVPPHHVCKGSYFSLSG
EECCEEEEECCCCCEEEEHEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHCCCCEEEECC
RPPFQRLIYPTPGEASLGLHYTRDLAGRGRFGPDAVWLDDPDPGRFDYRVAADGALAFVE
CCCHHHEEECCCCCCCCCEEEEHHHCCCCCCCCCEEECCCCCCCCEEEEEECCHHHHHHH
AIRRYWPELTAERLTPDYSGMRPKIQAAGEPAHDFVIHGPSATGVNGYIALYGIESPGLT
HHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCEEEECCCCCCCCCEEEEEEECCCCHH
SCLAIADLVAEEARCV
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 8297211; 7984428 [H]