Click here to switch to the map view.

The map label for this gene is zraS [H]

Identifier: 83593851

GI number: 83593851

Start: 2924856

End: 2927273

Strand: Direct

Name: zraS [H]

Synonym: Rru_A2516

Alternate gene names: 83593851

Gene position: 2924856-2927273 (Clockwise)

Preceding gene: 83593850

Following gene: 83593853

Centisome position: 67.19

GC content: 66.42

Gene sequence:

>2418_bases
TTGGCAGGACTGAGGTTTGGCGTCCGCTCCCGTCTGGTCCTCGCCTTTTCGGCGATGGCGGCAATGACCCTGGTCACCAG
CGCCGTCGCCATCTTGTCCTTTAGCGAAGTCGAAGCGCGCTTCATCGAGCTGACGACGACACGCCTTCCGGCGATGGCGG
CGGCGACCAAGCTGAGTCAACAGGCCGAAAGCATCGTCGCCCAGGCTCCGGCCCTGGTGGCGGCGAGCAGCCCCACCGAG
CTTCATACCATCGATTTCCGCATCCGTGATCAGCTGAGCTGGCTTGCCGAACTCATCGAGAGGGTCCGCAAGACCGATGG
CGAAGCCATCGCCATGGCCCGGGTCGACGACCTCGCCCGCGAACTGGAACGCCGCTTCGTCGATCTGGCCACCCAGGTCG
AACGCCGGCTGAGCATGGAGGCCCTTGATCGCCAGACCCTGGGGCGGCTGCTTGTCCTGGGCAGAACGATCACCGGCATA
AGGGACCAACGCGAGACCGAGGGCCCGCCGGAAGACGCCGCCATCGCCCGGCGCTGGGCGGCCGGCGCCCAGGATGCCAA
CACCGTGCTGATCGCCGCCCTGGCCACCACCGACGCCGCGATCTTGCGCAACCTGGGCGAGGCCTTTGGCGACCTGCTCG
AGACGGCCGAAACCGAGAGCGCCAGACTGAGCGACCCCTTGTCGCAAGACATGCGCCGCTCGACCGCCGAATTGCGCCAC
CTTGGGCTTGGCGAGGCTGGGATCTTCAACCGGCGCCAAGCCCATATGGACATCACCCGCGGCATTCAGGGAACACTGAC
GCGCAACCGCCTGAGCGGCGATCTGCTATCGGGTGCCTCGTCCCAATTGGCCGACCGCATCGCCGAAGAGGCGGTCAAAA
GCGCCCTTGTCTTGCGCGCGGAACTGCACAACCGGGGCGCCATGATGATCGTCCTGTCGCTTTTCGGCGTGTTCGGCGCC
GGCATCGTCCTTCTTCACCTCCAGCGCACCGTGCTGCGCCGTCTGGCCACCCTGCGGGCGGCGATGACCGCCCCGCTCTC
GACCCGGCCGCTGGTATTGGAGGGCAGCGACGACGCCGACGAGATCGGCGATATGGCCCGCGCCCTCAAAGGTTACGCCC
AGGCCATCGCCGACCGCGAACACGCCTTGCGTCAAAGCGAGGGCCGCTTCCGCGCCATGGCCACCAATGTCCCCGGCGTG
CTGTTCCAGTGGTTCTGGCGCCCGCTTGGCGAACCCCGTTTCCTCTATGTCAGCCCGCGCTGTCAGGATCTGTTCGGCGT
TTCACCGGCCCTGGTCCTGGCCGATTGGCGCAAGCTGGGGTTCAGCCTGGAAGACCAGCGGGCCTGGGTGGTCCGCGCCG
CCCAAGCCGCCCGCGACTCCCGGGACTGGATCCAGGAAGGACGGATCGCCCTGGCCAATGGCGGCGAACGCTGGTGGCGG
GTGGTCGCCGCCCCCACCCCGGGGGAAGAACCCGACACCATCATCCTCAATGGCGTGCTGATCGACATCACCGCCCTCAA
GGACAACGAACGCGATTTGAGGGCCGCGCGCCAGCAGGCCGAACAGGCGTTAAGCGATCTGCGCTCGACCCAGGACACCC
TGGTCCAGGCCGAGAAGCTGGCCTCTCTCGGCCAGTTGGTGGCGGGCATCGCCCATGAGATCAACACGCCCCTGGGAACG
GGCATCACGGGGGCGACCTTCCTCGATCAGGAGACCCGCCAAATCGCCGGGCGCTTCCGCTCGGGCACGCTGCGGCGCTC
GGAATTGGCCGATTACATGGAGCGGGCCGAGGAAACCGCCCGTCTGATCTTCACCAATCTCAGCCGCGCCGGCGATCTGG
TGCAGAGCTTCAAACAAGTCGCGGTCGATCAGGTGAGCGATGACCGCCGCACCTTCGCGCTTGATACCTACATCGACGAG
ATCTTCCAAAGCCTCAATCCCCGGCTGCGCCAAACCCGCCTGACCGTCGAACGCGCCATCGAACCGGGGTTGATGGTTGA
TGGTTATCCCGGGGTGCTGTTTCGCATTCTGTCCAATCTCGTCATGAACACCCTGATGCATGGCTTCGAGCCCCACGAGA
CCGGCACCATCCGCGTCGAAGCCAGACTGCTGCCCGACAGCGCCCCCGGGCGCGTCGAGCTGGTCTATTTCGATACGGGC
AAAGGCATCCCCCACGAGATCCAGGGCCGGGTCTTCGATCCCTTCTTCACCACCCGCCGGGGCCAGGGCGGCACCGGCCT
CGGCCTCAACATCGTCTATAATCTGGTCACCCAGTCGCTAGGCGGAACGATGACGCTGAGCAGCCACCCCGGCACCGGCA
CCACCTTCACCGTGGTTTTCCCGATCAAGGCCCCCCGGGGCGTTCAAGCCGTCCCGTCTCCCCAGCCGATCAAGGACAGC
GGAGCGGCGACGGCCTGA

Upstream 100 bases:

>100_bases
AGATCGGCCTTGACCGGGGCGTGAACGCGTTGTGGTCCGAAGGCGGGTTGATGATTTCACCGCCGCTGCAATAGCCGCGG
CCAGACACGATGAGGGACCT

Downstream 100 bases:

>100_bases
CCGCCTTATCGGGCGATCAAGCCGGCCGCCAGCTCGGCCAGGGCCCGGCGGTCGATTTTCCCCGTCAGGGTGCGAGGCAG
GGCGCTAACGCCGATAATCC

Product: multi-sensor Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 805; Mature: 804

Protein sequence:

>805_residues
MAGLRFGVRSRLVLAFSAMAAMTLVTSAVAILSFSEVEARFIELTTTRLPAMAAATKLSQQAESIVAQAPALVAASSPTE
LHTIDFRIRDQLSWLAELIERVRKTDGEAIAMARVDDLARELERRFVDLATQVERRLSMEALDRQTLGRLLVLGRTITGI
RDQRETEGPPEDAAIARRWAAGAQDANTVLIAALATTDAAILRNLGEAFGDLLETAETESARLSDPLSQDMRRSTAELRH
LGLGEAGIFNRRQAHMDITRGIQGTLTRNRLSGDLLSGASSQLADRIAEEAVKSALVLRAELHNRGAMMIVLSLFGVFGA
GIVLLHLQRTVLRRLATLRAAMTAPLSTRPLVLEGSDDADEIGDMARALKGYAQAIADREHALRQSEGRFRAMATNVPGV
LFQWFWRPLGEPRFLYVSPRCQDLFGVSPALVLADWRKLGFSLEDQRAWVVRAAQAARDSRDWIQEGRIALANGGERWWR
VVAAPTPGEEPDTIILNGVLIDITALKDNERDLRAARQQAEQALSDLRSTQDTLVQAEKLASLGQLVAGIAHEINTPLGT
GITGATFLDQETRQIAGRFRSGTLRRSELADYMERAEETARLIFTNLSRAGDLVQSFKQVAVDQVSDDRRTFALDTYIDE
IFQSLNPRLRQTRLTVERAIEPGLMVDGYPGVLFRILSNLVMNTLMHGFEPHETGTIRVEARLLPDSAPGRVELVYFDTG
KGIPHEIQGRVFDPFFTTRRGQGGTGLGLNIVYNLVTQSLGGTMTLSSHPGTGTTFTVVFPIKAPRGVQAVPSPQPIKDS
GAATA

Sequences:

>Translated_805_residues
MAGLRFGVRSRLVLAFSAMAAMTLVTSAVAILSFSEVEARFIELTTTRLPAMAAATKLSQQAESIVAQAPALVAASSPTE
LHTIDFRIRDQLSWLAELIERVRKTDGEAIAMARVDDLARELERRFVDLATQVERRLSMEALDRQTLGRLLVLGRTITGI
RDQRETEGPPEDAAIARRWAAGAQDANTVLIAALATTDAAILRNLGEAFGDLLETAETESARLSDPLSQDMRRSTAELRH
LGLGEAGIFNRRQAHMDITRGIQGTLTRNRLSGDLLSGASSQLADRIAEEAVKSALVLRAELHNRGAMMIVLSLFGVFGA
GIVLLHLQRTVLRRLATLRAAMTAPLSTRPLVLEGSDDADEIGDMARALKGYAQAIADREHALRQSEGRFRAMATNVPGV
LFQWFWRPLGEPRFLYVSPRCQDLFGVSPALVLADWRKLGFSLEDQRAWVVRAAQAARDSRDWIQEGRIALANGGERWWR
VVAAPTPGEEPDTIILNGVLIDITALKDNERDLRAARQQAEQALSDLRSTQDTLVQAEKLASLGQLVAGIAHEINTPLGT
GITGATFLDQETRQIAGRFRSGTLRRSELADYMERAEETARLIFTNLSRAGDLVQSFKQVAVDQVSDDRRTFALDTYIDE
IFQSLNPRLRQTRLTVERAIEPGLMVDGYPGVLFRILSNLVMNTLMHGFEPHETGTIRVEARLLPDSAPGRVELVYFDTG
KGIPHEIQGRVFDPFFTTRRGQGGTGLGLNIVYNLVTQSLGGTMTLSSHPGTGTTFTVVFPIKAPRGVQAVPSPQPIKDS
GAATA
>Mature_804_residues
AGLRFGVRSRLVLAFSAMAAMTLVTSAVAILSFSEVEARFIELTTTRLPAMAAATKLSQQAESIVAQAPALVAASSPTEL
HTIDFRIRDQLSWLAELIERVRKTDGEAIAMARVDDLARELERRFVDLATQVERRLSMEALDRQTLGRLLVLGRTITGIR
DQRETEGPPEDAAIARRWAAGAQDANTVLIAALATTDAAILRNLGEAFGDLLETAETESARLSDPLSQDMRRSTAELRHL
GLGEAGIFNRRQAHMDITRGIQGTLTRNRLSGDLLSGASSQLADRIAEEAVKSALVLRAELHNRGAMMIVLSLFGVFGAG
IVLLHLQRTVLRRLATLRAAMTAPLSTRPLVLEGSDDADEIGDMARALKGYAQAIADREHALRQSEGRFRAMATNVPGVL
FQWFWRPLGEPRFLYVSPRCQDLFGVSPALVLADWRKLGFSLEDQRAWVVRAAQAARDSRDWIQEGRIALANGGERWWRV
VAAPTPGEEPDTIILNGVLIDITALKDNERDLRAARQQAEQALSDLRSTQDTLVQAEKLASLGQLVAGIAHEINTPLGTG
ITGATFLDQETRQIAGRFRSGTLRRSELADYMERAEETARLIFTNLSRAGDLVQSFKQVAVDQVSDDRRTFALDTYIDEI
FQSLNPRLRQTRLTVERAIEPGLMVDGYPGVLFRILSNLVMNTLMHGFEPHETGTIRVEARLLPDSAPGRVELVYFDTGK
GIPHEIQGRVFDPFFTTRRGQGGTGLGLNIVYNLVTQSLGGTMTLSSHPGTGTTFTVVFPIKAPRGVQAVPSPQPIKDSG
AATA

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=261, Percent_Identity=33.3333333333333, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI1788549, Length=279, Percent_Identity=27.5985663082437, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI145693157, Length=294, Percent_Identity=28.2312925170068, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI1789149, Length=271, Percent_Identity=29.1512915129151, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1788713, Length=133, Percent_Identity=33.0827067669173, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 88143; Mature: 88012

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGLRFGVRSRLVLAFSAMAAMTLVTSAVAILSFSEVEARFIELTTTRLPAMAAATKLSQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAESIVAQAPALVAASSPTELHTIDFRIRDQLSWLAELIERVRKTDGEAIAMARVDDLAR
HHHHHHHHCCHHEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHH
ELERRFVDLATQVERRLSMEALDRQTLGRLLVLGRTITGIRDQRETEGPPEDAAIARRWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
AGAQDANTVLIAALATTDAAILRNLGEAFGDLLETAETESARLSDPLSQDMRRSTAELRH
CCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHH
LGLGEAGIFNRRQAHMDITRGIQGTLTRNRLSGDLLSGASSQLADRIAEEAVKSALVLRA
CCCCCCCCCCCHHHHHHHHCCCCCCHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHH
ELHNRGAMMIVLSLFGVFGAGIVLLHLQRTVLRRLATLRAAMTAPLSTRPLVLEGSDDAD
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHH
EIGDMARALKGYAQAIADREHALRQSEGRFRAMATNVPGVLFQWFWRPLGEPRFLYVSPR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCCEEEEECCC
CQDLFGVSPALVLADWRKLGFSLEDQRAWVVRAAQAARDSRDWIQEGRIALANGGERWWR
HHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHCCCEEEECCCCEEEE
VVAAPTPGEEPDTIILNGVLIDITALKDNERDLRAARQQAEQALSDLRSTQDTLVQAEKL
EEECCCCCCCCCEEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASLGQLVAGIAHEINTPLGTGITGATFLDQETRQIAGRFRSGTLRRSELADYMERAEETA
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
RLIFTNLSRAGDLVQSFKQVAVDQVSDDRRTFALDTYIDEIFQSLNPRLRQTRLTVERAI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCHHHHHHHHHHHHHC
EPGLMVDGYPGVLFRILSNLVMNTLMHGFEPHETGTIRVEARLLPDSAPGRVELVYFDTG
CCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCEEEEEEEECC
KGIPHEIQGRVFDPFFTTRRGQGGTGLGLNIVYNLVTQSLGGTMTLSSHPGTGTTFTVVF
CCCCHHHCCCEECCHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEEE
PIKAPRGVQAVPSPQPIKDSGAATA
EECCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AGLRFGVRSRLVLAFSAMAAMTLVTSAVAILSFSEVEARFIELTTTRLPAMAAATKLSQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAESIVAQAPALVAASSPTELHTIDFRIRDQLSWLAELIERVRKTDGEAIAMARVDDLAR
HHHHHHHHCCHHEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHH
ELERRFVDLATQVERRLSMEALDRQTLGRLLVLGRTITGIRDQRETEGPPEDAAIARRWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
AGAQDANTVLIAALATTDAAILRNLGEAFGDLLETAETESARLSDPLSQDMRRSTAELRH
CCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHHHHHHHH
LGLGEAGIFNRRQAHMDITRGIQGTLTRNRLSGDLLSGASSQLADRIAEEAVKSALVLRA
CCCCCCCCCCCHHHHHHHHCCCCCCHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHH
ELHNRGAMMIVLSLFGVFGAGIVLLHLQRTVLRRLATLRAAMTAPLSTRPLVLEGSDDAD
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHH
EIGDMARALKGYAQAIADREHALRQSEGRFRAMATNVPGVLFQWFWRPLGEPRFLYVSPR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCCCEEEEECCC
CQDLFGVSPALVLADWRKLGFSLEDQRAWVVRAAQAARDSRDWIQEGRIALANGGERWWR
HHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHCCCEEEECCCCEEEE
VVAAPTPGEEPDTIILNGVLIDITALKDNERDLRAARQQAEQALSDLRSTQDTLVQAEKL
EEECCCCCCCCCEEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASLGQLVAGIAHEINTPLGTGITGATFLDQETRQIAGRFRSGTLRRSELADYMERAEETA
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
RLIFTNLSRAGDLVQSFKQVAVDQVSDDRRTFALDTYIDEIFQSLNPRLRQTRLTVERAI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCHHHHHHHHHHHHHC
EPGLMVDGYPGVLFRILSNLVMNTLMHGFEPHETGTIRVEARLLPDSAPGRVELVYFDTG
CCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCEEEEEEEECC
KGIPHEIQGRVFDPFFTTRRGQGGTGLGLNIVYNLVTQSLGGTMTLSSHPGTGTTFTVVF
CCCCHHHCCCEECCHHHCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCEEEEEE
PIKAPRGVQAVPSPQPIKDSGAATA
EECCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503; 2666400; 11243806 [H]