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The map label for this gene is hipA [H]

Identifier: 83593778

GI number: 83593778

Start: 2842178

End: 2843485

Strand: Direct

Name: hipA [H]

Synonym: Rru_A2443

Alternate gene names: 83593778

Gene position: 2842178-2843485 (Clockwise)

Preceding gene: 83593777

Following gene: 83593779

Centisome position: 65.3

GC content: 59.94

Gene sequence:

>1308_bases
ATGCCGCGTCCGCACCAAGAGCCGCCGCTCGCGGTTTTCCTGAACAGCCGCCTCGTTGGTCGGCTTAATCGAACGGCGCG
TGGCGCCATCGATTTCCAGTACGATTCCTCCTGGCTTGAGTGGGATCGCGCCCTTCCCATCTCTCTCTCGCTGCCGCTTC
GCGAGGACCGGTATAGCGGCGCGGCAGTCAACGCGGTTCTGGAAAATCTGCTCCCCGATAGCGCCCTCATTCGTCGTCGG
ACCGCCGAACGCGTTCGGGCACAAGGATCCGATGCTTACAACCTGCTCGCTGCGATCGGCCGCGACTGTGTGGGGGCACT
CCAGTTCCTTCCCGATGGCGAGGCCCCCGGCACCGCTGGCACGGTGGATGGCATTCCCGTCGATGATCGGGAAATCGCCC
GTCTCATAAAGGAACTTTCCATTGCGCCCCTGGGATTGGGCGAAGATATAGATTTCCGAATTTCCATCGCCGGCGCCCAG
GAAAAGACCGCCCTTCTGCACTGGAAGGATCGCTGGTACAAACCCTGCGGCACCACGGCAACCACTCACATCCTGAAGCC
TCGGATCGGGCGCCTGTCCAATGGTCTGGATCTGACATCGAGTGTCGAAAACGAATTTCTCTGCCTCAAAGTGACCGCAG
CCCTTGGTATCCCGAGCGCCGATGTCGCCCTCGCCGATTTCGAAGACAATCGTGTGCTGGTGGTCGAACGGTTCGATCGC
CATTGGACCGCCGATGATCGCCTTTTGCGCCTTCCCCAGGAAGACTGCTGTCAGGCGCTTGGCGTTCCGCCAACGTTAAA
GTATCAGGCCGAAGGAGGCCCCGGTATTGAGGCCCTTTTGAATTTGCTCAAAGGCAGCGATGTTCCGAAGGTCGATCAAA
CGCGCTTTCTAAAAGCCACGGTCGCTTTCTGGCTTCTCGGCGCTACCGATGGCCACGCCAAAAATTTCAGCGTCTTCCTG
TCGTCGGGCGGGCGGTTCCGCATGACACCGCTCTATGACGTGATTTCCGCTCAGCCAAGCGCCGACGCGGGACAGATCCC
GCGCAATCGGATGAAACTGGCGATGTTCGTGGGCACGAACCGCCACTATGTCATCGACACCATCATGCCCAGACACTTCC
TTCAAACAGCCGCTGCCGCCGGACTCGGCGCCTCGCTGGTAGAACCGGTATTCGCCGATATCCTCGCTACCGCCCCGACC
GCGCTTGAGGATGTTATGGAGGCTTTACCCAAGGACTTTCCTCGCGATATCGCCGACTCCATCCTTGGTGGTTTCACCGA
ACGACTGCGAACCCTGGCGAAGGCATGA

Upstream 100 bases:

>100_bases
AAATCCGCACGCTCTGCGATATCCTGGCCGCCCTTGATCTGGAATTCGTCATACAGCCGCGAACCAAGGCATCGGTCGAC
GAAATCGGCGACATCTTTTA

Downstream 100 bases:

>100_bases
GCGCACGCCCGCCCCTTTTGAAACAGGGACATCGGCGCAAACCACCTCCCCTCGCCCCAAAACCGAAAAACGGAACGATA
CGGTCTCGTTTACTTGGCCG

Product: HipA protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MPRPHQEPPLAVFLNSRLVGRLNRTARGAIDFQYDSSWLEWDRALPISLSLPLREDRYSGAAVNAVLENLLPDSALIRRR
TAERVRAQGSDAYNLLAAIGRDCVGALQFLPDGEAPGTAGTVDGIPVDDREIARLIKELSIAPLGLGEDIDFRISIAGAQ
EKTALLHWKDRWYKPCGTTATTHILKPRIGRLSNGLDLTSSVENEFLCLKVTAALGIPSADVALADFEDNRVLVVERFDR
HWTADDRLLRLPQEDCCQALGVPPTLKYQAEGGPGIEALLNLLKGSDVPKVDQTRFLKATVAFWLLGATDGHAKNFSVFL
SSGGRFRMTPLYDVISAQPSADAGQIPRNRMKLAMFVGTNRHYVIDTIMPRHFLQTAAAAGLGASLVEPVFADILATAPT
ALEDVMEALPKDFPRDIADSILGGFTERLRTLAKA

Sequences:

>Translated_435_residues
MPRPHQEPPLAVFLNSRLVGRLNRTARGAIDFQYDSSWLEWDRALPISLSLPLREDRYSGAAVNAVLENLLPDSALIRRR
TAERVRAQGSDAYNLLAAIGRDCVGALQFLPDGEAPGTAGTVDGIPVDDREIARLIKELSIAPLGLGEDIDFRISIAGAQ
EKTALLHWKDRWYKPCGTTATTHILKPRIGRLSNGLDLTSSVENEFLCLKVTAALGIPSADVALADFEDNRVLVVERFDR
HWTADDRLLRLPQEDCCQALGVPPTLKYQAEGGPGIEALLNLLKGSDVPKVDQTRFLKATVAFWLLGATDGHAKNFSVFL
SSGGRFRMTPLYDVISAQPSADAGQIPRNRMKLAMFVGTNRHYVIDTIMPRHFLQTAAAAGLGASLVEPVFADILATAPT
ALEDVMEALPKDFPRDIADSILGGFTERLRTLAKA
>Mature_434_residues
PRPHQEPPLAVFLNSRLVGRLNRTARGAIDFQYDSSWLEWDRALPISLSLPLREDRYSGAAVNAVLENLLPDSALIRRRT
AERVRAQGSDAYNLLAAIGRDCVGALQFLPDGEAPGTAGTVDGIPVDDREIARLIKELSIAPLGLGEDIDFRISIAGAQE
KTALLHWKDRWYKPCGTTATTHILKPRIGRLSNGLDLTSSVENEFLCLKVTAALGIPSADVALADFEDNRVLVVERFDRH
WTADDRLLRLPQEDCCQALGVPPTLKYQAEGGPGIEALLNLLKGSDVPKVDQTRFLKATVAFWLLGATDGHAKNFSVFLS
SGGRFRMTPLYDVISAQPSADAGQIPRNRMKLAMFVGTNRHYVIDTIMPRHFLQTAAAAGLGASLVEPVFADILATAPTA
LEDVMEALPKDFPRDIADSILGGFTERLRTLAKA

Specific function: Unbalanced or excessive expression of hipA is toxic to the cell [H]

COG id: COG3550

COG function: function code R; Uncharacterized protein related to capsule biosynthesis enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae HI_0665 [H]

Homologues:

Organism=Escherichia coli, GI1787785, Length=425, Percent_Identity=41.8823529411765, Blast_Score=311, Evalue=5e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012893
- InterPro:   IPR012894
- InterPro:   IPR017508 [H]

Pfam domain/function: PF07804 HipA_C; PF07805 HipA_N [H]

EC number: NA

Molecular weight: Translated: 47511; Mature: 47380

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRPHQEPPLAVFLNSRLVGRLNRTARGAIDFQYDSSWLEWDRALPISLSLPLREDRYSG
CCCCCCCCCEEEEECCHHHHHHCHHHCCCEEEEECCHHHHHCCCCCEEEECCCCCCCCCC
AAVNAVLENLLPDSALIRRRTAERVRAQGSDAYNLLAAIGRDCVGALQFLPDGEAPGTAG
HHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
TVDGIPVDDREIARLIKELSIAPLGLGEDIDFRISIAGAQEKTALLHWKDRWYKPCGTTA
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCEEEEEHHHCCCCCCCCH
TTHILKPRIGRLSNGLDLTSSVENEFLCLKVTAALGIPSADVALADFEDNRVLVVERFDR
HHHHHCCHHHHHCCCCCCHHHHCCCEEEEEEEEHHCCCCCCEEEEECCCCEEEEEEECCC
HWTADDRLLRLPQEDCCQALGVPPTLKYQAEGGPGIEALLNLLKGSDVPKVDQTRFLKAT
CCCCCCHHEECCHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHH
VAFWLLGATDGHAKNFSVFLSSGGRFRMTPLYDVISAQPSADAGQIPRNRMKLAMFVGTN
HHHHHEECCCCCCCCEEEEEECCCCEEECHHHHHHCCCCCCCCCCCCHHHEEEEEEEECC
RHYVIDTIMPRHFLQTAAAAGLGASLVEPVFADILATAPTALEDVMEALPKDFPRDIADS
CCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHH
ILGGFTERLRTLAKA
HHHHHHHHHHHHHCC
>Mature Secondary Structure 
PRPHQEPPLAVFLNSRLVGRLNRTARGAIDFQYDSSWLEWDRALPISLSLPLREDRYSG
CCCCCCCCEEEEECCHHHHHHCHHHCCCEEEEECCHHHHHCCCCCEEEECCCCCCCCCC
AAVNAVLENLLPDSALIRRRTAERVRAQGSDAYNLLAAIGRDCVGALQFLPDGEAPGTAG
HHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
TVDGIPVDDREIARLIKELSIAPLGLGEDIDFRISIAGAQEKTALLHWKDRWYKPCGTTA
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCEEEEEHHHCCCCCCCCH
TTHILKPRIGRLSNGLDLTSSVENEFLCLKVTAALGIPSADVALADFEDNRVLVVERFDR
HHHHHCCHHHHHCCCCCCHHHHCCCEEEEEEEEHHCCCCCCEEEEECCCCEEEEEEECCC
HWTADDRLLRLPQEDCCQALGVPPTLKYQAEGGPGIEALLNLLKGSDVPKVDQTRFLKAT
CCCCCCHHEECCHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHH
VAFWLLGATDGHAKNFSVFLSSGGRFRMTPLYDVISAQPSADAGQIPRNRMKLAMFVGTN
HHHHHEECCCCCCCCEEEEEECCCCEEECHHHHHHCCCCCCCCCCCCHHHEEEEEEEECC
RHYVIDTIMPRHFLQTAAAAGLGASLVEPVFADILATAPTALEDVMEALPKDFPRDIADS
CCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHH
ILGGFTERLRTLAKA
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1715862; 9278503; 8021189 [H]