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The map label for this gene is prpC [H]

Identifier: 83593654

GI number: 83593654

Start: 2687112

End: 2688272

Strand: Direct

Name: prpC [H]

Synonym: Rru_A2319

Alternate gene names: 83593654

Gene position: 2687112-2688272 (Clockwise)

Preceding gene: 83593653

Following gene: 83593655

Centisome position: 61.73

GC content: 63.57

Gene sequence:

>1161_bases
ATGACCGAAACCACATTCAAGCCCAAGAAGTCCGTGGCGCTTTCGGGTATCGCCGCCGGCAATACGGCGCTGTGCACCGT
GGGCCGGAGCGGCAATGACCTCCATTACCGGGGCTATAACATCCTCGATATCGCGGAGACCTGCGAATTCGAGGAGATCG
CCCACCTGTTGATCCACGGCGGCCTGCCGACCGCCGCCCAATACGCCTCCTATAAAGCCAAGCTCAAGGTGTCGCGCGGC
CTGCCGCGCTCGGTGAAGGAGGCCTTGGAGACGATCCCGGCCGCCGCCCATCCCATGGATGTGATGCGCTCGGGCGTCTC
GGCGCTTGGCTGCGCCCTGCCCGAGGCCTACGACCACCATCCGGTCGACGCGCGCGACATCGCCGACCGCCTGATCGCCT
CTTTGGGATCGATGCTGCTGTATTGGTACCACTATGCCCACCACGGCCGCCGGATCGAGGTGGAAACCGATGAGGACAGC
ATCGGCGGCCATTTCCTGCGCCTGCTCCACGGCAAGCCCCCCAGCGACGACTTCGTGCAGGCCATGCACACCTCGCTGAT
TCTCTATGCCGAACACGAGTTCAACGCCTCGACCTTCACCGCGCGGGTGATCGCCGGCACCGGCTCGGATATGTACAGCT
GCATCTCCGGCGCCATCGGCGCCCTACGCGGGCCAAAGCACGGCGGCGCCAACGAGGTCGCCTTTGGCATCCAGAAACGC
TACGCCTCGTTACAGCATGCCGAAGAGGACATCCGCCGCCGGGTCGAGGCCAAGGAAGTCGTCATCGGTTTTGGTCACCC
GGTCTACACCACGGCCGATCCGCGCAACGCCGTGATCAAACGGGTCGCCAAGGGATTGGCCGACGAGGTGCGCTCCCATC
TGCAATATGACGTGGCCGAGCGCATCGAACAGGTGATGTGGGATACCAAGGCGATGTTTCCCAACCTCGATTGGTACAGC
GCCGTCTCCTATCACCTGATGGGCGTCCCCACCTCGATGTTCACGCCCTTGTTCGTCATCGCCCGCACCTGCGGCTGGGC
CGCCCACGTTATCGAACAGCGCCAGGACAACAAGATCATCCGCCCCTCGGCCAATTACACCGGCCCGGAAAACCTCGCCT
TCGTGCCCATGTCGGCCAGAAGCGACCATGTTTCGATGTGA

Upstream 100 bases:

>100_bases
GCTGACCGCGGACGAGGTCGCCCACCTGAGCTTCGTCGTCTCGCCTGACACCCTGGGGCCGGCCACGCCGCCCGGCATTT
TCTAAAAAGGGGACCGTCCG

Downstream 100 bases:

>100_bases
GGAACACAGATGCCCTATCTGATTGCCGACACCTTGCCAAAGGAAAGCGCGGGCACCCGCTTCCGGGCGCTTTTGAACCG
CCCGGAGATCCTCAGACTTC

Product: methylcitrate synthase

Products: NA

Alternate protein names: Citrate synthase 2; Methylcitrate synthase [H]

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MTETTFKPKKSVALSGIAAGNTALCTVGRSGNDLHYRGYNILDIAETCEFEEIAHLLIHGGLPTAAQYASYKAKLKVSRG
LPRSVKEALETIPAAAHPMDVMRSGVSALGCALPEAYDHHPVDARDIADRLIASLGSMLLYWYHYAHHGRRIEVETDEDS
IGGHFLRLLHGKPPSDDFVQAMHTSLILYAEHEFNASTFTARVIAGTGSDMYSCISGAIGALRGPKHGGANEVAFGIQKR
YASLQHAEEDIRRRVEAKEVVIGFGHPVYTTADPRNAVIKRVAKGLADEVRSHLQYDVAERIEQVMWDTKAMFPNLDWYS
AVSYHLMGVPTSMFTPLFVIARTCGWAAHVIEQRQDNKIIRPSANYTGPENLAFVPMSARSDHVSM

Sequences:

>Translated_386_residues
MTETTFKPKKSVALSGIAAGNTALCTVGRSGNDLHYRGYNILDIAETCEFEEIAHLLIHGGLPTAAQYASYKAKLKVSRG
LPRSVKEALETIPAAAHPMDVMRSGVSALGCALPEAYDHHPVDARDIADRLIASLGSMLLYWYHYAHHGRRIEVETDEDS
IGGHFLRLLHGKPPSDDFVQAMHTSLILYAEHEFNASTFTARVIAGTGSDMYSCISGAIGALRGPKHGGANEVAFGIQKR
YASLQHAEEDIRRRVEAKEVVIGFGHPVYTTADPRNAVIKRVAKGLADEVRSHLQYDVAERIEQVMWDTKAMFPNLDWYS
AVSYHLMGVPTSMFTPLFVIARTCGWAAHVIEQRQDNKIIRPSANYTGPENLAFVPMSARSDHVSM
>Mature_385_residues
TETTFKPKKSVALSGIAAGNTALCTVGRSGNDLHYRGYNILDIAETCEFEEIAHLLIHGGLPTAAQYASYKAKLKVSRGL
PRSVKEALETIPAAAHPMDVMRSGVSALGCALPEAYDHHPVDARDIADRLIASLGSMLLYWYHYAHHGRRIEVETDEDSI
GGHFLRLLHGKPPSDDFVQAMHTSLILYAEHEFNASTFTARVIAGTGSDMYSCISGAIGALRGPKHGGANEVAFGIQKRY
ASLQHAEEDIRRRVEAKEVVIGFGHPVYTTADPRNAVIKRVAKGLADEVRSHLQYDVAERIEQVMWDTKAMFPNLDWYSA
VSYHLMGVPTSMFTPLFVIARTCGWAAHVIEQRQDNKIIRPSANYTGPENLAFVPMSARSDHVSM

Specific function: Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate. Also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity [H]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786527, Length=376, Percent_Identity=72.0744680851064, Blast_Score=560, Evalue=1e-161,
Organism=Escherichia coli, GI1786939, Length=385, Percent_Identity=30.9090909090909, Blast_Score=178, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17555174, Length=357, Percent_Identity=25.7703081232493, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6319850, Length=357, Percent_Identity=25.4901960784314, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324328, Length=330, Percent_Identity=26.969696969697, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24640124, Length=330, Percent_Identity=24.5454545454545, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24640126, Length=330, Percent_Identity=24.5454545454545, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21356863, Length=382, Percent_Identity=24.6073298429319, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.5 [H]

Molecular weight: Translated: 42502; Mature: 42371

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETTFKPKKSVALSGIAAGNTALCTVGRSGNDLHYRGYNILDIAETCEFEEIAHLLIHG
CCCCCCCCCHHHEEECEECCCCEEEEECCCCCCEEECCCCEEEHHHHCCHHHHHHHHHHC
GLPTAAQYASYKAKLKVSRGLPRSVKEALETIPAAAHPMDVMRSGVSALGCALPEAYDHH
CCCHHHHHHHHHHEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
PVDARDIADRLIASLGSMLLYWYHYAHHGRRIEVETDEDSIGGHFLRLLHGKPPSDDFVQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCCCHHHHH
AMHTSLILYAEHEFNASTFTARVIAGTGSDMYSCISGAIGALRGPKHGGANEVAFGIQKR
HHHHHEEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
YASLQHAEEDIRRRVEAKEVVIGFGHPVYTTADPRNAVIKRVAKGLADEVRSHLQYDVAE
HHHHHHHHHHHHHHHHHHHEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RIEQVMWDTKAMFPNLDWYSAVSYHLMGVPTSMFTPLFVIARTCGWAAHVIEQRQDNKII
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
RPSANYTGPENLAFVPMSARSDHVSM
CCCCCCCCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure 
TETTFKPKKSVALSGIAAGNTALCTVGRSGNDLHYRGYNILDIAETCEFEEIAHLLIHG
CCCCCCCCHHHEEECEECCCCEEEEECCCCCCEEECCCCEEEHHHHCCHHHHHHHHHHC
GLPTAAQYASYKAKLKVSRGLPRSVKEALETIPAAAHPMDVMRSGVSALGCALPEAYDHH
CCCHHHHHHHHHHEEEECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
PVDARDIADRLIASLGSMLLYWYHYAHHGRRIEVETDEDSIGGHFLRLLHGKPPSDDFVQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCCCHHHHH
AMHTSLILYAEHEFNASTFTARVIAGTGSDMYSCISGAIGALRGPKHGGANEVAFGIQKR
HHHHHEEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
YASLQHAEEDIRRRVEAKEVVIGFGHPVYTTADPRNAVIKRVAKGLADEVRSHLQYDVAE
HHHHHHHHHHHHHHHHHHHEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RIEQVMWDTKAMFPNLDWYSAVSYHLMGVPTSMFTPLFVIARTCGWAAHVIEQRQDNKII
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
RPSANYTGPENLAFVPMSARSDHVSM
CCCCCCCCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 8508809; 9325432 [H]