Click here to switch to the map view.

The map label for this gene is nth [C]

Identifier: 83590403

GI number: 83590403

Start: 1602854

End: 1603627

Strand: Reverse

Name: nth [C]

Synonym: Moth_1560

Alternate gene names: 83590403

Gene position: 1603627-1602854 (Counterclockwise)

Preceding gene: 83590404

Following gene: 83590402

Centisome position: 61.0

GC content: 59.17

Gene sequence:

>774_bases
TTGCAGCAGGAAAAAAAGGCCGCCGGTGGCCCTGGCGGCCCGCAAACGGCCGGGCCGGACGTACCAGGAGGGACGACAGC
CCGGCTGATGGAGATATTTAACCGCCTCTACCGGTATTTTGGTCCCCGGCACTGGTGGCCGGCCGAGACGCCCTTCGAGG
TTATTGTCGGGGCCATCCTCACCCAGAATGTAGCCTGGAAAAATGTAGAAAAGGCCATTGCCAACCTCAAGGCCGCCGGG
CTCCTTTCCCCTGAGGCCATGGCCAGGGCCACAATAGAAGAGCTGGAACCTCATATCCGGCCGACCGGTTACTACCGGGT
GAAGGCGAAAAAGCTCAAGGCCTTTATGAATTACCTCCAGGAACGGTACAACGGCTCCCTGGAGGCCATGTTTGCCCGGC
CCTTGGAAGAATTACGGCCCGAGGTCCTGGGCGTTTTTGGTATTGGCCCGGAAACGGCCGACGCCATCCTTTGCTATGCC
GGTAACTATCCGATCATGGTCATGGACGCCTACACCCGCCGGGTCTTTTCCCGCCTGGGATTCTTCGGGGCCAGGGCTTC
CTACCAGGATATGCAGGACTTCTTTATGGTCCACCTGCCCCGGGATAACCGTCTTTACAATGAGTACCACGCCCTGATTG
ACGGTCTGGCCAACCGTATCTGCCTGAAAAAAGCGCCTGCCTGCTTAAGCTGCCCTCTGGCCGGGCTCTGCCCCCGCATT
GGCCTTGAGGAGACGGGGAAAAGTAAGTCTGAAGACTCTCCGGGTACGGGATGA

Upstream 100 bases:

>100_bases
GAATTATCCATCTGACGATTTTAGCTGTATAATAGCCTGGGGATAAAAGCTCCTTGTTTTACGAAGGTTAGACCCACTAG
AAGGGAAGGGTGCACAGGGT

Downstream 100 bases:

>100_bases
TTTTTACCCGGCAGGCGCAGGTGACCTGCTTTTTATGGTATAATAACCTTTAAGTTCCTGTAATTGGGGTGAACAATGAT
CAGACTTCTCCAACCGGATC

Product: DNA-3-methyladenine glycosylase III

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MQQEKKAAGGPGGPQTAGPDVPGGTTARLMEIFNRLYRYFGPRHWWPAETPFEVIVGAILTQNVAWKNVEKAIANLKAAG
LLSPEAMARATIEELEPHIRPTGYYRVKAKKLKAFMNYLQERYNGSLEAMFARPLEELRPEVLGVFGIGPETADAILCYA
GNYPIMVMDAYTRRVFSRLGFFGARASYQDMQDFFMVHLPRDNRLYNEYHALIDGLANRICLKKAPACLSCPLAGLCPRI
GLEETGKSKSEDSPGTG

Sequences:

>Translated_257_residues
MQQEKKAAGGPGGPQTAGPDVPGGTTARLMEIFNRLYRYFGPRHWWPAETPFEVIVGAILTQNVAWKNVEKAIANLKAAG
LLSPEAMARATIEELEPHIRPTGYYRVKAKKLKAFMNYLQERYNGSLEAMFARPLEELRPEVLGVFGIGPETADAILCYA
GNYPIMVMDAYTRRVFSRLGFFGARASYQDMQDFFMVHLPRDNRLYNEYHALIDGLANRICLKKAPACLSCPLAGLCPRI
GLEETGKSKSEDSPGTG
>Mature_257_residues
MQQEKKAAGGPGGPQTAGPDVPGGTTARLMEIFNRLYRYFGPRHWWPAETPFEVIVGAILTQNVAWKNVEKAIANLKAAG
LLSPEAMARATIEELEPHIRPTGYYRVKAKKLKAFMNYLQERYNGSLEAMFARPLEELRPEVLGVFGIGPETADAILCYA
GNYPIMVMDAYTRRVFSRLGFFGARASYQDMQDFFMVHLPRDNRLYNEYHALIDGLANRICLKKAPACLSCPLAGLCPRI
GLEETGKSKSEDSPGTG

Specific function: Has Both An Apurinic And/Or Apyrimidinic Endonuclease Activity And A DNA N-Glycosylase Activity. Incises Damaged DNA At Cytosines, Thymines And Guanines. Acts On A Damaged Strand, 5' From The Damaged Site. Required For The Repair Of Both Oxidative DNA Da

COG id: COG2231

COG function: function code L; Uncharacterized protein related to Endonuclease III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI4505471, Length=207, Percent_Identity=25.1207729468599, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1787920, Length=212, Percent_Identity=25, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR023170 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 4.2.99.18

Molecular weight: Translated: 28537; Mature: 28537

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQEKKAAGGPGGPQTAGPDVPGGTTARLMEIFNRLYRYFGPRHWWPAETPFEVIVGAIL
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
TQNVAWKNVEKAIANLKAAGLLSPEAMARATIEELEPHIRPTGYYRVKAKKLKAFMNYLQ
HCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHH
ERYNGSLEAMFARPLEELRPEVLGVFGIGPETADAILCYAGNYPIMVMDAYTRRVFSRLG
HHHCCCHHHHHHHHHHHHCHHHEEEECCCCCCCCEEEEEECCCCEEEEHHHHHHHHHHHH
FFGARASYQDMQDFFMVHLPRDNRLYNEYHALIDGLANRICLKKAPACLSCPLAGLCPRI
HHCCCCCHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHCCCHHHHCCCC
GLEETGKSKSEDSPGTG
CCHHCCCCCCCCCCCCC
>Mature Secondary Structure
MQQEKKAAGGPGGPQTAGPDVPGGTTARLMEIFNRLYRYFGPRHWWPAETPFEVIVGAIL
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
TQNVAWKNVEKAIANLKAAGLLSPEAMARATIEELEPHIRPTGYYRVKAKKLKAFMNYLQ
HCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHH
ERYNGSLEAMFARPLEELRPEVLGVFGIGPETADAILCYAGNYPIMVMDAYTRRVFSRLG
HHHCCCHHHHHHHHHHHHCHHHEEEECCCCCCCCEEEEEECCCCEEEEHHHHHHHHHHHH
FFGARASYQDMQDFFMVHLPRDNRLYNEYHALIDGLANRICLKKAPACLSCPLAGLCPRI
HHCCCCCHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHCCCHHHHCCCC
GLEETGKSKSEDSPGTG
CCHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Carbon-Oxygen Lyase [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]