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The map label for this gene is accC [H]

Identifier: 83590367

GI number: 83590367

Start: 1569058

End: 1570404

Strand: Reverse

Name: accC [H]

Synonym: Moth_1524

Alternate gene names: 83590367

Gene position: 1570404-1569058 (Counterclockwise)

Preceding gene: 83590368

Following gene: 83590366

Centisome position: 59.74

GC content: 59.39

Gene sequence:

>1347_bases
ATGTTTAGAAGGGTTTTAGTTGCCAACCGCGGCGAGATTGCCGTACGGATTATCCGGGCCTGCCGGGAACTGGATATTGA
AACGGTGGCCGTTTATTCAGAGGCTGACCGGGATTCCCTGCATACCCGCCTGGCCGATAAGGCCGTCTGTATCGGGCCGG
CCCCGGCTAACCGCAGCTACCTGCATATTCCCAGCATCATTACCGCCGCCAGGATGAGCGGAGCCGACGCCATTCACCCC
GGTTACGGTTTCCTGGCGGAGAATCCCTACTTCGCCGAGATGTGCGAAACGTCGGGGATTACCTTCATCGGCCCCTCGCC
TCGTTCCATGCAGCTTATGGGGGATAAGGCCACGGCCCGGGCAACCATGATCGCCGCCGGGGTGCCGGTAGTCCCCGGCT
CCGAGGGTGTAATCAAAGACCTGGACGCCGCCCTGGCGGTAGCCAAAGAGATAGGATACCCGGTGTTGATTAAAGCTGCG
GCCGGCGGTGGCGGCCGGGGGATCCGCGTCGCCCAGGGGCCCAGGGAGCTACGCCAGGCCGTTTTTACCGCCCAGCGGGA
AGCCGAGGCCGCCTTTGGAAACTCCCAGGTTTACCTGGAGAAATATATTGAAGAACCGCGCCATATAGAGTTTCAAATAA
TCGGCGACAGGGAAGGAAATATCATCCACCTTGGGGAGCGCGACTGCTCCTTGCAGCGGCGCAACCAGAAAATCCTGGAG
GAGGCTCCTTCAGGAGCCCTTACCCCCGAACTGCGCCAGGAAATGGGCGCCCTGGCCCTGAAGGCCGCCAGGGCCGCCAA
TTACTACAGCACCGGCACGGTAGAGTTTTTACTGGATAAATACGGCCATTACTATTTTATAGAAATGAATACCCGCATCC
AGGTGGAACACCCGGTTACCGAGGCCGTCACCGGCATCGACCTGGTTCAGGAACAGATTAAAATTGCCGCCGGCGAGCCG
CTGCGCCTGGCCCAGGAGGATGTCCAGATCCGTGGCCATGCCCTGGAGTGCCGGATCAATGCCGAGGACCCAGCCCATAA
CTTCCGGCCGGCCCCGGGCCGTATTGAACGCTATCACGCGCCAGGGGGATTCGGCATCCGGGTGGAGAGCGCTGTTTACA
GCGGTTACACCATCCCGCCCTTTTATGACTCCTTGATTGCCAAGGTTATTGCCTGGGCCCCGGACAGGGAAGCAGCCATC
AACCGCATGAGCGGGGCTTTGAAAGAAATGGTGATTGAAGGGGTGCCTACTACCATTCCCTTTCACCAGCAGATTATGGC
CAATGCCTTTTTCCGGCGCGGGGAGATCTACACCAACTTCATCCAGCGCCGCTTAATGGCCGGTTAA

Upstream 100 bases:

>100_bases
TGGTGGCCATCCTGGCCGAAAACGGCCAGCCGGTGGAATACGGCCAGGTCTTGTTCCAGATCAAGAAGGATTAAAGTCTG
CACAACTCTGGAGGCTAGCG

Downstream 100 bases:

>100_bases
GATTTACAGGCTGGCAGTTGAGGTCGCTGCCAGCCTTTGGTATAATAAAAGGACGAATAAATGGAGGTGGGCAGGGTGGA
TCAAATCCTGGAACAAGAGG

Product: acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha / biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MFRRVLVANRGEIAVRIIRACRELDIETVAVYSEADRDSLHTRLADKAVCIGPAPANRSYLHIPSIITAARMSGADAIHP
GYGFLAENPYFAEMCETSGITFIGPSPRSMQLMGDKATARATMIAAGVPVVPGSEGVIKDLDAALAVAKEIGYPVLIKAA
AGGGGRGIRVAQGPRELRQAVFTAQREAEAAFGNSQVYLEKYIEEPRHIEFQIIGDREGNIIHLGERDCSLQRRNQKILE
EAPSGALTPELRQEMGALALKAARAANYYSTGTVEFLLDKYGHYYFIEMNTRIQVEHPVTEAVTGIDLVQEQIKIAAGEP
LRLAQEDVQIRGHALECRINAEDPAHNFRPAPGRIERYHAPGGFGIRVESAVYSGYTIPPFYDSLIAKVIAWAPDREAAI
NRMSGALKEMVIEGVPTTIPFHQQIMANAFFRRGEIYTNFIQRRLMAG

Sequences:

>Translated_448_residues
MFRRVLVANRGEIAVRIIRACRELDIETVAVYSEADRDSLHTRLADKAVCIGPAPANRSYLHIPSIITAARMSGADAIHP
GYGFLAENPYFAEMCETSGITFIGPSPRSMQLMGDKATARATMIAAGVPVVPGSEGVIKDLDAALAVAKEIGYPVLIKAA
AGGGGRGIRVAQGPRELRQAVFTAQREAEAAFGNSQVYLEKYIEEPRHIEFQIIGDREGNIIHLGERDCSLQRRNQKILE
EAPSGALTPELRQEMGALALKAARAANYYSTGTVEFLLDKYGHYYFIEMNTRIQVEHPVTEAVTGIDLVQEQIKIAAGEP
LRLAQEDVQIRGHALECRINAEDPAHNFRPAPGRIERYHAPGGFGIRVESAVYSGYTIPPFYDSLIAKVIAWAPDREAAI
NRMSGALKEMVIEGVPTTIPFHQQIMANAFFRRGEIYTNFIQRRLMAG
>Mature_448_residues
MFRRVLVANRGEIAVRIIRACRELDIETVAVYSEADRDSLHTRLADKAVCIGPAPANRSYLHIPSIITAARMSGADAIHP
GYGFLAENPYFAEMCETSGITFIGPSPRSMQLMGDKATARATMIAAGVPVVPGSEGVIKDLDAALAVAKEIGYPVLIKAA
AGGGGRGIRVAQGPRELRQAVFTAQREAEAAFGNSQVYLEKYIEEPRHIEFQIIGDREGNIIHLGERDCSLQRRNQKILE
EAPSGALTPELRQEMGALALKAARAANYYSTGTVEFLLDKYGHYYFIEMNTRIQVEHPVTEAVTGIDLVQEQIKIAAGEP
LRLAQEDVQIRGHALECRINAEDPAHNFRPAPGRIERYHAPGGFGIRVESAVYSGYTIPPFYDSLIAKVIAWAPDREAAI
NRMSGALKEMVIEGVPTTIPFHQQIMANAFFRRGEIYTNFIQRRLMAG

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=442, Percent_Identity=48.1900452488688, Blast_Score=443, Evalue=1e-124,
Organism=Homo sapiens, GI65506442, Length=442, Percent_Identity=48.1900452488688, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI295821183, Length=442, Percent_Identity=48.1900452488688, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI116805327, Length=439, Percent_Identity=47.1526195899772, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI106049528, Length=444, Percent_Identity=50, Blast_Score=424, Evalue=1e-119,
Organism=Homo sapiens, GI106049295, Length=444, Percent_Identity=50, Blast_Score=424, Evalue=1e-119,
Organism=Homo sapiens, GI106049292, Length=444, Percent_Identity=50, Blast_Score=424, Evalue=1e-119,
Organism=Homo sapiens, GI38679971, Length=501, Percent_Identity=31.3373253493014, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI38679974, Length=501, Percent_Identity=31.3373253493014, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI38679977, Length=504, Percent_Identity=31.1507936507937, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI38679967, Length=504, Percent_Identity=31.1507936507937, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI38679960, Length=501, Percent_Identity=31.3373253493014, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI134142062, Length=504, Percent_Identity=29.9603174603175, Blast_Score=238, Evalue=7e-63,
Organism=Homo sapiens, GI18105007, Length=230, Percent_Identity=26.9565217391304, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1789654, Length=446, Percent_Identity=56.0538116591928, Blast_Score=511, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=46.8325791855204, Blast_Score=422, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI71987519, Length=450, Percent_Identity=47.5555555555556, Blast_Score=409, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17562816, Length=445, Percent_Identity=49.6629213483146, Blast_Score=405, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI133931226, Length=491, Percent_Identity=29.5315682281059, Blast_Score=221, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI71997163, Length=507, Percent_Identity=29.585798816568, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI71997168, Length=507, Percent_Identity=29.585798816568, Blast_Score=213, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6319695, Length=446, Percent_Identity=45.067264573991, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=42.8893905191874, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6321376, Length=446, Percent_Identity=45.9641255605381, Blast_Score=353, Evalue=2e-98,
Organism=Saccharomyces cerevisiae, GI6323863, Length=453, Percent_Identity=31.3465783664459, Blast_Score=225, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6324343, Length=507, Percent_Identity=29.7830374753452, Blast_Score=220, Evalue=3e-58,
Organism=Drosophila melanogaster, GI281363050, Length=445, Percent_Identity=48.5393258426966, Blast_Score=411, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652224, Length=445, Percent_Identity=48.5393258426966, Blast_Score=411, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652222, Length=445, Percent_Identity=48.5393258426966, Blast_Score=411, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652220, Length=445, Percent_Identity=48.5393258426966, Blast_Score=411, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652218, Length=445, Percent_Identity=48.5393258426966, Blast_Score=411, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652212, Length=445, Percent_Identity=48.5393258426966, Blast_Score=411, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652210, Length=445, Percent_Identity=48.5393258426966, Blast_Score=411, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652214, Length=445, Percent_Identity=48.5393258426966, Blast_Score=411, Evalue=1e-115,
Organism=Drosophila melanogaster, GI19921944, Length=445, Percent_Identity=48.5393258426966, Blast_Score=411, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24652216, Length=445, Percent_Identity=48.5393258426966, Blast_Score=411, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24651757, Length=444, Percent_Identity=45.2702702702703, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24651759, Length=408, Percent_Identity=44.6078431372549, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI161076409, Length=498, Percent_Identity=29.9196787148594, Blast_Score=231, Evalue=6e-61,
Organism=Drosophila melanogaster, GI161076407, Length=498, Percent_Identity=29.9196787148594, Blast_Score=231, Evalue=6e-61,
Organism=Drosophila melanogaster, GI24586460, Length=498, Percent_Identity=29.9196787148594, Blast_Score=231, Evalue=6e-61,
Organism=Drosophila melanogaster, GI24586458, Length=498, Percent_Identity=29.9196787148594, Blast_Score=231, Evalue=7e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49232; Mature: 49232

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRRVLVANRGEIAVRIIRACRELDIETVAVYSEADRDSLHTRLADKAVCIGPAPANRSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCEEEECCCCCCCCE
LHIPSIITAARMSGADAIHPGYGFLAENPYFAEMCETSGITFIGPSPRSMQLMGDKATAR
EECCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCEEEECCCCCCEEEECCCHHHH
ATMIAAGVPVVPGSEGVIKDLDAALAVAKEIGYPVLIKAAAGGGGRGIRVAQGPRELRQA
EEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEECCCHHHHHHH
VFTAQREAEAAFGNSQVYLEKYIEEPRHIEFQIIGDREGNIIHLGERDCSLQRRNQKILE
HHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
EAPSGALTPELRQEMGALALKAARAANYYSTGTVEFLLDKYGHYYFIEMNTRIQVEHPVT
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEEECCEEEECCCHH
EAVTGIDLVQEQIKIAAGEPLRLAQEDVQIRGHALECRINAEDPAHNFRPAPGRIERYHA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCEEEEC
PGGFGIRVESAVYSGYTIPPFYDSLIAKVIAWAPDREAAINRMSGALKEMVIEGVPTTIP
CCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
FHQQIMANAFFRRGEIYTNFIQRRLMAG
HHHHHHHHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MFRRVLVANRGEIAVRIIRACRELDIETVAVYSEADRDSLHTRLADKAVCIGPAPANRSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCEEEECCCCCCCCE
LHIPSIITAARMSGADAIHPGYGFLAENPYFAEMCETSGITFIGPSPRSMQLMGDKATAR
EECCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHCCCEEEECCCCCCEEEECCCHHHH
ATMIAAGVPVVPGSEGVIKDLDAALAVAKEIGYPVLIKAAAGGGGRGIRVAQGPRELRQA
EEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEECCCHHHHHHH
VFTAQREAEAAFGNSQVYLEKYIEEPRHIEFQIIGDREGNIIHLGERDCSLQRRNQKILE
HHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHHH
EAPSGALTPELRQEMGALALKAARAANYYSTGTVEFLLDKYGHYYFIEMNTRIQVEHPVT
HCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEEECCEEEECCCHH
EAVTGIDLVQEQIKIAAGEPLRLAQEDVQIRGHALECRINAEDPAHNFRPAPGRIERYHA
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCEEEEC
PGGFGIRVESAVYSGYTIPPFYDSLIAKVIAWAPDREAAINRMSGALKEMVIEGVPTTIP
CCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
FHQQIMANAFFRRGEIYTNFIQRRLMAG
HHHHHHHHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]