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The map label for this gene is ispA [C]

Identifier: 83590356

GI number: 83590356

Start: 1559114

End: 1560007

Strand: Reverse

Name: ispA [C]

Synonym: Moth_1513

Alternate gene names: 83590356

Gene position: 1560007-1559114 (Counterclockwise)

Preceding gene: 83590357

Following gene: 83590355

Centisome position: 59.34

GC content: 62.86

Gene sequence:

>894_bases
GTGAAAACCACGGAACTTGAAAGCTACCTGGCTGAACGGCGGCAACTGGTCCAGGAGGCCCTGGCCCGCAACCTGCCACC
TCCGGACACCTACCCGCCGGCGGTGCACCAGGCCATGCACTACAGCCTTTTTGCCGGGGGTAAAAGGCTAAGGCCTATCC
TCGTCCTGGCTGCCGGCGAAGCCGTGGGCAGCCAGCCGGAGCCCTTATTACCGGCAGCCTGCGCCGTGGAATTTATCCAC
ACCTATTCCCTTATCCACGATGACCTGCCGGCGATGGATAATGACGATTACCGCCGCGGCCGGCCGACATGCCATAAAGT
CTACGGTGAAGCTATCGCCCTGCTGGCCGGTGATGCCCTCCTGACCCTAGCTTTTGAAGTCTTGAGCAGGATACCGGCGA
CCATACCGCCGGAGAGAATTCTCCGGGCAACCAGGGAGCTGGCTGCCTCCGCCGGTAGCCAGGGGCTTATAGGCGGCCAG
GTGGTGGATATGGAGGCCGAAGGGCAGCCGGTTACTTTAGAAAAGGTAAACTACATTCATAACCATAAAACCGGTAGCCT
GATCCGGGCCTGCCTGCGCCTGGGGGGCATCCTGGGAGGCGCGGGAGAGGAACAACTGGCCTTACTGACCCGTTACGGGG
AAGCCCTGGGCCTGGCCTTCCAGATAACCGACGACATTCTGGATATTACCGGCGATTTCAGCCAGACGGGCAAGCAGGGC
GGGGTGGATGCCGCCCGGGGCAAGGCGACCTACCCGGCCTGCCTGGGGGTGGAGGCCTCCCGGCAAAAGGCCGGGGAATT
ATGCGCTGAGGCAGGAGCCTTGGCCAGGGCCCTGGGACCGGCGGCCGAACCCCTGGAACTCCTGGCAGGCTTTGTCCTAA
GGCGGCAAGGCTGA

Upstream 100 bases:

>100_bases
CGCCTGTGCCGGCAGCGCCTGAAAGAGGTTGAGGGTAAGCTCCAGGTGATCCTCCTCCAGGACGGGGAAGTAGTAACCAG
GGAGCTCTCCCTTCCCGGGG

Downstream 100 bases:

>100_bases
GCATGAAGGTGCCTCAGGGAGGGCAAAAGGTTACGCTGCCGGCCAGCAACTGAGGTCGCCTGTGGCCAACCGGGGACTTA
AGCCGTGGTGCTTGCCGATT

Product: farnesyl-diphosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MKTTELESYLAERRQLVQEALARNLPPPDTYPPAVHQAMHYSLFAGGKRLRPILVLAAGEAVGSQPEPLLPAACAVEFIH
TYSLIHDDLPAMDNDDYRRGRPTCHKVYGEAIALLAGDALLTLAFEVLSRIPATIPPERILRATRELAASAGSQGLIGGQ
VVDMEAEGQPVTLEKVNYIHNHKTGSLIRACLRLGGILGGAGEEQLALLTRYGEALGLAFQITDDILDITGDFSQTGKQG
GVDAARGKATYPACLGVEASRQKAGELCAEAGALARALGPAAEPLELLAGFVLRRQG

Sequences:

>Translated_297_residues
MKTTELESYLAERRQLVQEALARNLPPPDTYPPAVHQAMHYSLFAGGKRLRPILVLAAGEAVGSQPEPLLPAACAVEFIH
TYSLIHDDLPAMDNDDYRRGRPTCHKVYGEAIALLAGDALLTLAFEVLSRIPATIPPERILRATRELAASAGSQGLIGGQ
VVDMEAEGQPVTLEKVNYIHNHKTGSLIRACLRLGGILGGAGEEQLALLTRYGEALGLAFQITDDILDITGDFSQTGKQG
GVDAARGKATYPACLGVEASRQKAGELCAEAGALARALGPAAEPLELLAGFVLRRQG
>Mature_297_residues
MKTTELESYLAERRQLVQEALARNLPPPDTYPPAVHQAMHYSLFAGGKRLRPILVLAAGEAVGSQPEPLLPAACAVEFIH
TYSLIHDDLPAMDNDDYRRGRPTCHKVYGEAIALLAGDALLTLAFEVLSRIPATIPPERILRATRELAASAGSQGLIGGQ
VVDMEAEGQPVTLEKVNYIHNHKTGSLIRACLRLGGILGGAGEEQLALLTRYGEALGLAFQITDDILDITGDFSQTGKQG
GVDAARGKATYPACLGVEASRQKAGELCAEAGALARALGPAAEPLELLAGFVLRRQG

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=225, Percent_Identity=31.5555555555556, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI1786623, Length=285, Percent_Identity=47.3684210526316, Blast_Score=214, Evalue=8e-57,
Organism=Escherichia coli, GI1789578, Length=219, Percent_Identity=34.2465753424658, Blast_Score=121, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17505681, Length=252, Percent_Identity=28.1746031746032, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24651612, Length=324, Percent_Identity=25.3086419753086, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31551; Mature: 31551

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTELESYLAERRQLVQEALARNLPPPDTYPPAVHQAMHYSLFAGGKRLRPILVLAAGE
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECH
AVGSQPEPLLPAACAVEFIHTYSLIHDDLPAMDNDDYRRGRPTCHKVYGEAIALLAGDAL
HCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LTLAFEVLSRIPATIPPERILRATRELAASAGSQGLIGGQVVDMEAEGQPVTLEKVNYIH
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEHHHHHHHH
NHKTGSLIRACLRLGGILGGAGEEQLALLTRYGEALGLAFQITDDILDITGDFSQTGKQG
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEEEHHHHHHHCCCHHHCCCCC
GVDAARGKATYPACLGVEASRQKAGELCAEAGALARALGPAAEPLELLAGFVLRRQG
CCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKTTELESYLAERRQLVQEALARNLPPPDTYPPAVHQAMHYSLFAGGKRLRPILVLAAGE
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECH
AVGSQPEPLLPAACAVEFIHTYSLIHDDLPAMDNDDYRRGRPTCHKVYGEAIALLAGDAL
HCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LTLAFEVLSRIPATIPPERILRATRELAASAGSQGLIGGQVVDMEAEGQPVTLEKVNYIH
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEHHHHHHHH
NHKTGSLIRACLRLGGILGGAGEEQLALLTRYGEALGLAFQITDDILDITGDFSQTGKQG
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEEEHHHHHHHCCCHHHCCCCC
GVDAARGKATYPACLGVEASRQKAGELCAEAGALARALGPAAEPLELLAGFVLRRQG
CCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]