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The map label for this gene is norB [H]

Identifier: 82751036

GI number: 82751036

Start: 1423403

End: 1424923

Strand: Reverse

Name: norB [H]

Synonym: SAB1301c

Alternate gene names: 82751036

Gene position: 1424923-1423403 (Counterclockwise)

Preceding gene: 82751037

Following gene: 82751035

Centisome position: 51.96

GC content: 32.41

Gene sequence:

>1521_bases
ATGGATGGACTACTAATAAATTTGAAGTTTTACACATTAAAATCAAAAACCATTCAATTATTCTATCGAACAGACAAATT
TCTGTTATGGAATTTGTCTGTTTTCAAAAGTATAGGGAGGCAAATAGAGATGGAAAAGCCGTCAAGAGAGGCATTTGAAG
GCAATAATAAGTTGTTAATAGGAATTGTTTTAAGTGTAATAACGTTTTGGCTATTTGCACAATCATTGGTTAATGTTGTA
CTAATACTTGAAGATAGTTTCAATACAGATATTGGAACGGTTAATATCGCCGTTAGTATAACTGCTTTATTTTCAGGAAT
GTTTGTAGTAGGAGTAGGTGGTCTTGCTGATAAATATGGCAGAATTAAACTCACGAACATTGGTATTATCTTAAATATAT
TGGGTTCATTATTAATCATTATTTCAAATATTCCTTTATTACTTATTATAGGAAGATTAATTCAAGGACTTTCAGCAGCA
TGTATTATGCCTGCAACTTTGTCTATTATTAAGTCATATTATATTGGGAAAGATAGACAACGCGCTTTAAGTTATTGGTC
AATTGGCTCATGGGGCGGCTCTGGTGTTTGTTCATTTTTTGGAGGTGCAGTTGCAACGCTTTTAGGTTGGCGTTGGATTT
TCATCCTATCAATTATAATTTCATTAATTGCGCTGTTTCTTATTAAAGGAACTCCTGAAACTAAATCTAAATCGATTTCT
CTAAATAAATTTGACATTAAAGGTCTGGTTCTTTTAGTCATTATGCTCCTCAGTTTAAATATTTTAATTACTAAAGGATC
AGAATTAGGAGTTACCTCACTTCTTTTTATCACTTTATTAGCAATTGCAATTGGATCTTTTAGTTTATTTATAGTTCTTG
AAAAGCGTGCTACAAATCCTTTAATCGATTTTAAATTATTTAAAAATAAAGCTTATACAGGTGCAACAGCTTCAAACTTT
TTGTTAAATGGTGTTGCGGGAACATTAATAGTAGCCAACACATTTGTTCAAAGAGGTTTAGGATATTCTTTATTGCAAGC
AGGAAGTTTATCAATCACTTATTTAGTAATGGTACTAATTATGATTCGTGTTGGTGAAAAGTTACTTCAAACACTCGGAT
GCAAGAAACCAATGTTAATTGGAACAGGAGTGCTTATTGTCGGAGAATGTCTCATTTCATTAACATTTTTGCCAGAAATA
TTGTATGTCATTTGTTGTATTATAGGTTATTTATTCTTTGGTTTAGGACTAGGGATATATGCTACACCATCAACAGATAC
AGCAATTGCAAATGCACCGTTAGAAAAAGTAGGCGTTGCTGCAGGTATCTATAAAATGGCTTCTGCATTAGGTGGAGCAT
TTGGCGTCGCATTGAGTGGTGCAGTTTATGCAATCGTATCAAATATGACAAACATTTATACAGGTGCAATGATTGCATTA
TGGTTAAACGCAGGAATGGCAATTTTATCATTCGTTATCATTTTGTTACTTGTGCCTAAACAAAACGACACTCAATTATG
A

Upstream 100 bases:

>100_bases
CAATCATTGGAATTCTAATAACAGCACTTGGTATACCAGTTTATTACTATAAGAAGAAACAAAAAGCAACATAAGGTAAG
ATAACTAGCATTGAGAATAA

Downstream 100 bases:

>100_bases
TAATTGAGAATTAAATTGAAATCATACAAGTCGCTACAATATTAAACAAAAATATAAACCGATTCTTATGTGTCATTATT
TTAAATGAACATAGGGATTG

Product: transmembrane efflux protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MDGLLINLKFYTLKSKTIQLFYRTDKFLLWNLSVFKSIGRQIEMEKPSREAFEGNNKLLIGIVLSVITFWLFAQSLVNVV
LILEDSFNTDIGTVNIAVSITALFSGMFVVGVGGLADKYGRIKLTNIGIILNILGSLLIIISNIPLLLIIGRLIQGLSAA
CIMPATLSIIKSYYIGKDRQRALSYWSIGSWGGSGVCSFFGGAVATLLGWRWIFILSIIISLIALFLIKGTPETKSKSIS
LNKFDIKGLVLLVIMLLSLNILITKGSELGVTSLLFITLLAIAIGSFSLFIVLEKRATNPLIDFKLFKNKAYTGATASNF
LLNGVAGTLIVANTFVQRGLGYSLLQAGSLSITYLVMVLIMIRVGEKLLQTLGCKKPMLIGTGVLIVGECLISLTFLPEI
LYVICCIIGYLFFGLGLGIYATPSTDTAIANAPLEKVGVAAGIYKMASALGGAFGVALSGAVYAIVSNMTNIYTGAMIAL
WLNAGMAILSFVIILLLVPKQNDTQL

Sequences:

>Translated_506_residues
MDGLLINLKFYTLKSKTIQLFYRTDKFLLWNLSVFKSIGRQIEMEKPSREAFEGNNKLLIGIVLSVITFWLFAQSLVNVV
LILEDSFNTDIGTVNIAVSITALFSGMFVVGVGGLADKYGRIKLTNIGIILNILGSLLIIISNIPLLLIIGRLIQGLSAA
CIMPATLSIIKSYYIGKDRQRALSYWSIGSWGGSGVCSFFGGAVATLLGWRWIFILSIIISLIALFLIKGTPETKSKSIS
LNKFDIKGLVLLVIMLLSLNILITKGSELGVTSLLFITLLAIAIGSFSLFIVLEKRATNPLIDFKLFKNKAYTGATASNF
LLNGVAGTLIVANTFVQRGLGYSLLQAGSLSITYLVMVLIMIRVGEKLLQTLGCKKPMLIGTGVLIVGECLISLTFLPEI
LYVICCIIGYLFFGLGLGIYATPSTDTAIANAPLEKVGVAAGIYKMASALGGAFGVALSGAVYAIVSNMTNIYTGAMIAL
WLNAGMAILSFVIILLLVPKQNDTQL
>Mature_506_residues
MDGLLINLKFYTLKSKTIQLFYRTDKFLLWNLSVFKSIGRQIEMEKPSREAFEGNNKLLIGIVLSVITFWLFAQSLVNVV
LILEDSFNTDIGTVNIAVSITALFSGMFVVGVGGLADKYGRIKLTNIGIILNILGSLLIIISNIPLLLIIGRLIQGLSAA
CIMPATLSIIKSYYIGKDRQRALSYWSIGSWGGSGVCSFFGGAVATLLGWRWIFILSIIISLIALFLIKGTPETKSKSIS
LNKFDIKGLVLLVIMLLSLNILITKGSELGVTSLLFITLLAIAIGSFSLFIVLEKRATNPLIDFKLFKNKAYTGATASNF
LLNGVAGTLIVANTFVQRGLGYSLLQAGSLSITYLVMVLIMIRVGEKLLQTLGCKKPMLIGTGVLIVGECLISLTFLPEI
LYVICCIIGYLFFGLGLGIYATPSTDTAIANAPLEKVGVAAGIYKMASALGGAFGVALSGAVYAIVSNMTNIYTGAMIAL
WLNAGMAILSFVIILLLVPKQNDTQL

Specific function: Multidrug efflux pump that acts independently of norA and is one of the factors that confers resistance against diverse quinolones and chemical compounds [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=329, Percent_Identity=25.8358662613982, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI1790195, Length=375, Percent_Identity=24.2666666666667, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789042, Length=436, Percent_Identity=22.0183486238532, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI87081983, Length=354, Percent_Identity=23.728813559322, Blast_Score=79, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6324954, Length=277, Percent_Identity=24.5487364620939, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 54509; Mature: 54509

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGLLINLKFYTLKSKTIQLFYRTDKFLLWNLSVFKSIGRQIEMEKPSREAFEGNNKLLI
CCCEEEEEEEEEEECCEEEEEEECCCEEEEEHHHHHHHCCEEECCCCCHHHHCCCCCCHH
GIVLSVITFWLFAQSLVNVVLILEDSFNTDIGTVNIAVSITALFSGMFVVGVGGLADKYG
HHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCEEEEEEEHHHHHCCHHHEECCCHHHCCC
RIKLTNIGIILNILGSLLIIISNIPLLLIIGRLIQGLSAACIMPATLSIIKSYYIGKDRQ
CEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHH
RALSYWSIGSWGGSGVCSFFGGAVATLLGWRWIFILSIIISLIALFLIKGTPETKSKSIS
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
LNKFDIKGLVLLVIMLLSLNILITKGSELGVTSLLFITLLAIAIGSFSLFIVLEKRATNP
CEEECHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCC
LIDFKLFKNKAYTGATASNFLLNGVAGTLIVANTFVQRGLGYSLLQAGSLSITYLVMVLI
CEEHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHH
MIRVGEKLLQTLGCKKPMLIGTGVLIVGECLISLTFLPEILYVICCIIGYLFFGLGLGIY
HHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
ATPSTDTAIANAPLEKVGVAAGIYKMASALGGAFGVALSGAVYAIVSNMTNIYTGAMIAL
ECCCCCCHHCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLNAGMAILSFVIILLLVPKQNDTQL
HHHCCHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MDGLLINLKFYTLKSKTIQLFYRTDKFLLWNLSVFKSIGRQIEMEKPSREAFEGNNKLLI
CCCEEEEEEEEEEECCEEEEEEECCCEEEEEHHHHHHHCCEEECCCCCHHHHCCCCCCHH
GIVLSVITFWLFAQSLVNVVLILEDSFNTDIGTVNIAVSITALFSGMFVVGVGGLADKYG
HHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCEEEEEEEHHHHHCCHHHEECCCHHHCCC
RIKLTNIGIILNILGSLLIIISNIPLLLIIGRLIQGLSAACIMPATLSIIKSYYIGKDRQ
CEEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHH
RALSYWSIGSWGGSGVCSFFGGAVATLLGWRWIFILSIIISLIALFLIKGTPETKSKSIS
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
LNKFDIKGLVLLVIMLLSLNILITKGSELGVTSLLFITLLAIAIGSFSLFIVLEKRATNP
CEEECHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHCCEEEEEEEECCCCCC
LIDFKLFKNKAYTGATASNFLLNGVAGTLIVANTFVQRGLGYSLLQAGSLSITYLVMVLI
CEEHEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHH
MIRVGEKLLQTLGCKKPMLIGTGVLIVGECLISLTFLPEILYVICCIIGYLFFGLGLGIY
HHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
ATPSTDTAIANAPLEKVGVAAGIYKMASALGGAFGVALSGAVYAIVSNMTNIYTGAMIAL
ECCCCCCHHCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLNAGMAILSFVIILLLVPKQNDTQL
HHHCCHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA