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The map label for this gene is msrA

Identifier: 82751015

GI number: 82751015

Start: 1395934

End: 1396467

Strand: Reverse

Name: msrA

Synonym: SAB1279c

Alternate gene names: 82751015

Gene position: 1396467-1395934 (Counterclockwise)

Preceding gene: 82751016

Following gene: 82751014

Centisome position: 50.92

GC content: 35.77

Gene sequence:

>534_bases
ATGACAAAAGAATATGCAACATTAGCAGGAGGATGTTTCTGGTGCATGGTTAAACCATTTACATCATATCCAGGCATCAA
GTCAGTCGTATCTGGTTATAGTGGCGGTTATGTTGACAACCCAACTTATGAACAGGTATGTACGAATCAAACCGGCCATG
TCGAAGCAGCACAAATTACGTTTGATCCAGAGGTTACTTCCTTTGAGAATATATTAGACATATATTTCAAAACATTTGAC
CCAACTGATGATCAAGGACAATTTTTCGATAGAGGCGAAAGCTATCAACCAGTCATTTTCTATCATGATGAGCATCAAAA
AAAGGCTGCTGAGTTTAAAAAGCAACAATTAAATGAACAAGGTATTTTCAAGAAACCAGTGATTACACCTATTAAACCAT
ATAAAAATTTCTATCCAGCTGAAGACTACCATCAAGATTATTATAAAAAGAACCCGGTACATTATTACCAATATCAACGT
GGTTCAGGTAGAAAAGCGTTTATAGAATCACATTGGGGGAATCAAAATGCTTAA

Upstream 100 bases:

>100_bases
GTCCTTAAGAAGTAAATTTAATCTTTTCAGTGTTAATTACTTCCATTTCAATCCTTTATAGACTAAATTTATAATTAGAT
AGATAGAGGAGGTAATTCAT

Downstream 100 bases:

>100_bases
AAAAGATAAAAGTGAACTAACAGACATAGAATATATTGTTACACAAGAAAATGGCACTGAACCACCATTTATGAATGAAT
ATTGGAATCATTTTGATAAA

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MTKEYATLAGGCFWCMVKPFTSYPGIKSVVSGYSGGYVDNPTYEQVCTNQTGHVEAAQITFDPEVTSFENILDIYFKTFD
PTDDQGQFFDRGESYQPVIFYHDEHQKKAAEFKKQQLNEQGIFKKPVITPIKPYKNFYPAEDYHQDYYKKNPVHYYQYQR
GSGRKAFIESHWGNQNA

Sequences:

>Translated_177_residues
MTKEYATLAGGCFWCMVKPFTSYPGIKSVVSGYSGGYVDNPTYEQVCTNQTGHVEAAQITFDPEVTSFENILDIYFKTFD
PTDDQGQFFDRGESYQPVIFYHDEHQKKAAEFKKQQLNEQGIFKKPVITPIKPYKNFYPAEDYHQDYYKKNPVHYYQYQR
GSGRKAFIESHWGNQNA
>Mature_176_residues
TKEYATLAGGCFWCMVKPFTSYPGIKSVVSGYSGGYVDNPTYEQVCTNQTGHVEAAQITFDPEVTSFENILDIYFKTFDP
TDDQGQFFDRGESYQPVIFYHDEHQKKAAEFKKQQLNEQGIFKKPVITPIKPYKNFYPAEDYHQDYYKKNPVHYYQYQRG
SGRKAFIESHWGNQNA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=156, Percent_Identity=37.8205128205128, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI208609995, Length=156, Percent_Identity=37.8205128205128, Blast_Score=112, Evalue=1e-25,
Organism=Homo sapiens, GI208609993, Length=110, Percent_Identity=37.2727272727273, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=37.5, Blast_Score=111, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17533973, Length=145, Percent_Identity=33.1034482758621, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320881, Length=157, Percent_Identity=34.3949044585987, Blast_Score=86, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24664627, Length=149, Percent_Identity=34.8993288590604, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24664631, Length=149, Percent_Identity=34.2281879194631, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI45553131, Length=139, Percent_Identity=34.5323741007194, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 20586; Mature: 20455

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKEYATLAGGCFWCMVKPFTSYPGIKSVVSGYSGGYVDNPTYEQVCTNQTGHVEAAQIT
CCCCHHHHHCCEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCHHHHHCCCCCCEEEEEEE
FDPEVTSFENILDIYFKTFDPTDDQGQFFDRGESYQPVIFYHDEHQKKAAEFKKQQLNEQ
ECCCHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCEEEECCCHHHHHHHHHHHHHCCC
GIFKKPVITPIKPYKNFYPAEDYHQDYYKKNPVHYYQYQRGSGRKAFIESHWGNQNA
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCCCC
>Mature Secondary Structure 
TKEYATLAGGCFWCMVKPFTSYPGIKSVVSGYSGGYVDNPTYEQVCTNQTGHVEAAQIT
CCCHHHHHCCEEEEEECCCCCCCCHHHHHCCCCCCCCCCCCHHHHHCCCCCCEEEEEEE
FDPEVTSFENILDIYFKTFDPTDDQGQFFDRGESYQPVIFYHDEHQKKAAEFKKQQLNEQ
ECCCHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCEEEECCCHHHHHHHHHHHHHCCC
GIFKKPVITPIKPYKNFYPAEDYHQDYYKKNPVHYYQYQRGSGRKAFIESHWGNQNA
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11700354; 11779133 [H]