Click here to switch to the map view.

The map label for this gene is adhA

Identifier: 82750312

GI number: 82750312

Start: 621102

End: 622112

Strand: Direct

Name: adhA

Synonym: SAB0557

Alternate gene names: 82750312

Gene position: 621102-622112 (Clockwise)

Preceding gene: 82750311

Following gene: 82750313

Centisome position: 22.65

GC content: 36.2

Gene sequence:

>1011_bases
ATGAGAGCAGCAGTTGTAACGAAAGATCACAAAGTAAGTATTGAGGACAAAAAGTTAAGAGCTTTAAAACCTGGTGAAGC
ATTGGTACAAACGGAATATTGTGGCGTTTGTCATACCGATTTACATGTTAAGAATGCTGATTTTGGTGATGTTACAGGCG
TTACATTAGGTCATGAAGGTATTGGTAAAGTCATCGAAGTTGCAGAAGATGTAGAATCATTAAAAATTGGAGACCGTGTG
TCTATCGCTTGGATGTTCGAAAGCTGTGGAAGATGTGAATATTGTACAACAGGTCGTGAAACACTTTGCCGTAGTGTGAA
AAATGCTGGTTATACAGTAGATGGTGCAATGGCTGAACAAGTTATTGTTACTGCAGACTATGCTGTGAAAGTACCTGAAA
AATTAGATCCAGCAGCAGCGTCTTCTATTACATGCGCAGGTGTGACAACTTATAAAGCTGTAAAAGTAAGTAATGTAAAA
CCTGGACAATGGTTAGGTGTTTTTGGTATAGGTGGTTTAGGTAACCTAGCTTTACAATATGCTAAAAACGTTATGGGGGC
TAAAATTGTTGCCTTCGACATTAATGATGATAAATTAGCATTCGCGAAAGAATTAGGTGCAGATGCTATTATTAATTCTA
AAGACGTTGATCCAGTTGCAGAAGTTATGAAATTAACTGATAACAAAGGATTAGATGCAACAGTGGTAACTTCAGTTGCT
AAGACGCCATTTAACCAAGCGGTTGATGTTGTAAAAGCTGGTGCAAGAGTTGTTGCTGTTGGTTTACCTGTTGATAAAAT
GAACTTAGATATCCCAAGATTAGTGCTTGATGGTATTGAAGTAGTAGGTTCACTTGTTGGTACAAGACAAGACTTACGTG
AAGCGTTTGAATTTGCTGCTGAAAATAAAGTAACACCTAAAGTTCAATTAAGAAAATTAGAAGAAATCAATGATATTTTT
GAAGAAATGGAAAATGGTACTATAACTGGTAGAATGGTTATTAAATTTTAA

Upstream 100 bases:

>100_bases
TACAAATAAAAATTACATCTATAATTATTCGTTTTCATTTTTGAAAGTAATCGCCAATTAATATCATACATACTGGAGTG
ACTATAAGGAGGACATTATT

Downstream 100 bases:

>100_bases
AAATATCAACTGACTATATAGATAAAGAAGGTAGTGCTCTGAACACTATCATTATAATCAAACACGAGGTTTTCATGAAG
GATAGTGAAAATCTCGTGTT

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: ADH

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MRAAVVTKDHKVSIEDKKLRALKPGEALVQTEYCGVCHTDLHVKNADFGDVTGVTLGHEGIGKVIEVAEDVESLKIGDRV
SIAWMFESCGRCEYCTTGRETLCRSVKNAGYTVDGAMAEQVIVTADYAVKVPEKLDPAAASSITCAGVTTYKAVKVSNVK
PGQWLGVFGIGGLGNLALQYAKNVMGAKIVAFDINDDKLAFAKELGADAIINSKDVDPVAEVMKLTDNKGLDATVVTSVA
KTPFNQAVDVVKAGARVVAVGLPVDKMNLDIPRLVLDGIEVVGSLVGTRQDLREAFEFAAENKVTPKVQLRKLEEINDIF
EEMENGTITGRMVIKF

Sequences:

>Translated_336_residues
MRAAVVTKDHKVSIEDKKLRALKPGEALVQTEYCGVCHTDLHVKNADFGDVTGVTLGHEGIGKVIEVAEDVESLKIGDRV
SIAWMFESCGRCEYCTTGRETLCRSVKNAGYTVDGAMAEQVIVTADYAVKVPEKLDPAAASSITCAGVTTYKAVKVSNVK
PGQWLGVFGIGGLGNLALQYAKNVMGAKIVAFDINDDKLAFAKELGADAIINSKDVDPVAEVMKLTDNKGLDATVVTSVA
KTPFNQAVDVVKAGARVVAVGLPVDKMNLDIPRLVLDGIEVVGSLVGTRQDLREAFEFAAENKVTPKVQLRKLEEINDIF
EEMENGTITGRMVIKF
>Mature_336_residues
MRAAVVTKDHKVSIEDKKLRALKPGEALVQTEYCGVCHTDLHVKNADFGDVTGVTLGHEGIGKVIEVAEDVESLKIGDRV
SIAWMFESCGRCEYCTTGRETLCRSVKNAGYTVDGAMAEQVIVTADYAVKVPEKLDPAAASSITCAGVTTYKAVKVSNVK
PGQWLGVFGIGGLGNLALQYAKNVMGAKIVAFDINDDKLAFAKELGADAIINSKDVDPVAEVMKLTDNKGLDATVVTSVA
KTPFNQAVDVVKAGARVVAVGLPVDKMNLDIPRLVLDGIEVVGSLVGTRQDLREAFEFAAENKVTPKVQLRKLEEINDIF
EEMENGTITGRMVIKF

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family

Homologues:

Organism=Homo sapiens, GI34577061, Length=368, Percent_Identity=31.25, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4501933, Length=368, Percent_Identity=30.9782608695652, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI4501929, Length=361, Percent_Identity=31.5789473684211, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI71565154, Length=259, Percent_Identity=32.8185328185328, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI71743840, Length=377, Percent_Identity=27.5862068965517, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI262073058, Length=377, Percent_Identity=27.5862068965517, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI4501939, Length=363, Percent_Identity=25.8953168044077, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI156523966, Length=363, Percent_Identity=25.8953168044077, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI71565152, Length=363, Percent_Identity=24.2424242424242, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI156627571, Length=265, Percent_Identity=26.0377358490566, Blast_Score=72, Evalue=5e-13,
Organism=Escherichia coli, GI87081918, Length=336, Percent_Identity=69.0476190476191, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI1786518, Length=331, Percent_Identity=30.2114803625378, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI87082401, Length=317, Percent_Identity=29.6529968454259, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1790045, Length=336, Percent_Identity=25, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788073, Length=248, Percent_Identity=29.4354838709677, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI1787863, Length=270, Percent_Identity=29.2592592592593, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1786552, Length=371, Percent_Identity=30.188679245283, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1788075, Length=325, Percent_Identity=26.7692307692308, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1790718, Length=284, Percent_Identity=27.8169014084507, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI226510992, Length=321, Percent_Identity=25.5451713395639, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082125, Length=351, Percent_Identity=22.2222222222222, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1786825, Length=263, Percent_Identity=25.8555133079848, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788407, Length=195, Percent_Identity=28.2051282051282, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=341, Percent_Identity=36.0703812316716, Blast_Score=198, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17562584, Length=342, Percent_Identity=36.5497076023392, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17562582, Length=316, Percent_Identity=38.6075949367089, Blast_Score=194, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI17562876, Length=256, Percent_Identity=32.8125, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17562878, Length=218, Percent_Identity=32.5688073394495, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI25146526, Length=248, Percent_Identity=29.0322580645161, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71997431, Length=250, Percent_Identity=29.2, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17565904, Length=214, Percent_Identity=28.9719626168224, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323961, Length=329, Percent_Identity=38.2978723404255, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6319621, Length=332, Percent_Identity=35.8433734939759, Blast_Score=209, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6324486, Length=339, Percent_Identity=35.9882005899705, Blast_Score=207, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6323729, Length=329, Percent_Identity=34.0425531914894, Blast_Score=194, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6319949, Length=322, Percent_Identity=28.8819875776398, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6320033, Length=375, Percent_Identity=29.0666666666667, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6323980, Length=317, Percent_Identity=26.1829652996845, Blast_Score=105, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6323099, Length=335, Percent_Identity=25.9701492537313, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6322619, Length=345, Percent_Identity=26.3768115942029, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319955, Length=345, Percent_Identity=26.0869565217391, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319258, Length=292, Percent_Identity=26.027397260274, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6319257, Length=328, Percent_Identity=24.6951219512195, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17737895, Length=261, Percent_Identity=30.6513409961686, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17137530, Length=201, Percent_Identity=27.363184079602, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17737897, Length=250, Percent_Identity=26, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADH_STAA3 (Q2FJ31)

Other databases:

- EMBL:   CP000255
- RefSeq:   YP_493297.1
- ProteinModelPortal:   Q2FJ31
- SMR:   Q2FJ31
- STRING:   Q2FJ31
- EnsemblBacteria:   EBSTAT00000036786
- GeneID:   3914232
- GenomeReviews:   CP000255_GR
- KEGG:   saa:SAUSA300_0594
- eggNOG:   COG1064
- GeneTree:   EBGT00050000023958
- HOGENOM:   HBG753318
- OMA:   VRPGQWI
- ProtClustDB:   PRK09422
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR006140
- InterPro:   IPR011032
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11695

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N; SSF50129 GroES_like

EC number: =1.1.1.1

Molecular weight: Translated: 36048; Mature: 36048

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00059 ADH_ZINC; PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAAVVTKDHKVSIEDKKLRALKPGEALVQTEYCGVCHTDLHVKNADFGDVTGVTLGHEG
CCCEEEECCCEECCCCCHHHEECCCCHHEEHHHCCEEECCEEECCCCCCCCCEEEECCHH
IGKVIEVAEDVESLKIGDRVSIAWMFESCGRCEYCTTGRETLCRSVKNAGYTVDGAMAEQ
HHHHHHHHHHHHHHCCCCEEEEEEEEHHCCCCCCCCCCHHHHHHHHHHCCCEECCHHHCE
VIVTADYAVKVPEKLDPAAASSITCAGVTTYKAVKVSNVKPGQWLGVFGIGGLGNLALQY
EEEEECCEEECCCCCCCHHHCCEEEECEEEEEEEEECCCCCCCEEEEEECCCHHHHHHHH
AKNVMGAKIVAFDINDDKLAFAKELGADAIINSKDVDPVAEVMKLTDNKGLDATVVTSVA
HHHHCCCEEEEEECCCCHHHHHHHCCCCCEECCCCCCHHHHHHHHCCCCCCCHHHHHHHH
KTPFNQAVDVVKAGARVVAVGLPVDKMNLDIPRLVLDGIEVVGSLVGTRQDLREAFEFAA
HCCHHHHHHHHHCCCEEEEEECCHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ENKVTPKVQLRKLEEINDIFEEMENGTITGRMVIKF
CCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEC
>Mature Secondary Structure
MRAAVVTKDHKVSIEDKKLRALKPGEALVQTEYCGVCHTDLHVKNADFGDVTGVTLGHEG
CCCEEEECCCEECCCCCHHHEECCCCHHEEHHHCCEEECCEEECCCCCCCCCEEEECCHH
IGKVIEVAEDVESLKIGDRVSIAWMFESCGRCEYCTTGRETLCRSVKNAGYTVDGAMAEQ
HHHHHHHHHHHHHHCCCCEEEEEEEEHHCCCCCCCCCCHHHHHHHHHHCCCEECCHHHCE
VIVTADYAVKVPEKLDPAAASSITCAGVTTYKAVKVSNVKPGQWLGVFGIGGLGNLALQY
EEEEECCEEECCCCCCCHHHCCEEEECEEEEEEEEECCCCCCCEEEEEECCCHHHHHHHH
AKNVMGAKIVAFDINDDKLAFAKELGADAIINSKDVDPVAEVMKLTDNKGLDATVVTSVA
HHHHCCCEEEEEECCCCHHHHHHHCCCCCEECCCCCCHHHHHHHHCCCCCCCHHHHHHHH
KTPFNQAVDVVKAGARVVAVGLPVDKMNLDIPRLVLDGIEVVGSLVGTRQDLREAFEFAA
HCCHHHHHHHHHCCCEEEEEECCHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ENKVTPKVQLRKLEEINDIFEEMENGTITGRMVIKF
CCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA