Click here to switch to the map view.

The map label for this gene is mvaK2

Identifier: 82750297

GI number: 82750297

Start: 606680

End: 607756

Strand: Direct

Name: mvaK2

Synonym: SAB0542

Alternate gene names: 82750297

Gene position: 606680-607756 (Clockwise)

Preceding gene: 82750296

Following gene: 82750298

Centisome position: 22.12

GC content: 33.52

Gene sequence:

>1077_bases
ATGATTCAGGTCAAAGCACCCGGAAAACTTTATATTGCTGGAGAATATGCTGTAACAGAACCAGGATATAAATCTGTACT
TATTGCGTTAGATCGTTTTGTAACTGCTACTATTGAAGAAGCAGACCAATATAAAGGTACCATTCATTCAAAAGCATTAC
ATCATAACCCAGTTACATTTAGTAGAGATGAAGATAGTATTGTCATTTCAGATCCACATGCAGCAAAGCAATTAAATTAT
GTGGTCACAGCTATTGAAATATTTGAACAATACGCGAAAAGTTGCGATATAGCGATGAAGCATTTTCATCTGACTATTGA
TAGTAATTTAGATGATTCAAATGGTCATAAATATGGATTAGGTTCAAGTGCAGCAGTACTTGTATCAGTTATAAAAGTAT
TAAATGAATTTTATGATATGAAGTTATCTAATTTATACATTTATAAACTAGCAGTGATTGCAAATATGAAGTTACAAAGT
TTAAGTTCATGCGGAGATATTGCTGTGAGTGTATATAGTGGATGGTTAGCGTATAGTACTTTTGATCATGAATGGGTCAA
GCATCAAATTGAAGATACTACGGTTGAAGAAGTTTTAATCAAAAACTGGCCTGGATTGCACATCGAACCATTACAAGCAC
CTGAAAATATGGAAGTACTTATCGGTTGGACTGGCTCACCGGCGTCATCACCACACTTTGTTAGCGAAGTGAAACGTTTG
AAATCAGATCCTTCATTTTACGGTGACTTCTTAGAAGATTCACATCGTTGTGTTGAAAAACTTATTCATGCTTTTAAAAC
AAATAACATTAAAGGTGTGCAAAAGATGGTGCGTCAGAATCGTACAATTATTCAACGTATGGATAAAGAAGCTACAGTTG
ATATAGAAACTGAAAAGCTAAAATATTTGTGTGATATTGCTGAAAAGTATCACGGCGCATCTAAAACATCAGGCGCTGGT
GGTGGAGACTGTGGTATTACAATTATCAATAAAGATGTAGATAAAGAAAAAATTTATGATGAATGGACAAAACATGGTAT
TAAACCATTAAAATTTAATATTTATCATGGGCAATAA

Upstream 100 bases:

>100_bases
GATTATAGATAAATTATTAACACAGTTTGATAATAACCAAATTATTGATAGTGACATTATTGCCACAGGAATTGAAATAA
TTGAGTAAGGAAGAGATAAA

Downstream 100 bases:

>100_bases
ATGATTTGATAGGGGAGCAATCATCTAATTTAATTAGAAGATAAATGCTCCATTTTTTATTGCCAGCTGTGTTACGTATC
TTGAAAAAAATATTAAAAAG

Product: phosphomevalonate kinase

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MIQVKAPGKLYIAGEYAVTEPGYKSVLIALDRFVTATIEEADQYKGTIHSKALHHNPVTFSRDEDSIVISDPHAAKQLNY
VVTAIEIFEQYAKSCDIAMKHFHLTIDSNLDDSNGHKYGLGSSAAVLVSVIKVLNEFYDMKLSNLYIYKLAVIANMKLQS
LSSCGDIAVSVYSGWLAYSTFDHEWVKHQIEDTTVEEVLIKNWPGLHIEPLQAPENMEVLIGWTGSPASSPHFVSEVKRL
KSDPSFYGDFLEDSHRCVEKLIHAFKTNNIKGVQKMVRQNRTIIQRMDKEATVDIETEKLKYLCDIAEKYHGASKTSGAG
GGDCGITIINKDVDKEKIYDEWTKHGIKPLKFNIYHGQ

Sequences:

>Translated_358_residues
MIQVKAPGKLYIAGEYAVTEPGYKSVLIALDRFVTATIEEADQYKGTIHSKALHHNPVTFSRDEDSIVISDPHAAKQLNY
VVTAIEIFEQYAKSCDIAMKHFHLTIDSNLDDSNGHKYGLGSSAAVLVSVIKVLNEFYDMKLSNLYIYKLAVIANMKLQS
LSSCGDIAVSVYSGWLAYSTFDHEWVKHQIEDTTVEEVLIKNWPGLHIEPLQAPENMEVLIGWTGSPASSPHFVSEVKRL
KSDPSFYGDFLEDSHRCVEKLIHAFKTNNIKGVQKMVRQNRTIIQRMDKEATVDIETEKLKYLCDIAEKYHGASKTSGAG
GGDCGITIINKDVDKEKIYDEWTKHGIKPLKFNIYHGQ
>Mature_358_residues
MIQVKAPGKLYIAGEYAVTEPGYKSVLIALDRFVTATIEEADQYKGTIHSKALHHNPVTFSRDEDSIVISDPHAAKQLNY
VVTAIEIFEQYAKSCDIAMKHFHLTIDSNLDDSNGHKYGLGSSAAVLVSVIKVLNEFYDMKLSNLYIYKLAVIANMKLQS
LSSCGDIAVSVYSGWLAYSTFDHEWVKHQIEDTTVEEVLIKNWPGLHIEPLQAPENMEVLIGWTGSPASSPHFVSEVKRL
KSDPSFYGDFLEDSHRCVEKLIHAFKTNNIKGVQKMVRQNRTIIQRMDKEATVDIETEKLKYLCDIAEKYHGASKTSGAG
GGDCGITIINKDVDKEKIYDEWTKHGIKPLKFNIYHGQ

Specific function: Unknown

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 40217; Mature: 40217

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQVKAPGKLYIAGEYAVTEPGYKSVLIALDRFVTATIEEADQYKGTIHSKALHHNPVTF
CEEECCCCEEEEEECEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEE
SRDEDSIVISDPHAAKQLNYVVTAIEIFEQYAKSCDIAMKHFHLTIDSNLDDSNGHKYGL
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCCCEECC
GSSAAVLVSVIKVLNEFYDMKLSNLYIYKLAVIANMKLQSLSSCGDIAVSVYSGWLAYST
CCHHHHHHHHHHHHHHHHCCHHCCEEEEEHHHHHCCHHHHHHCHHHHHHHHHHHHHHCCC
FDHEWVKHQIEDTTVEEVLIKNWPGLHIEPLQAPENMEVLIGWTGSPASSPHFVSEVKRL
CCHHHHHHHHCCHHHHHHHHHCCCCCEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHH
KSDPSFYGDFLEDSHRCVEKLIHAFKTNNIKGVQKMVRQNRTIIQRMDKEATVDIETEKL
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHCCCCCEEEEHHHHH
KYLCDIAEKYHGASKTSGAGGGDCGITIINKDVDKEKIYDEWTKHGIKPLKFNIYHGQ
HHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCC
>Mature Secondary Structure
MIQVKAPGKLYIAGEYAVTEPGYKSVLIALDRFVTATIEEADQYKGTIHSKALHHNPVTF
CEEECCCCEEEEEECEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEE
SRDEDSIVISDPHAAKQLNYVVTAIEIFEQYAKSCDIAMKHFHLTIDSNLDDSNGHKYGL
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCCCEECC
GSSAAVLVSVIKVLNEFYDMKLSNLYIYKLAVIANMKLQSLSSCGDIAVSVYSGWLAYST
CCHHHHHHHHHHHHHHHHCCHHCCEEEEEHHHHHCCHHHHHHCHHHHHHHHHHHHHHCCC
FDHEWVKHQIEDTTVEEVLIKNWPGLHIEPLQAPENMEVLIGWTGSPASSPHFVSEVKRL
CCHHHHHHHHCCHHHHHHHHHCCCCCEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHH
KSDPSFYGDFLEDSHRCVEKLIHAFKTNNIKGVQKMVRQNRTIIQRMDKEATVDIETEKL
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHCCCCCEEEEHHHHH
KYLCDIAEKYHGASKTSGAGGGDCGITIINKDVDKEKIYDEWTKHGIKPLKFNIYHGQ
HHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA