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The map label for this gene is mvaK1

Identifier: 82750295

GI number: 82750295

Start: 604759

End: 605679

Strand: Direct

Name: mvaK1

Synonym: SAB0540

Alternate gene names: 82750295

Gene position: 604759-605679 (Clockwise)

Preceding gene: 82750294

Following gene: 82750296

Centisome position: 22.05

GC content: 38.11

Gene sequence:

>921_bases
ATGACAAGAAAAGGATATGGGGAATCGACAGGTAAGATTATTTTAATAGGAGAACATGCTGTTACATTTGGAGAGCCTGC
TATTGCAGTACCGTTTAACGCAGGTAAAATCAAAGTTTTAATAGAAGCCTTAGAGAGCGGGAACTATTCGTCTATTAAAA
GCGATGTTTACGATGGTATGTTATATGATGCGCCTGACCATCTTAAGTCTTTGGTGAACCGTTTTGTAGAATTAAATAAT
ATTACAGAGCCGCTAGCAGTAACGATCCAAACGAATTTACCACCATCACGTGGATTAGGATCGAGTGCAGCTGTCGCGGT
TGCTTTTGTTCGTGCGAGTTATGATTTTTTAGGGAAATCATTAACGAAAGAAGAACTCATTGAAAAGGCTAATTGGGCAG
AGCAAATTGCACATGGTAAACCAAGTGGTATTGATACGCAAACGATTGTATCAGGCAAACCAGTTTGGTTCCAAAAAGGT
CATGCTGAAACATTGAAAACGTTAAGTTTAGACGGCTATATGGTTGTTATTGATACTGGTGTGAAAGGTTCAACAAGACA
AGCGGTAGAAGATGTTCATAAACTTTGTGAGGACCCTCAGTACATGTCACATGTAAAACATATCGGTAAGTTAGTTTTAC
GTGCGAGTGATGTGATTGAACATCATAACTTTGAAGCCTTAGCGGATATTTTTAATGAATGTCATGCGGATTTAAAGGCG
TTGACAGTTAGTCATGATAAAATAGAACAATTAATGAAAATTGGTAAAGAAAATGGTGCGATTGCTGGAAAACTTACTGG
TGCTGGTCGTGGTGGAAGTATGTTATTGCTTGCCAAAGATTTACCAACAGCGAAAAATATTGTAAAAGCTGTAGAAAAAG
CTGGTGCAGCACATACATGGATTGAGAATTTAGGAGGTTAA

Upstream 100 bases:

>100_bases
ATTTAACGCGAATGCGTATGCAACTTAGAATATGATGTCTTTTATTAATAAATAAAAACAATGAATCAAGTATAGGATAA
ATATAAAAGGTGATATTGAC

Downstream 100 bases:

>100_bases
TGCGTTGATTAAAAGTGGCAAAGCACGTGCACATACGAATATTGCACTTATAAAATATTGGGGTAAAAAAGATGAAGCAC
TAATCATTCCAATGAATAAT

Product: mevalonate kinase

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MTRKGYGESTGKIILIGEHAVTFGEPAIAVPFNAGKIKVLIEALESGNYSSIKSDVYDGMLYDAPDHLKSLVNRFVELNN
ITEPLAVTIQTNLPPSRGLGSSAAVAVAFVRASYDFLGKSLTKEELIEKANWAEQIAHGKPSGIDTQTIVSGKPVWFQKG
HAETLKTLSLDGYMVVIDTGVKGSTRQAVEDVHKLCEDPQYMSHVKHIGKLVLRASDVIEHHNFEALADIFNECHADLKA
LTVSHDKIEQLMKIGKENGAIAGKLTGAGRGGSMLLLAKDLPTAKNIVKAVEKAGAAHTWIENLGG

Sequences:

>Translated_306_residues
MTRKGYGESTGKIILIGEHAVTFGEPAIAVPFNAGKIKVLIEALESGNYSSIKSDVYDGMLYDAPDHLKSLVNRFVELNN
ITEPLAVTIQTNLPPSRGLGSSAAVAVAFVRASYDFLGKSLTKEELIEKANWAEQIAHGKPSGIDTQTIVSGKPVWFQKG
HAETLKTLSLDGYMVVIDTGVKGSTRQAVEDVHKLCEDPQYMSHVKHIGKLVLRASDVIEHHNFEALADIFNECHADLKA
LTVSHDKIEQLMKIGKENGAIAGKLTGAGRGGSMLLLAKDLPTAKNIVKAVEKAGAAHTWIENLGG
>Mature_305_residues
TRKGYGESTGKIILIGEHAVTFGEPAIAVPFNAGKIKVLIEALESGNYSSIKSDVYDGMLYDAPDHLKSLVNRFVELNNI
TEPLAVTIQTNLPPSRGLGSSAAVAVAFVRASYDFLGKSLTKEELIEKANWAEQIAHGKPSGIDTQTIVSGKPVWFQKGH
AETLKTLSLDGYMVVIDTGVKGSTRQAVEDVHKLCEDPQYMSHVKHIGKLVLRASDVIEHHNFEALADIFNECHADLKAL
TVSHDKIEQLMKIGKENGAIAGKLTGAGRGGSMLLLAKDLPTAKNIVKAVEKAGAAHTWIENLGG

Specific function: Unknown

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

Organism=Drosophila melanogaster, GI78707210, Length=212, Percent_Identity=28.7735849056604, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 32919; Mature: 32788

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRKGYGESTGKIILIGEHAVTFGEPAIAVPFNAGKIKVLIEALESGNYSSIKSDVYDGM
CCCCCCCCCCCEEEEEECCEEECCCCCEEECCCCCHHHHHHHHHHCCCCHHHHHHHHCCC
LYDAPDHLKSLVNRFVELNNITEPLAVTIQTNLPPSRGLGSSAAVAVAFVRASYDFLGKS
CCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
LTKEELIEKANWAEQIAHGKPSGIDTQTIVSGKPVWFQKGHAETLKTLSLDGYMVVIDTG
CCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCEEECCCHHHHHHEECCCEEEEEECC
VKGSTRQAVEDVHKLCEDPQYMSHVKHIGKLVLRASDVIEHHNFEALADIFNECHADLKA
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LTVSHDKIEQLMKIGKENGAIAGKLTGAGRGGSMLLLAKDLPTAKNIVKAVEKAGAAHTW
HCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHCCCHHHH
IENLGG
HHHHCC
>Mature Secondary Structure 
TRKGYGESTGKIILIGEHAVTFGEPAIAVPFNAGKIKVLIEALESGNYSSIKSDVYDGM
CCCCCCCCCCEEEEEECCEEECCCCCEEECCCCCHHHHHHHHHHCCCCHHHHHHHHCCC
LYDAPDHLKSLVNRFVELNNITEPLAVTIQTNLPPSRGLGSSAAVAVAFVRASYDFLGKS
CCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
LTKEELIEKANWAEQIAHGKPSGIDTQTIVSGKPVWFQKGHAETLKTLSLDGYMVVIDTG
CCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCEEECCCHHHHHHEECCCEEEEEECC
VKGSTRQAVEDVHKLCEDPQYMSHVKHIGKLVLRASDVIEHHNFEALADIFNECHADLKA
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LTVSHDKIEQLMKIGKENGAIAGKLTGAGRGGSMLLLAKDLPTAKNIVKAVEKAGAAHTW
HCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHCCCHHHH
IENLGG
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]