Definition Staphylococcus aureus RF122, complete genome.
Accession NC_007622
Length 2,742,531

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The map label for this gene is proP

Identifier: 82750278

GI number: 82750278

Start: 589380

End: 590780

Strand: Direct

Name: proP

Synonym: SAB0523

Alternate gene names: 82750278

Gene position: 589380-590780 (Clockwise)

Preceding gene: 82750277

Following gene: 82750279

Centisome position: 21.49

GC content: 34.33

Gene sequence:

>1401_bases
ATGGATTTTAATAAAGAGAATATTAACATGGTGGATGCAAAGAAAGCTAAAAAGACTGTTGTTGCAACCGGTATCGGTAA
TGCAATGGAATGGTTCGATTTTGGTGTCTATGCATATACAACTGCGTACATTGGAGCGAACTTCTTCTCTCCAGTAGAGA
GTGCAGACATTCGACAAATGTTGACTTTCGTAGCATTAGCCATTGCGTTTTTATTAAGACCAATTGGTGGTGTTGTATTT
GGTATTATTGGTGACAAATATGGACGTAAAGTTGTATTAACATCAACAATTATTTTAATGGCATTTTCAACATTAACCAT
TGGATTATTGCCAAGCTATGATCAAATTGGACTTTGGGCACCAATACTATTATTGCTTGCAAGAGTACTACAAGGGTTTT
CAACAGGTGGAGAGTATGCGGGGGCAATGACATATGTTGCGGAGTCATCTCCAGATAAGCGTCGTAACTCATTAGGTAGT
GGACTAGAAATTGGGACATTATCAGGTTACATAGCTGCTTCAATTATGATTGCTGTATTAACATTCTTTTTAACAGATGA
ACAAATGGCATCATTTGGTTGGAGAATCCCATTCTTACTTGGTTTATTCCTAGGATTATTTGGCTTATATTTACGTCGTA
AGCTTGAAGAATCACCAGTTTTCGAAAATGATGTTGCAACACAACCAGAAAGAGATAACATTAACTTTTTACAAATCATC
AGATTTTATTACAAAGATATATTTGTATGTTTTGTAGCTGTTGTGTTCTTCAATGTTACGAACTATATGGTAACTGCATA
TTTACCAACCTATTTAGAACAAGTTATTAAATTAGATGCAACGACAACAAGTGTATTAATTACTTGTGTCATGGCAATAA
TGATTCCATTAGCATTAATGTTTGGTAAGTTAGCGGATAAAATAGGTGAAAAGAAAGTATTTTTAATTGGTACTGGTGGG
CTAACATTATTCAGCATCATCGCATTTATGTTATTGCATTCACAATCATTTGTTGTAATAGTAATCGGTATATTTATATT
AGGATTTTTCTTATTAACTTACGAAGCGACAATGCCAGGGTCGTTACCAACGATGTTTTACAGTCATATAAGATATCGAA
CTTTATCAGTAACATTTAATATCTCTGTTTCGATATTTGGTGGTACGACGCCATTAGTTGCAACATGGTTAGTTACGAAA
ACTGGAGATCCATTAGCACCTGCGTATTATTTAACAGCAATCAGTGTTATTGGCTTTTTAGTTATTACATTCTTACATTT
AAGTACAGCAGGAAAATCTCTAAAAGGTTCGTATCCAAATGTAGATAACGAGCAAGATAGAGCTTATTATGCAGAACACC
CAAAAGAAGCATTATGGTGGGTTAAAGAACGTAAAGATTAG

Upstream 100 bases:

>100_bases
ATACTTTTGTATTTATATAAAAGTTTAAATTCTTATAAATTTGACAAAACTAATTAACTCCGTATAATTATGAAACATAC
AAGAGTGAGTGTATGAATTC

Downstream 100 bases:

>100_bases
AGATTTCAGTAAATATAATAATCAATCGTATAAAAGCACTTTAAAGCTAGTAAACGCTACTAACTTTAAAGTGCTTTTTA
AATTGAGAACTGTAATTAAC

Product: proline/betaine transporter

Products: betaine [Cytoplasm]; Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MDFNKENINMVDAKKAKKTVVATGIGNAMEWFDFGVYAYTTAYIGANFFSPVESADIRQMLTFVALAIAFLLRPIGGVVF
GIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYDQIGLWAPILLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRNSLGS
GLEIGTLSGYIAASIMIAVLTFFLTDEQMASFGWRIPFLLGLFLGLFGLYLRRKLEESPVFENDVATQPERDNINFLQII
RFYYKDIFVCFVAVVFFNVTNYMVTAYLPTYLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIGTGG
LTLFSIIAFMLLHSQSFVVIVIGIFILGFFLLTYEATMPGSLPTMFYSHIRYRTLSVTFNISVSIFGGTTPLVATWLVTK
TGDPLAPAYYLTAISVIGFLVITFLHLSTAGKSLKGSYPNVDNEQDRAYYAEHPKEALWWVKERKD

Sequences:

>Translated_466_residues
MDFNKENINMVDAKKAKKTVVATGIGNAMEWFDFGVYAYTTAYIGANFFSPVESADIRQMLTFVALAIAFLLRPIGGVVF
GIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYDQIGLWAPILLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRNSLGS
GLEIGTLSGYIAASIMIAVLTFFLTDEQMASFGWRIPFLLGLFLGLFGLYLRRKLEESPVFENDVATQPERDNINFLQII
RFYYKDIFVCFVAVVFFNVTNYMVTAYLPTYLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIGTGG
LTLFSIIAFMLLHSQSFVVIVIGIFILGFFLLTYEATMPGSLPTMFYSHIRYRTLSVTFNISVSIFGGTTPLVATWLVTK
TGDPLAPAYYLTAISVIGFLVITFLHLSTAGKSLKGSYPNVDNEQDRAYYAEHPKEALWWVKERKD
>Mature_466_residues
MDFNKENINMVDAKKAKKTVVATGIGNAMEWFDFGVYAYTTAYIGANFFSPVESADIRQMLTFVALAIAFLLRPIGGVVF
GIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYDQIGLWAPILLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRNSLGS
GLEIGTLSGYIAASIMIAVLTFFLTDEQMASFGWRIPFLLGLFLGLFGLYLRRKLEESPVFENDVATQPERDNINFLQII
RFYYKDIFVCFVAVVFFNVTNYMVTAYLPTYLEQVIKLDATTTSVLITCVMAIMIPLALMFGKLADKIGEKKVFLIGTGG
LTLFSIIAFMLLHSQSFVVIVIGIFILGFFLLTYEATMPGSLPTMFYSHIRYRTLSVTFNISVSIFGGTTPLVATWLVTK
TGDPLAPAYYLTAISVIGFLVITFLHLSTAGKSLKGSYPNVDNEQDRAYYAEHPKEALWWVKERKD

Specific function: May be a proton symporter invoved in the uptake of osmolytes such as proline and glycine betaine [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Escherichia coli, GI1790550, Length=457, Percent_Identity=37.636761487965, Blast_Score=337, Evalue=1e-93,
Organism=Escherichia coli, GI1788292, Length=423, Percent_Identity=31.2056737588652, Blast_Score=197, Evalue=8e-52,
Organism=Escherichia coli, GI1788942, Length=430, Percent_Identity=30.4651162790698, Blast_Score=178, Evalue=6e-46,
Organism=Escherichia coli, GI1789941, Length=397, Percent_Identity=33.2493702770781, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI87082404, Length=398, Percent_Identity=27.1356783919598, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI87082231, Length=438, Percent_Identity=23.0593607305936, Blast_Score=87, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 51686; Mature: 51686

Theoretical pI: Translated: 8.11; Mature: 8.11

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFNKENINMVDAKKAKKTVVATGIGNAMEWFDFGVYAYTTAYIGANFFSPVESADIRQM
CCCCCCCCCCCCHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHH
LTFVALAIAFLLRPIGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYDQIGLWA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
PILLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRNSLGSGLEIGTLSGYIAASIMIAVL
HHHHHHHHHHHCCCCCCCHHHHHHEEECCCCHHHHHHCCCCCEECHHHHHHHHHHHHHHH
TFFLTDEQMASFGWRIPFLLGLFLGLFGLYLRRKLEESPVFENDVATQPERDNINFLQII
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHH
RFYYKDIFVCFVAVVFFNVTNYMVTAYLPTYLEQVIKLDATTTSVLITCVMAIMIPLALM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
FGKLADKIGEKKVFLIGTGGLTLFSIIAFMLLHSQSFVVIVIGIFILGFFLLTYEATMPG
HHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCC
SLPTMFYSHIRYRTLSVTFNISVSIFGGTTPLVATWLVTKTGDPLAPAYYLTAISVIGFL
CHHHHHHHHHHEEEEEEEEEEEEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
VITFLHLSTAGKSLKGSYPNVDNEQDRAYYAEHPKEALWWVKERKD
HHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHCCC
>Mature Secondary Structure
MDFNKENINMVDAKKAKKTVVATGIGNAMEWFDFGVYAYTTAYIGANFFSPVESADIRQM
CCCCCCCCCCCCHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHCCHHCCCCCHHHHHHH
LTFVALAIAFLLRPIGGVVFGIIGDKYGRKVVLTSTIILMAFSTLTIGLLPSYDQIGLWA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
PILLLLARVLQGFSTGGEYAGAMTYVAESSPDKRRNSLGSGLEIGTLSGYIAASIMIAVL
HHHHHHHHHHHCCCCCCCHHHHHHEEECCCCHHHHHHCCCCCEECHHHHHHHHHHHHHHH
TFFLTDEQMASFGWRIPFLLGLFLGLFGLYLRRKLEESPVFENDVATQPERDNINFLQII
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHH
RFYYKDIFVCFVAVVFFNVTNYMVTAYLPTYLEQVIKLDATTTSVLITCVMAIMIPLALM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
FGKLADKIGEKKVFLIGTGGLTLFSIIAFMLLHSQSFVVIVIGIFILGFFLLTYEATMPG
HHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCC
SLPTMFYSHIRYRTLSVTFNISVSIFGGTTPLVATWLVTKTGDPLAPAYYLTAISVIGFL
CHHHHHHHHHHEEEEEEEEEEEEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
VITFLHLSTAGKSLKGSYPNVDNEQDRAYYAEHPKEALWWVKERKD
HHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: betaine [Periplasm]; Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + betaine [Periplasm] = Proton [Cytoplasm] + betaine [Cytoplasm] Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10708580 [H]