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The map label for this gene is nagB [H]

Identifier: 82750274

GI number: 82750274

Start: 586101

End: 586859

Strand: Direct

Name: nagB [H]

Synonym: SAB0519

Alternate gene names: 82750274

Gene position: 586101-586859 (Clockwise)

Preceding gene: 82750269

Following gene: 82750275

Centisome position: 21.37

GC content: 34.12

Gene sequence:

>759_bases
ATGAAAGTATTAAACTTAGGATCGAAAAAACAAGCATCATTCTATGTTGCATGTGAGTTATATAAAGAGATGGCATTTAA
TCAGCACTGTAAACTAGGTTTAGCAACTGGTGGTACAATGACAGATTTGTATGAACAACTTGTTAAGTTATTAAATAAAA
ATCAGTTAAACGTAGACAATGTATCCACGTTTAATTTAGACGAATATGTAGGTTTAACCGCATCACATCCGCAAAGTTAT
CACTATTATATGGATGCCATGCTTTTCAAACAATATCCTTATTTTAATAGAAAGAACATTCATATTCCGAATGGAGATGC
CGATGATATGAATGCGGAAGCGTCAAAATATAATGACGTTTTAGAACAACAAGGTCAACGTGATATTCAAATTTTAGGTA
TTGGAGAAAATGGTCATATTGGATTTAATGAACCTGGTACGCCGTTTGATAGCGTTACTCATATTGTTGATTTGACTGAA
AGTACTATTAAGGCTAATAGTCGATATTTTGAAAACGAAGATGATGTTCCAAAGCAAGCCATTTCGATGGGACTCGCCAA
TATTCTTCAAGCTAAACGTATCATTTTACTCGCATTTGGTGAAAAGAAACGTGCTGCTATTACACATTTATTAAATCAGG
AAATTTCTGTTGATGTTCCAGCCACATTACTTCACAAACACCCGAATGTTGAGATATATTTAGACGACGAAGCTTGCCCG
AAAAATGTTGCGAAAATTCATGTCGATGAAATGGATTGA

Upstream 100 bases:

>100_bases
TTTAAAAAGTGTTAAACATTAAAATTGATGCTATATTAATGGTGTATGAATGAATTCATAAGTTTTTAAAATGTATTAAA
TTTGTGGAGGCATGTAAACA

Downstream 100 bases:

>100_bases
TTGCAATGTTTAATTAAGAAATGCCTCGGGAAAGGTTCCAATAGAAAGATAAAAAGCATTGGAAGGATGATTTTTAGTGG
AATTACAATTAGCAATTGAT

Product: glucosamine-6-phosphate deaminase

Products: NA

Alternate protein names: GlcN6P deaminase; GNPDA; Glucosamine-6-phosphate isomerase [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MKVLNLGSKKQASFYVACELYKEMAFNQHCKLGLATGGTMTDLYEQLVKLLNKNQLNVDNVSTFNLDEYVGLTASHPQSY
HYYMDAMLFKQYPYFNRKNIHIPNGDADDMNAEASKYNDVLEQQGQRDIQILGIGENGHIGFNEPGTPFDSVTHIVDLTE
STIKANSRYFENEDDVPKQAISMGLANILQAKRIILLAFGEKKRAAITHLLNQEISVDVPATLLHKHPNVEIYLDDEACP
KNVAKIHVDEMD

Sequences:

>Translated_252_residues
MKVLNLGSKKQASFYVACELYKEMAFNQHCKLGLATGGTMTDLYEQLVKLLNKNQLNVDNVSTFNLDEYVGLTASHPQSY
HYYMDAMLFKQYPYFNRKNIHIPNGDADDMNAEASKYNDVLEQQGQRDIQILGIGENGHIGFNEPGTPFDSVTHIVDLTE
STIKANSRYFENEDDVPKQAISMGLANILQAKRIILLAFGEKKRAAITHLLNQEISVDVPATLLHKHPNVEIYLDDEACP
KNVAKIHVDEMD
>Mature_252_residues
MKVLNLGSKKQASFYVACELYKEMAFNQHCKLGLATGGTMTDLYEQLVKLLNKNQLNVDNVSTFNLDEYVGLTASHPQSY
HYYMDAMLFKQYPYFNRKNIHIPNGDADDMNAEASKYNDVLEQQGQRDIQILGIGENGHIGFNEPGTPFDSVTHIVDLTE
STIKANSRYFENEDDVPKQAISMGLANILQAKRIILLAFGEKKRAAITHLLNQEISVDVPATLLHKHPNVEIYLDDEACP
KNVAKIHVDEMD

Specific function: Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily [H]

Homologues:

Organism=Homo sapiens, GI13027378, Length=244, Percent_Identity=32.3770491803279, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI19923881, Length=213, Percent_Identity=33.3333333333333, Blast_Score=135, Evalue=4e-32,
Organism=Escherichia coli, GI1786893, Length=244, Percent_Identity=32.3770491803279, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1789530, Length=196, Percent_Identity=28.5714285714286, Blast_Score=97, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17554876, Length=228, Percent_Identity=32.8947368421053, Blast_Score=136, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24581960, Length=214, Percent_Identity=34.5794392523364, Blast_Score=147, Evalue=4e-36,
Organism=Drosophila melanogaster, GI19920764, Length=214, Percent_Identity=34.5794392523364, Blast_Score=147, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006148
- InterPro:   IPR004547
- InterPro:   IPR018321 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.5.99.6 [H]

Molecular weight: Translated: 28425; Mature: 28425

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS01161 GLC_GALNAC_ISOMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVLNLGSKKQASFYVACELYKEMAFNQHCKLGLATGGTMTDLYEQLVKLLNKNQLNVDN
CCCCCCCCCCCCCEEHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCC
VSTFNLDEYVGLTASHPQSYHYYMDAMLFKQYPYFNRKNIHIPNGDADDMNAEASKYNDV
CEEECHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCHHHHHHHH
LEQQGQRDIQILGIGENGHIGFNEPGTPFDSVTHIVDLTESTIKANSRYFENEDDVPKQA
HHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
ISMGLANILQAKRIILLAFGEKKRAAITHLLNQEISVDVPATLLHKHPNVEIYLDDEACP
HHHHHHHHHHHCEEEEEEECCCHHHHHHHHHCCCCCCCCCHHHHHCCCCEEEEECCCCCC
KNVAKIHVDEMD
CCCEEEEEECCC
>Mature Secondary Structure
MKVLNLGSKKQASFYVACELYKEMAFNQHCKLGLATGGTMTDLYEQLVKLLNKNQLNVDN
CCCCCCCCCCCCCEEHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCC
VSTFNLDEYVGLTASHPQSYHYYMDAMLFKQYPYFNRKNIHIPNGDADDMNAEASKYNDV
CEEECHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCHHHHHHHH
LEQQGQRDIQILGIGENGHIGFNEPGTPFDSVTHIVDLTESTIKANSRYFENEDDVPKQA
HHHCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHH
ISMGLANILQAKRIILLAFGEKKRAAITHLLNQEISVDVPATLLHKHPNVEIYLDDEACP
HHHHHHHHHHHCEEEEEEECCCHHHHHHHHHCCCCCCCCCHHHHHCCCCEEEEECCCCCC
KNVAKIHVDEMD
CCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA