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The map label for this gene is yuxL [H]

Identifier: 82703420

GI number: 82703420

Start: 2619512

End: 2621359

Strand: Reverse

Name: yuxL [H]

Synonym: Nmul_A2303

Alternate gene names: 82703420

Gene position: 2621359-2619512 (Counterclockwise)

Preceding gene: 82703423

Following gene: 82703416

Centisome position: 82.32

GC content: 52.98

Gene sequence:

>1848_bases
ATGAAACGCTACACCATTGAACAATTCATGGCGACGACCTCCATAATGGGGGCGTCGTTCAGCGCGGATGAGGAGCGCAT
CCTGTTCAGCAGTAATGAATCGGGTATTTTCAATGCCTACACGCTGCCAGTGACAGGTGGTACGGCAGAGGCGTTGACCT
GCTCCGCCAGCGATACCACGTTTTCGGTCAGCTTCTTTCCGCATGATGATCGGGTACTGATTACCCGGGATTATCATGGC
GATGAAAATTATCATTTGTTCCTGCTCGCCCCCGACGGCGAGGAGGAAGATCTGACACCGGGAGAAAAGCTCAAGGCGCA
ATTCATGGGCTGGAGCCCCGATGGACAGGCTTTTTACGTCGCTACCAATGAGCTTGATGCCAGATTCTTCGATGTATACC
GTTATGACGCCGAGACTTTTGCGCGAACCTTGCTGTACCGGAATCACCAGGGGTTCGATCTTGGGCCCATCAGTCGCGAT
GAGCGCTGGATTGCACTGAACCGCTCGCATACCGCATCGGACAGTGACATTTACCTGTTCGATGTCGAAAAACGGGAAGT
AAGGCACCTCACGCCGCATGAGGGCTCCATCAGTTTCCATGCTGAGACCTTCGATTCCACTTCGCGCAAGCTCTTCTTTC
TTACCACGGAGGGAAGCGAATTCAAGCATTTGTGCACCTATGATCTCACTTCAGGGGTCGTCTGCGACCACGAGAGTGCC
GAGTGGGACGTGATGTACACCTATTTCTCATACGATGGCCGATTCCGCGTAACTGGCATCAACGCAGATGGAAGCATTGT
CGTTCGTGTTGTCGAAATTGAAGATGGAGAGAGGGAGAAACCTGTAAAACTGCCAGCACTACCCCAGGGAGAAATCCGGG
GTGTGGTCTTTTCGCAAAACAGCACGCGCATGGCCTTCTACGTAAATGGCGACCGCTCTCCCGATAATCTGTTCGTGCAC
GATTTCAGCACCGGGCAGTTTCGTCAACTCACGCAAAGCCTGAACAAGGAGATCGATCCATCAGATCTGGTGGAGGCGGA
AGTGGTGCGGTTCCGATCCTTCGATGGAATGATGATTCCCTCCATCTATTACAAGCCGCATGAAGCATCAGGCACCAACA
AGGTGCCTGCCATCGTGTACGTTCATGGAGGACCCGGCGGGCAGACCATGCGGGGTTATAACGCCCAGATTCAGTACCTC
GTGAATCATGGATATGCCGTGCTGGGCATCAATAACCGGGGAAGCTCCGGCTATGGTAAAACCTTCTTTACCGCGGCCAA
CCGCAAGCACGGACGAGAGCCCTTGTGGGATTGTGTGGAAGCGAAGACCTTTCTGGCCAGTCTCGGTTACATCGACCATG
AGCGCATCGGCATCATGGGCGCGAGTTATGGCGGTTACATGACACTTGCAGCCCTCGCGTTCCGGCCTGAAGCTTTCAAG
GTAGGGGTGGACATTTTCGGCGTCAGCAACTGGCTGCGTACCCTGGAGAGCATTCCTGTTTACTGGGAGTCCGTCCGCAA
AGCCATTTATGATGAAATTGGCGATCCCGTGGCGGACATCGATTTTCTTGTTGCGACTTCCCCCCTGTTCCATGCCAGGG
AAATACGAAAGCCTTTATTGGTCATCCAGGGAGTCAATGACCCTCGTGTGGTCAAGGCCGAGAGCGATGAAATGGTGGAG
GCGGTCAGGAAGCATGGCATTCCGGTGGAGTACATTGTTTTCCCTGATGAAGGCCATAGTTTTACCAAGAAAAAAAACCA
GATCGAGGCGAATCGGCGAATACTGGAGTTTCTGGACAAGTATCTGAAAGGTGATGTGAACAAGACTGCAAGCCAAGTGG
AAAAATAG

Upstream 100 bases:

>100_bases
TGGACGCTGGCAGACAATTGTTTGATCCCCGGCTCCTTCCAGCTCTATTCAGGTTTATCGCGAGCCAAAATCCAAATCCA
GCATCGCGGGGACGCTCGAT

Downstream 100 bases:

>100_bases
GACAACGTCCTTCCCCCCACCTTCCGATATCACCGGTGTAGGGCAGGCTTGCCCCGCCCCTTGCTTCCACGTAATGTAGT
ACATGAGAGAGCGAATAGCT

Product: peptidase S9, prolyl oligopeptidase active site region

Products: Hydrolyzed protein [C]

Alternate protein names: NA

Number of amino acids: Translated: 615; Mature: 615

Protein sequence:

>615_residues
MKRYTIEQFMATTSIMGASFSADEERILFSSNESGIFNAYTLPVTGGTAEALTCSASDTTFSVSFFPHDDRVLITRDYHG
DENYHLFLLAPDGEEEDLTPGEKLKAQFMGWSPDGQAFYVATNELDARFFDVYRYDAETFARTLLYRNHQGFDLGPISRD
ERWIALNRSHTASDSDIYLFDVEKREVRHLTPHEGSISFHAETFDSTSRKLFFLTTEGSEFKHLCTYDLTSGVVCDHESA
EWDVMYTYFSYDGRFRVTGINADGSIVVRVVEIEDGEREKPVKLPALPQGEIRGVVFSQNSTRMAFYVNGDRSPDNLFVH
DFSTGQFRQLTQSLNKEIDPSDLVEAEVVRFRSFDGMMIPSIYYKPHEASGTNKVPAIVYVHGGPGGQTMRGYNAQIQYL
VNHGYAVLGINNRGSSGYGKTFFTAANRKHGREPLWDCVEAKTFLASLGYIDHERIGIMGASYGGYMTLAALAFRPEAFK
VGVDIFGVSNWLRTLESIPVYWESVRKAIYDEIGDPVADIDFLVATSPLFHAREIRKPLLVIQGVNDPRVVKAESDEMVE
AVRKHGIPVEYIVFPDEGHSFTKKKNQIEANRRILEFLDKYLKGDVNKTASQVEK

Sequences:

>Translated_615_residues
MKRYTIEQFMATTSIMGASFSADEERILFSSNESGIFNAYTLPVTGGTAEALTCSASDTTFSVSFFPHDDRVLITRDYHG
DENYHLFLLAPDGEEEDLTPGEKLKAQFMGWSPDGQAFYVATNELDARFFDVYRYDAETFARTLLYRNHQGFDLGPISRD
ERWIALNRSHTASDSDIYLFDVEKREVRHLTPHEGSISFHAETFDSTSRKLFFLTTEGSEFKHLCTYDLTSGVVCDHESA
EWDVMYTYFSYDGRFRVTGINADGSIVVRVVEIEDGEREKPVKLPALPQGEIRGVVFSQNSTRMAFYVNGDRSPDNLFVH
DFSTGQFRQLTQSLNKEIDPSDLVEAEVVRFRSFDGMMIPSIYYKPHEASGTNKVPAIVYVHGGPGGQTMRGYNAQIQYL
VNHGYAVLGINNRGSSGYGKTFFTAANRKHGREPLWDCVEAKTFLASLGYIDHERIGIMGASYGGYMTLAALAFRPEAFK
VGVDIFGVSNWLRTLESIPVYWESVRKAIYDEIGDPVADIDFLVATSPLFHAREIRKPLLVIQGVNDPRVVKAESDEMVE
AVRKHGIPVEYIVFPDEGHSFTKKKNQIEANRRILEFLDKYLKGDVNKTASQVEK
>Mature_615_residues
MKRYTIEQFMATTSIMGASFSADEERILFSSNESGIFNAYTLPVTGGTAEALTCSASDTTFSVSFFPHDDRVLITRDYHG
DENYHLFLLAPDGEEEDLTPGEKLKAQFMGWSPDGQAFYVATNELDARFFDVYRYDAETFARTLLYRNHQGFDLGPISRD
ERWIALNRSHTASDSDIYLFDVEKREVRHLTPHEGSISFHAETFDSTSRKLFFLTTEGSEFKHLCTYDLTSGVVCDHESA
EWDVMYTYFSYDGRFRVTGINADGSIVVRVVEIEDGEREKPVKLPALPQGEIRGVVFSQNSTRMAFYVNGDRSPDNLFVH
DFSTGQFRQLTQSLNKEIDPSDLVEAEVVRFRSFDGMMIPSIYYKPHEASGTNKVPAIVYVHGGPGGQTMRGYNAQIQYL
VNHGYAVLGINNRGSSGYGKTFFTAANRKHGREPLWDCVEAKTFLASLGYIDHERIGIMGASYGGYMTLAALAFRPEAFK
VGVDIFGVSNWLRTLESIPVYWESVRKAIYDEIGDPVADIDFLVATSPLFHAREIRKPLLVIQGVNDPRVVKAESDEMVE
AVRKHGIPVEYIVFPDEGHSFTKKKNQIEANRRILEFLDKYLKGDVNKTASQVEK

Specific function: Cleaves Peptide Bonds On The C-Terminal Side Of Lysyl And Argininyl Residues. [C]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI194394146, Length=315, Percent_Identity=27.3015873015873, Blast_Score=103, Evalue=7e-22,
Organism=Homo sapiens, GI18450280, Length=270, Percent_Identity=28.1481481481481, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI37577089, Length=270, Percent_Identity=28.1481481481481, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI23510451, Length=252, Percent_Identity=23.015873015873, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI18765694, Length=218, Percent_Identity=26.605504587156, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI16933540, Length=233, Percent_Identity=26.6094420600858, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI295849272, Length=329, Percent_Identity=22.1884498480243, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI295842403, Length=329, Percent_Identity=22.1884498480243, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI85787627, Length=329, Percent_Identity=22.1884498480243, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI52426756, Length=329, Percent_Identity=22.1884498480243, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI295842359, Length=329, Percent_Identity=22.1884498480243, Blast_Score=71, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI25144537, Length=648, Percent_Identity=26.2345679012346, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI25144540, Length=231, Percent_Identity=42.8571428571429, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI25144543, Length=560, Percent_Identity=23.0357142857143, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17552908, Length=365, Percent_Identity=24.6575342465753, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17508019, Length=270, Percent_Identity=29.2592592592593, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17508017, Length=263, Percent_Identity=29.277566539924, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17550672, Length=295, Percent_Identity=24.0677966101695, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25149159, Length=254, Percent_Identity=25.5905511811024, Blast_Score=75, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17564632, Length=241, Percent_Identity=26.1410788381743, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17564634, Length=241, Percent_Identity=26.1410788381743, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324793, Length=237, Percent_Identity=28.2700421940928, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45550825, Length=257, Percent_Identity=29.9610894941634, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI45553511, Length=257, Percent_Identity=29.9610894941634, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI45551969, Length=257, Percent_Identity=29.9610894941634, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24582257, Length=219, Percent_Identity=26.9406392694064, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI221510989, Length=486, Percent_Identity=22.8395061728395, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011042
- InterPro:   IPR011659
- InterPro:   IPR001375 [H]

Pfam domain/function: PF07676 PD40; PF00326 Peptidase_S9 [H]

EC number: 3.4.21.83 [C]

Molecular weight: Translated: 69443; Mature: 69443

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00708 PRO_ENDOPEP_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRYTIEQFMATTSIMGASFSADEERILFSSNESGIFNAYTLPVTGGTAEALTCSASDTT
CCCEEHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEEEEEEECCCCCCEEEEECCCCE
FSVSFFPHDDRVLITRDYHGDENYHLFLLAPDGEEEDLTPGEKLKAQFMGWSPDGQAFYV
EEEEEECCCCEEEEEEECCCCCCEEEEEECCCCCCCCCCCCHHHHEEEECCCCCCCEEEE
ATNELDARFFDVYRYDAETFARTLLYRNHQGFDLGPISRDERWIALNRSHTASDSDIYLF
EECCCCCEEEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEE
DVEKREVRHLTPHEGSISFHAETFDSTSRKLFFLTTEGSEFKHLCTYDLTSGVVCDHESA
ECCHHHHHCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCEEEEEECCCCEEECCCCC
EWDVMYTYFSYDGRFRVTGINADGSIVVRVVEIEDGEREKPVKLPALPQGEIRGVVFSQN
CEEEEEEEEECCCEEEEEEECCCCEEEEEEEEECCCCCCCCEECCCCCCCCEEEEEEECC
STRMAFYVNGDRSPDNLFVHDFSTGQFRQLTQSLNKEIDPSDLVEAEVVRFRSFDGMMIP
CCEEEEEECCCCCCCCEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEECC
SIYYKPHEASGTNKVPAIVYVHGGPGGQTMRGYNAQIQYLVNHGYAVLGINNRGSSGYGK
EEEECCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEECCEEEEEECCCCCCCCCC
TFFTAANRKHGREPLWDCVEAKTFLASLGYIDHERIGIMGASYGGYMTLAALAFRPEAFK
EEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHEEHHHHCCCCEEE
VGVDIFGVSNWLRTLESIPVYWESVRKAIYDEIGDPVADIDFLVATSPLFHAREIRKPLL
EEEEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHCCEEEEECCCCHHHHHHCCCEE
VIQGVNDPRVVKAESDEMVEAVRKHGIPVEYIVFPDEGHSFTKKKNQIEANRRILEFLDK
EEECCCCCEEEEECCHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
YLKGDVNKTASQVEK
HHCCCCHHHHHHHCC
>Mature Secondary Structure
MKRYTIEQFMATTSIMGASFSADEERILFSSNESGIFNAYTLPVTGGTAEALTCSASDTT
CCCEEHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEEEEEEECCCCCCEEEEECCCCE
FSVSFFPHDDRVLITRDYHGDENYHLFLLAPDGEEEDLTPGEKLKAQFMGWSPDGQAFYV
EEEEEECCCCEEEEEEECCCCCCEEEEEECCCCCCCCCCCCHHHHEEEECCCCCCCEEEE
ATNELDARFFDVYRYDAETFARTLLYRNHQGFDLGPISRDERWIALNRSHTASDSDIYLF
EECCCCCEEEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEE
DVEKREVRHLTPHEGSISFHAETFDSTSRKLFFLTTEGSEFKHLCTYDLTSGVVCDHESA
ECCHHHHHCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCEEEEEECCCCEEECCCCC
EWDVMYTYFSYDGRFRVTGINADGSIVVRVVEIEDGEREKPVKLPALPQGEIRGVVFSQN
CEEEEEEEEECCCEEEEEEECCCCEEEEEEEEECCCCCCCCEECCCCCCCCEEEEEEECC
STRMAFYVNGDRSPDNLFVHDFSTGQFRQLTQSLNKEIDPSDLVEAEVVRFRSFDGMMIP
CCEEEEEECCCCCCCCEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCEECC
SIYYKPHEASGTNKVPAIVYVHGGPGGQTMRGYNAQIQYLVNHGYAVLGINNRGSSGYGK
EEEECCCCCCCCCCCCEEEEEECCCCCCCCCCCCCEEEEEEECCEEEEEECCCCCCCCCC
TFFTAANRKHGREPLWDCVEAKTFLASLGYIDHERIGIMGASYGGYMTLAALAFRPEAFK
EEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHEEHHHHCCCCEEE
VGVDIFGVSNWLRTLESIPVYWESVRKAIYDEIGDPVADIDFLVATSPLFHAREIRKPLL
EEEEEEEHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHCCEEEEECCCCHHHHHHCCCEE
VIQGVNDPRVVKAESDEMVEAVRKHGIPVEYIVFPDEGHSFTKKKNQIEANRRILEFLDK
EEECCCCCEEEEECCHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
YLKGDVNKTASQVEK
HHCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+ [C]

Kcat value (1/min): 11820 [C]

Specific activity: NA

Km value (mM): 0.92 {benzoyl-Lys} 0.6 {N-benzoyl-Arg} 0.23 {tosyl-Arg} 0.5 {benzoyl-Arg} 0.48 {benzoyl-Arg} 0.25 {benzoyl-Arg} 0.33 {N-benzyloxycarbonyl-Lys} 0.31 {N-benzyloxycarbonyl-Lys} 80 {acetyl-tyrosine} 0.47 {tosyl-Lys-methyl} [C]

Substrates: Protein; H2O [C]

Specific reaction: Protein + H2O = hydrolyzed protein [C]

General reaction: Peptide bond hydrolysis [C]

Inhibitor: Antipain; Aromaticamidines; Benzamidine; Co2+; DFP; Fe2+; Hg2+; L-Arginine; Leupeptin sulfhydryl agents, trypsin inhibitors, 1, 10-phenanthroline; p-Aminobenzamidine; Tosyl -Leuchloromethyl ketone; Zn2+ [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 3098560 [H]