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The map label for this gene is ybdR [H]

Identifier: 82703268

GI number: 82703268

Start: 2439775

End: 2440935

Strand: Direct

Name: ybdR [H]

Synonym: Nmul_A2149

Alternate gene names: 82703268

Gene position: 2439775-2440935 (Clockwise)

Preceding gene: 82703267

Following gene: 82703269

Centisome position: 76.62

GC content: 54.61

Gene sequence:

>1161_bases
ATGCGCGCACTCACTTATCATGGAAGTTACGACGTTCGCGTGGATACCGTACCCGACCCGATACTTCAGGAACCGGACGA
TATTGTTCTAAAAATAACTGCTACTGCGATCTGTGGCTCCGACTTGCATCTGTACCGGGGCAAAATGCCGGAACTCAAGA
ATGGCGACATACTCGGCCATGAGTTTATGGGAACAGTCGTCGACGCGGGCCCGGAGGTTACAGCGTTGCGAAAGGGCGAC
CGGGTGGTGGTCCCCTTCGTCATCGCCTGCGGACAATGCTTCTTCTGCGAGAGGCAATTGTACGCCGCTTGTGAAACGAC
CAACCCGGATCGTGGCGCAATCATGAACAAAAAAAACGTGCGTTCAGGCGCAGCGTTCTTTGGCTATACGCACCTGTATG
GGGGAGTGCCGGGCGGCCAGGCTGAATATGTAAGAGTGCCGAAGGCGAATGTAGGCCCCATCAAGATCCCTGAAACGCTT
CCGGATGAGAAAGTCCTGTTCCTGAGTGATATTCTGCCTACCGGTTACCAGGCTGTACTGAATGCAGAGATAGGCCCCGG
TTCCAGCGTTGTGATTTTTGGCGCCGGTCCGGTGGGACTGATGTCGGCGGCTTGCGCGCGGCTTCTGGGAGCGGAAACGA
TTTTCATGGTCGACCATCATCCGTATCGACTCGAATTTGCCCGCCAAACATATGACGTTATCCCCCTCAATTTCGATGAG
GTCGACCCTGCCGAGGTCATTGTCGAGAAAACTTCTTATAGAGGTGTCGATGCGGCCATCGATGCAATAGGATTTGAGGC
CAAAGGCAGCGCGCTGGAAACCGTCATGACCAACCTGAAACTGGAAGGCAGCAGCGGCGTGGCCTTGCGCCAATGCATCG
CAGCAGTAAGGCGGGGCGGCACAATCAGCGTGCCGGGAGTATATGCCGGTTTTATCCATGCCTTCCTTTTCGGTGATGCT
TTCGAGAAAGGCGTGACCTTCAGAATGGGGCAAACTCATGTCCAGCGCTTCCTCCCCGAACTGCTGGAGCATGTCGAATC
CGGAAAGCTACAACCGGATGTCATTATCAGTCACCGGATGCCGCTTGCTGAAGCAGCTAGCGCATATAAAATCTTCGAAA
AAAAAGAAGACGACTGCCGCAAGGTTGTCCTGACCCCCTGA

Upstream 100 bases:

>100_bases
TGAGATAGCGAGGTAAATCTGGCTCGAGGATCAGCATCCTCGAGCCAATATTGTCCCGCCTGTCTGTTAAACCGCCACTC
GCCCTTCAGAGGAGAAACCA

Downstream 100 bases:

>100_bases
CCCCCATACATCGAAGAGCCCCAAGTTCTCGTCCTGAGCTTTCGTCCAGCCTTACCTGACCGTTTGTCCCGGGTAGTCGC
AAGGTGGAGATGAGCTCACA

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: S-formylglutathione; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MRALTYHGSYDVRVDTVPDPILQEPDDIVLKITATAICGSDLHLYRGKMPELKNGDILGHEFMGTVVDAGPEVTALRKGD
RVVVPFVIACGQCFFCERQLYAACETTNPDRGAIMNKKNVRSGAAFFGYTHLYGGVPGGQAEYVRVPKANVGPIKIPETL
PDEKVLFLSDILPTGYQAVLNAEIGPGSSVVIFGAGPVGLMSAACARLLGAETIFMVDHHPYRLEFARQTYDVIPLNFDE
VDPAEVIVEKTSYRGVDAAIDAIGFEAKGSALETVMTNLKLEGSSGVALRQCIAAVRRGGTISVPGVYAGFIHAFLFGDA
FEKGVTFRMGQTHVQRFLPELLEHVESGKLQPDVIISHRMPLAEAASAYKIFEKKEDDCRKVVLTP

Sequences:

>Translated_386_residues
MRALTYHGSYDVRVDTVPDPILQEPDDIVLKITATAICGSDLHLYRGKMPELKNGDILGHEFMGTVVDAGPEVTALRKGD
RVVVPFVIACGQCFFCERQLYAACETTNPDRGAIMNKKNVRSGAAFFGYTHLYGGVPGGQAEYVRVPKANVGPIKIPETL
PDEKVLFLSDILPTGYQAVLNAEIGPGSSVVIFGAGPVGLMSAACARLLGAETIFMVDHHPYRLEFARQTYDVIPLNFDE
VDPAEVIVEKTSYRGVDAAIDAIGFEAKGSALETVMTNLKLEGSSGVALRQCIAAVRRGGTISVPGVYAGFIHAFLFGDA
FEKGVTFRMGQTHVQRFLPELLEHVESGKLQPDVIISHRMPLAEAASAYKIFEKKEDDCRKVVLTP
>Mature_386_residues
MRALTYHGSYDVRVDTVPDPILQEPDDIVLKITATAICGSDLHLYRGKMPELKNGDILGHEFMGTVVDAGPEVTALRKGD
RVVVPFVIACGQCFFCERQLYAACETTNPDRGAIMNKKNVRSGAAFFGYTHLYGGVPGGQAEYVRVPKANVGPIKIPETL
PDEKVLFLSDILPTGYQAVLNAEIGPGSSVVIFGAGPVGLMSAACARLLGAETIFMVDHHPYRLEFARQTYDVIPLNFDE
VDPAEVIVEKTSYRGVDAAIDAIGFEAKGSALETVMTNLKLEGSSGVALRQCIAAVRRGGTISVPGVYAGFIHAFLFGDA
FEKGVTFRMGQTHVQRFLPELLEHVESGKLQPDVIISHRMPLAEAASAYKIFEKKEDDCRKVVLTP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI156523966, Length=371, Percent_Identity=25.6064690026954, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI4501939, Length=360, Percent_Identity=25.5555555555556, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI71565152, Length=357, Percent_Identity=27.4509803921569, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI71565154, Length=359, Percent_Identity=28.133704735376, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4501929, Length=364, Percent_Identity=24.4505494505494, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI262073058, Length=361, Percent_Identity=26.0387811634349, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI71743840, Length=361, Percent_Identity=26.0387811634349, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI34577061, Length=360, Percent_Identity=25.2777777777778, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI4501933, Length=266, Percent_Identity=29.6992481203008, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1786825, Length=388, Percent_Identity=68.5567010309278, Blast_Score=565, Evalue=1e-162,
Organism=Escherichia coli, GI1790045, Length=289, Percent_Identity=29.4117647058824, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI87082125, Length=383, Percent_Identity=26.6318537859008, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1787863, Length=366, Percent_Identity=25.1366120218579, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788073, Length=368, Percent_Identity=26.6304347826087, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI226510992, Length=350, Percent_Identity=28, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1786552, Length=372, Percent_Identity=27.1505376344086, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788075, Length=221, Percent_Identity=30.316742081448, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1788407, Length=314, Percent_Identity=26.4331210191083, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI87081918, Length=224, Percent_Identity=29.0178571428571, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790718, Length=268, Percent_Identity=26.1194029850746, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI25146526, Length=362, Percent_Identity=27.0718232044199, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71997431, Length=361, Percent_Identity=26.8698060941828, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=366, Percent_Identity=27.0491803278689, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562876, Length=374, Percent_Identity=24.5989304812834, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6319258, Length=307, Percent_Identity=28.0130293159609, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319257, Length=243, Percent_Identity=29.6296296296296, Blast_Score=83, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=377, Percent_Identity=25.7294429708223, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17737895, Length=361, Percent_Identity=28.5318559556787, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17137530, Length=374, Percent_Identity=27.2727272727273, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45550770, Length=192, Percent_Identity=28.125, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45551930, Length=192, Percent_Identity=28.125, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI221457811, Length=317, Percent_Identity=22.397476340694, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.2.1.1

Molecular weight: Translated: 41879; Mature: 41879

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALTYHGSYDVRVDTVPDPILQEPDDIVLKITATAICGSDLHLYRGKMPELKNGDILGH
CCEEEECCCEEEEEECCCCHHHCCCCCEEEEEEEEEECCCCCHHHCCCCCCCCCCCEECH
EFMGTVVDAGPEVTALRKGDRVVVPFVIACGQCFFCERQLYAACETTNPDRGAIMNKKNV
HHHHHHHCCCCCEEEEECCCEEEEEHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
RSGAAFFGYTHLYGGVPGGQAEYVRVPKANVGPIKIPETLPDEKVLFLSDILPTGYQAVL
CCCHHHEEHHHHHCCCCCCCCCEEECCCCCCCCEECCCCCCCCCEEEEHHCCCCCCEEEE
NAEIGPGSSVVIFGAGPVGLMSAACARLLGAETIFMVDHHPYRLEFARQTYDVIPLNFDE
ECCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCEEEEECCCCEEEEECCCCC
VDPAEVIVEKTSYRGVDAAIDAIGFEAKGSALETVMTNLKLEGSSGVALRQCIAAVRRGG
CCHHHHEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHCEECCCCCHHHHHHHHHHHCCC
TISVPGVYAGFIHAFLFGDAFEKGVTFRMGQTHVQRFLPELLEHVESGKLQPDVIISHRM
EEECCHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHCCCCCCCEEEECCC
PLAEAASAYKIFEKKEDDCRKVVLTP
CHHHHHHHHHHHHCCCCCCCEEEECC
>Mature Secondary Structure
MRALTYHGSYDVRVDTVPDPILQEPDDIVLKITATAICGSDLHLYRGKMPELKNGDILGH
CCEEEECCCEEEEEECCCCHHHCCCCCEEEEEEEEEECCCCCHHHCCCCCCCCCCCEECH
EFMGTVVDAGPEVTALRKGDRVVVPFVIACGQCFFCERQLYAACETTNPDRGAIMNKKNV
HHHHHHHCCCCCEEEEECCCEEEEEHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
RSGAAFFGYTHLYGGVPGGQAEYVRVPKANVGPIKIPETLPDEKVLFLSDILPTGYQAVL
CCCHHHEEHHHHHCCCCCCCCCEEECCCCCCCCEECCCCCCCCCEEEEHHCCCCCCEEEE
NAEIGPGSSVVIFGAGPVGLMSAACARLLGAETIFMVDHHPYRLEFARQTYDVIPLNFDE
ECCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCEEEEECCCCEEEEECCCCC
VDPAEVIVEKTSYRGVDAAIDAIGFEAKGSALETVMTNLKLEGSSGVALRQCIAAVRRGG
CCHHHHEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHCEECCCCCHHHHHHHHHHHCCC
TISVPGVYAGFIHAFLFGDAFEKGVTFRMGQTHVQRFLPELLEHVESGKLQPDVIISHRM
EEECCHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHCCCCCCCEEEECCC
PLAEAASAYKIFEKKEDDCRKVVLTP
CHHHHHHHHHHHHCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: formaldehyde; glutathione; NAD+

Specific reaction: formaldehyde + glutathione + NAD+ = S-formylglutathione + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]