Click here to switch to the map view.

The map label for this gene is hisN [H]

Identifier: 82703266

GI number: 82703266

Start: 2438342

End: 2439148

Strand: Direct

Name: hisN [H]

Synonym: Nmul_A2147

Alternate gene names: 82703266

Gene position: 2438342-2439148 (Clockwise)

Preceding gene: 82703265

Following gene: 82703267

Centisome position: 76.58

GC content: 56.01

Gene sequence:

>807_bases
ATGGATCAAGAGGAAGCGTTAGAATTCGCCCAACACCTGGCTGATGTGTCCCGGTCCATCGCGCTACGATATTTCCGTAC
TTCCATGGATATCTGCTGGAAGAAAGACACGAGTCCCGTGACGATTGCAGATTGCAAGATCGAAAGTACGCTCCGTAGCG
TCATACGCAGTCGATATCCGGACCATGGCATTATCGGGGAAGAATATGACTGCATTCCCGGGGGGCGCTATAGCTGGATC
CTGGACCCGATTGACGGGACGAAGAGCTTTACAATGGGGAATCCCCTGTTCGGCACCCTCATTGGACTACTGGATGACGG
CCAGCCTATCGCCGGACTGGTCGATCTTCCTGCAATGGGAGAGCGATGGGGTGGGACGGGCAGAAGGACAACATTCACGG
ACGGGATCAGCAACGGCCAGGCGAATGTCAGCGGCTGCCGCTCCATTGACGCAGCCCGGCTTTATATCGCAGCCTCGTCG
GGAGCCGATTCCGATGAGAAATATGCAGGGATCGAGACATTGTACCGCGTCGCTGCCATCACTCGTCCTGTCTGCGACTG
CTATGCATACGGCTTGCTCGCCTCCGGCTATTGCGACCTGGTAATCGAGGACAACCTGGAGCCTTGCGATTACCTGCCGC
TCATACCGATAATTAACGGTGCGGGCGGGCAGATTACAGACTGGACAGGAAAACCCCTTACCTTGAATTCGGATGGCCGG
GTCATTGCCGCTTCCACTGAATCCCTGTTGAACGCGGCAATAGAGGTGCTACGCAGTTCGCTCTCGGCAGATTCAATCAC
CCGGTAG

Upstream 100 bases:

>100_bases
TGAGGAAGACGGCGAAATTAGCATATTGCGAAATGACGGCAAGGAACCGGAAAACCCGCCGGGCAAGCCTAAAAGTAAAA
AGACTATTTAGGAAAGCCTG

Downstream 100 bases:

>100_bases
TTCACTCATGCTGTTAGTGCGATTCCGCACCGAGAATCCTATCTTCCCAAAATAGAATCCCGTTTTAGAATCCCGTTTCC
GATCGGTCGTTTGTTTCCTG

Product: inositol monophosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MDQEEALEFAQHLADVSRSIALRYFRTSMDICWKKDTSPVTIADCKIESTLRSVIRSRYPDHGIIGEEYDCIPGGRYSWI
LDPIDGTKSFTMGNPLFGTLIGLLDDGQPIAGLVDLPAMGERWGGTGRRTTFTDGISNGQANVSGCRSIDAARLYIAASS
GADSDEKYAGIETLYRVAAITRPVCDCYAYGLLASGYCDLVIEDNLEPCDYLPLIPIINGAGGQITDWTGKPLTLNSDGR
VIAASTESLLNAAIEVLRSSLSADSITR

Sequences:

>Translated_268_residues
MDQEEALEFAQHLADVSRSIALRYFRTSMDICWKKDTSPVTIADCKIESTLRSVIRSRYPDHGIIGEEYDCIPGGRYSWI
LDPIDGTKSFTMGNPLFGTLIGLLDDGQPIAGLVDLPAMGERWGGTGRRTTFTDGISNGQANVSGCRSIDAARLYIAASS
GADSDEKYAGIETLYRVAAITRPVCDCYAYGLLASGYCDLVIEDNLEPCDYLPLIPIINGAGGQITDWTGKPLTLNSDGR
VIAASTESLLNAAIEVLRSSLSADSITR
>Mature_268_residues
MDQEEALEFAQHLADVSRSIALRYFRTSMDICWKKDTSPVTIADCKIESTLRSVIRSRYPDHGIIGEEYDCIPGGRYSWI
LDPIDGTKSFTMGNPLFGTLIGLLDDGQPIAGLVDLPAMGERWGGTGRRTTFTDGISNGQANVSGCRSIDAARLYIAASS
GADSDEKYAGIETLYRVAAITRPVCDCYAYGLLASGYCDLVIEDNLEPCDYLPLIPIINGAGGQITDWTGKPLTLNSDGR
VIAASTESLLNAAIEVLRSSLSADSITR

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Localized On The Inner Face Of The Cytoplasm Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=263, Percent_Identity=27.7566539923954, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI221625487, Length=263, Percent_Identity=27.7566539923954, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1790659, Length=96, Percent_Identity=36.4583333333333, Blast_Score=65, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21357957, Length=278, Percent_Identity=27.6978417266187, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24664918, Length=272, Percent_Identity=28.3088235294118, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21357329, Length=270, Percent_Identity=27.037037037037, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24664926, Length=250, Percent_Identity=27.6, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 28934; Mature: 28934

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQEEALEFAQHLADVSRSIALRYFRTSMDICWKKDTSPVTIADCKIESTLRSVIRSRYP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEECCHHHHHHHHHHHHCCC
DHGIIGEEYDCIPGGRYSWILDPIDGTKSFTMGNPLFGTLIGLLDDGQPIAGLVDLPAMG
CCCCCCCCCCCCCCCCEEEEEECCCCCCCEECCCHHHHHHHHHHCCCCCCCCEECCCCCC
ERWGGTGRRTTFTDGISNGQANVSGCRSIDAARLYIAASSGADSDEKYAGIETLYRVAAI
HHCCCCCCCCEECCCCCCCCCCCCHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHH
TRPVCDCYAYGLLASGYCDLVIEDNLEPCDYLPLIPIINGAGGQITDWTGKPLTLNSDGR
HHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEECCCCCEECCCCCCEEECCCCC
VIAASTESLLNAAIEVLRSSLSADSITR
EEEECHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDQEEALEFAQHLADVSRSIALRYFRTSMDICWKKDTSPVTIADCKIESTLRSVIRSRYP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEECCHHHHHHHHHHHHCCC
DHGIIGEEYDCIPGGRYSWILDPIDGTKSFTMGNPLFGTLIGLLDDGQPIAGLVDLPAMG
CCCCCCCCCCCCCCCCEEEEEECCCCCCCEECCCHHHHHHHHHHCCCCCCCCEECCCCCC
ERWGGTGRRTTFTDGISNGQANVSGCRSIDAARLYIAASSGADSDEKYAGIETLYRVAAI
HHCCCCCCCCEECCCCCCCCCCCCHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHH
TRPVCDCYAYGLLASGYCDLVIEDNLEPCDYLPLIPIINGAGGQITDWTGKPLTLNSDGR
HHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEECCCCCEECCCCCCEEECCCCC
VIAASTESLLNAAIEVLRSSLSADSITR
EEEECHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]