Click here to switch to the map view.

The map label for this gene is alr

Identifier: 82703234

GI number: 82703234

Start: 2410595

End: 2411668

Strand: Reverse

Name: alr

Synonym: Nmul_A2115

Alternate gene names: 82703234

Gene position: 2411668-2410595 (Counterclockwise)

Preceding gene: 82703236

Following gene: 82703223

Centisome position: 75.74

GC content: 57.64

Gene sequence:

>1074_bases
ATGTCGCGTCCCATCCAGGCGTTGATTGATCCCGCCGCGCTCGAGCGCAACCTCGCTATCGTTCGTCGCCATGCGCCACG
TTCACGCGTGATGGCCGTCATCAAGGCGGATGCATACGGTCATGGATTGCTGTGTGCTGCCGAGGCCCTGGCGGAGGCAG
AGGGATTTGCCCTGCTCGAACTAGATGCTGCCGTGCGTTTAAGAGAAGCGGGCTATCGCCAGACGATCCTGTTGCTTGAA
GGTTTTTTCGACATAGACGAACTGAGCTGGATCGAGCAATACCGTTTAAGTACCGTGGTGCATCACCCTGAGCAGCTTGC
CATGCTGGAGGCGGTTCGAAGGCGGGCAACGCTGGATGTATTTCTGAAGCTCAATAGCGGCATGAACCGGCTCGGATTTA
CGCCCACGGAATTTCCCGCTGCGCTGGAGCACCTCAAAGCGAATCCGGCAGTGCGGCAGATAACCCTTATGACTCATTTT
GCATGTGCCGACGAACCGGACAGAAACGACAGTATTGCGGCGCAACTGCAATGTTTCAATCTGGCAGCGGGAGGGAGATA
TATGCCCCGTTCGCTCGCGAATTCTGCCGCCATTCTTCGTTTTCCCGAAGCACATGCTGACTGGGTGCGCCCCGGCATCA
TGCTTTATGGCTCCTCGCCGCTTGCGCACACGACCGCAGAGCAATTGGGTTTGCAACCTGCCATGACTGTATCGAGCAGG
ATTATCTCCGTGCAAACGCTCAGGCCAAACGACGGAGTGGGTTACGGGCACGCTTTTCGGGCTGGTAGCTCGATGCGAGT
GGGCATTGTTGCAGGCGGCTATGCGGATGGCTATCCCCGCCATGCCCCTACTGGTACCCCGGTGCTTGTAAAGGGAAGAC
GAACGCGGATCGTGGGACGCATCTCCATGGACATGTTGCATGTGGACCTGAGCGAGATCGAGGATGCAGGTGTAGGCAGT
CCGGTAACGCTATGGGGAAGGGGTATGCCGGTTGATGAGGTTGCGCGGGCCGCTGGCACACTGGGTTATGAACTGTTGTG
CGCGATTGCGCCGAGAATGCAAAGGGTAACGTAA

Upstream 100 bases:

>100_bases
CCGCAAAACGGCTTGATCCGGAGCATTCATAAGAATTCCCGGTTCCCGCAAAATCCCTTCAAAGAAAATCTTCAAAAACT
TTCGGATATCCTGAATTACC

Downstream 100 bases:

>100_bases
AATTCTTCTCTTTTACTGTAGGACAGAACAAAAAAGGCAGCCTGGGCTGCCTTTTTGTCTCGGAATTGCGCTTCCTGGTA
GAAGGAATAAGGAAATAAAG

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MSRPIQALIDPAALERNLAIVRRHAPRSRVMAVIKADAYGHGLLCAAEALAEAEGFALLELDAAVRLREAGYRQTILLLE
GFFDIDELSWIEQYRLSTVVHHPEQLAMLEAVRRRATLDVFLKLNSGMNRLGFTPTEFPAALEHLKANPAVRQITLMTHF
ACADEPDRNDSIAAQLQCFNLAAGGRYMPRSLANSAAILRFPEAHADWVRPGIMLYGSSPLAHTTAEQLGLQPAMTVSSR
IISVQTLRPNDGVGYGHAFRAGSSMRVGIVAGGYADGYPRHAPTGTPVLVKGRRTRIVGRISMDMLHVDLSEIEDAGVGS
PVTLWGRGMPVDEVARAAGTLGYELLCAIAPRMQRVT

Sequences:

>Translated_357_residues
MSRPIQALIDPAALERNLAIVRRHAPRSRVMAVIKADAYGHGLLCAAEALAEAEGFALLELDAAVRLREAGYRQTILLLE
GFFDIDELSWIEQYRLSTVVHHPEQLAMLEAVRRRATLDVFLKLNSGMNRLGFTPTEFPAALEHLKANPAVRQITLMTHF
ACADEPDRNDSIAAQLQCFNLAAGGRYMPRSLANSAAILRFPEAHADWVRPGIMLYGSSPLAHTTAEQLGLQPAMTVSSR
IISVQTLRPNDGVGYGHAFRAGSSMRVGIVAGGYADGYPRHAPTGTPVLVKGRRTRIVGRISMDMLHVDLSEIEDAGVGS
PVTLWGRGMPVDEVARAAGTLGYELLCAIAPRMQRVT
>Mature_356_residues
SRPIQALIDPAALERNLAIVRRHAPRSRVMAVIKADAYGHGLLCAAEALAEAEGFALLELDAAVRLREAGYRQTILLLEG
FFDIDELSWIEQYRLSTVVHHPEQLAMLEAVRRRATLDVFLKLNSGMNRLGFTPTEFPAALEHLKANPAVRQITLMTHFA
CADEPDRNDSIAAQLQCFNLAAGGRYMPRSLANSAAILRFPEAHADWVRPGIMLYGSSPLAHTTAEQLGLQPAMTVSSRI
ISVQTLRPNDGVGYGHAFRAGSSMRVGIVAGGYADGYPRHAPTGTPVLVKGRRTRIVGRISMDMLHVDLSEIEDAGVGSP
VTLWGRGMPVDEVARAAGTLGYELLCAIAPRMQRVT

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1787439, Length=358, Percent_Identity=52.7932960893855, Blast_Score=361, Evalue=1e-101,
Organism=Escherichia coli, GI1790487, Length=348, Percent_Identity=43.9655172413793, Blast_Score=282, Evalue=3e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR_NITMU (Q2Y763)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_412800.1
- HSSP:   P10724
- ProteinModelPortal:   Q2Y763
- SMR:   Q2Y763
- STRING:   Q2Y763
- GeneID:   3786653
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A2115
- eggNOG:   COG0787
- HOGENOM:   HBG712172
- OMA:   WGKQVLA
- PhylomeDB:   Q2Y763
- ProtClustDB:   CLSK2772842
- BioCyc:   NMUL323848:NMUL_A2115-MONOMER
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 38865; Mature: 38734

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 35-35 ACT_SITE 255-255

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRPIQALIDPAALERNLAIVRRHAPRSRVMAVIKADAYGHGLLCAAEALAEAEGFALLE
CCCCHHHHHCHHHHHCCHHHHHHCCCHHHEEEEEEECCCCCHHHHHHHHHHHCCCEEEEE
LDAAVRLREAGYRQTILLLEGFFDIDELSWIEQYRLSTVVHHPEQLAMLEAVRRRATLDV
EHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCEEEE
FLKLNSGMNRLGFTPTEFPAALEHLKANPAVRQITLMTHFACADEPDRNDSIAAQLQCFN
EEEECCCCCCCCCCCCHHHHHHHHHCCCCHHHEEEEHHHHHCCCCCCCCCCCEEEEEEEE
LAAGGRYMPRSLANSAAILRFPEAHADWVRPGIMLYGSSPLAHTTAEQLGLQPAMTVSSR
ECCCCCCCCHHHCCCEEEEECCCCHHHHCCCCEEEECCCCCCHHHHHHHCCCHHHHHHHE
IISVQTLRPNDGVGYGHAFRAGSSMRVGIVAGGYADGYPRHAPTGTPVLVKGRRTRIVGR
EEEEEEECCCCCCCCCHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEECCCEEEEEE
ISMDMLHVDLSEIEDAGVGSPVTLWGRGMPVDEVARAAGTLGYELLCAIAPRMQRVT
EEHHHEECCHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SRPIQALIDPAALERNLAIVRRHAPRSRVMAVIKADAYGHGLLCAAEALAEAEGFALLE
CCCHHHHHCHHHHHCCHHHHHHCCCHHHEEEEEEECCCCCHHHHHHHHHHHCCCEEEEE
LDAAVRLREAGYRQTILLLEGFFDIDELSWIEQYRLSTVVHHPEQLAMLEAVRRRATLDV
EHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCEEEE
FLKLNSGMNRLGFTPTEFPAALEHLKANPAVRQITLMTHFACADEPDRNDSIAAQLQCFN
EEEECCCCCCCCCCCCHHHHHHHHHCCCCHHHEEEEHHHHHCCCCCCCCCCCEEEEEEEE
LAAGGRYMPRSLANSAAILRFPEAHADWVRPGIMLYGSSPLAHTTAEQLGLQPAMTVSSR
ECCCCCCCCHHHCCCEEEEECCCCHHHHCCCCEEEECCCCCCHHHHHHHCCCHHHHHHHE
IISVQTLRPNDGVGYGHAFRAGSSMRVGIVAGGYADGYPRHAPTGTPVLVKGRRTRIVGR
EEEEEEECCCCCCCCCHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCEEEECCCEEEEEE
ISMDMLHVDLSEIEDAGVGSPVTLWGRGMPVDEVARAAGTLGYELLCAIAPRMQRVT
EEHHHEECCHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA