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The map label for this gene is ppiD [C]

Identifier: 82703233

GI number: 82703233

Start: 2409683

End: 2410480

Strand: Direct

Name: ppiD [C]

Synonym: Nmul_A2114

Alternate gene names: 82703233

Gene position: 2409683-2410480 (Clockwise)

Preceding gene: 82703232

Following gene: 82703235

Centisome position: 75.68

GC content: 54.51

Gene sequence:

>798_bases
ATGCATTTTATGAAATTTACTCGACTTGCGGCACTGGGTATCTCCGGGCTGATCGCCGCGACGACCGTTCAGGCCCAAAC
CGGCTCAACTATGGCAAAAGTGAATGGTACGCCGATTCCCCAATCGCGCCTCGAATTCATAATGAAGGCGCGTGCCAGCC
AGGGCCAGCCGGATACGCCGGAGGCGAGGAAAGCCTTGCGCGAGGATCTCATCACTGAAGAGGTAATCGCCCAGGAAGCG
AAGAAGAAGGGGCTGGACAGGGATCCGGACTTTATCACCCAGCTCGACATGGCGCGCCAGACAGCGATGGTCAGGGCATA
CCAGATCGATTACATAAAGAACCACCCGGTAAGCGACGAAGAGCTGCATAAGGAATATGAAACGGTAAAGACGCAGATGG
GGGATAAGGAATACAAGGCTCACCATATTCTGGTGGCTACAGAAGAGGAAGCCAAAGACATTATCGCCAAGTTAAAAAAA
GGCGCAAAGTTTGACAAACTTGCCGGGGAAAAATCCCTGGACACGGGCAGCAAGAGCAAGGGGGGCGAACTGGACTGGAG
CCCGGCCGCAAGCTATGTTCAACCTTTTGCCGAGGCCTTGACCAAGCTGCACAAGGGCCAGCTCACCGACCAGCCGGTAA
AAACCCCCTTCGGCTGGCATGTGATCCGCCTGGATGATGTGCGACCCCTGAAAATTCCCCCGTTCGAGGAAATAAAACAA
AACCTGGCCCAGCGCGTGTTGCAACGTCAATTTGCGGCCTCGATCAACGATCTCCGCTCGAAAGCGAAAGTCGAGTAA

Upstream 100 bases:

>100_bases
CGATACCCTGCGCGAGATGATGCACAAGAATATTCACGCCTTGGGTGTAAAAGCGTATACTCCCGAGGAATTTGATTCGA
TCCACTGAGAAGGAAACTTC

Downstream 100 bases:

>100_bases
ATTTTCCTCCTAAGCTTTATTTCCTTATTCCTTCTACCAGGAAGCGCAATTCCGAGACAAAAAGGCAGCCCAGGCTGCCT
TTTTTGTTCTGTCCTACAGT

Product: PpiC-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MHFMKFTRLAALGISGLIAATTVQAQTGSTMAKVNGTPIPQSRLEFIMKARASQGQPDTPEARKALREDLITEEVIAQEA
KKKGLDRDPDFITQLDMARQTAMVRAYQIDYIKNHPVSDEELHKEYETVKTQMGDKEYKAHHILVATEEEAKDIIAKLKK
GAKFDKLAGEKSLDTGSKSKGGELDWSPAASYVQPFAEALTKLHKGQLTDQPVKTPFGWHVIRLDDVRPLKIPPFEEIKQ
NLAQRVLQRQFAASINDLRSKAKVE

Sequences:

>Translated_265_residues
MHFMKFTRLAALGISGLIAATTVQAQTGSTMAKVNGTPIPQSRLEFIMKARASQGQPDTPEARKALREDLITEEVIAQEA
KKKGLDRDPDFITQLDMARQTAMVRAYQIDYIKNHPVSDEELHKEYETVKTQMGDKEYKAHHILVATEEEAKDIIAKLKK
GAKFDKLAGEKSLDTGSKSKGGELDWSPAASYVQPFAEALTKLHKGQLTDQPVKTPFGWHVIRLDDVRPLKIPPFEEIKQ
NLAQRVLQRQFAASINDLRSKAKVE
>Mature_265_residues
MHFMKFTRLAALGISGLIAATTVQAQTGSTMAKVNGTPIPQSRLEFIMKARASQGQPDTPEARKALREDLITEEVIAQEA
KKKGLDRDPDFITQLDMARQTAMVRAYQIDYIKNHPVSDEELHKEYETVKTQMGDKEYKAHHILVATEEEAKDIIAKLKK
GAKFDKLAGEKSLDTGSKSKGGELDWSPAASYVQPFAEALTKLHKGQLTDQPVKTPFGWHVIRLDDVRPLKIPPFEEIKQ
NLAQRVLQRQFAASINDLRSKAKVE

Specific function: Ppiases Accelerate The Folding Of Proteins. Seems To Be Involved In The Folding Of Outer Membrane Proteins. Its Preference At The P1 Position Of The Peptide Substrate Is Glu > Leu > Ala > His > Val > Phe > Ile > Gly > Lys > Thr. [C]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Type II Membrane Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=147, Percent_Identity=31.9727891156463, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1786238, Length=102, Percent_Identity=40.1960784313725, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 29677; Mature: 29677

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFMKFTRLAALGISGLIAATTVQAQTGSTMAKVNGTPIPQSRLEFIMKARASQGQPDTP
CCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCH
EARKALREDLITEEVIAQEAKKKGLDRDPDFITQLDMARQTAMVRAYQIDYIKNHPVSDE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
ELHKEYETVKTQMGDKEYKAHHILVATEEEAKDIIAKLKKGAKFDKLAGEKSLDTGSKSK
HHHHHHHHHHHHCCCHHHCCEEEEEECHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCC
GGELDWSPAASYVQPFAEALTKLHKGQLTDQPVKTPFGWHVIRLDDVRPLKIPPFEEIKQ
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHH
NLAQRVLQRQFAASINDLRSKAKVE
HHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHFMKFTRLAALGISGLIAATTVQAQTGSTMAKVNGTPIPQSRLEFIMKARASQGQPDTP
CCHHHHHHHHHHHHHHHHHHHEEECCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCH
EARKALREDLITEEVIAQEAKKKGLDRDPDFITQLDMARQTAMVRAYQIDYIKNHPVSDE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
ELHKEYETVKTQMGDKEYKAHHILVATEEEAKDIIAKLKKGAKFDKLAGEKSLDTGSKSK
HHHHHHHHHHHHCCCHHHCCEEEEEECHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCC
GGELDWSPAASYVQPFAEALTKLHKGQLTDQPVKTPFGWHVIRLDDVRPLKIPPFEEIKQ
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHH
NLAQRVLQRQFAASINDLRSKAKVE
HHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12910271 [H]