Click here to switch to the map view.

The map label for this gene is czcC [H]

Identifier: 82703225

GI number: 82703225

Start: 2399177

End: 2400592

Strand: Direct

Name: czcC [H]

Synonym: Nmul_A2106

Alternate gene names: 82703225

Gene position: 2399177-2400592 (Clockwise)

Preceding gene: 82703224

Following gene: 82703226

Centisome position: 75.35

GC content: 58.33

Gene sequence:

>1416_bases
ATGAACTTTCATGCGTTGTTCATCATCAGCCGGTGTGTGCGTGTGGGAGCCATGCTTGTCCTTGCGATGACTTGCTTGCC
CTCAGCAGGTGCTGACAGTTCCTTTACGGGCATCCGCACGCTTGAGGACGCGCACTCTCCCAGTGCTGCCGGCCCTGAGG
TCAAGAGCAATCTCACCCTGCGGGATGCGGTGCGGCTTACGCTTCAGCACAACCCCGAACTGTCCTCCTTCGATAAGGAG
ATGCGCGCTCTGGAGGGTGTTACGTTGCAGGCCGGGTTGTTGCGCAACCCTCAGTTGTCGGTGGACGTCGACAATGCCGG
AAACATGGGAGGCGTAAGTGGACAAGGAGCCATCAAGCAAAATGTCGAGCAGCAGGATTTGATCATTCGCATCAGCCAAT
TGGTCGAGTTGGGAGGAAAACGTGCAGCGCGGGTAAATGCTGCGTCGCTCGGGCAGGCACTGGCGGGCAAGGACTTCGAA
ACCAAACGGCTCGAACTCGTGGCACGGGTAGCGAACGTATTTACAGAGGTGCTGGCGGGGCAGGAGCAGTTGCGGCTGGC
CGAGGAGAGTCAGCAGCTGGCTCAGCGCGTGGTGGATACTGTCAAGCGCCGGGTGCAGGCGGGAAAAGTGCCGCCCATAG
AAGAGACTAAAGTGGGAGTAGCATTTTCCACGACGCGAATTGCCCTGGGCCAGGCGCAACGCGAGCTGGCCGCCGCGCGC
AAACGCCTTGCGCTGCTATGGGGTGACAATTCGCCCCAGTTTGGGGAAGCGCTAGGAGCTCTGGAATCGAGGATCGTCCT
GCCCGATTTGGCCGCATTGACCGAGCGAGTCTTGTCGAGTCCCATGGCGGATCGCGCCAGAAAAGGCATAGAACATCGCC
AGGCGCTGCTCGAAGTGGAGCAATCCCGCCGCATTCCCGATATCACCCTTGCGGGCGGCATGATCAAGCATTGGGAATCA
GGGGGAACGACTGCGATCGTAGGCGTCTCCATGCCGCTGCAATTCTTCGACCGGAACCAGGGAAACCTGCGGGAAGCCTA
TCAACGCCTGGATAAGGCACAGGATGAGCAAGCCGCGACCGACCTGCGCCTCAAGGCGGAACTGGTACAGGCCTACGAAT
CGTTGACCGCAGCCGAGAACGAGATATCGATATTGCGCGGGGAGATATTGCCTGCGGCCCGAAGTGCTTTCGATGTGACG
AACAAGGGTTATGAGCTCGGCAAATTCGGCTTTCTTGAAGTGCTCGACGCACAGCGCACCTTGTTTCAGAACCAGGTTTT
ATATGTGCGTGCGCTCGCCAATTACCACCGCCTTGTCAATGAAATCGAACGTTTGATTGCAGCCCCCCTCGATGGGAGGG
CGAGACAGGACACCGATGAACCGGCCTATACCGATTTTACGGATGATAAGGAGTAG

Upstream 100 bases:

>100_bases
TCAGGGTGAACAGGAGGCTAAGGACTTGAGGCGAAACTGCTATTTTATGTAATTAACCATAGGTTATGCGTTTCCCTTGA
TTACTCGTGAAGAAATTTCC

Downstream 100 bases:

>100_bases
AAGTGAATAACAGGAAGAAACTGATTTCAATCCTTTCCGTAATCGCCGCAGGAATTGCACTCGGCGGGTTGATACTCAGA
TCCGATAAGACTTCGCAATC

Product: Outer membrane efflux protein

Products: NA

Alternate protein names: Cation efflux system protein CzcC [H]

Number of amino acids: Translated: 471; Mature: 471

Protein sequence:

>471_residues
MNFHALFIISRCVRVGAMLVLAMTCLPSAGADSSFTGIRTLEDAHSPSAAGPEVKSNLTLRDAVRLTLQHNPELSSFDKE
MRALEGVTLQAGLLRNPQLSVDVDNAGNMGGVSGQGAIKQNVEQQDLIIRISQLVELGGKRAARVNAASLGQALAGKDFE
TKRLELVARVANVFTEVLAGQEQLRLAEESQQLAQRVVDTVKRRVQAGKVPPIEETKVGVAFSTTRIALGQAQRELAAAR
KRLALLWGDNSPQFGEALGALESRIVLPDLAALTERVLSSPMADRARKGIEHRQALLEVEQSRRIPDITLAGGMIKHWES
GGTTAIVGVSMPLQFFDRNQGNLREAYQRLDKAQDEQAATDLRLKAELVQAYESLTAAENEISILRGEILPAARSAFDVT
NKGYELGKFGFLEVLDAQRTLFQNQVLYVRALANYHRLVNEIERLIAAPLDGRARQDTDEPAYTDFTDDKE

Sequences:

>Translated_471_residues
MNFHALFIISRCVRVGAMLVLAMTCLPSAGADSSFTGIRTLEDAHSPSAAGPEVKSNLTLRDAVRLTLQHNPELSSFDKE
MRALEGVTLQAGLLRNPQLSVDVDNAGNMGGVSGQGAIKQNVEQQDLIIRISQLVELGGKRAARVNAASLGQALAGKDFE
TKRLELVARVANVFTEVLAGQEQLRLAEESQQLAQRVVDTVKRRVQAGKVPPIEETKVGVAFSTTRIALGQAQRELAAAR
KRLALLWGDNSPQFGEALGALESRIVLPDLAALTERVLSSPMADRARKGIEHRQALLEVEQSRRIPDITLAGGMIKHWES
GGTTAIVGVSMPLQFFDRNQGNLREAYQRLDKAQDEQAATDLRLKAELVQAYESLTAAENEISILRGEILPAARSAFDVT
NKGYELGKFGFLEVLDAQRTLFQNQVLYVRALANYHRLVNEIERLIAAPLDGRARQDTDEPAYTDFTDDKE
>Mature_471_residues
MNFHALFIISRCVRVGAMLVLAMTCLPSAGADSSFTGIRTLEDAHSPSAAGPEVKSNLTLRDAVRLTLQHNPELSSFDKE
MRALEGVTLQAGLLRNPQLSVDVDNAGNMGGVSGQGAIKQNVEQQDLIIRISQLVELGGKRAARVNAASLGQALAGKDFE
TKRLELVARVANVFTEVLAGQEQLRLAEESQQLAQRVVDTVKRRVQAGKVPPIEETKVGVAFSTTRIALGQAQRELAAAR
KRLALLWGDNSPQFGEALGALESRIVLPDLAALTERVLSSPMADRARKGIEHRQALLEVEQSRRIPDITLAGGMIKHWES
GGTTAIVGVSMPLQFFDRNQGNLREAYQRLDKAQDEQAATDLRLKAELVQAYESLTAAENEISILRGEILPAARSAFDVT
NKGYELGKFGFLEVLDAQRTLFQNQVLYVRALANYHRLVNEIERLIAAPLDGRARQDTDEPAYTDFTDDKE

Specific function: CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 51525; Mature: 51525

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFHALFIISRCVRVGAMLVLAMTCLPSAGADSSFTGIRTLEDAHSPSAAGPEVKSNLTL
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCCCHHCCCCH
RDAVRLTLQHNPELSSFDKEMRALEGVTLQAGLLRNPQLSVDVDNAGNMGGVSGQGAIKQ
HHHHHHHHCCCCCHHHHHHHHHHHCCCEEECCCCCCCCEEEEECCCCCCCCCCCCCHHHH
NVEQQDLIIRISQLVELGGKRAARVNAASLGQALAGKDFETKRLELVARVANVFTEVLAG
CCCHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
QEQLRLAEESQQLAQRVVDTVKRRVQAGKVPPIEETKVGVAFSTTRIALGQAQRELAAAR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHH
KRLALLWGDNSPQFGEALGALESRIVLPDLAALTERVLSSPMADRARKGIEHRQALLEVE
HHEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
QSRRIPDITLAGGMIKHWESGGTTAIVGVSMPLQFFDRNQGNLREAYQRLDKAQDEQAAT
HHCCCCCEEECCCHHHHHCCCCCEEEEEECCCHHHHCCCCCCHHHHHHHHHHHHHHHHHH
DLRLKAELVQAYESLTAAENEISILRGEILPAARSAFDVTNKGYELGKFGFLEVLDAQRT
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
LFQNQVLYVRALANYHRLVNEIERLIAAPLDGRARQDTDEPAYTDFTDDKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNFHALFIISRCVRVGAMLVLAMTCLPSAGADSSFTGIRTLEDAHSPSAAGPEVKSNLTL
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCCCHHCCCCH
RDAVRLTLQHNPELSSFDKEMRALEGVTLQAGLLRNPQLSVDVDNAGNMGGVSGQGAIKQ
HHHHHHHHCCCCCHHHHHHHHHHHCCCEEECCCCCCCCEEEEECCCCCCCCCCCCCHHHH
NVEQQDLIIRISQLVELGGKRAARVNAASLGQALAGKDFETKRLELVARVANVFTEVLAG
CCCHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
QEQLRLAEESQQLAQRVVDTVKRRVQAGKVPPIEETKVGVAFSTTRIALGQAQRELAAAR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHH
KRLALLWGDNSPQFGEALGALESRIVLPDLAALTERVLSSPMADRARKGIEHRQALLEVE
HHEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
QSRRIPDITLAGGMIKHWESGGTTAIVGVSMPLQFFDRNQGNLREAYQRLDKAQDEQAAT
HHCCCCCEEECCCHHHHHCCCCCEEEEEECCCHHHHCCCCCCHHHHHHHHHHHHHHHHHH
DLRLKAELVQAYESLTAAENEISILRGEILPAARSAFDVTNKGYELGKFGFLEVLDAQRT
HHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
LFQNQVLYVRALANYHRLVNEIERLIAAPLDGRARQDTDEPAYTDFTDDKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2678100; 7766206 [H]