Click here to switch to the map view.

The map label for this gene is srpG [H]

Identifier: 82703192

GI number: 82703192

Start: 2363366

End: 2364319

Strand: Direct

Name: srpG [H]

Synonym: Nmul_A2072

Alternate gene names: 82703192

Gene position: 2363366-2364319 (Clockwise)

Preceding gene: 82703185

Following gene: 82703193

Centisome position: 74.22

GC content: 57.34

Gene sequence:

>954_bases
ATGCCGCACTGGTTCAAAGATAATTCCCAGACCAGCGGGGCCACCCCGCTGGTCCGGCTTAACCGCATTACGGATGGCGC
TCCGGCAATGGTACTGGCCAAGATCGAAGGGCGTAATCCCGCTTATTCCGTAAAATGCCGTATCGGCGCCGCCATGATCG
AAGATGCGGAACATCGCGGGCTGCTTTATGCCGGAATAGAGCTGGTGGAACCTACCAGCGGCAATACCGGTATCGCCCTC
GCCTCTGTTGCTGCCGCGCGCGGCATACCCCTGACATTGACCATGCCCGAAACCATGGGGCTGGAACGCCGCAAGCTGCT
TCTCGCCTACGGGGCAAAACTGGTTCTGACCGAGGGCGCGCGGGGCATGAAAGGTGCGGTAGCAAAGGCAGAGGAAATCG
TTGCTTCCAATCCGGGCCGATACCTCCTGCTCCAGCAATTCTCCAACCCGGCCAACCCTGCTATTCACGAGCGCACCACA
GGGCCAGAGATCTGGAACGATACCGACGGGGCAGTTGATATTTTTGTTGCCGGCGTGGGTACGGGAGGCACCATTACCGG
TGTTTCGCGGTATATAAAGGGGACGAAGAAAAAATCCATTCTCTCGGTCGCCGTTGAGCCTGCTGCCAGCCCAGTGATCA
CGCAACACCGGGCTGGCGAACCCCTGGCACCCGGACCTCATCGGATTCCGGGAATTGGCGCAGGATTCATTCCTGCCAAC
CTGGATCTCTCCCTCGTGGATGAGGTACAGCAAATCAGCAATGAAGACGCAATTCACTATGCACGCCGTCTTGCACGCGA
AGAAGGCATTATCTCGGGGATTTCATGCGGAGCAGCGGTTGCAGCCGCGTTAAATCATGCGAAGCGAACGGAGAATGCCG
GAAAAACCATTGTTGTCGTTCTGCCGGATTCGGGAGAACGCTATCTGAGCTCCAACCTTTTTGAGGAGATGTAA

Upstream 100 bases:

>100_bases
CTCCAATTCCGAATAAATAATAAGCACAATTGCCTCCGGGAAGCAGATCGCGTCCGAATCCATATTTCCCGGACAAATCG
AATGGAAGGATGCATCGAAA

Downstream 100 bases:

>100_bases
AAGGCTCAGGAATAGGCGGGCTTGATAATAATAAATGGAGGAGTATTTTTCATTGAAACGAACAGCGCTGAAACTTGGCG
ATGTGGTGTCCGAACTGCGC

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MPHWFKDNSQTSGATPLVRLNRITDGAPAMVLAKIEGRNPAYSVKCRIGAAMIEDAEHRGLLYAGIELVEPTSGNTGIAL
ASVAAARGIPLTLTMPETMGLERRKLLLAYGAKLVLTEGARGMKGAVAKAEEIVASNPGRYLLLQQFSNPANPAIHERTT
GPEIWNDTDGAVDIFVAGVGTGGTITGVSRYIKGTKKKSILSVAVEPAASPVITQHRAGEPLAPGPHRIPGIGAGFIPAN
LDLSLVDEVQQISNEDAIHYARRLAREEGIISGISCGAAVAAALNHAKRTENAGKTIVVVLPDSGERYLSSNLFEEM

Sequences:

>Translated_317_residues
MPHWFKDNSQTSGATPLVRLNRITDGAPAMVLAKIEGRNPAYSVKCRIGAAMIEDAEHRGLLYAGIELVEPTSGNTGIAL
ASVAAARGIPLTLTMPETMGLERRKLLLAYGAKLVLTEGARGMKGAVAKAEEIVASNPGRYLLLQQFSNPANPAIHERTT
GPEIWNDTDGAVDIFVAGVGTGGTITGVSRYIKGTKKKSILSVAVEPAASPVITQHRAGEPLAPGPHRIPGIGAGFIPAN
LDLSLVDEVQQISNEDAIHYARRLAREEGIISGISCGAAVAAALNHAKRTENAGKTIVVVLPDSGERYLSSNLFEEM
>Mature_316_residues
PHWFKDNSQTSGATPLVRLNRITDGAPAMVLAKIEGRNPAYSVKCRIGAAMIEDAEHRGLLYAGIELVEPTSGNTGIALA
SVAAARGIPLTLTMPETMGLERRKLLLAYGAKLVLTEGARGMKGAVAKAEEIVASNPGRYLLLQQFSNPANPAIHERTTG
PEIWNDTDGAVDIFVAGVGTGGTITGVSRYIKGTKKKSILSVAVEPAASPVITQHRAGEPLAPGPHRIPGIGAGFIPANL
DLSLVDEVQQISNEDAIHYARRLAREEGIISGISCGAAVAAALNHAKRTENAGKTIVVVLPDSGERYLSSNLFEEM

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=317, Percent_Identity=38.801261829653, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI295821200, Length=317, Percent_Identity=38.801261829653, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI4557415, Length=317, Percent_Identity=38.801261829653, Blast_Score=182, Evalue=5e-46,
Organism=Escherichia coli, GI1788754, Length=318, Percent_Identity=71.3836477987421, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI2367138, Length=307, Percent_Identity=44.6254071661238, Blast_Score=221, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI17535051, Length=306, Percent_Identity=50, Blast_Score=267, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI17562970, Length=313, Percent_Identity=46.9648562300319, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI115535073, Length=306, Percent_Identity=52.2875816993464, Blast_Score=260, Evalue=7e-70,
Organism=Caenorhabditis elegans, GI32566674, Length=305, Percent_Identity=48.1967213114754, Blast_Score=258, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17561720, Length=312, Percent_Identity=49.3589743589744, Blast_Score=244, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI32566672, Length=223, Percent_Identity=47.9820627802691, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17534315, Length=315, Percent_Identity=36.8253968253968, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI25147552, Length=325, Percent_Identity=33.8461538461538, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17561716, Length=128, Percent_Identity=46.09375, Blast_Score=98, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6321594, Length=320, Percent_Identity=34.0625, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6321449, Length=320, Percent_Identity=33.4375, Blast_Score=118, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24643623, Length=304, Percent_Identity=38.1578947368421, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI20129101, Length=304, Percent_Identity=38.1578947368421, Blast_Score=165, Evalue=4e-41,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33399; Mature: 33267

Theoretical pI: Translated: 7.70; Mature: 7.70

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHWFKDNSQTSGATPLVRLNRITDGAPAMVLAKIEGRNPAYSVKCRIGAAMIEDAEHRG
CCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCEEEEEEECHHHHHCHHHCC
LLYAGIELVEPTSGNTGIALASVAAARGIPLTLTMPETMGLERRKLLLAYGAKLVLTEGA
EEEECEEEECCCCCCCCCHHHHHHHHCCCEEEEECCHHHCHHHHHHHHHHCCEEEEECCC
RGMKGAVAKAEEIVASNPGRYLLLQQFSNPANPAIHERTTGPEIWNDTDGAVDIFVAGVG
CCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECC
TGGTITGVSRYIKGTKKKSILSVAVEPAASPVITQHRAGEPLAPGPHRIPGIGAGFIPAN
CCCHHHHHHHHHHCCCCHHEEEEEECCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCC
LDLSLVDEVQQISNEDAIHYARRLAREEGIISGISCGAAVAAALNHAKRTENAGKTIVVV
CCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHCCCCCCEEEEE
LPDSGERYLSSNLFEEM
ECCCCCHHHHHHHHHCC
>Mature Secondary Structure 
PHWFKDNSQTSGATPLVRLNRITDGAPAMVLAKIEGRNPAYSVKCRIGAAMIEDAEHRG
CCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCEEEEEEECHHHHHCHHHCC
LLYAGIELVEPTSGNTGIALASVAAARGIPLTLTMPETMGLERRKLLLAYGAKLVLTEGA
EEEECEEEECCCCCCCCCHHHHHHHHCCCEEEEECCHHHCHHHHHHHHHHCCEEEEECCC
RGMKGAVAKAEEIVASNPGRYLLLQQFSNPANPAIHERTTGPEIWNDTDGAVDIFVAGVG
CCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECC
TGGTITGVSRYIKGTKKKSILSVAVEPAASPVITQHRAGEPLAPGPHRIPGIGAGFIPAN
CCCHHHHHHHHHHCCCCHHEEEEEECCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCC
LDLSLVDEVQQISNEDAIHYARRLAREEGIISGISCGAAVAAALNHAKRTENAGKTIVVV
CCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHCCCCCCEEEEE
LPDSGERYLSSNLFEEM
ECCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7603442 [H]