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The map label for this gene is cobD [H]

Identifier: 82703115

GI number: 82703115

Start: 2290882

End: 2291793

Strand: Reverse

Name: cobD [H]

Synonym: Nmul_A1994

Alternate gene names: 82703115

Gene position: 2291793-2290882 (Counterclockwise)

Preceding gene: 82703116

Following gene: 82703114

Centisome position: 71.97

GC content: 56.36

Gene sequence:

>912_bases
ATGAATTTTCTTTCGTTGATTTTCGCTCTTCTGCTGGATCAGTGGCGCTCCGGCAGTGCGCGCAAACATATTGTCTCCTC
TTTCCTCTCCTATGCCGATTCGCTGGAGGGTCATTTCAACACCGGCATCCATCGGCACGGCATCATTGCCTGGGTGGCCG
CGGCAGGACCTTTCCTTATACTCTCCCTCCTGGTTTATTATTTATTATATGGAGCCAGTCCGCTGCTGGCGTGGGCGTGG
AATGTGGCAATACTTTATCTCACCACGAGTTTTCGCCAGTTCAGCTATTCCCTGACTGAAATAAAGGAGGCGCTCAGGAA
CGAAGATTTGCCGCTTGCACGCGATCTCTTGAAGGAATACTACGGGATGGAGGCGGAGAGTGCCAGCAGTGAGGATATTT
CGCGGATTGCCATCGAGTTGGGGTTGATCCATGCTCATCGTAACATGCTTGGCGTCATCGTTTGGTTCACCTTGCTGCCG
GGGCCGCTCGGGCCCATGCTCTACCGTCTTGCGGAATTGTTGAATGACGCCTGGGGGGAGCGCCCGGATGGTTTTGGTGT
TTTTGCGGTAAAGGCGTTTTACGTCATCGATTGGCTACCCGCGAGGATAACAGCGCTGAGCTTTGCCATTGCAGGCAACT
TCGAGGATGCGGTTTATTGCTGGCGCGCGCAGGCGGCATCATGGGGGGATCAGAACCAGGGAACCATTCTTGCCAGTGGC
GCAGGTGCGCTTGGCGTGCGCCTGGGAGATCCGTTGCGGGAAGAGACCGGCGCATATCACCGCCCCGAGGTAGGCGTGGG
TGAAGAAGCCGACATGGATTTTCTGCAGGGCACCGTCGGCCTCATCTGGCGTACCCTGGTGCTATGGCTCGTCCTGCTGC
TGTTGCTCGAGATCGCTGGCTGGACAGGGTGA

Upstream 100 bases:

>100_bases
GAAATCCCGCTGAGATGGGCAAGGTTCTCAAGTCCGCATTGGGTTGAATAATGCTTATCCCTGAAACTGCTTTGAAGGAA
AGCAGCATGATTTTCTCGCA

Downstream 100 bases:

>100_bases
GCAAGTAAGAAAAAACTGATACAGTTCGCATAAAGCCGATATACAGAGCTTGTAAGCTGCATTTATGAGGGCACTATGGC
ACCACCGCTGCTGATCGCGC

Product: CobD/CbiB family protein

Products: ADP; phosphate; Adenosyl cobinamide phosphate; Adenosyl cobinamide

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MNFLSLIFALLLDQWRSGSARKHIVSSFLSYADSLEGHFNTGIHRHGIIAWVAAAGPFLILSLLVYYLLYGASPLLAWAW
NVAILYLTTSFRQFSYSLTEIKEALRNEDLPLARDLLKEYYGMEAESASSEDISRIAIELGLIHAHRNMLGVIVWFTLLP
GPLGPMLYRLAELLNDAWGERPDGFGVFAVKAFYVIDWLPARITALSFAIAGNFEDAVYCWRAQAASWGDQNQGTILASG
AGALGVRLGDPLREETGAYHRPEVGVGEEADMDFLQGTVGLIWRTLVLWLVLLLLLEIAGWTG

Sequences:

>Translated_303_residues
MNFLSLIFALLLDQWRSGSARKHIVSSFLSYADSLEGHFNTGIHRHGIIAWVAAAGPFLILSLLVYYLLYGASPLLAWAW
NVAILYLTTSFRQFSYSLTEIKEALRNEDLPLARDLLKEYYGMEAESASSEDISRIAIELGLIHAHRNMLGVIVWFTLLP
GPLGPMLYRLAELLNDAWGERPDGFGVFAVKAFYVIDWLPARITALSFAIAGNFEDAVYCWRAQAASWGDQNQGTILASG
AGALGVRLGDPLREETGAYHRPEVGVGEEADMDFLQGTVGLIWRTLVLWLVLLLLLEIAGWTG
>Mature_303_residues
MNFLSLIFALLLDQWRSGSARKHIVSSFLSYADSLEGHFNTGIHRHGIIAWVAAAGPFLILSLLVYYLLYGASPLLAWAW
NVAILYLTTSFRQFSYSLTEIKEALRNEDLPLARDLLKEYYGMEAESASSEDISRIAIELGLIHAHRNMLGVIVWFTLLP
GPLGPMLYRLAELLNDAWGERPDGFGVFAVKAFYVIDWLPARITALSFAIAGNFEDAVYCWRAQAASWGDQNQGTILASG
AGALGVRLGDPLREETGAYHRPEVGVGEEADMDFLQGTVGLIWRTLVLWLVLLLLLEIAGWTG

Specific function: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group [H]

COG id: COG1270

COG function: function code H; Cobalamin biosynthesis protein CobD/CbiB

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobD/CbiB family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004485 [H]

Pfam domain/function: PF03186 CobD_Cbib [H]

EC number: 6.3.1.10

Molecular weight: Translated: 33608; Mature: 33608

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFLSLIFALLLDQWRSGSARKHIVSSFLSYADSLEGHFNTGIHRHGIIAWVAAAGPFLI
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHCCHHHH
LSLLVYYLLYGASPLLAWAWNVAILYLTTSFRQFSYSLTEIKEALRNEDLPLARDLLKEY
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
YGMEAESASSEDISRIAIELGLIHAHRNMLGVIVWFTLLPGPLGPMLYRLAELLNDAWGE
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
RPDGFGVFAVKAFYVIDWLPARITALSFAIAGNFEDAVYCWRAQAASWGDQNQGTILASG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEEECC
AGALGVRLGDPLREETGAYHRPEVGVGEEADMDFLQGTVGLIWRTLVLWLVLLLLLEIAG
CCEEECCCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
WTG
CCC
>Mature Secondary Structure
MNFLSLIFALLLDQWRSGSARKHIVSSFLSYADSLEGHFNTGIHRHGIIAWVAAAGPFLI
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHCCHHHH
LSLLVYYLLYGASPLLAWAWNVAILYLTTSFRQFSYSLTEIKEALRNEDLPLARDLLKEY
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
YGMEAESASSEDISRIAIELGLIHAHRNMLGVIVWFTLLPGPLGPMLYRLAELLNDAWGE
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
RPDGFGVFAVKAFYVIDWLPARITALSFAIAGNFEDAVYCWRAQAASWGDQNQGTILASG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCEEEECC
AGALGVRLGDPLREETGAYHRPEVGVGEEADMDFLQGTVGLIWRTLVLWLVLLLLLEIAG
CCEEECCCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
WTG
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyric acid; (R)-1-aminopropan-2-yl phosphate; (R)-1-aminopropan-2-ol

Specific reaction: (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate; (2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA