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The map label for this gene is queD [H]

Identifier: 82703065

GI number: 82703065

Start: 2235989

End: 2236438

Strand: Direct

Name: queD [H]

Synonym: Nmul_A1944

Alternate gene names: 82703065

Gene position: 2235989-2236438 (Clockwise)

Preceding gene: 82703063

Following gene: 82703066

Centisome position: 70.22

GC content: 54.0

Gene sequence:

>450_bases
ATGTTGATTACACGCAGGCTGGAATTCGACGCCGGCCATCGTATACCTTCCCACAAGAGCCAGTGCCGGCATCTGCACGG
CCATCGTTACGCCATAGAAATTACCCTGTCAGGCGAAATTATCACTGAGCCTGGCATCTCCGAGCAAGGCATGGTCATGG
ATTATTCGGAGGTCAAACGCATTGCGAAAGAAGTGCTGGTGGATAAATGGGACCATGCGTTCCTTGCCTATGCGGAAGAC
CACAAGTTGCTGGAATTCCTCCAATCCCTCGAAGACCACAAAACCGTGGTGCTGGATACGCCCCCCACGGCGGAAAACCT
GGCTCTGACCGCTTTCTACATACTCGATGAAGCATATCAGGATCGCTATGGCAATCATCTAAGGCTGGAGCAAGTGCGCC
TGTTCGAAACCCCCAACTGCTGGGCGGATGCGGTGCGAGGACAACCCTGA

Upstream 100 bases:

>100_bases
CGAAATAACGGGATAAACATAGGTCATCCCGGTTATATCGCGGCTATGATCTGCTACATCCAATCGTTTGGAAATTTGCT
GCAATGCTACAATCCCGATA

Downstream 100 bases:

>100_bases
TTGTTCCCCTATCCCATGTCACCTGTTTGATGATGATCACAACATGGCAATAACCGGAACAGGCATTTATGAAATCAAGA
GGATTGAGACTACCGGTTTT

Product: putative 6-pyruvoyl tetrahydropterin synthase

Products: 6-pyruvoyl-5,6,7,8-tetrahydropterin; triphosphate

Alternate protein names: CPH4 synthase; Queuosine biosynthesis protein queD [H]

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MLITRRLEFDAGHRIPSHKSQCRHLHGHRYAIEITLSGEIITEPGISEQGMVMDYSEVKRIAKEVLVDKWDHAFLAYAED
HKLLEFLQSLEDHKTVVLDTPPTAENLALTAFYILDEAYQDRYGNHLRLEQVRLFETPNCWADAVRGQP

Sequences:

>Translated_149_residues
MLITRRLEFDAGHRIPSHKSQCRHLHGHRYAIEITLSGEIITEPGISEQGMVMDYSEVKRIAKEVLVDKWDHAFLAYAED
HKLLEFLQSLEDHKTVVLDTPPTAENLALTAFYILDEAYQDRYGNHLRLEQVRLFETPNCWADAVRGQP
>Mature_149_residues
MLITRRLEFDAGHRIPSHKSQCRHLHGHRYAIEITLSGEIITEPGISEQGMVMDYSEVKRIAKEVLVDKWDHAFLAYAED
HKLLEFLQSLEDHKTVVLDTPPTAENLALTAFYILDEAYQDRYGNHLRLEQVRLFETPNCWADAVRGQP

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin triphosphate (H2NTP) to 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) and acetaldehyde [H]

COG id: COG0720

COG function: function code H; 6-pyruvoyl-tetrahydropterin synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTPS family. QueD subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007115 [H]

Pfam domain/function: PF01242 PTPS [H]

EC number: 4.2.3.12

Molecular weight: Translated: 17242; Mature: 17242

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLITRRLEFDAGHRIPSHKSQCRHLHGHRYAIEITLSGEIITEPGISEQGMVMDYSEVKR
CEEEEECCCCCCCCCCCCHHHHHHHCCCEEEEEEEECCEEEECCCCCCCCEEECHHHHHH
IAKEVLVDKWDHAFLAYAEDHKLLEFLQSLEDHKTVVLDTPPTAENLALTAFYILDEAYQ
HHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
DRYGNHLRLEQVRLFETPNCWADAVRGQP
HHCCCCEEEEEEEEECCCCHHHHHCCCCC
>Mature Secondary Structure
MLITRRLEFDAGHRIPSHKSQCRHLHGHRYAIEITLSGEIITEPGISEQGMVMDYSEVKR
CEEEEECCCCCCCCCCCCHHHHHHHCCCEEEEEEEECCEEEECCCCCCCCEEECHHHHHH
IAKEVLVDKWDHAFLAYAEDHKLLEFLQSLEDHKTVVLDTPPTAENLALTAFYILDEAYQ
HHHHHHHCCCCCEEEEEECCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
DRYGNHLRLEQVRLFETPNCWADAVRGQP
HHCCCCEEEEEEEEECCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin

Specific reaction: 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA