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The map label for this gene is barA [H]

Identifier: 82702685

GI number: 82702685

Start: 1782516

End: 1786709

Strand: Reverse

Name: barA [H]

Synonym: Nmul_A1556

Alternate gene names: 82702685

Gene position: 1786709-1782516 (Counterclockwise)

Preceding gene: 82702686

Following gene: 82702684

Centisome position: 56.11

GC content: 55.34

Gene sequence:

>4194_bases
ATGATACGCTTTACCTCGCTTACACAGCGTTTTGCTGTCTGGTTTGTAGCCGTTTCCTTGCTGCCTATCCTGATCATTGG
TTATGCCCTGTTGGGCACCTTTGAGACGGAGGCGGAAAAAAGCGCGATTCAACAGGTATCAGCAATCGCCGACATGAAAG
CGGAACAGATTGACAGCTATCTGCGCGAGCGTTTGCTGGACGCGAGGGTGATCCAGACAACCAGTACGACACGCATGGCT
ATACAGGACTTCAGCCGGGTGTACGTGAAGAGTGGAGTGGACTCCAATGCCTATCGGCAACTGGATACATTTTATCGCGA
ACATTTCAAGCGCTTCGTAGAGGATGCGGGGTATTACGATCTATTCCTCATCTCCCCCCAAGGTGAAATCGTCTACAGCC
AAGCCCATGAATCGGATTTTGCGACGAGCTTGATCACCGGCCCGTATCGAAACAGCGGTTTTGCCTTTGTTGTGCGTGCT
GCACTCAATACCTTGCAGAGCGGCGTCTCGGATTTCGAATACTACCCGCCCTCGAGAGGCGCAATTGCCGCCTTCATGGC
ATTGCCCATCATGGCTGATGGAAAACTGGAAGGTGTTTTGGCGCTGCAAATCTACAGCGAACGCGTGTTCGAGGTTGTCA
CTGATAATGTGGGACTGGGAACAAGCGGTGAAACTGTCGTAACGCGCCTTCTCAACGATCGCACTGCGCTTGTGATCGCG
CCGCTCAAGCATCAGTCGAATGCCGCACTGCAATACAGGATACCTCTCTCCACTCCACCATTTTCAATTGTAGTTCATAG
CGGATTGCACGGAGAGCGGGGGGGCGGAGTGAAAATGGATTACCGCAACAAGGAAGTGGTGGCCGCCTGGCGTTACCTGC
CGCGCATGAACTGGGGTATCGAGGTCAAGATGGATGCTGAGGAAGTGTTTGCTTTTGTTCCGAGGGTGCGCAACTACAGC
TTGATCGTCCTGGGCTTCATCCTGATTGCTGCCATGCTGGGAGCTTTGCTGTTCAGCAGGCGCGTGGTTACCACACTGAA
AAATCTCAGCCATAGCGCGCAGCACATCGCCGGTGGAAATCTCAAGCAGCGTGTTCCCGTTGCGGGATGGGACGAAATCG
GCCAGCTCGCCAGTACTTTCAACACAATGACCGAGCGCCTGACCGCCAGCAATCGCCAGCGAGATGTAGCTGAAAACGAT
TTGCGCCAGCTCAACCAGGACCTCGAAAACCATGTTGCCGAACGCACAGCTGACCTGGAGCAGGCGAATGCAGTGCTCAT
CAGCAAGGAAGAGGAAATGCGCTCGATCGTGGAGCACATGGTGGACTGCATCATTACGATCGACGACAAAAGCATAATAC
GCTCGGTCAATCCCGTTATCGAAAAACTCTTCGGTTACACCCGGGAGGAAGTAATCGGTCAACCCGTCTCCATTCTGATG
CCCGAACCTTTCCGCAGCGGTCATGAGGGATACGTCGAAAGATACTACCGGACCGGAAGGGGGCGGTGCGAATTCGATCA
CATTCTGACGCTGGAAGTCGAAGGAGTGCATAACATCGGCATGGGCCGCGAAGTGGAAGGCCGGCACAAGAATGGTGAAC
TCATCGATCTGTATGTCGCAGTCAGTGAATACTTCGTGGGGGGCAAACGTTATTTCACCGGGGTTTTGCGCGATATCCGC
GAACGCAAGCGGGTCGAACAGGCTTTGCGCAACAGTGAACAACGTTTTCGAGCCATCGTGGATAATCTGGCCGCTCTTGT
TGGCGAAATGACCCCCGATGGAGTGCTGGTGGAGATGAATCGCACCGCTCTGGAGGTGGGCGGCCTGCAGAGCGGAGATG
TCATTGGCAAATGTTTGTCCGAGACCGAATGGTTTTCCTATAAGCCGGAGGTGCAACAACAGATCCGCGACGACATCCGG
CGGGCAGTGGCGGGCGAGATCGTGCGCCATGACGTTGCGATTCGCATTGCCAATGGCGATCTCATGACAATCGATTTCAT
GCTGGTACCGGTGCGTGATGATAAAGGCAAGGTGATCAAGCTGATTCCGTCCGGCATCAATGTCAGTGAGAGAATCAGGA
TTCTCAAGGACCTCGAACAGGCTCGGCATGAGGCGGAGCAGGCCAACGAGGCAAAATCCATCTTTCTTGCAGCCATGAGC
CACGAGATACGCACTCCCATGAATGGCGTGATCGGCATGGCTGACGTGCTGCAGCAAACCAGCCTGAGCGGTTATCAGAT
GGAGATGGTCGATCTCATCCGTGAATCGGCTTTTGCGCTGCTGGAAATCATCGAGGATATCCTGGATTTTTCAAAAATCG
AAGCAGGAAGACTCGAAATCGAGCAGGCGCCGATGTCCGTGGAAAAGGTCGTGGAAAAAGCATGTGCCATGCTCGAAAGC
CTGGCTGCCAGGAAAGCTGTGGAACTTACCCTGTTTCTCGACCCGGCGATACCTGATGAAGTCCTCGGTGATGCACTGCG
GTTGCGCCAAGTGCTCGTCAATCTTGCCAATAACGCTATCAAGTTTTCCAGCGGATTACAGGAGCCGGGGCGGGTGTCGG
TGCGTGCGCTGCTCGTTGAGCACGACCAGGATACGGTAACGGTGGAATTCGAGATAACCGATAATGGCATAGGCATGAAC
GAGGAGGTACAGTCGCGGCTTTTCACCTCTTTTACCCAAGGAGATACGTCCACCACCCGGCGGTATGGTGGAACCGGACT
GGGGCTGGCGATCACTCATCATCTGGTGGAATTGATGGGAGGGAGTATCCAGGTCCGGAGTGCTCCGGGCGAAGGGTCGG
TTTTCACTGTGCGGTTGAGCTTTGACCTCATTCCTTCCTCGCACATGGAAGATAAGGTTATCGATCTCACCGGCATCTCC
TGCCTGGTAATCGGTGCTGAAAAAGGTTTGGCGGACGATCTGGCGGTATATCTGAGATACAGCGGCGCGGTTGCAGAGCG
AGTGATCGATTTGCCAGCCGCACTCAAGCGAATCGAGGTACTTCCGCCCGGCCTGTGGCTGCTGGTCATAGATGCCGGGC
ATGAAACACCCCCCCTTGAAGAGTTGCGTGCCGCCTTCCGTTCCCGTCCTGACCTGGATCCGCATTTCGTAGTCCTCGAG
CACGGCCATCACGAGCCTGATATTGAGCCCCGCTTTGTCGTCATTCGTCGCGGGCGGAGGCGGCATGAGCGTACCGAAGA
GGTCGATACCGTTACGCTGGATGGCGATGTCATGCACCGTGACGCCTTCCTGCGGGCAGTCGCGCTCGCTGCCGGAAGGC
TGCAGGAGGAATTACCCGTCCCGCCCTCCGAGGAGGTGAAGGCGGTAGCGTTGCCGTCGCGAGAAAAGGCACTCAGTGAA
GGCAGGCTCATTCTCGTCGCTGAAGACAGCGAAATCAACCAGAAAGTGATCCGGCAGCAGCTTTCCCTGCTCGGTTATGC
GGCGGATATTGCGAAGGATGGAGGGGAGGCGCTCAAACGCTGGGAAAGCAACAACTATGCATTGCTGCTGACAGACTTGC
ATATGCCGGAAATCGACGGGTATCAACTGACCGCGGCAATTCGCCTCAAAGAGGGGGAGCAAGGCGCTGCGCGCAAGCCG
ATTATTGCCATTACGGCCAATGCACTCAAGGGTGAGGCTGAACATTGCCGGGCGGTGGGCATGGATGACTATTTGAGCAA
GCCGGTGCAGCTCTCGCATTTGAAAGCGGTGCTACAGAAGTGGCTTCCTTCTCCCGGCAGCAGCACTGAATTGCTCGAAC
TGGCTCCACCAGGTTCTATCGCGCCTTCCGCCATACCTGTTGCTCCCGCTACGCCCGGGGAATCTGCTGCTACCGGCGCC
CCCGCTCTATCCACGGTTGTGGCAAAACCTGTCGATGTCCATATCCTTGAACAACTTGTAGGGAACGACCCCGCCGTGAT
CAATGAATTCCTCCAGGATTTCCGGGCGAGTGCACGAAAAACAGCAGAGGAGTTGCAGGCAGCGTGTCTGGCCGGTGATG
CGAAAATAGCCGGCGGTATCGGACACAAGCTTAAGTCCTCGGCTCGCTCCATAGGCGCATTGCAATTGGGTGAGTTGTGC
GCTCAAATGGAACAGGCGGGCAAGGCGGGTGACATGACTCGGTTGAATGAGCTATTGCCATCTTTCGAATCGGAATTCGC
CGCTGTGGATAAGTATATCGGCTCATTGGCATAA

Upstream 100 bases:

>100_bases
GTCCTGCTGGAGAAGGTGCTGAACACGCCTCCGATCCTGCAGACCACACAATTCAAGGGAAAACCCGCCGGTGCTTCCCC
GAAGCCGGGAGGGTGAGACG

Downstream 100 bases:

>100_bases
TATCGTCGGCTGATAGACAGGTTGCCCCCAGCGATGTTCGAATTCAGAAACCTGACTGAACAATAACTGAAAAGATAAAC
GTTATGGTCGAACGATCGGC

Product: multi-sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 1397; Mature: 1397

Protein sequence:

>1397_residues
MIRFTSLTQRFAVWFVAVSLLPILIIGYALLGTFETEAEKSAIQQVSAIADMKAEQIDSYLRERLLDARVIQTTSTTRMA
IQDFSRVYVKSGVDSNAYRQLDTFYREHFKRFVEDAGYYDLFLISPQGEIVYSQAHESDFATSLITGPYRNSGFAFVVRA
ALNTLQSGVSDFEYYPPSRGAIAAFMALPIMADGKLEGVLALQIYSERVFEVVTDNVGLGTSGETVVTRLLNDRTALVIA
PLKHQSNAALQYRIPLSTPPFSIVVHSGLHGERGGGVKMDYRNKEVVAAWRYLPRMNWGIEVKMDAEEVFAFVPRVRNYS
LIVLGFILIAAMLGALLFSRRVVTTLKNLSHSAQHIAGGNLKQRVPVAGWDEIGQLASTFNTMTERLTASNRQRDVAEND
LRQLNQDLENHVAERTADLEQANAVLISKEEEMRSIVEHMVDCIITIDDKSIIRSVNPVIEKLFGYTREEVIGQPVSILM
PEPFRSGHEGYVERYYRTGRGRCEFDHILTLEVEGVHNIGMGREVEGRHKNGELIDLYVAVSEYFVGGKRYFTGVLRDIR
ERKRVEQALRNSEQRFRAIVDNLAALVGEMTPDGVLVEMNRTALEVGGLQSGDVIGKCLSETEWFSYKPEVQQQIRDDIR
RAVAGEIVRHDVAIRIANGDLMTIDFMLVPVRDDKGKVIKLIPSGINVSERIRILKDLEQARHEAEQANEAKSIFLAAMS
HEIRTPMNGVIGMADVLQQTSLSGYQMEMVDLIRESAFALLEIIEDILDFSKIEAGRLEIEQAPMSVEKVVEKACAMLES
LAARKAVELTLFLDPAIPDEVLGDALRLRQVLVNLANNAIKFSSGLQEPGRVSVRALLVEHDQDTVTVEFEITDNGIGMN
EEVQSRLFTSFTQGDTSTTRRYGGTGLGLAITHHLVELMGGSIQVRSAPGEGSVFTVRLSFDLIPSSHMEDKVIDLTGIS
CLVIGAEKGLADDLAVYLRYSGAVAERVIDLPAALKRIEVLPPGLWLLVIDAGHETPPLEELRAAFRSRPDLDPHFVVLE
HGHHEPDIEPRFVVIRRGRRRHERTEEVDTVTLDGDVMHRDAFLRAVALAAGRLQEELPVPPSEEVKAVALPSREKALSE
GRLILVAEDSEINQKVIRQQLSLLGYAADIAKDGGEALKRWESNNYALLLTDLHMPEIDGYQLTAAIRLKEGEQGAARKP
IIAITANALKGEAEHCRAVGMDDYLSKPVQLSHLKAVLQKWLPSPGSSTELLELAPPGSIAPSAIPVAPATPGESAATGA
PALSTVVAKPVDVHILEQLVGNDPAVINEFLQDFRASARKTAEELQAACLAGDAKIAGGIGHKLKSSARSIGALQLGELC
AQMEQAGKAGDMTRLNELLPSFESEFAAVDKYIGSLA

Sequences:

>Translated_1397_residues
MIRFTSLTQRFAVWFVAVSLLPILIIGYALLGTFETEAEKSAIQQVSAIADMKAEQIDSYLRERLLDARVIQTTSTTRMA
IQDFSRVYVKSGVDSNAYRQLDTFYREHFKRFVEDAGYYDLFLISPQGEIVYSQAHESDFATSLITGPYRNSGFAFVVRA
ALNTLQSGVSDFEYYPPSRGAIAAFMALPIMADGKLEGVLALQIYSERVFEVVTDNVGLGTSGETVVTRLLNDRTALVIA
PLKHQSNAALQYRIPLSTPPFSIVVHSGLHGERGGGVKMDYRNKEVVAAWRYLPRMNWGIEVKMDAEEVFAFVPRVRNYS
LIVLGFILIAAMLGALLFSRRVVTTLKNLSHSAQHIAGGNLKQRVPVAGWDEIGQLASTFNTMTERLTASNRQRDVAEND
LRQLNQDLENHVAERTADLEQANAVLISKEEEMRSIVEHMVDCIITIDDKSIIRSVNPVIEKLFGYTREEVIGQPVSILM
PEPFRSGHEGYVERYYRTGRGRCEFDHILTLEVEGVHNIGMGREVEGRHKNGELIDLYVAVSEYFVGGKRYFTGVLRDIR
ERKRVEQALRNSEQRFRAIVDNLAALVGEMTPDGVLVEMNRTALEVGGLQSGDVIGKCLSETEWFSYKPEVQQQIRDDIR
RAVAGEIVRHDVAIRIANGDLMTIDFMLVPVRDDKGKVIKLIPSGINVSERIRILKDLEQARHEAEQANEAKSIFLAAMS
HEIRTPMNGVIGMADVLQQTSLSGYQMEMVDLIRESAFALLEIIEDILDFSKIEAGRLEIEQAPMSVEKVVEKACAMLES
LAARKAVELTLFLDPAIPDEVLGDALRLRQVLVNLANNAIKFSSGLQEPGRVSVRALLVEHDQDTVTVEFEITDNGIGMN
EEVQSRLFTSFTQGDTSTTRRYGGTGLGLAITHHLVELMGGSIQVRSAPGEGSVFTVRLSFDLIPSSHMEDKVIDLTGIS
CLVIGAEKGLADDLAVYLRYSGAVAERVIDLPAALKRIEVLPPGLWLLVIDAGHETPPLEELRAAFRSRPDLDPHFVVLE
HGHHEPDIEPRFVVIRRGRRRHERTEEVDTVTLDGDVMHRDAFLRAVALAAGRLQEELPVPPSEEVKAVALPSREKALSE
GRLILVAEDSEINQKVIRQQLSLLGYAADIAKDGGEALKRWESNNYALLLTDLHMPEIDGYQLTAAIRLKEGEQGAARKP
IIAITANALKGEAEHCRAVGMDDYLSKPVQLSHLKAVLQKWLPSPGSSTELLELAPPGSIAPSAIPVAPATPGESAATGA
PALSTVVAKPVDVHILEQLVGNDPAVINEFLQDFRASARKTAEELQAACLAGDAKIAGGIGHKLKSSARSIGALQLGELC
AQMEQAGKAGDMTRLNELLPSFESEFAAVDKYIGSLA
>Mature_1397_residues
MIRFTSLTQRFAVWFVAVSLLPILIIGYALLGTFETEAEKSAIQQVSAIADMKAEQIDSYLRERLLDARVIQTTSTTRMA
IQDFSRVYVKSGVDSNAYRQLDTFYREHFKRFVEDAGYYDLFLISPQGEIVYSQAHESDFATSLITGPYRNSGFAFVVRA
ALNTLQSGVSDFEYYPPSRGAIAAFMALPIMADGKLEGVLALQIYSERVFEVVTDNVGLGTSGETVVTRLLNDRTALVIA
PLKHQSNAALQYRIPLSTPPFSIVVHSGLHGERGGGVKMDYRNKEVVAAWRYLPRMNWGIEVKMDAEEVFAFVPRVRNYS
LIVLGFILIAAMLGALLFSRRVVTTLKNLSHSAQHIAGGNLKQRVPVAGWDEIGQLASTFNTMTERLTASNRQRDVAEND
LRQLNQDLENHVAERTADLEQANAVLISKEEEMRSIVEHMVDCIITIDDKSIIRSVNPVIEKLFGYTREEVIGQPVSILM
PEPFRSGHEGYVERYYRTGRGRCEFDHILTLEVEGVHNIGMGREVEGRHKNGELIDLYVAVSEYFVGGKRYFTGVLRDIR
ERKRVEQALRNSEQRFRAIVDNLAALVGEMTPDGVLVEMNRTALEVGGLQSGDVIGKCLSETEWFSYKPEVQQQIRDDIR
RAVAGEIVRHDVAIRIANGDLMTIDFMLVPVRDDKGKVIKLIPSGINVSERIRILKDLEQARHEAEQANEAKSIFLAAMS
HEIRTPMNGVIGMADVLQQTSLSGYQMEMVDLIRESAFALLEIIEDILDFSKIEAGRLEIEQAPMSVEKVVEKACAMLES
LAARKAVELTLFLDPAIPDEVLGDALRLRQVLVNLANNAIKFSSGLQEPGRVSVRALLVEHDQDTVTVEFEITDNGIGMN
EEVQSRLFTSFTQGDTSTTRRYGGTGLGLAITHHLVELMGGSIQVRSAPGEGSVFTVRLSFDLIPSSHMEDKVIDLTGIS
CLVIGAEKGLADDLAVYLRYSGAVAERVIDLPAALKRIEVLPPGLWLLVIDAGHETPPLEELRAAFRSRPDLDPHFVVLE
HGHHEPDIEPRFVVIRRGRRRHERTEEVDTVTLDGDVMHRDAFLRAVALAAGRLQEELPVPPSEEVKAVALPSREKALSE
GRLILVAEDSEINQKVIRQQLSLLGYAADIAKDGGEALKRWESNNYALLLTDLHMPEIDGYQLTAAIRLKEGEQGAARKP
IIAITANALKGEAEHCRAVGMDDYLSKPVQLSHLKAVLQKWLPSPGSSTELLELAPPGSIAPSAIPVAPATPGESAATGA
PALSTVVAKPVDVHILEQLVGNDPAVINEFLQDFRASARKTAEELQAACLAGDAKIAGGIGHKLKSSARSIGALQLGELC
AQMEQAGKAGDMTRLNELLPSFESEFAAVDKYIGSLA

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=701, Percent_Identity=29.5292439372325, Blast_Score=249, Evalue=1e-66,
Organism=Escherichia coli, GI145693157, Length=360, Percent_Identity=34.4444444444444, Blast_Score=184, Evalue=4e-47,
Organism=Escherichia coli, GI48994928, Length=393, Percent_Identity=29.0076335877863, Blast_Score=149, Evalue=1e-36,
Organism=Escherichia coli, GI87081816, Length=269, Percent_Identity=34.2007434944238, Blast_Score=142, Evalue=2e-34,
Organism=Escherichia coli, GI1788713, Length=260, Percent_Identity=32.6923076923077, Blast_Score=139, Evalue=1e-33,
Organism=Escherichia coli, GI1786912, Length=261, Percent_Identity=26.8199233716475, Blast_Score=97, Evalue=8e-21,
Organism=Escherichia coli, GI1788393, Length=250, Percent_Identity=26.4, Blast_Score=91, Evalue=5e-19,
Organism=Escherichia coli, GI1788549, Length=383, Percent_Identity=22.7154046997389, Blast_Score=89, Evalue=2e-18,
Organism=Escherichia coli, GI1786600, Length=245, Percent_Identity=28.9795918367347, Blast_Score=88, Evalue=5e-18,
Organism=Escherichia coli, GI1790436, Length=228, Percent_Identity=27.6315789473684, Blast_Score=86, Evalue=2e-17,
Organism=Escherichia coli, GI1786783, Length=231, Percent_Identity=29.004329004329, Blast_Score=78, Evalue=5e-15,
Organism=Escherichia coli, GI1790300, Length=249, Percent_Identity=27.3092369477912, Blast_Score=76, Evalue=1e-14,
Organism=Escherichia coli, GI87081921, Length=177, Percent_Identity=29.3785310734463, Blast_Score=76, Evalue=2e-14,
Organism=Escherichia coli, GI1788279, Length=244, Percent_Identity=30.327868852459, Blast_Score=75, Evalue=3e-14,
Organism=Escherichia coli, GI87082128, Length=259, Percent_Identity=27.7992277992278, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=124, Percent_Identity=35.4838709677419, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR019247
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF09984 DUF2222; PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 154044; Mature: 154044

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS50885 HAMP ; PS50894 HPT ; PS50112 PAS ; PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS00107 PROTEIN_KINASE_ATP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRFTSLTQRFAVWFVAVSLLPILIIGYALLGTFETEAEKSAIQQVSAIADMKAEQIDSY
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRERLLDARVIQTTSTTRMAIQDFSRVYVKSGVDSNAYRQLDTFYREHFKRFVEDAGYYD
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEE
LFLISPQGEIVYSQAHESDFATSLITGPYRNSGFAFVVRAALNTLQSGVSDFEYYPPSRG
EEEECCCCCEEEECCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHHCCCCCCCCH
AIAAFMALPIMADGKLEGVLALQIYSERVFEVVTDNVGLGTSGETVVTRLLNDRTALVIA
HHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEEE
PLKHQSNAALQYRIPLSTPPFSIVVHSGLHGERGGGVKMDYRNKEVVAAWRYLPRMNWGI
ECCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCCEEECCCCCHHHHHHHHHCCCCCCE
EVKMDAEEVFAFVPRVRNYSLIVLGFILIAAMLGALLFSRRVVTTLKNLSHSAQHIAGGN
EEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LKQRVPVAGWDEIGQLASTFNTMTERLTASNRQRDVAENDLRQLNQDLENHVAERTADLE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QANAVLISKEEEMRSIVEHMVDCIITIDDKSIIRSVNPVIEKLFGYTREEVIGQPVSILM
HCCEEEEECHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHCCCHHHHCCCCCEEEC
PEPFRSGHEGYVERYYRTGRGRCEFDHILTLEVEGVHNIGMGREVEGRHKNGELIDLYVA
CCCCCCCCHHHHHHHHHCCCCCEEECEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEE
VSEYFVGGKRYFTGVLRDIRERKRVEQALRNSEQRFRAIVDNLAALVGEMTPDGVLVEMN
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
RTALEVGGLQSGDVIGKCLSETEWFSYKPEVQQQIRDDIRRAVAGEIVRHDVAIRIANGD
CCEEEECCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCC
LMTIDFMLVPVRDDKGKVIKLIPSGINVSERIRILKDLEQARHEAEQANEAKSIFLAAMS
EEEEEEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HEIRTPMNGVIGMADVLQQTSLSGYQMEMVDLIRESAFALLEIIEDILDFSKIEAGRLEI
HHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
EQAPMSVEKVVEKACAMLESLAARKAVELTLFLDPAIPDEVLGDALRLRQVLVNLANNAI
HHCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCE
KFSSGLQEPGRVSVRALLVEHDQDTVTVEFEITDNGIGMNEEVQSRLFTSFTQGDTSTTR
ECCCCCCCCCCEEEEEEEEECCCCEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHH
RYGGTGLGLAITHHLVELMGGSIQVRSAPGEGSVFTVRLSFDLIPSSHMEDKVIDLTGIS
HCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEEEEEECCCCCCCCCEEEEECCE
CLVIGAEKGLADDLAVYLRYSGAVAERVIDLPAALKRIEVLPPGLWLLVIDAGHETPPLE
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHH
ELRAAFRSRPDLDPHFVVLEHGHHEPDIEPRFVVIRRGRRRHERTEEVDTVTLDGDVMHR
HHHHHHHCCCCCCCCEEEEECCCCCCCCCCCEEEEECCCHHHHHHHHCCEEEECCCHHHH
DAFLRAVALAAGRLQEELPVPPSEEVKAVALPSREKALSEGRLILVAEDSEINQKVIRQQ
HHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHCCCCEEEEECCCHHHHHHHHHH
LSLLGYAADIAKDGGEALKRWESNNYALLLTDLHMPEIDGYQLTAAIRLKEGEQGAARKP
HHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEEECCCCCCCCCC
IIAITANALKGEAEHCRAVGMDDYLSKPVQLSHLKAVLQKWLPSPGSSTELLELAPPGSI
EEEEECHHHCCCHHHHHHCCCHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCC
APSAIPVAPATPGESAATGAPALSTVVAKPVDVHILEQLVGNDPAVINEFLQDFRASARK
CCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
TAEELQAACLAGDAKIAGGIGHKLKSSARSIGALQLGELCAQMEQAGKAGDMTRLNELLP
HHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHH
SFESEFAAVDKYIGSLA
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIRFTSLTQRFAVWFVAVSLLPILIIGYALLGTFETEAEKSAIQQVSAIADMKAEQIDSY
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRERLLDARVIQTTSTTRMAIQDFSRVYVKSGVDSNAYRQLDTFYREHFKRFVEDAGYYD
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEE
LFLISPQGEIVYSQAHESDFATSLITGPYRNSGFAFVVRAALNTLQSGVSDFEYYPPSRG
EEEECCCCCEEEECCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHHCCCCCCCCH
AIAAFMALPIMADGKLEGVLALQIYSERVFEVVTDNVGLGTSGETVVTRLLNDRTALVIA
HHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCEEEEE
PLKHQSNAALQYRIPLSTPPFSIVVHSGLHGERGGGVKMDYRNKEVVAAWRYLPRMNWGI
ECCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCCEEECCCCCHHHHHHHHHCCCCCCE
EVKMDAEEVFAFVPRVRNYSLIVLGFILIAAMLGALLFSRRVVTTLKNLSHSAQHIAGGN
EEEECHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LKQRVPVAGWDEIGQLASTFNTMTERLTASNRQRDVAENDLRQLNQDLENHVAERTADLE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QANAVLISKEEEMRSIVEHMVDCIITIDDKSIIRSVNPVIEKLFGYTREEVIGQPVSILM
HCCEEEEECHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHHCCCHHHHCCCCCEEEC
PEPFRSGHEGYVERYYRTGRGRCEFDHILTLEVEGVHNIGMGREVEGRHKNGELIDLYVA
CCCCCCCCHHHHHHHHHCCCCCEEECEEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEE
VSEYFVGGKRYFTGVLRDIRERKRVEQALRNSEQRFRAIVDNLAALVGEMTPDGVLVEMN
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
RTALEVGGLQSGDVIGKCLSETEWFSYKPEVQQQIRDDIRRAVAGEIVRHDVAIRIANGD
CCEEEECCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCC
LMTIDFMLVPVRDDKGKVIKLIPSGINVSERIRILKDLEQARHEAEQANEAKSIFLAAMS
EEEEEEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HEIRTPMNGVIGMADVLQQTSLSGYQMEMVDLIRESAFALLEIIEDILDFSKIEAGRLEI
HHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
EQAPMSVEKVVEKACAMLESLAARKAVELTLFLDPAIPDEVLGDALRLRQVLVNLANNAI
HHCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCE
KFSSGLQEPGRVSVRALLVEHDQDTVTVEFEITDNGIGMNEEVQSRLFTSFTQGDTSTTR
ECCCCCCCCCCEEEEEEEEECCCCEEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHH
RYGGTGLGLAITHHLVELMGGSIQVRSAPGEGSVFTVRLSFDLIPSSHMEDKVIDLTGIS
HCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEEEEEECCCCCCCCCEEEEECCE
CLVIGAEKGLADDLAVYLRYSGAVAERVIDLPAALKRIEVLPPGLWLLVIDAGHETPPLE
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHH
ELRAAFRSRPDLDPHFVVLEHGHHEPDIEPRFVVIRRGRRRHERTEEVDTVTLDGDVMHR
HHHHHHHCCCCCCCCEEEEECCCCCCCCCCCEEEEECCCHHHHHHHHCCEEEECCCHHHH
DAFLRAVALAAGRLQEELPVPPSEEVKAVALPSREKALSEGRLILVAEDSEINQKVIRQQ
HHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHCCCCEEEEECCCHHHHHHHHHH
LSLLGYAADIAKDGGEALKRWESNNYALLLTDLHMPEIDGYQLTAAIRLKEGEQGAARKP
HHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEEECCCCCCCCCC
IIAITANALKGEAEHCRAVGMDDYLSKPVQLSHLKAVLQKWLPSPGSSTELLELAPPGSI
EEEEECHHHCCCHHHHHHCCCHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCC
APSAIPVAPATPGESAATGAPALSTVVAKPVDVHILEQLVGNDPAVINEFLQDFRASARK
CCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
TAEELQAACLAGDAKIAGGIGHKLKSSARSIGALQLGELCAQMEQAGKAGDMTRLNELLP
HHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCHHHHHHHHH
SFESEFAAVDKYIGSLA
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]