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The map label for this gene is pheP [H]

Identifier: 82543022

GI number: 82543022

Start: 451800

End: 453176

Strand: Direct

Name: pheP [H]

Synonym: SBO_0437

Alternate gene names: 82543022

Gene position: 451800-453176 (Clockwise)

Preceding gene: 82543021

Following gene: 82543030

Centisome position: 10.0

GC content: 52.65

Gene sequence:

>1377_bases
GTGAAAAACGCGTCAACCGTATCGGAAGATACTGCGTCAAATCAAGAGCCGACGCTTCATCGCGGATTACATAACCGTCA
TATTCAACTGATTGCGCTGGGTGGCGCAATTGGTACTGGTCTGTTTCTTGGCATTGGCCCGGCGATTCAGATGGCGGGTC
CGGCTGTATTGCTGGGCTACGGCGTCGCCGGGATCATCGCTTTCCTGATTATGCGCCAGCTCGGCGAGATGGTGGTCGAA
GAGCCGGTATCCGGTTCATTTGCCCACTTTGCCTATAAATACTGGGGACCGTTTGCGGGCTTCCTCTCTGGCTGGAACTA
CTGGGTAATGTTCGTGCTGGTGGGAATGGCAGAGCTGACCGCTGCGGGCATCTATATGCAGTACTGGTTCCCGGATGTTC
CAACGTGGATTTGGGCTGCCGCCTTCTTTATTATCATCAACGCCGTTAACCTGGTGAACGTGCGCTTATATGGCGAAACC
GAGTTCTGGTTTGCGTTGATTAAAGTGCTGGCAATCATCGGTATGATCGGCTTTGGCCTGTGGCTGCTGTTTTCTGGTCA
CGGCGGCGAGAAAGCCAGTATCGACAACCTCTGGCGCTACGGTGGTTTCTTCGCCACCGGCTGGAATGGGCTGATTTTGT
CGCTGGCGGTAATTATGTTCTCCTTCGGCGGTCTGGAGCTGATTGGGATTACTGCCGCTGAAGCGCGCGATCCGGAAAAA
AGCATTCCAAAAGCGGTAAATCAGGTGGTGTATCGCATCCTGCTGTTTTACATCTGTTCACTGGTGGTTTTACTGGCGCT
CTATCCGTGGGTGGAAGTGAAATCCAACAGTAGCCCGTTTGTGATGATTTTCCATAATCTCGACAGCAACGAGGTAGCTT
CTGCGCTGAACTTCGTCATTCTGGTAGCATCGCTGTCAGTGTATAACAGCGGGGTTTACTCTAACAGCCGCATGCTGTTT
GGCCTTTCTGTGCAGGGTAATGCGCCGAAGTTTTTGACTCGCGTCAGCCATCGCGGCGTGCCGATTAACTCGCTGATGCT
TTCCGGAGCGATCACTTCGCTGGTGGTGTTAATCAACTATCTGCTGCCGCAAAAAGCGTTTGGTCTGCTGATGGCGCTGG
TGGTAGCAACGCTGCTGTTGAACTGGATTATGATCTGCCTGGCGCATCTGCGTTTTCGCGCGGCGATGCGACGTCAGGGA
CGTGAAACACAGTTTAAGGCGCTGCTTTATCCGTTCGGCAACTATCTTTGCATTGCCTTCCTCGGCATGATTTTGCTGCT
GATGTGCACGATGGATGATATGCGCTTGTCAGCGATCCTGCTGCCGGTGTGGATTGTATTCCTGTTTGTGGCATTTAAAA
CGCTGCGTCGGAAATAA

Upstream 100 bases:

>100_bases
AGCAGGATACCCCGTTTAACCGTGTGGATTGTGTCTTGCGACGATGGGCACTAAATGTTAAAAGGTGCCCCTCAACAAAA
AAGACACACAGGGGAAAGGC

Downstream 100 bases:

>100_bases
GGCATTCACGCTACATCCGACAAAACGATGTCCGCTCTCATCCATTCGATGAGAGCGGTTTTTTTAATTACTGCTTAAAT
GCACCCGCCAGAGAGCGAAT

Product: phenylalanine transporter

Products: Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MKNASTVSEDTASNQEPTLHRGLHNRHIQLIALGGAIGTGLFLGIGPAIQMAGPAVLLGYGVAGIIAFLIMRQLGEMVVE
EPVSGSFAHFAYKYWGPFAGFLSGWNYWVMFVLVGMAELTAAGIYMQYWFPDVPTWIWAAAFFIIINAVNLVNVRLYGET
EFWFALIKVLAIIGMIGFGLWLLFSGHGGEKASIDNLWRYGGFFATGWNGLILSLAVIMFSFGGLELIGITAAEARDPEK
SIPKAVNQVVYRILLFYICSLVVLLALYPWVEVKSNSSPFVMIFHNLDSNEVASALNFVILVASLSVYNSGVYSNSRMLF
GLSVQGNAPKFLTRVSHRGVPINSLMLSGAITSLVVLINYLLPQKAFGLLMALVVATLLLNWIMICLAHLRFRAAMRRQG
RETQFKALLYPFGNYLCIAFLGMILLLMCTMDDMRLSAILLPVWIVFLFVAFKTLRRK

Sequences:

>Translated_458_residues
MKNASTVSEDTASNQEPTLHRGLHNRHIQLIALGGAIGTGLFLGIGPAIQMAGPAVLLGYGVAGIIAFLIMRQLGEMVVE
EPVSGSFAHFAYKYWGPFAGFLSGWNYWVMFVLVGMAELTAAGIYMQYWFPDVPTWIWAAAFFIIINAVNLVNVRLYGET
EFWFALIKVLAIIGMIGFGLWLLFSGHGGEKASIDNLWRYGGFFATGWNGLILSLAVIMFSFGGLELIGITAAEARDPEK
SIPKAVNQVVYRILLFYICSLVVLLALYPWVEVKSNSSPFVMIFHNLDSNEVASALNFVILVASLSVYNSGVYSNSRMLF
GLSVQGNAPKFLTRVSHRGVPINSLMLSGAITSLVVLINYLLPQKAFGLLMALVVATLLLNWIMICLAHLRFRAAMRRQG
RETQFKALLYPFGNYLCIAFLGMILLLMCTMDDMRLSAILLPVWIVFLFVAFKTLRRK
>Mature_458_residues
MKNASTVSEDTASNQEPTLHRGLHNRHIQLIALGGAIGTGLFLGIGPAIQMAGPAVLLGYGVAGIIAFLIMRQLGEMVVE
EPVSGSFAHFAYKYWGPFAGFLSGWNYWVMFVLVGMAELTAAGIYMQYWFPDVPTWIWAAAFFIIINAVNLVNVRLYGET
EFWFALIKVLAIIGMIGFGLWLLFSGHGGEKASIDNLWRYGGFFATGWNGLILSLAVIMFSFGGLELIGITAAEARDPEK
SIPKAVNQVVYRILLFYICSLVVLLALYPWVEVKSNSSPFVMIFHNLDSNEVASALNFVILVASLSVYNSGVYSNSRMLF
GLSVQGNAPKFLTRVSHRGVPINSLMLSGAITSLVVLINYLLPQKAFGLLMALVVATLLLNWIMICLAHLRFRAAMRRQG
RETQFKALLYPFGNYLCIAFLGMILLLMCTMDDMRLSAILLPVWIVFLFVAFKTLRRK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of phenylalanine [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=290, Percent_Identity=27.5862068965517, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI181337167, Length=402, Percent_Identity=24.8756218905473, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI115648063, Length=460, Percent_Identity=21.9565217391304, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI115648022, Length=460, Percent_Identity=21.9565217391304, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786789, Length=458, Percent_Identity=99.1266375545851, Blast_Score=907, Evalue=0.0,
Organism=Escherichia coli, GI1786302, Length=434, Percent_Identity=63.8248847926267, Blast_Score=588, Evalue=1e-169,
Organism=Escherichia coli, GI48994972, Length=429, Percent_Identity=43.5897435897436, Blast_Score=363, Evalue=1e-102,
Organism=Escherichia coli, GI1786602, Length=452, Percent_Identity=44.4690265486726, Blast_Score=347, Evalue=1e-96,
Organism=Escherichia coli, GI1790653, Length=453, Percent_Identity=37.9690949227373, Blast_Score=336, Evalue=2e-93,
Organism=Escherichia coli, GI87081915, Length=425, Percent_Identity=36, Blast_Score=295, Evalue=3e-81,
Organism=Escherichia coli, GI1789017, Length=431, Percent_Identity=36.8909512761021, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI1788480, Length=418, Percent_Identity=37.5598086124402, Blast_Score=271, Evalue=5e-74,
Organism=Escherichia coli, GI87081708, Length=447, Percent_Identity=34.8993288590604, Blast_Score=264, Evalue=1e-71,
Organism=Escherichia coli, GI87081869, Length=175, Percent_Identity=28.5714285714286, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI87082023, Length=359, Percent_Identity=22.5626740947075, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI2367353, Length=370, Percent_Identity=21.3513513513514, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17540018, Length=383, Percent_Identity=23.4986945169713, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17531343, Length=374, Percent_Identity=21.1229946524064, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=442, Percent_Identity=35.5203619909502, Blast_Score=246, Evalue=5e-66,
Organism=Saccharomyces cerevisiae, GI6324061, Length=443, Percent_Identity=35.2144469525959, Blast_Score=245, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6322892, Length=424, Percent_Identity=35.6132075471698, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6324990, Length=441, Percent_Identity=32.1995464852608, Blast_Score=213, Evalue=7e-56,
Organism=Saccharomyces cerevisiae, GI6324059, Length=450, Percent_Identity=34, Blast_Score=213, Evalue=7e-56,
Organism=Saccharomyces cerevisiae, GI6319824, Length=449, Percent_Identity=31.8485523385301, Blast_Score=209, Evalue=7e-55,
Organism=Saccharomyces cerevisiae, GI6321629, Length=416, Percent_Identity=31.9711538461538, Blast_Score=206, Evalue=6e-54,
Organism=Saccharomyces cerevisiae, GI6324924, Length=448, Percent_Identity=31.25, Blast_Score=203, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6324553, Length=399, Percent_Identity=33.0827067669173, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6320717, Length=484, Percent_Identity=27.4793388429752, Blast_Score=193, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6321053, Length=439, Percent_Identity=31.4350797266515, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6319543, Length=436, Percent_Identity=31.651376146789, Blast_Score=187, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6322967, Length=395, Percent_Identity=31.1392405063291, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6320251, Length=488, Percent_Identity=27.8688524590164, Blast_Score=183, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6319542, Length=480, Percent_Identity=26.4583333333333, Blast_Score=173, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6324981, Length=416, Percent_Identity=32.4519230769231, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6319608, Length=413, Percent_Identity=29.5399515738499, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6320364, Length=487, Percent_Identity=27.3100616016427, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24666159, Length=426, Percent_Identity=22.7699530516432, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI221512776, Length=426, Percent_Identity=22.7699530516432, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI161077963, Length=416, Percent_Identity=22.3557692307692, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24667468, Length=427, Percent_Identity=22.7166276346604, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI221331183, Length=351, Percent_Identity=23.6467236467236, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17647653, Length=351, Percent_Identity=23.6467236467236, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24664379, Length=351, Percent_Identity=23.6467236467236, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50703; Mature: 50703

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNASTVSEDTASNQEPTLHRGLHNRHIQLIALGGAIGTGLFLGIGPAIQMAGPAVLLGY
CCCCCCCCCCCCCCCCCHHHHCCCCCCEEEEEECCHHHHHHHHHCCHHHHHCCCHHHHHH
GVAGIIAFLIMRQLGEMVVEEPVSGSFAHFAYKYWGPFAGFLSGWNYWVMFVLVGMAELT
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
AAGIYMQYWFPDVPTWIWAAAFFIIINAVNLVNVRLYGETEFWFALIKVLAIIGMIGFGL
HHHHHHEECCCCCHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHHHHHHHHHHH
WLLFSGHGGEKASIDNLWRYGGFFATGWNGLILSLAVIMFSFGGLELIGITAAEARDPEK
HHHCCCCCCCCCCHHHHHHHCCEEECCHHHHHHHHHHHHHHCCCEEEEEEEHHCCCCCHH
SIPKAVNQVVYRILLFYICSLVVLLALYPWVEVKSNSSPFVMIFHNLDSNEVASALNFVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEECCCCHHHHHHHHHHH
LVASLSVYNSGVYSNSRMLFGLSVQGNAPKFLTRVSHRGVPINSLMLSGAITSLVVLINY
HHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LLPQKAFGLLMALVVATLLLNWIMICLAHLRFRAAMRRQGRETQFKALLYPFGNYLCIAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LGMILLLMCTMDDMRLSAILLPVWIVFLFVAFKTLRRK
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNASTVSEDTASNQEPTLHRGLHNRHIQLIALGGAIGTGLFLGIGPAIQMAGPAVLLGY
CCCCCCCCCCCCCCCCCHHHHCCCCCCEEEEEECCHHHHHHHHHCCHHHHHCCCHHHHHH
GVAGIIAFLIMRQLGEMVVEEPVSGSFAHFAYKYWGPFAGFLSGWNYWVMFVLVGMAELT
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
AAGIYMQYWFPDVPTWIWAAAFFIIINAVNLVNVRLYGETEFWFALIKVLAIIGMIGFGL
HHHHHHEECCCCCHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHHHHHHHHHHHHHHHH
WLLFSGHGGEKASIDNLWRYGGFFATGWNGLILSLAVIMFSFGGLELIGITAAEARDPEK
HHHCCCCCCCCCCHHHHHHHCCEEECCHHHHHHHHHHHHHHCCCEEEEEEEHHCCCCCHH
SIPKAVNQVVYRILLFYICSLVVLLALYPWVEVKSNSSPFVMIFHNLDSNEVASALNFVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEEECCCCHHHHHHHHHHH
LVASLSVYNSGVYSNSRMLFGLSVQGNAPKFLTRVSHRGVPINSLMLSGAITSLVVLINY
HHHHHHHHHCCCCCCCEEEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LLPQKAFGLLMALVVATLLLNWIMICLAHLRFRAAMRRQGRETQFKALLYPFGNYLCIAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LGMILLLMCTMDDMRLSAILLPVWIVFLFVAFKTLRRK
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] + L-phenylalanine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1711024; 8905232; 9278503; 8626334 [H]