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The map label for this gene is gmhB [H]

Identifier: 78779719

GI number: 78779719

Start: 1249763

End: 1251016

Strand: Reverse

Name: gmhB [H]

Synonym: PMT9312_1335

Alternate gene names: 78779719

Gene position: 1251016-1249763 (Counterclockwise)

Preceding gene: 78779720

Following gene: 78779718

Centisome position: 73.19

GC content: 26.79

Gene sequence:

>1254_bases
GTGTGGTTTAAAATAATGGATATTACAGCGGTAACCTCTATTGGGGGGAAAGGAACGAGAATCGAATCTATTTCTTATGG
TAAACCAAAGGGACTACTTGAAATAAACGGTAAAACAGTTATTTATAAAATTGCTGAGCAAATTGCTTTATGCGGTATTA
AAAAGCTATTTCTTTTAAGAGGATACAAAAGTGAATTATTTGATAATGAAATAATAAAAATTGAAAACCAACTTGATTTG
GAGATAACTTCTTATATAGAAAAAGAACCGTTAGGTGAATGCGGAGCATTATGGGAAATAAGAAATCAAATTAATTCAAA
AGATGTATTGTTTGTACTTGGGGATATTGTTTTTGATGTAGATCTTCAAAGATTTATTGATTTTCATGAAAGACTTGATA
GCCAGTTTAGTTTGATAACCCACATTACATCTCATCCAGAAGATTCAGACTTAATTAGGGCCACAAATGGTACTCAAATA
TCCGATTTTAAATTTAAGAATCAAGAAAAAAATAATAGTTTTAGGGGATTTTTAGGTAATGCCGGAATTTCTTTATTTAA
TACAGAAATTCTTGATCTTATAAAATCAGATTCAAATATTAAAAATAAAACAGTATTTAGAAATTTAGCTTATGAATTTT
TTAAATTGTTTAAGAGAATATATTCTTATAATACTTCTGAATATATTAAAGATATTGGTACTCCAGAGAGGTTAAAAAAA
GTAATTGAAGATGATAAAAATAATCAAATAAAAGAAAAAAATTATAAGTTTAAACAAAAATGCTTATTTCTTGATAGGGA
TAATACTTTAATAAAATGCACGAAAGGTAATTATATTCTTGATCCAAATGATATTCAAATAAAAAAAGATAAAATTTCAA
AGATTATTAATTTACGAAAAAATTTTGATTTATGCATAGTTATCACTAATCAGCCACAAATTTCTATGGGTCTTTTGAAT
TTAGAAACTTTATATGATATTAATAGTTTATTAATTGTAAGGTTATTAGATTTGGGTTTAAAAATAGACGAAATTTCTTA
TTGCCCGCATCATCCGCATAAAGGTTTTCAGGGGGAGATATCCATTCTTAAAGAAGATTGTTTTTGTCGCAAACCTAATC
CAGGAATGATCTTTCAGCAAACTTTTTTGAGAAATATTGATTTAAAGAGTTCTGTTTTAGTGGGAGATAGTAAATCTGAT
ATGTTGGCTGCTATGAATTCCGGAATGAAATTTATAGATATTGAAGATTTATAG

Upstream 100 bases:

>100_bases
TTATCTTCAAAGGTAGATATTAATGAGGCGTTATCTTTTTTATCAAATAAAGATATTAAAGCTTTAAAAGTTGAATTGAG
CAAAGAAGGTATTTCAGCTT

Downstream 100 bases:

>100_bases
ATACCTTAATAATAAATTTGATATAGTGTAAAATTATAAATTATAAATAAAATTGAAGAAAAATTTTTTGATTACCGGTG
GTGCTGGTTTTATAGGTTCT

Product: histidinol-phosphate phosphatase

Products: NA

Alternate protein names: D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MWFKIMDITAVTSIGGKGTRIESISYGKPKGLLEINGKTVIYKIAEQIALCGIKKLFLLRGYKSELFDNEIIKIENQLDL
EITSYIEKEPLGECGALWEIRNQINSKDVLFVLGDIVFDVDLQRFIDFHERLDSQFSLITHITSHPEDSDLIRATNGTQI
SDFKFKNQEKNNSFRGFLGNAGISLFNTEILDLIKSDSNIKNKTVFRNLAYEFFKLFKRIYSYNTSEYIKDIGTPERLKK
VIEDDKNNQIKEKNYKFKQKCLFLDRDNTLIKCTKGNYILDPNDIQIKKDKISKIINLRKNFDLCIVITNQPQISMGLLN
LETLYDINSLLIVRLLDLGLKIDEISYCPHHPHKGFQGEISILKEDCFCRKPNPGMIFQQTFLRNIDLKSSVLVGDSKSD
MLAAMNSGMKFIDIEDL

Sequences:

>Translated_417_residues
MWFKIMDITAVTSIGGKGTRIESISYGKPKGLLEINGKTVIYKIAEQIALCGIKKLFLLRGYKSELFDNEIIKIENQLDL
EITSYIEKEPLGECGALWEIRNQINSKDVLFVLGDIVFDVDLQRFIDFHERLDSQFSLITHITSHPEDSDLIRATNGTQI
SDFKFKNQEKNNSFRGFLGNAGISLFNTEILDLIKSDSNIKNKTVFRNLAYEFFKLFKRIYSYNTSEYIKDIGTPERLKK
VIEDDKNNQIKEKNYKFKQKCLFLDRDNTLIKCTKGNYILDPNDIQIKKDKISKIINLRKNFDLCIVITNQPQISMGLLN
LETLYDINSLLIVRLLDLGLKIDEISYCPHHPHKGFQGEISILKEDCFCRKPNPGMIFQQTFLRNIDLKSSVLVGDSKSD
MLAAMNSGMKFIDIEDL
>Mature_417_residues
MWFKIMDITAVTSIGGKGTRIESISYGKPKGLLEINGKTVIYKIAEQIALCGIKKLFLLRGYKSELFDNEIIKIENQLDL
EITSYIEKEPLGECGALWEIRNQINSKDVLFVLGDIVFDVDLQRFIDFHERLDSQFSLITHITSHPEDSDLIRATNGTQI
SDFKFKNQEKNNSFRGFLGNAGISLFNTEILDLIKSDSNIKNKTVFRNLAYEFFKLFKRIYSYNTSEYIKDIGTPERLKK
VIEDDKNNQIKEKNYKFKQKCLFLDRDNTLIKCTKGNYILDPNDIQIKKDKISKIINLRKNFDLCIVITNQPQISMGLLN
LETLYDINSLLIVRLLDLGLKIDEISYCPHHPHKGFQGEISILKEDCFCRKPNPGMIFQQTFLRNIDLKSSVLVGDSKSD
MLAAMNSGMKFIDIEDL

Specific function: Converts the D-glycero-alpha-D-manno-heptose 1,7- bisphosphate intermediate into D-glycero-alpha-D-manno-heptose 1- phosphate by removing the phosphate group at the C-7 position [H]

COG id: COG0241

COG function: function code E; Histidinol phosphatase and related phosphatases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gmhB family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=232, Percent_Identity=25.8620689655172, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI11761619, Length=232, Percent_Identity=25.8620689655172, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1786399, Length=154, Percent_Identity=33.1168831168831, Blast_Score=83, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI133931050, Length=229, Percent_Identity=24.8908296943231, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320148, Length=231, Percent_Identity=26.8398268398268, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355443, Length=229, Percent_Identity=25.3275109170306, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24644084, Length=229, Percent_Identity=25.3275109170306, Blast_Score=79, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR004446
- InterPro:   IPR006543
- InterPro:   IPR013954 [H]

Pfam domain/function: PF08645 PNK3P [H]

EC number: 3.1.1.-

Molecular weight: Translated: 48021; Mature: 48021

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS00589 PTS_HPR_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWFKIMDITAVTSIGGKGTRIESISYGKPKGLLEINGKTVIYKIAEQIALCGIKKLFLLR
CEEEEEEEEEEECCCCCCCEEEEECCCCCCCEEEECCCEEEHHHHHHHHHHHHHHHHHHC
GYKSELFDNEIIKIENQLDLEITSYIEKEPLGECGALWEIRNQINSKDVLFVLGDIVFDV
CCHHHHCCCCEEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEEHHHHHH
DLQRFIDFHERLDSQFSLITHITSHPEDSDLIRATNGTQISDFKFKNQEKNNSFRGFLGN
HHHHHHHHHHHHCHHHHHHHHHHCCCCCCCEEEECCCCEEECEEECCCCCCCCCCEECCC
AGISLFNTEILDLIKSDSNIKNKTVFRNLAYEFFKLFKRIYSYNTSEYIKDIGTPERLKK
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHH
VIEDDKNNQIKEKNYKFKQKCLFLDRDNTLIKCTKGNYILDPNDIQIKKDKISKIINLRK
HHCCCCCCCCHHCCCCEEHEEEEEECCCCEEEECCCCEEECCCCCEEEHHHHHHHHHHHC
NFDLCIVITNQPQISMGLLNLETLYDINSLLIVRLLDLGLKIDEISYCPHHPHKGFQGEI
CCCEEEEEECCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHH
SILKEDCFCRKPNPGMIFQQTFLRNIDLKSSVLVGDSKSDMLAAMNSGMKFIDIEDL
EEEECCCCCCCCCCCEEEHHHHHHCCCCCCEEEECCCCHHHHHHHHCCCEEEEECCC
>Mature Secondary Structure
MWFKIMDITAVTSIGGKGTRIESISYGKPKGLLEINGKTVIYKIAEQIALCGIKKLFLLR
CEEEEEEEEEEECCCCCCCEEEEECCCCCCCEEEECCCEEEHHHHHHHHHHHHHHHHHHC
GYKSELFDNEIIKIENQLDLEITSYIEKEPLGECGALWEIRNQINSKDVLFVLGDIVFDV
CCHHHHCCCCEEEECCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEEHHHHHH
DLQRFIDFHERLDSQFSLITHITSHPEDSDLIRATNGTQISDFKFKNQEKNNSFRGFLGN
HHHHHHHHHHHHCHHHHHHHHHHCCCCCCCEEEECCCCEEECEEECCCCCCCCCCEECCC
AGISLFNTEILDLIKSDSNIKNKTVFRNLAYEFFKLFKRIYSYNTSEYIKDIGTPERLKK
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHH
VIEDDKNNQIKEKNYKFKQKCLFLDRDNTLIKCTKGNYILDPNDIQIKKDKISKIINLRK
HHCCCCCCCCHHCCCCEEHEEEEEECCCCEEEECCCCEEECCCCCEEEHHHHHHHHHHHC
NFDLCIVITNQPQISMGLLNLETLYDINSLLIVRLLDLGLKIDEISYCPHHPHKGFQGEI
CCCEEEEEECCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHH
SILKEDCFCRKPNPGMIFQQTFLRNIDLKSSVLVGDSKSDMLAAMNSGMKFIDIEDL
EEEECCCCCCCCCCCEEEHHHHHHCCCCCCEEEECCCCHHHHHHHHCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11279237; 12101286 [H]