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The map label for this gene is apt

Identifier: 78779516

GI number: 78779516

Start: 1048619

End: 1049131

Strand: Reverse

Name: apt

Synonym: PMT9312_1133

Alternate gene names: 78779516

Gene position: 1049131-1048619 (Counterclockwise)

Preceding gene: 78779517

Following gene: 78779515

Centisome position: 61.38

GC content: 31.58

Gene sequence:

>513_bases
ATGGAAAAACTTGAGAAATTGATTTCTACTTATGAAAACTATCCAAAAGCCGGGGTGAGTTTTAAGGATGTTATTGAAAT
TGTTCAACACCCTTCAATTTTTCGACAATTAATTTTAGAAATGGCGAAAAGTAAAATCATAAAAGAAGCTGAAGCATTAA
TTTCTATAGACGCAAGAGGTTTTATTTTTGGTTCCGCAATATCTATACAGGCTGCAAAACCAATGATAGTTGCAAGAAAA
CCTGGCAAACTTCCAGGAGAATTAGTTACAAAAAAATATAGTTTAGAGTATGGCGAGAATTCCCTTTCAATTCAGAAAAA
AGCACTTAAAAAATATAACTCTTTTGCAATTATTGATGATCTATTAGCAACTGGGGGAACAGTTAATTGCGTTTCTGAGC
TAATAAATAATAATAATAAGAAAGTTGTAGGTCTTTTAGTAGTGGCTGAATTAAGCAAGTTTGATGGAAGATCGAGATTT
AATTTCCCAGTCGAATCATCAATTCTTTTTTGA

Upstream 100 bases:

>100_bases
TTTCAACACTATTTTTTAAGGTTGAAAAAATAATTTTCGCTAGAATTACATGAAAGTAAGATTTATATTAGATAGGTCAT
AAAGATTCTCAAATTAATTT

Downstream 100 bases:

>100_bases
AAATAAATAAAGTTTTCAATTTAAAAAATTTAATCATGAAGATCAATATTGAAGTTTTTAAAAAGTCTTGAAAAACACAT
AGTGTAAATCTAATATGAAC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MEKLEKLISTYENYPKAGVSFKDVIEIVQHPSIFRQLILEMAKSKIIKEAEALISIDARGFIFGSAISIQAAKPMIVARK
PGKLPGELVTKKYSLEYGENSLSIQKKALKKYNSFAIIDDLLATGGTVNCVSELINNNNKKVVGLLVVAELSKFDGRSRF
NFPVESSILF

Sequences:

>Translated_170_residues
MEKLEKLISTYENYPKAGVSFKDVIEIVQHPSIFRQLILEMAKSKIIKEAEALISIDARGFIFGSAISIQAAKPMIVARK
PGKLPGELVTKKYSLEYGENSLSIQKKALKKYNSFAIIDDLLATGGTVNCVSELINNNNKKVVGLLVVAELSKFDGRSRF
NFPVESSILF
>Mature_170_residues
MEKLEKLISTYENYPKAGVSFKDVIEIVQHPSIFRQLILEMAKSKIIKEAEALISIDARGFIFGSAISIQAAKPMIVARK
PGKLPGELVTKKYSLEYGENSLSIQKKALKKYNSFAIIDDLLATGGTVNCVSELINNNNKKVVGLLVVAELSKFDGRSRF
NFPVESSILF

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=163, Percent_Identity=33.7423312883436, Blast_Score=109, Evalue=9e-25,
Organism=Homo sapiens, GI71773201, Length=128, Percent_Identity=35.15625, Blast_Score=90, Evalue=9e-19,
Organism=Escherichia coli, GI1786675, Length=163, Percent_Identity=32.5153374233129, Blast_Score=100, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17509087, Length=160, Percent_Identity=34.375, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6323619, Length=169, Percent_Identity=31.9526627218935, Blast_Score=89, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6320649, Length=160, Percent_Identity=26.875, Blast_Score=63, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17136334, Length=166, Percent_Identity=36.7469879518072, Blast_Score=108, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_PROM9 (Q31AA3)

Other databases:

- EMBL:   CP000111
- RefSeq:   YP_397628.1
- HSSP:   P07741
- ProteinModelPortal:   Q31AA3
- SMR:   Q31AA3
- STRING:   Q31AA3
- GeneID:   3765938
- GenomeReviews:   CP000111_GR
- KEGG:   pmi:PMT9312_1133
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   PMAR74546:PMT9312_1133-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18827; Mature: 18827

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLEKLISTYENYPKAGVSFKDVIEIVQHPSIFRQLILEMAKSKIIKEAEALISIDARG
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
FIFGSAISIQAAKPMIVARKPGKLPGELVTKKYSLEYGENSLSIQKKALKKYNSFAIIDD
EEEECEEEEECCCCEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHH
LLATGGTVNCVSELINNNNKKVVGLLVVAELSKFDGRSRFNFPVESSILF
HHHCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEKLEKLISTYENYPKAGVSFKDVIEIVQHPSIFRQLILEMAKSKIIKEAEALISIDARG
CHHHHHHHHHHHCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
FIFGSAISIQAAKPMIVARKPGKLPGELVTKKYSLEYGENSLSIQKKALKKYNSFAIIDD
EEEECEEEEECCCCEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHH
LLATGGTVNCVSELINNNNKKVVGLLVVAELSKFDGRSRFNFPVESSILF
HHHCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA