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The map label for this gene is hisA [H]

Identifier: 78779188

GI number: 78779188

Start: 749033

End: 749800

Strand: Reverse

Name: hisA [H]

Synonym: PMT9312_0804

Alternate gene names: 78779188

Gene position: 749800-749033 (Counterclockwise)

Preceding gene: 78779190

Following gene: 78779187

Centisome position: 43.87

GC content: 32.16

Gene sequence:

>768_bases
ATGGAACTAATACCAGCTATTGATTTAATGAATGGTAAGTGCGTAAGACTTTTTAAGGGTGACTTTAATAAAAGAAAAGA
CTTTACAAAAGAACCTCATGAGCAGGCTAAATATTGGGAAAGCGAAGGAGCAAAATATATACATATAGTTGATTTAGATG
CTGCAAAAACTGGATCACCCACCAACGATAAATCAATAAAGGATATTGCAAAAACAGTTAACATTCCTATTCAAATAGGT
GGGGGAATAAGATCTCAGGAAAGGATAGAACAATTATTTTCTTATGGTATCGAGAAAGTTATAATGGGAACATCTGCAAT
AGAAAATAAAGAATTAGTTAAAGACTTATCAAATAAATTTCCAGGAAGGATAATTGTTGGTATTGACGCAAAAGACGGAA
AAGTTAGTACAAGGGGTTGGCTTGAGCAATCTAATATTTTAGCCACTGATCTAGTAAGGGAGTTTTCTTCCTTTAAAATC
GCTAGTTTTATTGTTACAGATATCAATACAGATGGAACATTAGAGGGAACTAATGAAGAATTCATAAAAAGGATTCTAGA
GATTACAGATATTCCAGTAATAGCATCAGGAGGGGTAGGTTCAATTTCTGATTTATTATCTTTAGTAAAACTTGAGAATT
CTGGACTATTTGGCGTGATTGTAGGTAAAGCTCTATATGAAAATAAATTTAAAATAAGCGAAGCGATTAATGTATTGTCA
TCAGAGAGACTAACTGACTTTGATTTAAACAACAATTACTACGCTTAA

Upstream 100 bases:

>100_bases
ATTTTCATATTCAAAAAATATTTAACTGAAGTAGTAATCTTAAATAGAATTACATATTGAATAGTACTACTAAGAAGTAA
TTAATGAAAAGGATGATTCT

Downstream 100 bases:

>100_bases
AAGAGTATAAAAATCGATTTAAGGCTGGTATTTGCAGTAATTGTTAGTTAATTTTGTATAAGAGATAAGAAATTTAGTCT
TGGAATTAATTTCAAAAAAA

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MELIPAIDLMNGKCVRLFKGDFNKRKDFTKEPHEQAKYWESEGAKYIHIVDLDAAKTGSPTNDKSIKDIAKTVNIPIQIG
GGIRSQERIEQLFSYGIEKVIMGTSAIENKELVKDLSNKFPGRIIVGIDAKDGKVSTRGWLEQSNILATDLVREFSSFKI
ASFIVTDINTDGTLEGTNEEFIKRILEITDIPVIASGGVGSISDLLSLVKLENSGLFGVIVGKALYENKFKISEAINVLS
SERLTDFDLNNNYYA

Sequences:

>Translated_255_residues
MELIPAIDLMNGKCVRLFKGDFNKRKDFTKEPHEQAKYWESEGAKYIHIVDLDAAKTGSPTNDKSIKDIAKTVNIPIQIG
GGIRSQERIEQLFSYGIEKVIMGTSAIENKELVKDLSNKFPGRIIVGIDAKDGKVSTRGWLEQSNILATDLVREFSSFKI
ASFIVTDINTDGTLEGTNEEFIKRILEITDIPVIASGGVGSISDLLSLVKLENSGLFGVIVGKALYENKFKISEAINVLS
SERLTDFDLNNNYYA
>Mature_255_residues
MELIPAIDLMNGKCVRLFKGDFNKRKDFTKEPHEQAKYWESEGAKYIHIVDLDAAKTGSPTNDKSIKDIAKTVNIPIQIG
GGIRSQERIEQLFSYGIEKVIMGTSAIENKELVKDLSNKFPGRIIVGIDAKDGKVSTRGWLEQSNILATDLVREFSSFKI
ASFIVTDINTDGTLEGTNEEFIKRILEITDIPVIASGGVGSISDLLSLVKLENSGLFGVIVGKALYENKFKISEAINVLS
SERLTDFDLNNNYYA

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=244, Percent_Identity=34.0163934426229, Blast_Score=158, Evalue=3e-40,
Organism=Escherichia coli, GI1788336, Length=251, Percent_Identity=24.7011952191235, Blast_Score=86, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 28242; Mature: 28242

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELIPAIDLMNGKCVRLFKGDFNKRKDFTKEPHEQAKYWESEGAKYIHIVDLDAAKTGSP
CCCCCCEECCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCC
TNDKSIKDIAKTVNIPIQIGGGIRSQERIEQLFSYGIEKVIMGTSAIENKELVKDLSNKF
CCCHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHCC
PGRIIVGIDAKDGKVSTRGWLEQSNILATDLVREFSSFKIASFIVTDINTDGTLEGTNEE
CCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCCCHH
FIKRILEITDIPVIASGGVGSISDLLSLVKLENSGLFGVIVGKALYENKFKISEAINVLS
HHHHHHHHHCCCEEECCCCCCHHHHHHHHHHCCCCEEEEEHHHHHHCCCHHHHHHHHHHH
SERLTDFDLNNNYYA
CCCCEEEECCCCCCC
>Mature Secondary Structure
MELIPAIDLMNGKCVRLFKGDFNKRKDFTKEPHEQAKYWESEGAKYIHIVDLDAAKTGSP
CCCCCCEECCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCC
TNDKSIKDIAKTVNIPIQIGGGIRSQERIEQLFSYGIEKVIMGTSAIENKELVKDLSNKF
CCCHHHHHHHHHHCCEEEECCCCCCHHHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHCC
PGRIIVGIDAKDGKVSTRGWLEQSNILATDLVREFSSFKIASFIVTDINTDGTLEGTNEE
CCEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCCCHH
FIKRILEITDIPVIASGGVGSISDLLSLVKLENSGLFGVIVGKALYENKFKISEAINVLS
HHHHHHHHHCCCEEECCCCCCHHHHHHHHHHCCCCEEEEEHHHHHHCCCHHHHHHHHHHH
SERLTDFDLNNNYYA
CCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA