Click here to switch to the map view.

The map label for this gene is cobW [H]

Identifier: 78779170

GI number: 78779170

Start: 732756

End: 733820

Strand: Direct

Name: cobW [H]

Synonym: PMT9312_0786

Alternate gene names: 78779170

Gene position: 732756-733820 (Clockwise)

Preceding gene: 78779169

Following gene: 78779171

Centisome position: 42.87

GC content: 28.54

Gene sequence:

>1065_bases
ATGAAAAAAAAAAAACCAGTTATAGTTGTTTCGGGATTTCTTGGTTCAGGTAAAACAACTTTTCTAAGATATCTATTAAA
AGAGAGTAATAAAAAATTTGGTTTAATAATTAATGAATTTGGTGATGTTGGAATTGACGGTGATTTGATTAAAAGTTGTG
ATAAATGTGATGAATCTGAAGACGACTGCGTAATCGAATTAAATAATGGATGTTTATGTTGTACTGTTCAAGATGATTTT
GTTCCATCAATAAAAGCTCTCTTAGAATTTAATCCTCCTATCGAATCAATAATTATCGAAACAAGTGGCCTGGCACTACC
AATTCCCTTAATTCAAGCCCTTAACTGGCCTGAGATTAGGTCTTCCATATACCTTGATGTTGTTGTTGGTATCGTTAATG
GAGAATCAATGCTTAATGGTTCACCAATTAATGATTTAAATAAAATAACAAAACAATATAATGAAACAGATAAAATTGAT
CACAACGCCACTATAGATGAACTTTTTGAGGAGCAACTAGAAGTTTCTGATATCGTTTTAGTCTCTAGATCAGATATCTT
AAATGATGATCAGTTTGACGTTATAAAAAATAAAATTCAAGGAAGTCTAAACTCATCTACACCAGTCCTTAAATCCAAGA
ATGGCAAAATTGATTTAAATTATCTATTTGATTTTAATTTTAAAAAAGAGACTTATAAAGAATTTTTAACTGAAGAACAT
GACCATAATCATGTTGATCTTGTATCAGATTCATTTAAATTAAATTATTTCCTTGAAAAAAATGACTTTGAAAAGGAGAT
GTCAAAAATCTTGGATGAATTAAATATTCTTCGAATAAAAGGACGTATTTGGATCCCAAACAAATCATTGCCTTTACAAG
TACAAATTGTTGGAAAGAAAATTAATACTTGGTTTGAAGAAGCTCCAGAAAATTGTTGGAGACCAAATGATAATGCTGGG
CTTGAATTAGTAATAATTTCTTTTGATGAAAAATCTATAAAAACTTTCAATAGAAAAATTAAAGAGAAATTTAAGATTTT
AAGTGACCCAAAAATAGCAATTTGA

Upstream 100 bases:

>100_bases
TAGTCGTACACAACAAAAACAATTATGTGCGATTGCTAATGGCACAAATAGTTCTACAGGAGAGAGTACAGAATATAGTT
TAGGTTGTTAATCATCAAAG

Downstream 100 bases:

>100_bases
CTTTATAGTTAGCTGTCGGGATACTTACTACAGTAGACAGTCCAAGATGGAAAATCCAAAAATTGCTTTAAAACAAATAA
TCTCTAACGAAGTCACATCA

Product: putative cobalamin synthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MKKKKPVIVVSGFLGSGKTTFLRYLLKESNKKFGLIINEFGDVGIDGDLIKSCDKCDESEDDCVIELNNGCLCCTVQDDF
VPSIKALLEFNPPIESIIIETSGLALPIPLIQALNWPEIRSSIYLDVVVGIVNGESMLNGSPINDLNKITKQYNETDKID
HNATIDELFEEQLEVSDIVLVSRSDILNDDQFDVIKNKIQGSLNSSTPVLKSKNGKIDLNYLFDFNFKKETYKEFLTEEH
DHNHVDLVSDSFKLNYFLEKNDFEKEMSKILDELNILRIKGRIWIPNKSLPLQVQIVGKKINTWFEEAPENCWRPNDNAG
LELVIISFDEKSIKTFNRKIKEKFKILSDPKIAI

Sequences:

>Translated_354_residues
MKKKKPVIVVSGFLGSGKTTFLRYLLKESNKKFGLIINEFGDVGIDGDLIKSCDKCDESEDDCVIELNNGCLCCTVQDDF
VPSIKALLEFNPPIESIIIETSGLALPIPLIQALNWPEIRSSIYLDVVVGIVNGESMLNGSPINDLNKITKQYNETDKID
HNATIDELFEEQLEVSDIVLVSRSDILNDDQFDVIKNKIQGSLNSSTPVLKSKNGKIDLNYLFDFNFKKETYKEFLTEEH
DHNHVDLVSDSFKLNYFLEKNDFEKEMSKILDELNILRIKGRIWIPNKSLPLQVQIVGKKINTWFEEAPENCWRPNDNAG
LELVIISFDEKSIKTFNRKIKEKFKILSDPKIAI
>Mature_354_residues
MKKKKPVIVVSGFLGSGKTTFLRYLLKESNKKFGLIINEFGDVGIDGDLIKSCDKCDESEDDCVIELNNGCLCCTVQDDF
VPSIKALLEFNPPIESIIIETSGLALPIPLIQALNWPEIRSSIYLDVVVGIVNGESMLNGSPINDLNKITKQYNETDKID
HNATIDELFEEQLEVSDIVLVSRSDILNDDQFDVIKNKIQGSLNSSTPVLKSKNGKIDLNYLFDFNFKKETYKEFLTEEH
DHNHVDLVSDSFKLNYFLEKNDFEKEMSKILDELNILRIKGRIWIPNKSLPLQVQIVGKKINTWFEEAPENCWRPNDNAG
LELVIISFDEKSIKTFNRKIKEKFKILSDPKIAI

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI148727351, Length=348, Percent_Identity=27.2988505747126, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI126722884, Length=348, Percent_Identity=27.0114942528736, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI146231952, Length=349, Percent_Identity=26.0744985673352, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI33469141, Length=352, Percent_Identity=26.4204545454545, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI223941779, Length=333, Percent_Identity=27.027027027027, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI223941776, Length=343, Percent_Identity=26.530612244898, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI119120938, Length=167, Percent_Identity=34.1317365269461, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI87082430, Length=308, Percent_Identity=26.6233766233766, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788499, Length=239, Percent_Identity=26.3598326359833, Blast_Score=85, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6324356, Length=232, Percent_Identity=28.8793103448276, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 40327; Mature: 40327

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKKKPVIVVSGFLGSGKTTFLRYLLKESNKKFGLIINEFGDVGIDGDLIKSCDKCDESE
CCCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCC
DDCVIELNNGCLCCTVQDDFVPSIKALLEFNPPIESIIIETSGLALPIPLIQALNWPEIR
CCEEEEECCCEEEEEECCCHHHHHHHHHHCCCCHHHEEEECCCCEECHHHHHHCCCHHHH
SSIYLDVVVGIVNGESMLNGSPINDLNKITKQYNETDKIDHNATIDELFEEQLEVSDIVL
HHEEEEEEEEEECCCHHCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCHHHEEE
VSRSDILNDDQFDVIKNKIQGSLNSSTPVLKSKNGKIDLNYLFDFNFKKETYKEFLTEEH
EECCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCEEEEEEEEEECCCHHHHHHHHCCCC
DHNHVDLVSDSFKLNYFLEKNDFEKEMSKILDELNILRIKGRIWIPNKSLPLQVQIVGKK
CCCEEEEEECCEEEEEEECCCCHHHHHHHHHHHCCEEEEECEEEECCCCCCEEEEEECCH
INTWFEEAPENCWRPNDNAGLELVIISFDEKSIKTFNRKIKEKFKILSDPKIAI
HHHHHHHCCHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKKKKPVIVVSGFLGSGKTTFLRYLLKESNKKFGLIINEFGDVGIDGDLIKSCDKCDESE
CCCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCC
DDCVIELNNGCLCCTVQDDFVPSIKALLEFNPPIESIIIETSGLALPIPLIQALNWPEIR
CCEEEEECCCEEEEEECCCHHHHHHHHHHCCCCHHHEEEECCCCEECHHHHHHCCCHHHH
SSIYLDVVVGIVNGESMLNGSPINDLNKITKQYNETDKIDHNATIDELFEEQLEVSDIVL
HHEEEEEEEEEECCCHHCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCHHHEEE
VSRSDILNDDQFDVIKNKIQGSLNSSTPVLKSKNGKIDLNYLFDFNFKKETYKEFLTEEH
EECCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCEEEEEEEEEECCCHHHHHHHHCCCC
DHNHVDLVSDSFKLNYFLEKNDFEKEMSKILDELNILRIKGRIWIPNKSLPLQVQIVGKK
CCCEEEEEECCEEEEEEECCCCHHHHHHHHHHHCCEEEEECEEEECCCCCCEEEEEECCH
INTWFEEAPENCWRPNDNAGLELVIISFDEKSIKTFNRKIKEKFKILSDPKIAI
HHHHHHHCCHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1655697 [H]