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The map label for this gene is preA [H]

Identifier: 78779003

GI number: 78779003

Start: 583347

End: 584318

Strand: Direct

Name: preA [H]

Synonym: PMT9312_0618

Alternate gene names: 78779003

Gene position: 583347-584318 (Clockwise)

Preceding gene: 78779002

Following gene: 78779004

Centisome position: 34.13

GC content: 34.67

Gene sequence:

>972_bases
ATGAATACAGTAACAGAGCTACTACAACCAGTTGAAAATGATCTTGATGATCTTATTTTTGAACTGAAAAATCTAATAGG
AGCTGGTCATCCAATTCTTCAAGCTGCAGCAGAACATCTCTTTAGTGCTGGGGGGAAGAGACTGAGACCTGGTATAGTGC
TATTGATTTCAAAAGCAATATCTTCTGAATTTTGTTTAACAAATAAACACAAGAGGCTTGCTGAAATAACTGAAATGATT
CATACAGCATCATTAGTCCATGATGATGTTGTTGATGAAGCGTCTACAAGAAGAGGAGTAGATACAGTTCATAGTAGATT
TAATACCAGAGTTGCTGTTTTAGCTGGTGACTTTTTATTCGCTCAAGCAAGTTGGCATTTAGCAAATCTTGATAATGTAA
ATGTAGTTAAATTACTAAGTAGAGTAATAATGGATTTAGCCGAAGGTGAAATCAAACAAAATTTAAATAGATTTGATTCG
GCTCAATCTTTTTCCAAATACATCAATAAAAGCTATTGTAAAACAGCATCATTAATAGCTAACAGTTGTAAAGCAGCTGG
AGTTTTGAGTGATCTTTCCGATGAAAAATTAAACTCTCTGTACGATTTTGGCAAAAATATTGGTTTGGCTTTCCAAGTTG
TAGATGACATACTTGACTTTACTGGAAACGATAAACAACTTGGAAAACCTGCTGTAAGTGATCTTGCTAGTGGTTATCTT
ACTGCGCCAGTTTTATATGCCTTAGAAGAAAATAAGAAATTGTCTGTTCTTATAAACAGAGAACTTGCTGAAAAAGATGA
TTTAGATGAGGCTCTTAATATCATTATGAATTCTAAATCTATCGAAAGTTCTAGAAAACTAGCTGAGGATTTTGCAATGC
TCTCTAAAGAAGCTATAATTTGGCTTCCTGATTCAGAGTACAAGAGAGCGTTGCTGGCCCTCCCAGAATTTGTTCTCAGC
CGCATTTATTAG

Upstream 100 bases:

>100_bases
TTCCAAAAAAGTAAAATTTTGGCTTGGAATTAATAAAGAAATTAGTTTGGTTAACCTCCGAAGTAATGTTTGATTCTTTA
AGATATATTAGAGGTCAATC

Downstream 100 bases:

>100_bases
ATCTGTTAAAATAGATTTCTCCAGCTAACTTAATATTAAAATTTTTGAAAACCATAAATTTTTCGACTAGTTTTATTAAG
CATAGATTTATTTAATGTCA

Product: polyprenyl synthetase; solanesyl diphosphate synthase (sds)

Products: diphosphate; all-trans-nonaprenyl diphosphate

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MNTVTELLQPVENDLDDLIFELKNLIGAGHPILQAAAEHLFSAGGKRLRPGIVLLISKAISSEFCLTNKHKRLAEITEMI
HTASLVHDDVVDEASTRRGVDTVHSRFNTRVAVLAGDFLFAQASWHLANLDNVNVVKLLSRVIMDLAEGEIKQNLNRFDS
AQSFSKYINKSYCKTASLIANSCKAAGVLSDLSDEKLNSLYDFGKNIGLAFQVVDDILDFTGNDKQLGKPAVSDLASGYL
TAPVLYALEENKKLSVLINRELAEKDDLDEALNIIMNSKSIESSRKLAEDFAMLSKEAIIWLPDSEYKRALLALPEFVLS
RIY

Sequences:

>Translated_323_residues
MNTVTELLQPVENDLDDLIFELKNLIGAGHPILQAAAEHLFSAGGKRLRPGIVLLISKAISSEFCLTNKHKRLAEITEMI
HTASLVHDDVVDEASTRRGVDTVHSRFNTRVAVLAGDFLFAQASWHLANLDNVNVVKLLSRVIMDLAEGEIKQNLNRFDS
AQSFSKYINKSYCKTASLIANSCKAAGVLSDLSDEKLNSLYDFGKNIGLAFQVVDDILDFTGNDKQLGKPAVSDLASGYL
TAPVLYALEENKKLSVLINRELAEKDDLDEALNIIMNSKSIESSRKLAEDFAMLSKEAIIWLPDSEYKRALLALPEFVLS
RIY
>Mature_323_residues
MNTVTELLQPVENDLDDLIFELKNLIGAGHPILQAAAEHLFSAGGKRLRPGIVLLISKAISSEFCLTNKHKRLAEITEMI
HTASLVHDDVVDEASTRRGVDTVHSRFNTRVAVLAGDFLFAQASWHLANLDNVNVVKLLSRVIMDLAEGEIKQNLNRFDS
AQSFSKYINKSYCKTASLIANSCKAAGVLSDLSDEKLNSLYDFGKNIGLAFQVVDDILDFTGNDKQLGKPAVSDLASGYL
TAPVLYALEENKKLSVLINRELAEKDDLDEALNIIMNSKSIESSRKLAEDFAMLSKEAIIWLPDSEYKRALLALPEFVLS
RIY

Specific function: Possible role in synthesis of the nonaprenyl side chain of plastoquinone or in synthesis of other prenyl chains such as undekaprenyl pyrophosphate [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=294, Percent_Identity=39.4557823129252, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI169808399, Length=324, Percent_Identity=29.6296296296296, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI4758430, Length=222, Percent_Identity=25.6756756756757, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI83700220, Length=222, Percent_Identity=25.6756756756757, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1789578, Length=287, Percent_Identity=33.7979094076655, Blast_Score=176, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17505681, Length=293, Percent_Identity=35.4948805460751, Blast_Score=196, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6319475, Length=298, Percent_Identity=37.9194630872483, Blast_Score=193, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24651612, Length=312, Percent_Identity=36.5384615384615, Blast_Score=215, Evalue=4e-56,
Organism=Drosophila melanogaster, GI21356309, Length=355, Percent_Identity=25.6338028169014, Blast_Score=98, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR014120
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: 2.5.1.11

Molecular weight: Translated: 35727; Mature: 35727

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTVTELLQPVENDLDDLIFELKNLIGAGHPILQAAAEHLFSAGGKRLRPGIVLLISKAI
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
SSEFCLTNKHKRLAEITEMIHTASLVHDDVVDEASTRRGVDTVHSRFNTRVAVLAGDFLF
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCEEEEEECHHHH
AQASWHLANLDNVNVVKLLSRVIMDLAEGEIKQNLNRFDSAQSFSKYINKSYCKTASLIA
HHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NSCKAAGVLSDLSDEKLNSLYDFGKNIGLAFQVVDDILDFTGNDKQLGKPAVSDLASGYL
HHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHCCCHHHHHHHCCHH
TAPVLYALEENKKLSVLINRELAEKDDLDEALNIIMNSKSIESSRKLAEDFAMLSKEAII
HHHHHHHHHCCCEEEEEECHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEE
WLPDSEYKRALLALPEFVLSRIY
ECCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNTVTELLQPVENDLDDLIFELKNLIGAGHPILQAAAEHLFSAGGKRLRPGIVLLISKAI
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
SSEFCLTNKHKRLAEITEMIHTASLVHDDVVDEASTRRGVDTVHSRFNTRVAVLAGDFLF
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCEEEEEECHHHH
AQASWHLANLDNVNVVKLLSRVIMDLAEGEIKQNLNRFDSAQSFSKYINKSYCKTASLIA
HHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NSCKAAGVLSDLSDEKLNSLYDFGKNIGLAFQVVDDILDFTGNDKQLGKPAVSDLASGYL
HHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHCCCHHHHHHHCCHH
TAPVLYALEENKKLSVLINRELAEKDDLDEALNIIMNSKSIESSRKLAEDFAMLSKEAII
HHHHHHHHHCCCEEEEEECHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEE
WLPDSEYKRALLALPEFVLSRIY
ECCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: all-trans-octaprenyl diphosphate; isopentenyl diphosphate

Specific reaction: all-trans-octaprenyl diphosphate + isopentenyl diphosphate = diphosphate + all-trans-nonaprenyl diphosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]